PROTEIN KINASE C (PKC) SIGNALING PATHWAY (PW:0000840)

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Description

The protein kinase C family (PKC) comprises ~2% of the human kinome and can be subdivided into three subclasses: conventional or classical (cPKC), novel (nPKC) and atypical (aPKC). All isoforms contain a C-terminal kinase domain and an N-terminal autoinhibitory pseudosubstrate but differ in their responsiveness to second messengers. A tandem DAG-sensitive C1 domain is present in cPKC and nPKC with the latter group displaying a higher sensitivity. The C2 domain is Ca2+ sensitive in cPKC only. The

Pathway Diagram:

Elsevier Inc. Ca2+ calcium transport pathway GPCRs upstream PKC G protein mediated signaling pathway via Galphaq family Phlpp1 ---| cPKC cPKC Phlpp1 ---| nPKC Phlpp2 ---| nPKC Phlpp2 ---| cPKC Pdpk1 --+> nPKC Pdpk1 --+> cPKC Pdpk1 --+> aPKC GPCRs upstream PKC --+> PLC-B members PLC-B members Phlpp1 Phlpp2 Pdpk1 Hsp90aa1 Cdc37 IP3 PKC interactors aPKC nPKC cPKC ---- PKC interactors nPKC ---- PKC interactors aPKC ---- PKC interactors Cdc37 ---- nPKC Cdc37 ---- cPKC Ca2+ ---- cPKC Hsp90aa1 ---- nPKC cPKC ---- Hsp90aa1 cPKC ---- DAG DAG ---- nPKC PIP2 ---> DAG PIP2 DAG PIP2 ---> IP3 cell polarity cell death cell proliferation cell differentiation cPKC ---> cell differentiation cPKC ---> cell proliferation nPKC ---> cell proliferation IP3 --+> Ca2+ calcium/calcium-mediated signaling pathway nPKC ---> cell death aPKC ---> cell polarity cPKC ---> cell death nPKC ---> cell differentiation
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Genes in Pathway:

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protein kinase C (PKC) signaling pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Btk Bruton agammaglobulinemia tyrosine kinase GBrowse link X 121,998,935 122,030,289 RGD:5131492
G Cdc37 cell division cycle 37 GBrowse link 8 20,164,150 20,176,763 RGD:5131489
G Copb1 coatomer protein complex, subunit beta 1 GBrowse link 1 172,199,676 172,233,765 RGD:5131491
G Fscn1 fascin actin-bundling protein 1 RGD:5131492
G Fyn FYN proto-oncogene, Src family tyrosine kinase GBrowse link 20 43,501,853 43,695,567 RGD:5131492
G Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 GBrowse link 10 34,067,237 34,072,593 RGD:5131491
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 GBrowse link 6 135,413,616 135,419,147 RGD:5131489
G Lck LCK proto-oncogene, Src family tyrosine kinase GBrowse link 5 148,707,505 148,718,296 RGD:5131492
G Ldb3 LIM domain binding 3 GBrowse link 16 10,221,362 10,247,798 RGD:5131491
RGD:5131492
G Pard3 par-3 family cell polarity regulator GBrowse link 19 57,015,742 57,603,133 RGD:5132275
G Pard6a par-6 family cell polarity regulator alpha GBrowse link 19 35,533,395 35,535,711 RGD:5132275
G Pard6b par-6 family cell polarity regulator beta GBrowse link 3 159,230,673 159,251,755 RGD:5132275
G Pard6g par-6 family cell polarity regulator gamma GBrowse link 18 76,942,285 77,007,923 RGD:5132275
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link 10 13,329,708 13,394,080 RGD:5131489
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 GBrowse link 13 12,315,824 12,565,692 RGD:5131497
RGD:8693633
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 GBrowse link 19 39,741,655 39,808,301 RGD:5131497
G Pick1 protein interacting with PRKCA 1 GBrowse link 7 117,213,299 117,232,651 RGD:5131491
G Plcb1 phospholipase C, beta 1 (phosphoinositide-specific) GBrowse link 3 122,797,718 123,523,675 RGD:5131502
G Plcb2 phospholipase C, beta 2 GBrowse link 3 105,203,524 105,223,342 RGD:5131502
G Plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) GBrowse link 1 209,628,425 209,643,694 RGD:5131502
G Plcb4 phospholipase C, beta 4 GBrowse link 3 123,706,313 124,077,381 RGD:5131502
G Prkca protein kinase C, alpha GBrowse link 10 97,367,196 97,638,910 RGD:5131489
G Prkcb protein kinase C, beta GBrowse link 1 181,117,512 181,459,856 RGD:5131489
G Prkcd protein kinase C, delta GBrowse link 16 5,954,218 5,975,743 RGD:5131489
G Prkce protein kinase C, epsilon GBrowse link 6 9,631,234 10,097,311 RGD:5131489
G Prkcg protein kinase C, gamma GBrowse link 1 64,145,749 64,172,712 RGD:5131489
G Prkch protein kinase C, eta GBrowse link 6 96,069,354 96,281,790 RGD:5131489
RGD:5131657
G Prkci protein kinase C, iota GBrowse link 2 116,739,625 116,801,084 RGD:5131489
RGD:5132275
G Prkcq protein kinase C, theta GBrowse link 17 78,486,998 78,566,741 RGD:5131489
G Prkcz protein kinase C, zeta GBrowse link 5 172,061,825 172,172,793 RGD:5131489
RGD:5131661
RGD:5132275

