PROTEIN KINASE C (PKC) SIGNALING PATHWAY (PW:0000840)

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Description

The protein kinase C family (PKC) comprises ~2% of the human kinome and can be subdivided into three subclasses: conventional or classical (cPKC), novel (nPKC) and atypical (aPKC). All isoforms contain a C-terminal kinase domain and an N-terminal autoinhibitory pseudosubstrate but differ in their responsiveness to second messengers. A tandem DAG-sensitive C1 domain is present in cPKC and nPKC with the latter group displaying a higher sensitivity. The C2 domain is Ca2+ sensitive in cPKC only. The

Pathway Diagram:

Elsevier Inc. Ca2+ calcium transport pathway GPCRs upstream PKC G protein mediated signaling pathway via Galphaq family Phlpp1 ---| cPKC cPKC Phlpp1 ---| nPKC Phlpp2 ---| nPKC Phlpp2 ---| cPKC Pdpk1 --+> nPKC Pdpk1 --+> cPKC Pdpk1 --+> aPKC GPCRs upstream PKC --+> PLC-B members PLC-B members Phlpp1 Phlpp2 Pdpk1 Hsp90aa1 Cdc37 IP3 PKC interactors aPKC nPKC cPKC ---- PKC interactors nPKC ---- PKC interactors aPKC ---- PKC interactors Cdc37 ---- nPKC Cdc37 ---- cPKC Ca2+ ---- cPKC Hsp90aa1 ---- nPKC cPKC ---- Hsp90aa1 cPKC ---- DAG DAG ---- nPKC PIP2 ---> DAG PIP2 DAG PIP2 ---> IP3 cell polarity cell death cell proliferation cell differentiation cPKC ---> cell differentiation cPKC ---> cell proliferation nPKC ---> cell proliferation IP3 --+> Ca2+ calcium/calcium-mediated signaling pathway nPKC ---> cell death aPKC ---> cell polarity cPKC ---> cell death nPKC ---> cell differentiation
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Genes in Pathway:

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protein kinase C (PKC) signaling pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Btk Bruton agammaglobulinemia tyrosine kinase GBrowse link X 105,250,666 105,279,934 RGD:5131492
G Cdc37 cell division cycle 37 GBrowse link 8 22,217,096 22,229,971 RGD:5131489
G Copb1 coatomer protein complex, subunit beta 1 GBrowse link 1 190,670,320 190,704,834 RGD:5131491
G Fscn1 fascin actin-bundling protein 1 GBrowse link 12 15,688,989 15,702,125 RGD:5131492
G Fyn FYN proto-oncogene, Src family tyrosine kinase GBrowse link 20 46,160,734 46,353,456 RGD:5131492
G Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 GBrowse link 10 33,920,259 33,939,101 RGD:5131491
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 GBrowse link 6 144,182,009 144,187,540 RGD:5131489
G Lck LCK proto-oncogene, Src family tyrosine kinase GBrowse link 5 151,480,214 151,509,064 RGD:5131492
G Ldb3 LIM domain binding 3 GBrowse link 16 9,203,392 9,267,999 RGD:5131491
RGD:5131492
G Pard3 par-3 family cell polarity regulator GBrowse link 19 70,690,939 71,249,213 RGD:5132275
G Pard6a par-6 family cell polarity regulator alpha GBrowse link 19 48,534,837 48,537,154 RGD:5132275
G Pard6b par-6 family cell polarity regulator beta GBrowse link 3 170,968,975 170,990,259 RGD:5132275
G Pard6g par-6 family cell polarity regulator gamma GBrowse link 18 72,178,893 72,246,274 RGD:5132275
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link 10 13,262,177 13,339,277 RGD:5131489
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 GBrowse link 13 31,302,241 31,550,366 RGD:5131497
RGD:8693633
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 GBrowse link 19 52,555,245 52,621,851 RGD:5131497
G Pick1 protein interacting with PRKCA 1 GBrowse link 7 120,459,118 120,478,470 RGD:5131491
G Plcb1 phospholipase C, beta 1 (phosphoinositide-specific) GBrowse link 3 134,211,557 134,908,321 RGD:5131502
G Plcb2 phospholipase C, beta 2 GBrowse link 3 117,038,677 117,058,132 RGD:5131502
G Plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) GBrowse link 1 229,198,739 229,215,831 RGD:5131502
G Plcb4 phospholipase C, beta 4 GBrowse link 3 135,089,551 135,459,248 RGD:5131502
G Prkca protein kinase C, alpha GBrowse link 10 95,919,013 96,311,328 RGD:5131489
G Prkcb protein kinase C, beta GBrowse link 1 199,295,067 199,639,140 RGD:5131489
G Prkcd protein kinase C, delta GBrowse link 16 6,588,990 6,608,725 RGD:5131489
G Prkce protein kinase C, epsilon GBrowse link 6 9,404,548 9,883,579 RGD:5131489
G Prkcg protein kinase C, gamma GBrowse link 1 63,399,153 63,425,645 RGD:5131489
G Prkch protein kinase C, eta GBrowse link 6 105,910,127 106,109,230 RGD:5131489
RGD:5131657
G Prkci protein kinase C, iota GBrowse link 2 135,636,956 135,697,732 RGD:5131489
RGD:5132275
G Prkcq protein kinase C, theta GBrowse link 17 72,669,688 72,800,895 RGD:5131489
G Prkcz protein kinase C, zeta GBrowse link 5 176,116,787 176,228,206 RGD:5131489
RGD:5131661
RGD:5132275
G Rasa1 RAS p21 protein activator (GTPase activating protein) 1 GBrowse link 2 13,470,580 13,551,782 RGD:10002727

