PROTEIN KINASE C (PKC) SIGNALING PATHWAY (PW:0000840)

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Description

The protein kinase C family (PKC) comprises ~2% of the human kinome and can be subdivided into three subclasses: conventional or classical (cPKC), novel (nPKC) and atypical (aPKC). All isoforms contain a C-terminal kinase domain and an N-terminal autoinhibitory pseudosubstrate but differ in their responsiveness to second messengers. A tandem DAG-sensitive C1 domain is present in cPKC and nPKC with the latter group displaying a higher sensitivity. The C2 domain is Ca2+ sensitive in cPKC only. The

Pathway Diagram:

Elsevier Inc. Ca2+ calcium transport pathway GPCRs upstream PKC G protein mediated signaling pathway via Galphaq family Phlpp1 ---| cPKC cPKC Phlpp1 ---| nPKC Phlpp2 ---| nPKC Phlpp2 ---| cPKC Pdpk1 --+> nPKC Pdpk1 --+> cPKC Pdpk1 --+> aPKC GPCRs upstream PKC --+> PLC-B members PLC-B members Phlpp1 Phlpp2 Pdpk1 Hsp90aa1 Cdc37 IP3 PKC interactors aPKC nPKC cPKC ---- PKC interactors nPKC ---- PKC interactors aPKC ---- PKC interactors Cdc37 ---- nPKC Cdc37 ---- cPKC Ca2+ ---- cPKC Hsp90aa1 ---- nPKC cPKC ---- Hsp90aa1 cPKC ---- DAG DAG ---- nPKC PIP2 ---> DAG PIP2 DAG PIP2 ---> IP3 cell polarity cell death cell proliferation cell differentiation cPKC ---> cell differentiation cPKC ---> cell proliferation nPKC ---> cell proliferation IP3 --+> Ca2+ calcium/calcium-mediated signaling pathway nPKC ---> cell death aPKC ---> cell polarity cPKC ---> cell death nPKC ---> cell differentiation
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Genes in Pathway:

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protein kinase C (PKC) signaling pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Btk Bruton agammaglobulinemia tyrosine kinase GBrowse link X 121,998,935 122,030,289 RGD:5131492
G Cdc37 cell division cycle 37 GBrowse link 8 20,164,150 20,176,763 RGD:5131489
G Copb1 coatomer protein complex, subunit beta 1 GBrowse link 1 172,199,676 172,233,765 RGD:5131491
G Fscn1 fascin actin-bundling protein 1 RGD:5131492
G Fyn FYN proto-oncogene, Src family tyrosine kinase GBrowse link 20 43,501,853 43,695,567 RGD:5131492
G Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 GBrowse link 10 34,067,237 34,072,593 RGD:5131491
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 GBrowse link 6 135,413,616 135,419,147 RGD:5131489
G Lck LCK proto-oncogene, Src family tyrosine kinase GBrowse link 5 148,707,505 148,718,296 RGD:5131492
G Ldb3 LIM domain binding 3 GBrowse link 16 10,221,362 10,247,798 RGD:5131491
RGD:5131492
G Pard3 par-3 family cell polarity regulator GBrowse link 19 57,015,742 57,603,133 RGD:5132275
G Pard6a par-6 family cell polarity regulator alpha GBrowse link 19 35,533,395 35,535,711 RGD:5132275
G Pard6b par-6 family cell polarity regulator beta GBrowse link 3 159,230,673 159,251,755 RGD:5132275
G Pard6g par-6 family cell polarity regulator gamma GBrowse link 18 76,942,285 77,007,923 RGD:5132275
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link 10 13,329,708 13,394,080 RGD:5131489
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 GBrowse link 13 12,315,824 12,565,692 RGD:5131497
RGD:8693633
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 GBrowse link 19 39,741,655 39,808,301 RGD:5131497
G Pick1 protein interacting with PRKCA 1 GBrowse link 7 117,213,299 117,232,651 RGD:5131491
G Plcb1 phospholipase C, beta 1 (phosphoinositide-specific) GBrowse link 3 122,797,718 123,523,675 RGD:5131502
G Plcb2 phospholipase C, beta 2 GBrowse link 3 105,203,524 105,223,342 RGD:5131502
G Plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) GBrowse link 1 209,628,425 209,643,694 RGD:5131502
G Plcb4 phospholipase C, beta 4 GBrowse link 3 123,706,313 124,077,381 RGD:5131502
G Prkca protein kinase C, alpha GBrowse link 10 97,367,196 97,638,910 RGD:5131489
G Prkcb protein kinase C, beta GBrowse link 1 181,117,512 181,459,856 RGD:5131489
G Prkcd protein kinase C, delta GBrowse link 16 5,954,218 5,975,743 RGD:5131489
G Prkce protein kinase C, epsilon GBrowse link 6 9,631,234 10,097,311 RGD:5131489
G Prkcg protein kinase C, gamma GBrowse link 1 64,145,749 64,172,712 RGD:5131489
G Prkch protein kinase C, eta GBrowse link 6 96,069,354 96,281,790 RGD:5131489
RGD:5131657
G Prkci protein kinase C, iota GBrowse link 2 116,739,625 116,801,084 RGD:5131489
RGD:5132275
G Prkcq protein kinase C, theta GBrowse link 17 78,486,998 78,566,741 RGD:5131489
G Prkcz protein kinase C, zeta GBrowse link 5 172,061,825 172,172,793 RGD:5131489
RGD:5131661
RGD:5132275