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassaPKCatypical protein kinase C members
Functional ClasscPKCclassical or conventional protein kinase C members
Small MoleculeDAGdiacylglycerol
Small MoleculeIP3inositol 1,4,5-triphosphate
Functional ClassnPKCnovel protein kinase C members
Small MoleculePIP2phosphoinositide-4,5-bisphosphate
Gene GroupPKC interactorsvarious proteins, binding partners and substrates

Pathway Gene Annotations

Disease Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Disease TermsGene Symbols
Pancreatic NeoplasmsFscn1
AgammaglobulinemiaBtk
IschemiaPrkca
Skin UlcerPlcb3
ObesityPrkcb , Prkcd
Retinitis PigmentosaPrkcg
HyperammonemiaPrkcq
CholangiocarcinomaFscn1
Bile Duct NeoplasmsFscn1
CardiomegalyPlcb1 , Prkca , Prkcb , Prkcd , Prkce
Muscular DiseasesPrkcd
Cardiomyopathy, DilatedLck , Prkca , Prkcb
Gallbladder NeoplasmsFscn1
Fatty LiverPrkcd
Ovarian NeoplasmsPrkca , Prkci
Fetal DiseasesPrkcb
Breast NeoplasmsPrkca , Prkci , Hsp90aa1
Spinocerebellar AtaxiasPrkcg
Urinary Bladder NeoplasmsPrkca
Alzheimer DiseaseFyn
Epilepsy, Temporal LobeFyn
HypertensionPrkca , Prkcb , Prkcd , Prkce
Hypogammaglobulinemia and Isolated growth hormone deficiency, X-linkedBtk
Spinocerebellar ataxia 14Prkcg
Prostatic NeoplasmsPrkca , Phlpp1 , Prkcq
SilicosisPrkcb
Bruton type agammaglobulinemiaBtk
Cerebral InfarctionPrkch
Insulin ResistancePrkcb , Prkcz , Prkcd , Prkcq
Hypertension, PortalHsp90aa1 , Prkcd
HyperinsulinismPrkcd , Prkcq
HIV InfectionsLck
Myocardial IschemiaPrkcd
Immune System DiseasesPrkcb
BurnsFyn , Prkcd
Carcinoma, Intraductal, NoninfiltratingPrkca
Cardiomyopathy, RestrictivePrkcd
Brain IschemiaPrkca , Prkcd
Common Bile Duct NeoplasmsFscn1
Conjunctivitis, AllergicLck
Diabetes Mellitus, ExperimentalPrkcb , Plcb3 , Prkcd , Prkci , Hsp90aa1
Diabetic NephropathiesPrkcb
Heart FailurePrkca , Prkcb
HyperalgesiaPrkcb
HyperglycemiaPrkcb , Prkcz
Neoplasm MetastasisFscn1
Myocardial InfarctionPlcb1 , Plcb3
Pituitary NeoplasmsPrkca
SchizophreniaFyn
SepsisFyn , Prkcq
Status EpilepticusPrkcb
Reperfusion InjuryPrkca
Myocardial Reperfusion InjuryPrkcb , Prkcd
Endometrial NeoplasmsPrkca
Hypertrophy, Left VentricularPrkca , Prkcb , Prkcz , Prkcd
Hypertrophy, Right VentricularPrkca , Prkcd
Carcinoma, Large CellPrkca
StrokePrkcd
Carcinoma, Pancreatic DuctalFscn1
MYOPATHY, MYOFIBRILLAR, 4Ldb3
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 12Plcb1
Cardiomyopathy, Dilated, 1CLdb3
Pathway Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Pathway TermsGene Symbols
mitogen activated protein kinase signaling pathwayPrkca , Prkcb , Prkcg
Wnt signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
Alzheimer disease pathwayPlcb1 , Plcb3 , Plcb2 , Plcb4
Huntington disease pathwayPlcb1 , Plcb3 , Plcb2 , Plcb4
prion diseases pathwayFyn
long term potentiationPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
long term depressionPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPrkcd
Hedgehog signaling pathwayPrkcd
insulin signaling pathwayPrkca , Prkcb , Prkcg , Prkcz , Pdpk1 , Prkci , Prkcq , Pard6a
inositol phosphate metabolic pathwayPlcb1 , Plcb3 , Plcb2 , Plcb4
epidermal growth factor/neuregulin signaling pathwayPrkca , Prkcb , Prkcg , Prkcz , Hsp90aa1
mTOR signaling pathwayPdpk1 , Prkca
type 2 diabetes mellitus pathwayPrkcz , Prkce , Prkcd
G protein mediated signaling pathway via Galphaq familyPlcb1 , Plcb3 , Plcb2 , Plcb4
phosphatidylinositol 3-kinase-Akt signaling pathwayPdpk1 , Hsp90aa1
tumor necrosis factor mediated signaling pathwayPrkcz , Gnb2l1 , Prkci
insulin-like growth factor signaling pathwayPrkcz , Prkcd , Gnb2l1 , Pdpk1
vascular endothelial growth factor signaling pathwayFyn , Prkca , Prkcb , Prkcg , Prkcz , Prkcd , Pdpk1 , Hsp90aa1