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassaPKCatypical protein kinase C members
Functional ClasscPKCclassical or conventional protein kinase C members
Small MoleculeDAGdiacylglycerol
Small MoleculeIP3inositol 1,4,5-triphosphate
Functional ClassnPKCnovel protein kinase C members
Small MoleculePIP2phosphoinositide-4,5-bisphosphate
Gene GroupPKC interactorsvarious proteins, binding partners and substrates

Pathway Gene Annotations

Disease Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Disease TermsGene Symbols
AgammaglobulinemiaBtk
Alzheimer DiseaseFyn
Arteriovenous MalformationsRasa1
AURICULOCONDYLAR SYNDROME 2Plcb4
Bile Duct NeoplasmsFscn1
Brain IschemiaPrkca , Prkcd
Breast NeoplasmsHsp90aa1 , Prkca , Prkci
Bruton type agammaglobulinemiaBtk
BurnsFyn , Prkcd
Capillary Malformation-Arteriovenous MalformationRasa1
Carcinoma, Basal CellRasa1
Carcinoma, Intraductal, NoninfiltratingPrkca
Carcinoma, Large CellPrkca
Carcinoma, Pancreatic DuctalFscn1
CardiomegalyPrkca , Prkcb , Prkcd , Prkce
CardiomyopathiesLdb3
Cardiomyopathy, DilatedLck , Ldb3 , Prkca , Prkcb
Cardiomyopathy, Dilated, 1CLdb3
Cardiomyopathy, Dilated, with Left Ventricular NoncompactionLdb3
Cardiomyopathy, Familial Hypertrophic, 1Ldb3
Cardiomyopathy, HypertrophicLdb3
Cardiomyopathy, Hypertrophic, FamilialLdb3
Cardiomyopathy, RestrictivePrkcd
Cerebral InfarctionPrkch
CholangiocarcinomaFscn1
Common Bile Duct NeoplasmsFscn1
Common Variable ImmunodeficiencyPrkcd
Conjunctivitis, AllergicLck
Diabetes Mellitus, ExperimentalHsp90aa1 , Plcb3 , Prkcb , Prkcd , Prkci
Diabetic NephropathiesPrkcb
Endometrial NeoplasmsPrkca
Epilepsy, Temporal LobeFyn
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 12Plcb1
Fatty LiverPrkcd
Fetal DiseasesPrkcb
Gallbladder NeoplasmsFscn1
Heart FailurePrkca , Prkcb
HIV InfectionsLck
HyperalgesiaPrkcb
HyperammonemiaPrkcq
HyperglycemiaPrkcb , Prkcz
HyperinsulinismPrkcd , Prkcq
HypertensionPrkca , Prkcb , Prkcd , Prkce
Hypertension, PortalHsp90aa1 , Prkcd
Hypertrophy, Left VentricularPrkca , Prkcb , Prkcd , Prkcz , Rasa1
Hypertrophy, Right VentricularPrkca , Prkcd
Hypogammaglobulinemia and Isolated growth hormone deficiency, X-linkedBtk
Hypogammaglobulinemia, X-LinkedBtk
Immune System DiseasesPrkcb
Insulin ResistancePrkcb , Prkcd , Prkcq , Prkcz
IschemiaPrkca
Ischemic Attack, TransientGnb2l1
Muscular DiseasesPrkcd
Myocardial InfarctionPlcb1 , Plcb3
Myocardial IschemiaPrkcd
Myocardial Reperfusion InjuryPrkcb , Prkcd
Myofibrillar MyopathyLdb3
MYOPATHY, MYOFIBRILLAR, 4Ldb3
Myopathy, Myofibrillar, Zasp-RelatedLdb3
Neoplasm MetastasisFscn1
ObesityPrkcb , Prkcd
Ovarian NeoplasmsPrkca , Prkci
Pancreatic NeoplasmsFscn1
Pituitary NeoplasmsPrkca
