RGD Reference Report - Protein kinase C: poised to signal. - Rat Genome Database

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Protein kinase C: poised to signal.

Authors: Newton, AC 
Citation: Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
RGD ID: 5131489
Pubmed: PMID:19934406   (View Abstract at PubMed)
PMCID: PMC2838521   (View Article at PubMed Central)
DOI: DOI:10.1152/ajpendo.00477.2009   (Journal Full-text)

Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are poised to transduce signals emanating from the cell surface. Cell membranes provide the platform for PKC function, supporting the maturation of PKC through phosphorylation, its allosteric activation by binding specific lipids, and, ultimately, promoting the downregulation of the enzyme. These regulatory mechanisms precisely control the level of signaling-competent PKC in the cell. Disruption of this regulation results in pathophysiological states, most notably cancer, where PKC levels are often grossly altered. This review introduces the PKC family and then focuses on recent advances in understanding the cellular regulation of its diacylglycerol-regulated members.

Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Cdc37  (cell division cycle 37, HSP90 cochaperone)
Hsp90aa1  (heat shock protein 90 alpha family class A member 1)
Pdpk1  (3-phosphoinositide dependent protein kinase-1)
Prkca  (protein kinase C, alpha)
Prkcb  (protein kinase C, beta)
Prkcd  (protein kinase C, delta)
Prkce  (protein kinase C, epsilon)
Prkcg  (protein kinase C, gamma)
Prkch  (protein kinase C, eta)
Prkci  (protein kinase C, iota)
Prkcq  (protein kinase C, theta)
Prkcz  (protein kinase C, zeta)

Genes (Mus musculus)
Cdc37  (cell division cycle 37)
Hsp90aa1  (heat shock protein 90, alpha (cytosolic), class A member 1)
Pdpk1  (3-phosphoinositide dependent protein kinase 1)
Prkca  (protein kinase C, alpha)
Prkcb  (protein kinase C, beta)
Prkcd  (protein kinase C, delta)
Prkce  (protein kinase C, epsilon)
Prkcg  (protein kinase C, gamma)
Prkch  (protein kinase C, eta)
Prkci  (protein kinase C, iota)
Prkcq  (protein kinase C, theta)
Prkcz  (protein kinase C, zeta)

Genes (Homo sapiens)
CDC37  (cell division cycle 37, HSP90 cochaperone)
HSP90AA1  (heat shock protein 90 alpha family class A member 1)
PDPK1  (3-phosphoinositide dependent protein kinase 1)
PRKCA  (protein kinase C alpha)
PRKCB  (protein kinase C beta)
PRKCD  (protein kinase C delta)
PRKCE  (protein kinase C epsilon)
PRKCG  (protein kinase C gamma)
PRKCH  (protein kinase C eta)
PRKCI  (protein kinase C iota)
PRKCQ  (protein kinase C theta)
PRKCZ  (protein kinase C zeta)


Additional Information