PROTEIN KINASE C (PKC) SIGNALING PATHWAY (PW:0000840)

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Description

The protein kinase C family (PKC) comprises ~2% of the human kinome and can be subdivided into three subclasses: conventional or classical (cPKC), novel (nPKC) and atypical (aPKC). All isoforms contain a C-terminal kinase domain and an N-terminal autoinhibitory pseudosubstrate but differ in their responsiveness to second messengers. A tandem DAG-sensitive C1 domain is present in cPKC and nPKC with the latter group displaying a higher sensitivity. The C2 domain is Ca2+ sensitive in cPKC only. The

Pathway Diagram:

Elsevier Inc. Ca2+ calcium transport pathway GPCRs upstream PKC G protein mediated signaling pathway via Galphaq family Phlpp1 ---| cPKC cPKC Phlpp1 ---| nPKC Phlpp2 ---| nPKC Phlpp2 ---| cPKC Pdpk1 --+> nPKC Pdpk1 --+> cPKC Pdpk1 --+> aPKC GPCRs upstream PKC --+> PLC-B members PLC-B members Phlpp1 Phlpp2 Pdpk1 Hsp90aa1 Cdc37 IP3 PKC interactors aPKC nPKC cPKC ---- PKC interactors nPKC ---- PKC interactors aPKC ---- PKC interactors Cdc37 ---- nPKC Cdc37 ---- cPKC Ca2+ ---- cPKC Hsp90aa1 ---- nPKC cPKC ---- Hsp90aa1 cPKC ---- DAG DAG ---- nPKC PIP2 ---> DAG PIP2 DAG PIP2 ---> IP3 cell polarity cell death cell proliferation cell differentiation cPKC ---> cell differentiation cPKC ---> cell proliferation nPKC ---> cell proliferation IP3 --+> Ca2+ calcium/calcium-mediated signaling pathway nPKC ---> cell death aPKC ---> cell polarity cPKC ---> cell death nPKC ---> cell differentiation
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Genes in Pathway:

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protein kinase C (PKC) signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:5131492
G Cdc37 cell division cycle 37 JBrowse link 8 22,160,922 22,173,797 RGD:5131489
G Copb1 coatomer protein complex, subunit beta 1 JBrowse link 1 183,695,480 183,729,569 RGD:5131491
G Fscn1 fascin actin-bundling protein 1 JBrowse link 12 13,655,459 13,668,595 RGD:5131492
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:5131492
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:5131489
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,624 RGD:5131492
G Ldb3 LIM domain binding 3 JBrowse link 16 10,878,355 10,941,464 RGD:5131491
RGD:5131492
G Pard3 par-3 family cell polarity regulator JBrowse link 19 60,017,746 60,580,628 RGD:5132275
G Pard6a par-6 family cell polarity regulator alpha JBrowse link 19 37,668,133 37,670,450 RGD:5132275
G Pard6b par-6 family cell polarity regulator beta JBrowse link 3 164,822,111 164,843,395 RGD:5132275
G Pard6g par-6 family cell polarity regulator gamma JBrowse link 18 76,559,877 76,627,843 RGD:5132275
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:5131489
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:5131497
RGD:8693633
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 JBrowse link 19 41,731,845 41,798,451 RGD:5131497
G Pick1 protein interacting with PRKCA 1 JBrowse link 7 120,465,472 120,484,824 RGD:5131491
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,421,288 RGD:5131502
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,261 RGD:5131502
G Plcb3 phospholipase C beta 3 JBrowse link 1 222,207,887 222,224,987 RGD:5131502
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,185 128,971,720 RGD:5131502
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,184 RGD:5131489
G Prkcb protein kinase C, beta JBrowse link 1 192,233,780 192,575,339 RGD:5131489
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:5131489
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:5131489
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,703 RGD:5131489
G Prkch protein kinase C, eta JBrowse link 6 96,479,243 96,677,368 RGD:5131489
RGD:5131657
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:5131489
RGD:5132275
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:5131489
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:5131489
RGD:5131661
RGD:5132275
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:5131491
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:10002727