Port-Wine StainRasa1
Prostatic NeoplasmsPard3 , Phlpp1 , Plcb4 , Prkca , Prkcq
Reperfusion InjuryPrkca
Retinitis PigmentosaPrkcg
SchizophreniaFyn
SepsisFyn , Prkcq
SilicosisPrkcb
Skin UlcerPlcb3
Spinocerebellar ataxia 14Prkcg
Spinocerebellar AtaxiasPrkcg
Status EpilepticusPrkcb
StrokePrkcd
Sturge-Weber SyndromeRasa1
Urinary Bladder NeoplasmsPrkca
Pathway Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Pathway TermsGene Symbols
aldosterone signaling pathwayHsp90aa1 , Pdpk1 , Prkca , Prkcb , Prkcg
altered Reelin signaling pathwayFyn
Alzheimer disease pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
androgen signaling pathwayHsp90aa1
angiotensin II signaling pathwayPdpk1 , Prkcz
antigen processing and presentation pathwayHsp90aa1
B cell receptor signaling pathwayBtk , Prkcb
calcium/calcium-mediated signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
ceramide signaling pathwayPrkcd , Prkcz
chemokine mediated signaling pathwayPard3 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkcb , Prkcd , Prkcz
cortisol signaling pathwayHsp90aa1
E-cadherin signaling pathwayFyn
eicosanoid signaling pathwayFyn , Lck , Plcb2 , Prkca , Prkcd , Prkce , Prkcg , Prkch , Prkcq , Prkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayPard3 , Pard6a , Pard6b , Pard6g , Prkci , Prkcz
endometrial cancer pathwayPdpk1
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1
endothelin signaling pathwayPlcb1 , Plcb2 , Plcb3 , Prkca , Prkcd , Prkce , Prkcg , Prkch , Prkcq
Entamoeba histolyca infection pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
ephrin - ephrin receptor bidirectional signaling axisFyn , Lck , Rasa1
epidermal growth factor/neuregulin signaling pathwayHsp90aa1 , Prkca , Prkcb , Prkcg , Prkcz , Rasa1
erythropoietin signaling pathwayBtk
estrogen signaling pathwayHsp90aa1
FasL mediated signaling pathwayBtk , Pdpk1
Fc epsilon receptor mediated signaling pathwayBtk , Fyn , Prkca , Prkcd , Prkce , Prkcg
Fc gamma receptor mediated signaling pathwayPrkca , Prkcb , Prkcd , Prkce , Prkcg
fibroblast growth factor signaling pathwayPdpk1
G protein mediated signaling pathway via Galphaq familyPlcb1 , Plcb2 , Plcb3 , Plcb4
glioma pathwayPrkca , Prkcb , Prkcg
glutamate signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
glypican signaling pathwayFyn , Lck
gonadotropin-releasing hormone signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcd
Hedgehog signaling pathwayPrkcd
Huntington disease pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
hypoxia inducible factor pathwayGnb2l1
influenza A virus infection pathwayPrkca , Prkcb
inositol phosphate metabolic pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkci , Prkcz
