Smad3 (SMAD family member 3) - Rat Genome Database

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Gene: Smad3 (SMAD family member 3) Rattus norvegicus
Analyze
Symbol: Smad3
Name: SMAD family member 3
RGD ID: 3032
Description: Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component biogenesis; and regulation of macromolecule metabolic process. Located in nucleus. Part of transcription regulator complex. Used to study cocaine dependence and pre-malignant neoplasm. Biomarker of alcoholic cardiomyopathy and alcoholic liver cirrhosis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (-)-ephedrine; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; MAD homolog 3 (Drosophila); mad3; Madh3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,022,204 - 73,132,324 (-)NCBIGRCr8
mRatBN7.2864,126,829 - 64,236,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx869,641,910 - 69,752,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,914,370 - 68,024,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,784,499 - 65,894,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Smad3Ratalcoholic cardiomyopathy  IEP 597830061protein:increased expression:heartRGD 
Smad3Ratalcoholic liver cirrhosis treatmentIEP 597830076 RGD 
Smad3RatCarotid Artery Injuries treatmentIEP 597830142 RGD 
Smad3Ratcervical squamous cell carcinoma severityISOSMAD3 (Homo sapiens)38455996 RGD 
Smad3Ratcocaine dependence amelioratesIMP 597830060 RGD 
Smad3Ratcocaine dependence amelioratesIMP 597830063 RGD 
Smad3Ratendometrial cancer  ISOSMAD3 (Homo sapiens)2299970protein:increased expression:endometriumRGD 
Smad3RatExperimental Arthritis treatmentIEP 597830147 RGD 
Smad3RatExperimental Colitis  ISOSmad3 (Mus musculus)597830080protein:increased expression:colonRGD 
Smad3RatExperimental Liver Cirrhosis treatmentIEP 151665755 RGD 
Smad3RatExperimental Liver Cirrhosis treatmentIEP 401976485 RGD 
Smad3RatHypertrophic Cicatrix treatmentIEP 597830078 RGD 
Smad3RatHypoglossal Nerve Injuries  IEP 1643227mRNA:increased expression:hypoglossal nucleusRGD 
Smad3Rathypospadias  IEP 597830139mRNA and protein:increased expression:penisRGD 
Smad3Ratlung non-small cell carcinoma  ISOSMAD3 (Homo sapiens)11074609protein:increased expression:lung (human)RGD 
Smad3RatLynch syndrome  ISOSMAD3 (Homo sapiens)1599900 RGD 
Smad3Ratmyocardial infarction amelioratesISOSmad3 (Mus musculus)401794430 RGD 
Smad3RatMyocardial Reperfusion Injury treatmentIDA 12903950 RGD 
Smad3Ratpancreatic cancer  ISOSMAD3 (Homo sapiens)5490966DNA:mutations:exonRGD 
Smad3Ratpre-malignant neoplasm  IDA 12903951protein:increased phosphorylation:liverRGD 
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Smad3RatAneurysm  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: AneurysmClinVarPMID:25741868
Smad3Rataortic aneurysm  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Aortic aneurysmClinVarPMID:25741868
Smad3Rataortic disease  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial aortopathyClinVarPMID:16199547 more ...
Smad3Rataortic dissection  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Ascending aortic dissectionClinVarPMID:20301312 more ...
Smad3Rataortic valve disease 2  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Aortic valve disease 2ClinVarPMID:28492532
Smad3RatARTERIAL DISSECTION  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Arterial dissectionClinVarPMID:25741868 and PMID:28492532
Smad3RatBloom syndrome  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
Smad3Ratcolorectal cancer  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
Smad3Ratconnective tissue disease  ISOSMAD3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21217753 more ...
Smad3Ratcoronary artery disease  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Coronary artery diseaseClinVarPMID:25741868
Smad3RatEhlers-Danlos syndrome  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndromeClinVarPMID:15350224 more ...