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassaPKCatypical protein kinase C members
Functional ClasscPKCclassical or conventional protein kinase C members
Small MoleculeDAGdiacylglycerol
Small MoleculeIP3inositol 1,4,5-triphosphate
Functional ClassnPKCnovel protein kinase C members
Small MoleculePIP2phosphoinositide-4,5-bisphosphate
Gene GroupPKC interactorsvarious proteins, binding partners and substrates

Pathway Gene Annotations

Disease Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Disease TermsGene Symbols
AgammaglobulinemiaBtk
Alzheimer DiseaseFyn , Hsp90aa1
AnaphylaxisBtk
Arteriovenous MalformationsRasa1
Arthritis, ExperimentalBtk
Arthritis, RheumatoidHsp90aa1
Arthus ReactionBtk
Auriculo-condylar syndromePlcb4
Auriculocondylar Syndrome 2Plcb4
Bile Duct NeoplasmsFscn1
Brain IschemiaPrkca , Prkcd
Breast NeoplasmsHsp90aa1 , Prkca , Prkci
Bruton type agammaglobulinemiaBtk
BurnsFyn , Prkcd
Capillary Malformation-Arteriovenous MalformationRasa1
Carcinoma, Basal CellRasa1
Carcinoma, Intraductal, NoninfiltratingPrkca
Carcinoma, Large CellPrkca
Carcinoma, Pancreatic DuctalFscn1
CardiomegalyPrkca , Prkcb , Prkcd , Prkce
CardiomyopathiesLdb3
Cardiomyopathy, DilatedLck , Ldb3 , Prkca , Prkcb
Cardiomyopathy, Dilated, 1CLdb3
Cardiomyopathy, Dilated, with Left Ventricular NoncompactionLdb3
Cardiomyopathy, Familial Hypertrophic, 1Ldb3
Cardiomyopathy, HypertrophicLdb3
Cardiomyopathy, Hypertrophic, FamilialLdb3
Cardiomyopathy, RestrictivePrkcd
Cerebral InfarctionPrkch
CholangiocarcinomaFscn1
Common Bile Duct NeoplasmsFscn1
Common Variable ImmunodeficiencyPrkcd
Conjunctivitis, AllergicLck
Diabetes Mellitus, ExperimentalHsp90aa1 , Plcb3 , Prkcb , Prkcd , Prkci
Diabetic NephropathiesPrkcb
Endometrial NeoplasmsPrkca
Epilepsy, Temporal LobeFyn
Epileptic Encephalopathy, Early Infantile, 12Plcb1
Fatty LiverPrkcd
Fetal DiseasesPrkcb
Frontotemporal Lobar DegenerationHsp90aa1
Gallbladder NeoplasmsFscn1
Heart FailurePrkca , Prkcb
HIV InfectionsLck
HyperalgesiaPrkcb
HyperammonemiaPrkcq
HyperglycemiaPrkcb , Prkcz
HyperinsulinismPrkcd , Prkcq
HypertensionPrkca , Prkcb , Prkcd , Prkce
Hypertension, PortalHsp90aa1 , Prkcd
Hypertrophy, Left VentricularPrkca , Prkcb , Prkcd , Prkcz , Rasa1
Hypertrophy, Right VentricularPrkca , Prkcd
Hypogammaglobulinemia and Isolated Growth Hormone Deficiency, X-LinkedBtk
Hypogammaglobulinemia, X-LinkedBtk
Immune System DiseasesPrkcb
Immunologic Deficiency SyndromesBtk
Insulin ResistancePrkcb , Prkcd , Prkcq , Prkcz
IschemiaPrkca
Ischemic Attack, TransientRack1
Leukemia, Lymphocytic, Chronic, B-CellBtk
Long QT SyndromePlcb4
Lymphoma, B-CellBtk
Lymphoma, Mantle-CellBtk
Mild Cognitive ImpairmentHsp90aa1
Muscular DiseasesPrkcd
Myocardial InfarctionPlcb1 , Plcb3
Myocardial IschemiaPrkcd
Myocardial Reperfusion InjuryPrkcb , Prkcd
MYOPATHY, MYOFIBRILLAR, 4Ldb3
Myopathy, Myofibrillar, Zasp-RelatedLdb3
Neoplasm MetastasisFscn1
ObesityPrkcb , Prkcd
Osteoarthritis, KneeHsp90aa1
Ovarian NeoplasmsPrkca , Prkci
Pancreatic NeoplasmsFscn1
Pituitary NeoplasmsPrkca
Port-Wine StainRasa1
Prostatic NeoplasmsPard3 , Phlpp1 , Plcb4 , Prkca , Prkcq
Reperfusion InjuryPrkca
Retinitis PigmentosaPrkcg
SchizophreniaFyn
SepsisFyn , Prkcq
SilicosisPrkcb
Skin UlcerPlcb3
Spinocerebellar Ataxia 14Prkcg
Spinocerebellar AtaxiasPrkcg
Status EpilepticusPrkcb
StrokePrkcd
Sturge-Weber SyndromeRasa1