angiotensin II signaling pathwayPrkcz , Pdpk1
endocytosis pathwayPrkcz , Pard3 , Prkci , Pard6a , Pard6g , Pard6b
platelet-derived growth factor signaling pathwayFyn , Lck , Prkca , Prkcd , Prkce
ephrin - ephrin receptor bidirectional signaling axisFyn , Lck
fibroblast growth factor signaling pathwayPdpk1
hypoxia inducible factor pathwayGnb2l1
Reelin signaling pathwayFyn
altered Reelin signaling pathwayFyn
transforming growth factor-beta Smad dependent signaling pathwayPard6a , Pdpk1
nuclear factor kappa B signaling pathwayLck , Prkca
endothelin signaling pathwayPlcb1 , Prkca , Prkcg , Prkce , Plcb3 , Prkcd , Plcb2 , Prkch , Prkcq
estrogen signaling pathwayHsp90aa1
interleukin-6 signaling pathwayPrkcd
androgen signaling pathwayHsp90aa1
eicosanoid signaling pathwayFyn , Lck , Prkca , Prkcg , Prkcz , Prkce , Prkcd , Prkcq , Plcb2 , Prkch
aldosterone signaling pathwayPrkca , Prkcb , Pdpk1 , Hsp90aa1 , Prkcg
cortisol signaling pathwayHsp90aa1
neurotrophic factor signaling pathwayPrkcd
phosphatidylinositol 3-kinase signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
Wnt signaling, non-canonical pathwayPrkcz
prostate cancer pathwayHsp90aa1 , Pdpk1
endometrial cancer pathwayPdpk1
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkcz , Prkci
glypican signaling pathwayFyn , Lck
syndecan signaling pathwayFyn , Prkca , Prkcd , Gnb2l1
FasL mediated signaling pathwayBtk , Pdpk1
non-small cell lung cancer pathwayPrkca , Prkcb , Pdpk1 , Prkcg
glioma pathwayPrkca , Prkcb , Prkcg
p53 signaling pathwayPrkcd
NOD-like receptor signaling pathwayHsp90aa1
T cell receptor signaling pathwayFyn , Lck
B cell receptor signaling pathwayBtk , Prkcb
antigen processing and presentation pathwayHsp90aa1
chemokine mediated signaling pathwayPlcb1 , Plcb4 , Prkcb , Prkcz , Plcb3 , Prkcd , Pard3 , Plcb2
protein kinase C (PKC) signaling pathwayFyn , Lck , Plcb1 , Plcb4 , Prkca , Prkcb , Prkcg , Prkcz , Prkce , Plcb3 , Prkcd , Gnb2l1 , Pick1 , Cdc37 , Pdpk1 , Pard3 , Copb1 , Prkci , Prkcq , Plcb2 , Phlpp1 , Prkch , Hsp90aa1 , Pard6a , Pard6g , Pard6b , Btk , Phlpp2 , Ldb3 , Fscn1
glutamate signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
interleukin-1 signaling pathwayPrkcz , Prkci
type II interferon signaling pathwayPrkcd
interleukin-2 signaling pathwayFyn , Lck , Prkcb , Prkce
interleukin-12 signaling pathwayLck
sphingosine 1-phosphate signaling pathwayPlcb2
ceramide signaling pathwayPrkcz , Prkcd
phosphatidylinositol 3-kinase class I signaling pathwayFyn , Lck , Hsp90aa1 , Btk , Pdpk1
erythropoietin signaling pathwayBtk
E-cadherin signaling pathwayFyn
primary immunodeficiency disease pathwayBtk , Lck
myocarditis pathwayFyn
Leishmania infection pathwayPrkcb
Trypanosoma brucei infection pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
Trypanosoma cruzi infection pathwayPlcb1 , Plcb3 , Plcb2 , Plcb4
Entamoeba histolyca infection pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
influenza A virus infection pathwayPrkca , Prkcb
measles infection pathwayFyn , Gnb2l1 , Prkcq
gonadotropin-releasing hormone signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcd
calcium/calcium-mediated signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
Fc gamma receptor mediated signaling pathwayPrkca , Prkcb , Prkce , Prkcd , Prkcg
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
Fc epsilon receptor mediated signaling pathwayFyn , Prkca , Prkce , Prkcd , Btk , Prkcg
Phenotype Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway

References Associated with the protein kinase C (PKC) signaling pathway:

Ontology Path Diagram:

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