Smad3RatFamilial Thoracic Aortic Aneurysm 1  ISOSMAD3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:28492532
Smad3RatFamilial Thoracic Aortic Aneurysm 6  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Aortic aneurysm and familial thoracic 6ClinVarPMID:25741868
Smad3RatLoeys-Dietz syndrome  ISOSMAD3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21217753 more ...
Smad3RatLoeys-Dietz syndrome  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Loeys-Dietz syndromeClinVarPMID:21217753 more ...
Smad3RatLoeys-Dietz syndrome  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Loeys-Dietz syndromeClinVarPMID:17576681 more ...
Smad3RatLoeys-Dietz syndrome  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Loeys-Dietz syndromeClinVarPMID:16199547 more ...
Smad3RatLoeys-Dietz syndrome 3  ISOSMAD3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10092624 more ...
Smad3Ratlung cancer  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: EGFR-related lung cancerClinVarPMID:21515830 more ...
Smad3Ratneuronal ceroid lipofuscinosis  ISOSMAD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuronal ceroid lipofuscinosisClinVarPMID:28492532
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Original Reference(s)
Smad3Ratalcoholic liver cirrhosis  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23274713
Smad3Rataortic aneurysm  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21217753
Smad3RatCocaine-Related Disorders  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27422367
Smad3RatColorectal Neoplasms  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30510241
Smad3RatCraniofacial Abnormalities  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15183723 and PMID:21217753
Smad3RatCrohn's disease  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21102463
Smad3RatDissecting Aneurysm  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21217753
Smad3Ratjuvenile rheumatoid arthritis  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
Smad3Ratleiomyoma  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22228119
Smad3Ratliver cirrhosis  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21605584
Smad3RatLoeys-Dietz syndrome  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22772368
Smad3Ratosteoarthritis  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21217753 and PMID:22772368
Smad3RatOsteoarthritis, Hip  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30374069
Smad3Ratureteral obstruction  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28318631
Smad3RatUterine Neoplasms  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22228119
Smad3RatVentricular Remodeling  ISOSMAD3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16635409
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Smad3Ratosteoarthritis  ISSSmad3 (Mus musculus)13592920 MouseDO 
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Smad3RatLoeys-Dietz syndrome 3  ISOSMAD3 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Smad3Rat(-)-ephedrine increases expressionEXP 6480464Ephedrine results in increased expression of SMAD3 mRNA and Ephedrine results in increased expression of SMAD3 proteinCTDPMID:32729338
Smad3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOSMAD3 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNACTDPMID:22079256
Smad3Rat(-)-epigallocatechin 3-gallate decreases expressionISOSmad3 (Mus musculus)6480464epigallocatechin gallate results in decreased expression of SMAD3 proteinCTDPMID:34600025
Smad3Rat(-)-epigallocatechin 3-gallate increases expressionISOSmad3 (Mus musculus)6480464epigallocatechin gallate results in increased expression of SMAD3 proteinCTDPMID:35863485
Smad3Rat(R)-lipoic acid multiple interactionsISOSmad3 (Mus musculus)6480464Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein]CTDPMID:35187969
Smad3Rat(S)-nicotine multiple interactionsISOSmad3 (Mus musculus)6480464[Nicotine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Smad3Rat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of SMAD3 mRNACTDPMID:29660438
Smad3Rat(S)-nicotine multiple interactionsEXP 6480464Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 proteinCTDPMID:22691361
Smad3Rat1,2-dimethylhydrazine increases expressionISOSmad3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of SMAD3 mRNACTDPMID:22206623
Smad3Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOSmad3 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Smad3Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOSmad3 (Mus musculus)6480464[Caffeine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Smad3Rat1-O-oleoyl-sn-glycero-3-phosphocholine decreases abundanceISOSmad3 (Mus musculus)6480464SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholineCTDPMID:23034213