Urinary Bladder NeoplasmsPrkca
Pathway Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPlcb1
adenosine signaling pathwayPard6a , Pdpk1 , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPlcb1
aldosterone signaling pathwayHsp90aa1 , Pdpk1 , Prkca , Prkcb , Prkcg
altered Reelin signaling pathwayFyn
Alzheimer disease pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
amiodarone pharmacodynamics pathwayPlcb1
amlodipine pharmacodynamics pathwayPlcb1
androgen signaling pathwayHsp90aa1
angiotensin II signaling pathwayPdpk1 , Prkcz
antigen processing and presentation pathwayHsp90aa1
atenolol pharmacodynamics pathwayPlcb1
B cell receptor signaling pathwayBtk , Prkcb
betaxolol pharmacodynamics pathwayPlcb1
bisoprolol pharmacodynamics pathwayPlcb1
bupranolol drug pathwayPlcb1
bupranolol pharmacodynamics pathwayPlcb1
calcium/calcium-mediated signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
carvedilol pharmacodynamics pathwayPlcb1
ceramide signaling pathwayPrkcd , Prkcz
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayPard3 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkcb , Prkcd , Prkcz
cortisol signaling pathwayHsp90aa1
diltiazem pharmacodynamics pathwayPlcb1
disopyramide pharmacodynamics pathwayPlcb1
dobutamine pharmacodynamics pathwayPlcb1
E-cadherin signaling pathwayFyn
eicosanoid signaling pathwayFyn , Lck , Plcb2 , Prkca , Prkcd , Prkce , Prkcg , Prkch , Prkcq , Prkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayPard3 , Pard6a , Pard6b , Pard6g , Prkci , Prkcz
endometrial cancer pathwayPdpk1
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1
endothelin signaling pathwayPlcb1 , Plcb2 , Plcb3 , Prkca , Prkcd , Prkce , Prkcg , Prkch , Prkcq
Entamoeba histolyca infection pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
ephrin - ephrin receptor bidirectional signaling axisFyn , Lck , Rasa1
epidermal growth factor/neuregulin signaling pathwayHsp90aa1 , Prkca , Prkcb , Prkcg , Prkcz , Rasa1
erythropoietin signaling pathwayBtk
esmolol pharmacodynamics pathwayPlcb1
estrogen signaling pathwayHsp90aa1
FasL mediated signaling pathwayBtk , Pdpk1
Fc epsilon receptor mediated signaling pathwayBtk , Fyn , Prkca , Prkcd , Prkce , Prkcg
Fc gamma receptor mediated signaling pathwayPrkca , Prkcb , Prkcd , Prkce , Prkcg
fibroblast growth factor signaling pathwayPdpk1
flecainde pharmacodynamics pathwayPlcb1
fosphenytoin pharmacodynamics pathwayPlcb1
G protein mediated signaling pathway via Galphaq familyPlcb1 , Plcb2 , Plcb3 , Plcb4
glioma pathwayPrkca , Prkcb , Prkcg
glutamate signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
glypican signaling pathwayFyn , Lck
gonadotropin-releasing hormone signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcd
Hedgehog signaling pathwayPrkcd
Huntington disease pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
hypoxia inducible factor pathwayRack1
ibutilide pharmacodynamics pathwayPlcb1
influenza A virus infection pathwayPrkca , Prkcb
inositol phosphate metabolic pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkci , Prkcz
insulin signaling pathwayPard6a , Pdpk1 , Prkca , Prkcb , Prkcg , Prkci , Prkcq , Prkcz , Rasa1
insulin-like growth factor signaling pathwayPdpk1 , Prkcd , Prkcz , Rack1
interleukin-1 signaling pathwayPrkci , Prkcz
interleukin-12 signaling pathwayLck
interleukin-2 signaling pathwayFyn , Lck , Prkcb , Prkce , Rasa1
