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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67383
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkcd
Name: protein kinase C, delta
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcdaffects expressionISOPRKCD (Homo sapiens)6480464CTDTretinoin affects the expression of PRKCD mRNA alternative formPMID:17017122
Prkcddecreases expressionISOPRKCD (Homo sapiens)6480464CTDTretinoin results in decreased expression of PRKCD mRNAPMID:23724009
Prkcdincreases expressionISOPRKCD (Homo sapiens)6480464CTDTretinoin results in increased expression of PRKCD mRNA; Tretinoin results in increased expression of PRKCD proteinPMID:15498508 PMID:16322068 PMID:21393419 PMID:33167477
Prkcdmultiple interactionsISOPRKCD (Homo sapiens)6480464CTD[Tretinoin co-treated with CNTF protein] results in increased expression of PRKCD mRNA alternative form; PRKCD mutant form inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]; PRKCD protein affects the reaction [Tretinoin results in increased activity of STS protein]PMID:16178010 PMID:17017122 PMID:21393419
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