Smad3Rat17alpha-ethynylestradiol decreases expressionISOSmad3 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of SMAD3 mRNACTDPMID:17942748
Smad3Rat17alpha-ethynylestradiol multiple interactionsISOSmad3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNACTDPMID:17942748
Smad3Rat17beta-estradiol decreases expressionISOSMAD3 (Homo sapiens)6480464Estradiol results in decreased expression of SMAD3 mRNACTDPMID:19167446 and PMID:24758408
Smad3Rat17beta-estradiol increases expressionISOSMAD3 (Homo sapiens)6480464Estradiol results in increased expression of SMAD3 proteinCTDPMID:33181973
Smad3Rat17beta-estradiol increases expressionISOSmad3 (Mus musculus)6480464Estradiol results in increased expression of SMAD3 mRNACTDPMID:39298647
Smad3Rat17beta-estradiol decreases phosphorylationISOSMAD3 (Homo sapiens)6480464Estradiol results in decreased phosphorylation of SMAD3 proteinCTDPMID:24308608 and PMID:26407941
Smad3Rat17beta-estradiol affects expressionISOSMAD3 (Homo sapiens)6480464Estradiol affects the expression of SMAD3 mRNACTDPMID:14699072 and PMID:22574217
Smad3Rat17beta-estradiol multiple interactionsISOSMAD3 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in decreased expression of SMAD3 mRNA more ...CTDPMID:20660070 more ...

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Biological Process
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Smad3Ratactivin receptor signaling pathway involved_inISOSMAD3 (Homo sapiens)1624291 PMID:15150278RGDPMID:15150278
Smad3Ratactivin receptor signaling pathway involved_inIBAFB:FBgn0025800 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Smad3Ratactivin receptor signaling pathway involved_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratadrenal gland development  IDA 728125 RGD 
Smad3Ratanatomical structure morphogenesis involved_inIBAFB:FBgn0011648 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Smad3Ratapoptotic process acts_upstream_of_or_withinISOSmad3 (Mus musculus)1624291 PMID:19679673RGDPMID:19679673
Smad3Ratapoptotic process acts_upstream_of_or_withinIEAUniProtKB:Q8BUN5 and ensembl:ENSMUSP000000349731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratapoptotic signaling pathway involved_inISOSMAD3 (Homo sapiens)1624291 PMID:15107418RGDPMID:15107418
Smad3Ratapoptotic signaling pathway involved_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcell differentiation involved_inIBAFB:FBgn0011648 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Smad3Ratcell population proliferation acts_upstream_of_or_withinISOSmad3 (Mus musculus)1624291MGI:108051 PMID:19679673RGDPMID:19679673
Smad3Ratcell population proliferation acts_upstream_of_or_withinIEAUniProtKB:Q8BUN5 and ensembl:ENSMUSP000000349731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcell-cell junction organization involved_inISOSMAD3 (Homo sapiens)1624291 PMID:18505915RGDPMID:18505915
Smad3Ratcell-cell junction organization involved_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcellular response to glucose stimulus  IEP 401824679 RGD 
Smad3Ratcellular response to platelet-derived growth factor stimulus  IEP 597830142 RGD 
Smad3Ratcellular response to transforming growth factor beta stimulus  IEP 401794430 RGD 
Smad3Ratcellular response to transforming growth factor beta stimulus involved_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcellular response to transforming growth factor beta stimulus involved_inISOSMAD3 (Homo sapiens)1624291 PMID:12902338RGDPMID:12902338
Smad3Ratcellular response to virus involved_inISOSmad3 (Mus musculus)1624291 PMID:18802055RGDPMID:18802055
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Cellular Component
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Original Reference(s)
Smad3Ratchromatin located_inISOSMAD3 (Homo sapiens)1624291 PMID:21828274RGDPMID:21828274
Smad3Ratchromatin located_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratciliary basal body located_inISOSMAD3 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Smad3Ratciliary basal body located_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Smad3Ratcytoplasm located_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcytoplasm located_inIEAUniProtKB:Q8BUN5 and ensembl:ENSMUSP000000349731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcytoplasm located_inISOSMAD3 (Homo sapiens)1624291 PMID:12446380 more ...RGDPMID:12446380 more ...