insulin signaling pathwayPard6a , Pdpk1 , Prkca , Prkcb , Prkcg , Prkci , Prkcq , Prkcz , Rasa1
insulin-like growth factor signaling pathwayGnb2l1 , Pdpk1 , Prkcd , Prkcz
interleukin-1 signaling pathwayPrkci , Prkcz
interleukin-12 signaling pathwayLck
interleukin-2 signaling pathwayFyn , Lck , Prkcb , Prkce , Rasa1
interleukin-6 signaling pathwayPrkcd
Leishmania infection pathwayPrkcb
long term depressionPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
long term potentiationPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
measles infection pathwayFyn , Gnb2l1 , Prkcq
mitogen activated protein kinase signaling pathwayPrkca , Prkcb , Prkcg , Rasa1
mTOR signaling pathwayPdpk1 , Prkca
myocarditis pathwayFyn
neurotrophic factor signaling pathwayPrkcd
NOD-like receptor signaling pathwayHsp90aa1
non-small cell lung cancer pathwayPdpk1 , Prkca , Prkcb , Prkcg
nuclear factor kappa B signaling pathwayLck , Prkca
p53 signaling pathwayPrkcd
phosphatidylinositol 3-kinase class I signaling pathwayBtk , Fyn , Hsp90aa1 , Lck , Pdpk1
phosphatidylinositol 3-kinase signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayHsp90aa1 , Pdpk1
platelet-derived growth factor signaling pathwayFyn , Lck , Prkca , Prkcd , Prkce , Rasa1
primary immunodeficiency disease pathwayBtk , Lck
prion diseases pathwayFyn
prostate cancer pathwayHsp90aa1 , Pdpk1
protein kinase C (PKC) signaling pathwayBtk , Cdc37 , Copb1 , Fscn1 , Fyn , Gnb2l1 , Hsp90aa1 , Lck , Ldb3 , Pard3 , Pard6a , Pard6b , Pard6g , Pdpk1 , Phlpp1 , Phlpp2 , Pick1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcd , Prkce , Prkcg , Prkch , Prkci , Prkcq , Prkcz , Rasa1
Reelin signaling pathwayFyn
ribosome biogenesis pathwayGnb2l1 , Prkcb
sphingosine 1-phosphate signaling pathwayPlcb2
syndecan signaling pathwayFyn , Gnb2l1 , Prkca , Prkcd , Rasa1
T cell receptor signaling pathwayFyn , Lck
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPrkcd
transforming growth factor-beta Smad dependent signaling pathwayPard6a , Pdpk1
Trypanosoma brucei infection pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
tumor necrosis factor mediated signaling pathwayGnb2l1 , Prkci , Prkcz
type 2 diabetes mellitus pathwayPrkcd , Prkce , Prkcz
type II interferon signaling pathwayPrkcd
vascular endothelial growth factor signaling pathwayFyn , Hsp90aa1 , Pdpk1 , Prkca , Prkcb , Prkcd , Prkcg , Prkcz
Wnt signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
Wnt signaling, non-canonical pathwayPrkcz
Phenotype Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway

References Associated with the protein kinase C (PKC) signaling pathway:

Ontology Path Diagram:

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