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 Gene Ontology

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Gene:
Prkcd ( Rattus norvegicus )
protein kinase C, delta
Description:a calcium-independent protein kinase, involved in MAPK signaling under many physiological and pathological conditions
Synonyms:Pkcd;  (details...)
ArrayIDs:6192260; 6482999; 6081765; 6202077; 6200098; 5905631; 6261296; 6559632; 6410418; M18330_at; 5988845; 5899357; 1387114_at; 6064478; A_42_P786924; 6197456; 6012340; A_44_P451071; 6161829; 6564496; M18330_g_at; 6280818; 6636206; 6132750; 5996262; 5805466; 5878674; 6688884; 6604913; 6241087;  (details...)
Gene Type:protein-coding
 
Additional Data
 
Homologs
Homo sapiens: PRKCD     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Prkcd     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusPrkcdgenome assembly 3.1165954214 - 5975741
  Rat Celera Assembly169398818 - 9419817
  RGSC genome assembly v3.4165954206 - 5975743
  Cytogenetic16p16
Mus musculusPrkcdMouse genome assembly build 36.11431408555 - 31431737
  Cytogenetic1414 B
Homo sapiensPRKCDhuman genome assembly353170262 - 53201771
  Human genome assembly build 36.2353170263 - 53201773
  Cytogenetic3p21.31
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
 
 Annotation
Molecular Function
NoteReference
binds phorbol esters61695, 628336
Gene Ontology
protein binding,  protein C-terminus binding,  enzyme activator activity ...  (details...)
Biological Process
NoteReference
involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain shedding upon TPA stimulation61695, 628336
Gene Ontology
cellular response to glucose starvation,  senescence,  positive regulation of apoptosis ...  (details...)
Cellular Component
NoteReference
translocates from cytosol into the nucleus upon treatment with etoposide; Intralipid + heparin (IH) induces translocation from the cytosolic to membrane fraction729633, 729667
Gene Ontology
nucleus,  mitochondrion,  cytoplasm ...  (details...)
Disease
Ontology
Brain Ischemia,  Myocardial Reperfusion Injury,  Hypertrophy, Left Ventricular ...  (details...)
Expression
NoteReference
expressed in pancreatic acini631304
Pathway
NoteReference
activation by the digitalis drug ouabain is linked to Na+/K+-ATPase through Src/EGFR, and is required for the activation of ERK1/2631304
Ontology
vascular endothelial growth factor signaling pathway,  the extracellular signal-regulated Raf/Mek/Erk signaling pathway (details...)
Regulation
NoteReference
tyrosine phosphorylation results in increased instability leading to degradation631304
administration of the digitalis drug ouabain with intact cardiac myocytes causes rapid translocation/activation from the soluble to the particulate pools of enzymes631304
protein is tyrosine phosphorylated by activated Cholecystokinin A receptor (Cckar) in pancreatic acinar cells631304
maximal activation requires phosphatidylserine and diacylglycerol61695, 628336
 