Smad3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Smad3Ratcytoplasm located_inISOSmad3 (Mus musculus)1624291 PMID:11160896 and PMID:21145499RGDPMID:11160896 and PMID:21145499
Smad3Ratcytosol located_inISOSMAD3 (Homo sapiens)1624291UniProtKB:Q96AC1 and PMID:23723426RGDPMID:23723426
Smad3Ratcytosol located_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratheteromeric SMAD protein complex part_ofISOSMAD3 (Homo sapiens)1624291 PMID:21828274RGDPMID:21828274
Smad3Ratheteromeric SMAD protein complex part_ofIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratheteromeric SMAD protein complex part_ofIBAFB:FBgn0011648 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Smad3Ratnuclear inner membrane located_inISOSMAD3 (Homo sapiens)1624291 PMID:15647271RGDPMID:15647271
Smad3Ratnuclear inner membrane located_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratnucleoplasm located_inIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratnucleoplasm located_inISOSMAD3 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Smad3Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Smad3Ratbeta-catenin binding enablesIDA 11079190PMID:20097766BHF-UCL 
Smad3RatbHLH transcription factor binding enablesISOSMAD3 (Homo sapiens)1624291UniProtKB:Q99081 and PMID:21828274RGDPMID:21828274
Smad3RatbHLH transcription factor binding enablesIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratchromatin binding enablesISOSmad3 (Mus musculus)1624291 PMID:16619037RGDPMID:16619037
Smad3Ratchromatin binding enablesIEAUniProtKB:Q8BUN5 and ensembl:ENSMUSP000000349731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratchromatin DNA binding enablesISOSmad3 (Mus musculus)1624291 PMID:16224064RGDPMID:16224064
Smad3Ratchromatin DNA binding enablesIEAUniProtKB:Q8BUN5 and ensembl:ENSMUSP000000349731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcis-regulatory region sequence-specific DNA binding enablesISSUniProtKB:P840221600115GO_REF:0000024UniProtGO_REF:0000024
Smad3Ratcis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcis-regulatory region sequence-specific DNA binding enablesISOSMAD3 (Homo sapiens)1624291 PMID:21947082 and PMID:32141990RGDPMID:21947082 and PMID:32141990
Smad3Ratco-SMAD binding enablesISOSMAD3 (Homo sapiens)1624291UniProtKB:Q13485 more ...RGDPMID:8774881 more ...
Smad3Ratco-SMAD binding enablesIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcollagen binding enablesIEAUniProtKB:Q8BUN5 and ensembl:ENSMUSP000000349731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3Ratcollagen binding enablesISOSmad3 (Mus musculus)1624291PR:P08121 more ...RGDPMID:14559231
Smad3RatDEAD/H-box RNA helicase binding enablesISOSMAD3 (Homo sapiens)1624291UniProtKB:P17844 and PMID:18548003RGDPMID:18548003
Smad3RatDEAD/H-box RNA helicase binding enablesIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3RatDNA binding enablesISOSMAD3 (Homo sapiens)1624291 PMID:28467929RGDPMID:28467929
Smad3RatDNA binding enablesIEAUniProtKB:P84022 and ensembl:ENSP000003329731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3RatDNA binding enablesIEAUniProtKB:Q8BUN5 and ensembl:ENSMUSP000000349731600115GO_REF:0000107EnsemblGO_REF:0000107
Smad3RatDNA binding enablesISOSmad3 (Mus musculus)1624291 PMID:27336669RGDPMID:27336669
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Imported Annotations - KEGG (archival)

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Smad3Ratcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
Smad3Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Smad3RatChagas disease pathway  IEA 6907045 KEGGrno:05142
Smad3Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Smad3Ratcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
Smad3Ratendocytosis pathway  IEA 6907045 KEGGrno:04144
Smad3Ratpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
Smad3Rattransforming growth factor-beta superfamily mediated signaling pathway  IEA 6907045 KEGGrno:04350
Smad3RatWnt signaling pathway  IEA 6907045 KEGGrno:04310
1 to 9 of 9 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Smad3Rathypoxia inducible factor pathway   ISOSMAD3 (Homo sapiens)6484113 PIDPID:200202
Smad3Rattransforming growth factor-beta Smad dependent signaling pathway   ISOSMAD3 (Homo sapiens)6484113 PIDPID:200227
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Smad3Ratliver fibrosis  IDA 2300428 RGD 

1 to 20 of 64 rows
#
Reference Title
Reference Citation
1. Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. Aoki H, etal., Am J Physiol Cell Physiol. 2006 Apr;290(4):C1100-8. Epub 2005 Dec 21.
2. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
3. Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins. Chen Y, etal., Proc Natl Acad Sci U S A 1996 Nov 12;93(23):12992-7.
4. Gene expression profiling in the hippocampus of adolescent rats after chronic alcohol administration. Choi MR, etal., Basic Clin Pharmacol Toxicol. 2020 Apr;126(4):389-398. doi: 10.1111/bcpt.13342. Epub 2019 Nov 15.
5. Cited2 modulates TGF-beta-mediated upregulation of MMP9. Chou YT, etal., Oncogene. 2006 Sep 7;25(40):5547-60. Epub 2006 Apr 17.
6. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
7. Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats. Elkiki SM, etal., Toxicol Mech Methods. 2021 Sep;31(7):538-545. doi: 10.1080/15376516.2021.1934765. Epub 2021 Jun 21.
8. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
9. p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Furukawa F, etal., Hepatology. 2003 Oct;38(4):879-89.
10. Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity. Gancarz AM, etal., Nat Neurosci. 2015 Jul;18(7):959-61. doi: 10.1038/nn.4036. Epub 2015 Jun 1.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. Gressner OA, etal., J Hepatol. 2008 Nov;49(5):758-67. Epub 2008 Apr 30.
13. Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Hara S, etal., Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34. doi: 10.1016/j.etp.2014.02.002. Epub 2014 Mar 26.
14. Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Hu B, etal., Am J Respir Cell Mol Biol 2003 Sep;29(3 Pt 1):397-404. Epub 2003 Apr 17.
15. Gut-enriched Kruppel-like factor interaction with Smad3 inhibits myofibroblast differentiation. Hu B, etal., Am J Respir Cell Mol Biol. 2007 Jan;36(1):78-84. Epub 2006 Jul 20.
16. Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFbeta. Hu B, etal., Oncogene. 2006 Feb 16;25(7):1030-41.
17. Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-beta Induced Smad3 activation in vascular smooth muscle cell. Huang D, etal., PLoS One. 2011;6(10):e27123. doi: 10.1371/journal.pone.0027123. Epub 2011 Oct 31.
18. [Expression of tenascin-X in alcoholic cardiomyopathy and relation thereof to myocardial fibrosis: experiment with rats]. Jing L, etal., Zhonghua Yi Xue Za Zhi. 2008 Sep 23;88(36):2570-3.
19. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
20. S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model. Karaa A, etal., Shock. 2008 Aug;30(2):197-205. doi: 10.1097/shk.0b013e318160f417.
