PROTEIN KINASE C (PKC) SIGNALING PATHWAY (PW:0000840)

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Description

The protein kinase C family (PKC) comprises ~2% of the human kinome and can be subdivided into three subclasses: conventional or classical (cPKC), novel (nPKC) and atypical (aPKC). All isoforms contain a C-terminal kinase domain and an N-terminal autoinhibitory pseudosubstrate but differ in their responsiveness to second messengers. A tandem DAG-sensitive C1 domain is present in cPKC and nPKC with the latter group displaying a higher sensitivity. The C2 domain is Ca2+ sensitive in cPKC only. The

Pathway Diagram:

Elsevier Inc. Ca2+ calcium transport pathway GPCRs upstream PKC G protein mediated signaling pathway via Galphaq family Phlpp1 ---| cPKC cPKC Phlpp1 ---| nPKC Phlpp2 ---| nPKC Phlpp2 ---| cPKC Pdpk1 --+> nPKC Pdpk1 --+> cPKC Pdpk1 --+> aPKC GPCRs upstream PKC --+> PLC-B members PLC-B members Phlpp1 Phlpp2 Pdpk1 Hsp90aa1 Cdc37 IP3 PKC interactors aPKC nPKC cPKC ---- PKC interactors nPKC ---- PKC interactors aPKC ---- PKC interactors Cdc37 ---- nPKC Cdc37 ---- cPKC Ca2+ ---- cPKC Hsp90aa1 ---- nPKC cPKC ---- Hsp90aa1 cPKC ---- DAG DAG ---- nPKC PIP2 ---> DAG PIP2 DAG PIP2 ---> IP3 cell polarity cell death cell proliferation cell differentiation cPKC ---> cell differentiation cPKC ---> cell proliferation nPKC ---> cell proliferation IP3 --+> Ca2+ calcium/calcium-mediated signaling pathway nPKC ---> cell death aPKC ---> cell polarity cPKC ---> cell death nPKC ---> cell differentiation
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Genes in Pathway:

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protein kinase C (PKC) signaling pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Btk Bruton agammaglobulinemia tyrosine kinase GBrowse link X 105,250,666 105,279,934 RGD:5131492
G Cdc37 cell division cycle 37 GBrowse link 8 22,217,096 22,229,971 RGD:5131489
G Copb1 coatomer protein complex, subunit beta 1 GBrowse link 1 190,670,320 190,704,834 RGD:5131491
G Fscn1 fascin actin-bundling protein 1 GBrowse link 12 15,688,989 15,702,125 RGD:5131492
G Fyn FYN proto-oncogene, Src family tyrosine kinase GBrowse link 20 46,160,734 46,353,456 RGD:5131492
G Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 GBrowse link 10 33,920,259 33,939,101 RGD:5131491
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 GBrowse link 6 144,182,009 144,187,540 RGD:5131489
G Lck LCK proto-oncogene, Src family tyrosine kinase GBrowse link 5 151,480,214 151,509,064 RGD:5131492
G Ldb3 LIM domain binding 3 GBrowse link 16 9,203,392 9,267,999 RGD:5131491
RGD:5131492
G Pard3 par-3 family cell polarity regulator GBrowse link 19 70,690,939 71,249,213 RGD:5132275
G Pard6a par-6 family cell polarity regulator alpha GBrowse link 19 48,534,837 48,537,154 RGD:5132275
G Pard6b par-6 family cell polarity regulator beta GBrowse link 3 170,968,975 170,990,259 RGD:5132275
G Pard6g par-6 family cell polarity regulator gamma GBrowse link 18 72,178,893 72,246,274 RGD:5132275
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link 10 13,262,177 13,339,277 RGD:5131489
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 GBrowse link 13 31,302,241 31,550,366 RGD:5131497
RGD:8693633
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 GBrowse link 19 52,555,245 52,621,851 RGD:5131497
G Pick1 protein interacting with PRKCA 1 GBrowse link 7 120,459,118 120,478,470 RGD:5131491
G Plcb1 phospholipase C, beta 1 (phosphoinositide-specific) GBrowse link 3 134,211,557 134,908,321 RGD:5131502
G Plcb2 phospholipase C, beta 2 GBrowse link 3 117,038,677 117,058,132 RGD:5131502
G Plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) GBrowse link 1 229,198,739 229,215,831 RGD:5131502
G Plcb4 phospholipase C, beta 4 GBrowse link 3 135,089,551 135,459,248 RGD:5131502
G Prkca protein kinase C, alpha GBrowse link 10 95,919,013 96,311,328 RGD:5131489
G Prkcb protein kinase C, beta GBrowse link 1 199,295,067 199,639,140 RGD:5131489
G Prkcd protein kinase C, delta GBrowse link 16 6,588,990 6,608,725 RGD:5131489
G Prkce protein kinase C, epsilon GBrowse link 6 9,404,548 9,883,579 RGD:5131489
G Prkcg protein kinase C, gamma GBrowse link 1 63,399,153 63,425,645 RGD:5131489
G Prkch protein kinase C, eta GBrowse link 6 105,910,127 106,109,230 RGD:5131489
RGD:5131657
G Prkci protein kinase C, iota GBrowse link 2 135,636,956 135,697,732 RGD:5131489
RGD:5132275
G Prkcq protein kinase C, theta GBrowse link 17 72,669,688 72,800,895 RGD:5131489
G Prkcz protein kinase C, zeta GBrowse link 5 176,116,787 176,228,206 RGD:5131489
RGD:5131661
RGD:5132275

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassaPKCatypical protein kinase C members
Functional ClasscPKCclassical or conventional protein kinase C members
Small MoleculeDAGdiacylglycerol
Small MoleculeIP3inositol 1,4,5-triphosphate
Functional ClassnPKCnovel protein kinase C members
Small MoleculePIP2phosphoinositide-4,5-bisphosphate
Gene GroupPKC interactorsvarious proteins, binding partners and substrates

References Associated with the protein kinase C (PKC) signaling pathway:

Ontology Path Diagram:

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