 External Links
Databases
DATABASEIDSOURCE
SMART:S_TKcIPI
SMART:S_TK_XIPI
SMART:C2IPI
SMART:C1IPI
PROSITE:ZF_DAG_PE_2IPI
PROSITE:ZF_DAG_PE_1IPI
PROSITE:PROTEIN_KINASE_STIPI
PROSITE:PROTEIN_KINASE_DOMIPI
PROSITE:PROTEIN_KINASE_ATPIPI
PROSITE:AGC_KINASE_CTERIPI
UNIPARC:UPI0001B79E2FIPI
UNIPARC:UPI000012DF6AIPI
UNIPARC:UPI0001B79E2EIPI
UNIPARC:UPI000002ACFCIPI
UNIPARC:UPI0001B79E30IPI
KEGG Report:rno:170538ENTREZGENE
HomoloGene Group ID:55963ENTREZGENE
Germonline:67383
Pfam:Pkinase_CIPI
Pfam:PkinaseIPI
Pfam:C1_1IPI
KEGG Pathway:04930ENTREZGENE
KEGG Pathway:04530ENTREZGENE
KEGG Pathway:04912ENTREZGENE
KEGG Pathway:04664ENTREZGENE
InterPro:Ser/Thr_prot_kinase_dom.IPI
InterPro:Ser/Thr_prot_kinase_AS.IPI
InterPro:Se/Thr_prot_kinase-like_dom.IPI
InterPro:Protein_kinase_ATP_BS.IPI
InterPro:Prot_kinase_cat_dom.IPI
InterPro:Prot_Kinase_C-like_PE/DAG_bd.IPI
InterPro:Prot_kin_PKC_delta.IPI
InterPro:Pkinase_C.IPI
InterPro:PKC.IPI
InterPro:Kinase-like_dom.IPI
InterPro:DAG/PE_bd.IPI
InterPro:C2_Ca/lipid-bd_reg_CaLB.IPI
InterPro:C2_Ca-dep.IPI
InterPro:AGC-kinase_C.IPI
Ensembl Protein:ENSRNOP00000060298IPI
Ensembl Protein:ENSRNOP00000025858IPI
Ensembl Protein:ENSRNOP00000022279IPI
Ensembl Protein:ENSRNOP00000050007IPI
Ensembl Protein:ENSRNOP00000061108IPI
IPI:IPI00949064IPI
IPI:IPI00212816IPI
IPI:IPI00563745IPI
IPI:IPI00231534IPI
IPI:IPI00951695IPI
Entrez Gene:PrkcdENTREZGENE
PIRSF:PKC_deltaIPI
IMAGE_CLONE:IMAGE:7099952IMAGE-MGC_LOAD
MGC_CLONE:MGC:91512IMAGE-MGC_LOAD
Ensembl Genes:ENSRNOG00000016346IPI
UniProt:KPCD_RATIPI
UniProt:KPCD_RATIPI
Superfamily-SCOP:Kinase_likeIPI
Superfamily-SCOP:C2_CaLBIPI
PANTHER:PKCIPI
BIND:134041
PRINTS:DAGPEDOMAIN.IPI
Sequences
Nucleotide:AJ230615Get FASTASearch GEO Profiles
Nucleotide:BC076505Get FASTASearch GEO Profiles
Nucleotide:AF219629Get FASTASearch GEO Profiles
Nucleotide:CH474046Get FASTASearch GEO Profiles
Nucleotide:AJ230633Get FASTASearch GEO Profiles
Nucleotide:AJ230632Get FASTASearch GEO Profiles
Nucleotide:AJ230631Get FASTASearch GEO Profiles
Nucleotide:AJ230630Get FASTASearch GEO Profiles
Nucleotide:AJ230629Get FASTASearch GEO Profiles
Nucleotide:AJ230628Get FASTASearch GEO Profiles
Nucleotide:AJ230627Get FASTASearch GEO Profiles
Nucleotide:AJ230626Get FASTASearch GEO Profiles
Nucleotide:AJ230625Get FASTASearch GEO Profiles
Nucleotide:AJ230624Get FASTASearch GEO Profiles
Nucleotide:AJ230623Get FASTASearch GEO Profiles
Nucleotide:AJ230622Get FASTASearch GEO Profiles
Nucleotide:AJ230621Get FASTASearch GEO Profiles
Nucleotide:AJ230620Get FASTASearch GEO Profiles
Nucleotide:AJ230619Get FASTASearch GEO Profiles
Nucleotide:AJ230618Get FASTASearch GEO Profiles
Nucleotide:AJ230617Get FASTASearch GEO Profiles
Nucleotide:AJ230616Get FASTASearch GEO Profiles
Nucleotide:M18330Get FASTASearch GEO Profiles
Nucleotide:NM_133307Get FASTASearch GEO Profiles
(View all 24 Nucleotide Accessions)
Protein:P09215Get FASTA
Protein:AAA41871Get FASTA
Protein:AAH76505Get FASTA
Protein:AAF32345Get FASTA
Protein:EDL88989Get FASTA
Protein:EDL88988Get FASTA
Protein:EDL88987Get FASTA
Protein:CAB75578Get FASTA
Protein:NP_579841Get FASTA
(View all 9 Protein Accessions)
Clusters
UniGene:98279
 
 References
Curated References
49 references in RGD related to Prkcd
Other References
125 other references at PubMed related to Prkcd
 
 Database Information
RGD ID67383
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
10-JUN-02: Prkcd protein kinase C, delta APPROVED Symbol and Name status set to approved 70586

       

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