1 to 20 of 64 rows
1 to 10 of 17 rows
PMID:8774881   PMID:9111321   PMID:9311995   PMID:9679056   PMID:9702197   PMID:9732876   PMID:9759503   PMID:10064594   PMID:10559937   PMID:10647776   PMID:10708948   PMID:10708949  
PMID:10823886   PMID:11160896   PMID:11278251   PMID:11585338   PMID:11711431   PMID:11937490   PMID:12411310   PMID:12446380   PMID:12543979   PMID:12686552   PMID:12845704   PMID:12874272  
PMID:12876289   PMID:12902338   PMID:12943993   PMID:14555988   PMID:14559231   PMID:14617288   PMID:14623893   PMID:14656760   PMID:14754879   PMID:15084457   PMID:15107418   PMID:15150273  
PMID:15150278   PMID:15183723   PMID:15239668   PMID:15282343   PMID:15326485   PMID:15334054   PMID:15464984   PMID:15489334   PMID:15647271   PMID:15761025   PMID:15799969   PMID:16007207  
PMID:16224064   PMID:16266486   PMID:16696323   PMID:16751101   PMID:16777850   PMID:16785237   PMID:16807527   PMID:16824956   PMID:16886151   PMID:16931807   PMID:16980030   PMID:17038494  
PMID:17159989   PMID:17215516   PMID:17251190   PMID:17392319   PMID:17541159   PMID:17723189   PMID:18022758   PMID:18057996   PMID:18395914   PMID:18466073   PMID:18505915   PMID:18548003  
PMID:18679024   PMID:18729074   PMID:18794808   PMID:18832382   PMID:19122240   PMID:19197123   PMID:19525370   PMID:19555739   PMID:19667256   PMID:19816956   PMID:19834880   PMID:19959709  
PMID:20129061   PMID:20182310   PMID:20226149   PMID:20375011   PMID:20404057   PMID:20423827   PMID:20739403   PMID:20874717   PMID:20943464   PMID:21035443   PMID:21158069   PMID:21307346  
PMID:21354414   PMID:21429339   PMID:21468608   PMID:21498085   PMID:21560355   PMID:21724602   PMID:21749980   PMID:21828274   PMID:21852586   PMID:21937600   PMID:21947082   PMID:22045334  
PMID:22338217   PMID:22384127   PMID:22447946   PMID:22674034   PMID:22926646   PMID:23056222   PMID:23064763   PMID:23176567   PMID:23291610   PMID:23390484   PMID:23403244   PMID:23690627  
1 to 10 of 17 rows



Smad3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,022,204 - 73,132,324 (-)NCBIGRCr8
mRatBN7.2864,126,829 - 64,236,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx869,641,910 - 69,752,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,914,370 - 68,024,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,784,499 - 65,894,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
SMAD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381567,065,602 - 67,195,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1567,063,763 - 67,195,173 (+)EnsemblGRCh38hg38GRCh38
GRCh371567,357,940 - 67,487,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,145,249 - 65,274,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 341565,145,248 - 65,274,586NCBI
Celera1544,246,635 - 44,375,039 (+)NCBICelera
Cytogenetic Map15q22.33NCBI
HuRef1544,193,465 - 44,321,904 (+)NCBIHuRef
CHM1_11567,476,260 - 67,605,488 (+)NCBICHM1_1
T2T-CHM13v2.01564,885,345 - 65,017,070 (+)NCBIT2T-CHM13v2.0
Smad3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)EnsemblGRCm39 Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBIMGSCv36mm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.22NCBI
Smad3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBIChiLan1.0ChiLan1.0
SMAD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21656,319,096 - 56,448,455 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11560,491,695 - 60,621,061 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11564,284,949 - 64,414,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)Ensemblpanpan1.1panPan2
SMAD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,246,313 - 31,360,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,245,657 - 31,363,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3031,175,971 - 31,289,442 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03031,444,224 - 31,557,937 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3031,444,224 - 31,561,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13031,371,657 - 31,485,227 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03031,431,846 - 31,545,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,673,713 - 31,787,293 (+)NCBIUU_Cfam_GSD_1.0