interleukin-6 signaling pathwayPrkcd
isoprenaline pharmacodynamics pathwayPlcb1
isradipine pharmacodynamics pathwayPlcb1
Leishmania infection pathwayPrkcb
levobunolol pharmacodynamics pathwayPlcb1
lidocaine pharmacodynamics pathwayPlcb1
long term depressionPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
long term potentiationPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
measles infection pathwayFyn , Prkcq , Rack1
metoprolol pharmacodynamics pathwayPlcb1
mexiletine pharmacodynamics pathwayPlcb1
mitogen activated protein kinase signaling pathwayPrkca , Prkcb , Prkcg , Rasa1
mTOR signaling pathwayPdpk1 , Prkca
myocarditis pathwayFyn
nadolol pharmacodynamics pathwayPlcb1
nebivolol pharmacodynamics pathwayPlcb1
neurotrophic factor signaling pathwayPrkcd
nifedipine pharmacodynamics pathwayPlcb1
nimodipine pharmacodynamics pathwayPlcb1
nisoldipine pharmacodynamics pathwayPlcb1
nitrendipine pharmacodynamics pathwayPlcb1
NOD-like receptor signaling pathwayHsp90aa1
non-small cell lung cancer pathwayPdpk1 , Prkca , Prkcb , Prkcg
nuclear factor kappa B signaling pathwayLck , Prkca
p53 signaling pathwayPrkcd
penbutolol pharmacodynamics pathwayPlcb1
phenytoin pharmacodynamics pathwayPlcb1
phosphatidylinositol 3-kinase class I signaling pathwayBtk , Fyn , Hsp90aa1 , Lck , Pdpk1
phosphatidylinositol 3-kinase signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayHsp90aa1 , Pdpk1
phosphoinositide metabolic pathwayPlcb1
pindolol pharmacodynamics pathwayPlcb1
platelet-derived growth factor signaling pathwayFyn , Lck , Prkca , Prkcd , Prkce , Rasa1
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
primary immunodeficiency disease pathwayBtk , Lck
prion diseases pathwayFyn
procainamide pharmacodynamics pathwayPlcb1
propranolol pharmacodynamics pathwayPlcb1
prostate cancer pathwayHsp90aa1 , Pdpk1
protein kinase C (PKC) signaling pathwayBtk , Cdc37 , Copb1 , Fscn1 , Fyn , Hsp90aa1 , Lck , Ldb3 , Pard3 , Pard6a , Pard6b , Pard6g , Pdpk1 , Phlpp1 , Phlpp2 , Pick1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcd , Prkce , Prkcg , Prkch , Prkci , Prkcq , Prkcz , Rack1 , Rasa1
quinidine pharmacodynamics pathwayPlcb1
Reelin signaling pathwayFyn
ribosome biogenesis pathwayPrkcb , Rack1
sotalol pharmacodynamics pathwayPlcb1
sphingosine 1-phosphate signaling pathwayPlcb2
syndecan signaling pathwayFyn , Prkca , Prkcd , Rack1 , Rasa1
T cell receptor signaling pathwayFyn , Lck
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPrkcd
timolol pharmacodynamics pathwayPlcb1
transforming growth factor-beta Smad dependent signaling pathwayPard6a , Pdpk1
Trypanosoma brucei infection pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
tumor necrosis factor mediated signaling pathwayPrkci , Prkcz , Rack1
type 2 diabetes mellitus pathwayPrkcd , Prkce , Prkcz
type II interferon signaling pathwayPrkcd
vascular endothelial growth factor signaling pathwayFyn , Hsp90aa1 , Pdpk1 , Prkca , Prkcb , Prkcd , Prkcg , Prkcz
verapamil pharmacodynamics pathwayPlcb1
Wnt signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
Wnt signaling, non-canonical pathwayPrkcz
Phenotype Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway

References Associated with the protein kinase C (PKC) signaling pathway:

Ontology Path Diagram:

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