Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	67383
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Prkcd
Name:	protein kinase C, delta

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Prkcd	increases cleavage	EXP		6480464	CTD	Cisplatin results in increased cleavage of PRKCD protein	PMID:19578154
Prkcd	affects expression	ISO	PRKCD (Homo sapiens)	6480464	CTD	Cisplatin affects the expression of PRKCD mRNA	PMID:23300844
Prkcd	increases cleavage	ISO	Prkcd (Mus musculus)	6480464	CTD	Cisplatin results in increased cleavage of PRKCD protein	PMID:21633170
Prkcd	increases expression	ISO	PRKCD (Homo sapiens)	6480464	CTD	Cisplatin results in increased expression of PRKCD mRNA	PMID:27392435
Prkcd	increases localization	ISO	Prkcd (Mus musculus)	6480464	CTD	Cisplatin results in increased localization of PRKCD protein	PMID:21633170
Prkcd	increases response to substance	ISO	Prkcd (Mus musculus)	6480464	CTD	PRKCD results in increased susceptibility to Cisplatin	PMID:21633170
Prkcd	multiple interactions	ISO	PRKCD (Homo sapiens)	6480464	CTD	[Cisplatin co-treated with jinfukang] results in increased expression of PRKCD mRNA	PMID:27392435
Prkcd	multiple interactions	ISO	Prkcd (Mus musculus)	6480464	CTD	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Cisplatin promotes the reaction [SRC protein binds to PRKCD protein]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of PRKCD protein]; [Cisplatin promotes the reaction [SRC protein binds to PRKCD protein]] which results in increased activity of PRKCD protein; AG 1879 inhibits the reaction [Cisplatin promotes the reaction [SRC protein binds to PRKCD protein]]; AG 1879 inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of PRKCD protein]; Cisplatin promotes the reaction [SRC protein binds to PRKCD protein]; Cisplatin results in increased phosphorylation of and results in increased activity of PRKCD protein; PRKCD affects the reaction [Cisplatin results in increased activity of MAPK1 protein]; PRKCD affects the reaction [Cisplatin results in increased activity of MAPK3 protein]	PMID:21633170

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