Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67383
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkcd
Name: protein kinase C, delta
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcdaffects localizationEXP 6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD proteinPMID:12755590 PMID:14678745
Prkcdmultiple interactionsEXP 6480464CTD1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]; calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]; Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of and affects the localization of PRKCD proteinPMID:14678745 PMID:16361709
Prkcdaffects localizationISOPRKCD (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD proteinPMID:15976015 PMID:18628248 PMID:20599481 PMID:21705328 PMID:22245252 PMID:29669290 PMID:30133131 PMID:9852137
Prkcdaffects phosphorylationISOPRKCD (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate affects the phosphorylation of PRKCD proteinPMID:15380616
Prkcddecreases expressionISOPRKCD (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in decreased expression of PRKCD proteinPMID:15949478 PMID:18313772
Prkcdincreases activityISOPRKCD (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased activity of PRKCD proteinPMID:23288142
Prkcdincreases activityISOPrkcd (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased activity of PRKCD proteinPMID:10567579
Prkcdincreases localizationISOPrkcd (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased localization of PRKCD proteinPMID:10656618
Prkcdincreases phosphorylationISOPRKCD (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD proteinPMID:15707588 PMID:20599481 PMID:21354279
Prkcdmultiple interactionsISOPRKCD (Homo sapiens)6480464CTD2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKCD protein]; 3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]; 3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]; [Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased phosphorylation of PRKCD protein; bisindolylmaleimide I affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKCD protein]; Docosahexaenoic Acids inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCD protein]; epigallocatechin gallate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein]; Oils, Volatile inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased phosphorylation of PRKCD protein]; Plant Oils inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased phosphorylation of PRKCD protein]; PRKCD protein affects the susceptibility to [Tetradecanoylphorbol Acetate co-treated with benz(a)anthracene]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of PRKCD protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein]; Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of PRKCD proteinPMID:11424089 PMID:15380616 PMID:18628248 PMID:20599481 PMID:22245252 PMID:22643241 PMID:23288142 PMID:23333628 PMID:23941771
Prkcdmultiple interactionsISOPrkcd (Mus musculus)6480464CTDPRKCD protein promotes the reaction [[Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of STAR protein] which results in increased abundance of Progesterone]; PRKCD protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA]; PRKCD protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR protein]; Tetradecanoylphorbol Acetate promotes the reaction [Quercetin affects the localization of PRKCD protein]; Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of PRKCD proteinPMID:15538571 PMID:21047949
Go Back to source page   Continue to Ontology report