Smad3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,232,767 - 109,341,735 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647127,080,575 - 27,189,793 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,998,103 - 165,124,449 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,998,457 - 165,124,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,902,348 - 182,926,370 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12616,319,959 - 16,446,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2616,320,933 - 16,446,527 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048125,021,354 - 125,151,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247815,795,652 - 5,890,371 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247815,795,652 - 5,890,047 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Smad3
484 total Variants

Predicted Target Of
Summary Value
Count of predictions:512
Count of miRNA genes:253
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000039730
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 55 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat

1 to 10 of 55 rows
Madh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,236,564 - 64,236,759 (+)MAPPERmRatBN7.2
Rnor_6.0868,677,954 - 68,678,148NCBIRnor6.0
Rnor_5.0868,397,332 - 68,397,526UniSTSRnor5.0
RGSC_v3.4867,951,661 - 67,951,855UniSTSRGSC3.4
Celera863,646,667 - 63,646,861UniSTS
Cytogenetic Map8q24UniSTS
RH130799  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,235,228 - 64,235,441 (+)MAPPERmRatBN7.2
Rnor_6.0868,676,610 - 68,676,822NCBIRnor6.0
Rnor_5.0868,396,418 - 68,396,630UniSTSRnor5.0
RGSC_v3.4867,950,063 - 67,950,275UniSTSRGSC3.4
Celera863,645,365 - 63,645,577UniSTS
RH 3.4 Map8810.0UniSTS
Cytogenetic Map8q24UniSTS
RH143351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,162,995 - 64,163,140 (+)MAPPERmRatBN7.2
Rnor_6.0868,605,604 - 68,605,748NCBIRnor6.0
Rnor_5.0868,327,124 - 68,327,268UniSTSRnor5.0
RGSC_v3.4867,856,537 - 67,856,681UniSTSRGSC3.4
Celera863,573,666 - 63,573,810UniSTS
RH 3.4 Map8805.0UniSTS
Cytogenetic Map8q24UniSTS
RH143448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,126,996 - 64,127,126 (+)MAPPERmRatBN7.2
Rnor_6.0868,569,698 - 68,569,827NCBIRnor6.0
Rnor_5.0868,291,095 - 68,291,224UniSTSRnor5.0
RGSC_v3.4867,820,872 - 67,821,001UniSTSRGSC3.4
Celera863,537,665 - 63,537,794UniSTS
RH 3.4 Map8809.9UniSTS
Cytogenetic Map8q24UniSTS
RH138729  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,126,876 - 64,127,014 (+)MAPPERmRatBN7.2
Rnor_6.0868,569,578 - 68,569,715NCBIRnor6.0
Rnor_5.0868,290,975 - 68,291,112UniSTSRnor5.0
RGSC_v3.4867,820,752 - 67,820,889UniSTSRGSC3.4
Celera863,537,545 - 63,537,682UniSTS
RH 3.4 Map8810.0UniSTS
Cytogenetic Map8q24UniSTS
PE5L-LSB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,216,656 - 64,217,035 (+)MAPPERmRatBN7.2
Rnor_6.0868,658,300 - 68,658,678NCBIRnor6.0
Rnor_5.0868,379,536 - 68,379,914UniSTSRnor5.0
RGSC_v3.4867,931,905 - 67,932,283UniSTSRGSC3.4
Celera863,626,945 - 63,627,323UniSTS
Cytogenetic Map8q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000039730   ⟹   ENSRNOP00000037346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)Ensembl
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099327   ⟹   ENSRNOP00000081624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,110,039 - 64,181,174 (-)Ensembl
RefSeq Acc Id: NM_013095   ⟹   NP_037227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,132,324 (-)NCBI
mRatBN7.2864,126,829 - 64,236,960 (-)NCBI
Rnor_6.0868,569,530 - 68,678,349 (-)NCBI
Rnor_5.0868,290,927 - 68,397,727 (-)NCBI
RGSC_v3.4867,803,909 - 67,952,056 (-)RGD
Celera863,537,497 - 63,647,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008766216   ⟹   XP_008764438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,042,099 (-)NCBI
mRatBN7.2864,126,829 - 64,146,730 (-)NCBI
Rnor_6.0868,569,530 - 68,589,751 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080896   ⟹   XP_038936824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,078,810 (-)NCBI
mRatBN7.2864,126,829 - 64,183,523 (-)NCBI
RefSeq Acc Id: XM_039080897   ⟹   XP_038936825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,099,691 (-)NCBI
mRatBN7.2864,126,829 - 64,191,240 (-)NCBI
1 to 12 of 12 rows
Protein RefSeqs NP_037227 (Get FASTA)   NCBI Sequence Viewer  
  XP_008764438 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936824 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936825 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52944 (Get FASTA)   NCBI Sequence Viewer  
  AAH64437 (Get FASTA)   NCBI Sequence Viewer  
  ABD66605 (Get FASTA)   NCBI Sequence Viewer  
  EDL95777 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037346
  ENSRNOP00000037346.3
  ENSRNOP00000081624
GenBank Protein P84025 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
RefSeq Acc Id: NP_037227   ⟸   NM_013095
- UniProtKB: P84025 (UniProtKB/Swiss-Prot),   A6J5A4 (UniProtKB/TrEMBL),   A0A8I5ZS20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764438   ⟸   XM_008766216
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000037346   ⟸   ENSRNOT00000039730
RefSeq Acc Id: XP_038936825   ⟸   XM_039080897
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZS20 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936824   ⟸   XM_039080896
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS20 (UniProtKB/TrEMBL)
MH1   MH2

Name Modeler Protein Id AA Range Protein Structure
AF-P84025-F1-model_v2 AlphaFold P84025 1-425 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696062
Promoter ID:EPDNEW_R6587
Type:multiple initiation site
Name:Smad3_1
Description:SMAD family member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0868,678,414 - 68,678,474EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-30124 BioCyc
Ensembl Genes ENSRNOG00000008620 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039730 ENTREZGENE
  ENSRNOT00000039730.5 UniProtKB/Swiss-Prot
  ENSRNOT00000099327 ENTREZGENE
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot
  3.90.520.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599910 IMAGE-MGC_LOAD
InterPro Dwarfin UniProtKB/Swiss-Prot
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot
  MAD_homology_MH1 UniProtKB/Swiss-Prot
  SMAD-like_dom_sf UniProtKB/Swiss-Prot
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot
  SMAD_MH1_sf UniProtKB/Swiss-Prot
KEGG Report rno:25631 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72529 IMAGE-MGC_LOAD
NCBI Gene 25631 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3 UniProtKB/Swiss-Prot
  PTHR13703 UniProtKB/Swiss-Prot
Pfam MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
PhenoGen Smad3 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008620 RatGTEx
SMART DWA UniProtKB/Swiss-Prot
  DWB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot
  SSF56366 UniProtKB/Swiss-Prot
TIGR TC221903
UniProt A0A8I5ZS20 ENTREZGENE, UniProtKB/TrEMBL
  A6J5A4 ENTREZGENE, UniProtKB/TrEMBL
  P84025 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O09064 UniProtKB/Swiss-Prot
  O09144 UniProtKB/Swiss-Prot
  O14510 UniProtKB/Swiss-Prot
  O35273 UniProtKB/Swiss-Prot
  Q92940 UniProtKB/Swiss-Prot
  Q93002 UniProtKB/Swiss-Prot
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Smad3  SMAD family member 3  Smad3  MAD homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Smad3  MAD homolog 3 (Drosophila)  Madh3    Symbol updated 1299863 APPROVED
2002-06-10 Madh3  MAD homolog 3 (Drosophila)      Name updated 70584 APPROVED

Note Type Note Reference
gene_cellular_localization translocated to the nucleus 727374
gene_disease may be involved in pulmonary fibrosis 625421
gene_drugs bleomycin at a dose of 9U/kg body weight causes down regulation of mRNA 625421
gene_process an essential downstream intracellular target of the TGF-beta receptor signaling pathway 625421
gene_process plays an important role in osteoblastic bone formation 727387
gene_process involved in folliculogenesis 727374
gene_product member of the family of Smad proteins 625421
gene_regulation phosphorylated by activated TGF-beta type 1 receptor which induces the translocation of the protein from the cytoplasm to the nucleus 625421