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassaPKCatypical protein kinase C members
Functional ClasscPKCclassical or conventional protein kinase C members
Small MoleculeDAGdiacylglycerol
Small MoleculeIP3inositol 1,4,5-triphosphate
Functional ClassnPKCnovel protein kinase C members
Small MoleculePIP2phosphoinositide-4,5-bisphosphate
Gene GroupPKC interactorsvarious proteins, binding partners and substrates

Pathway Gene Annotations

Disease Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Disease TermsGene Symbols
Pancreatic NeoplasmsFscn1
AgammaglobulinemiaBtk
IschemiaPrkca
Skin UlcerPlcb3
ObesityPrkcb , Prkcd
Retinitis PigmentosaPrkcg
HyperammonemiaPrkcq
CholangiocarcinomaFscn1
Bile Duct NeoplasmsFscn1
CardiomegalyPlcb1 , Prkca , Prkcb , Prkcd , Prkce
Muscular DiseasesPrkcd
Cardiomyopathy, DilatedLck , Prkca , Prkcb
Gallbladder NeoplasmsFscn1
Fatty LiverPrkcd
Ovarian NeoplasmsPrkca , Prkci
Fetal DiseasesPrkcb
Breast NeoplasmsPrkca , Prkci , Hsp90aa1
Spinocerebellar AtaxiasPrkcg
Urinary Bladder NeoplasmsPrkca
Alzheimer DiseaseFyn
Epilepsy, Temporal LobeFyn
HypertensionPrkca , Prkcb , Prkcd , Prkce
Hypogammaglobulinemia and Isolated growth hormone deficiency, X-linkedBtk
Spinocerebellar ataxia 14Prkcg
Prostatic NeoplasmsPrkca , Phlpp1 , Prkcq
SilicosisPrkcb
Bruton type agammaglobulinemiaBtk
Cerebral InfarctionPrkch
Insulin ResistancePrkcb , Prkcz , Prkcd , Prkcq
Hypertension, PortalHsp90aa1 , Prkcd
HyperinsulinismPrkcd , Prkcq
HIV InfectionsLck
Myocardial IschemiaPrkcd
Immune System DiseasesPrkcb
BurnsFyn , Prkcd
Carcinoma, Intraductal, NoninfiltratingPrkca
Cardiomyopathy, RestrictivePrkcd
Brain IschemiaPrkca , Prkcd
Common Bile Duct NeoplasmsFscn1
Conjunctivitis, AllergicLck
Diabetes Mellitus, ExperimentalPrkcb , Plcb3 , Prkcd , Prkci , Hsp90aa1
Diabetic NephropathiesPrkcb
Heart FailurePrkca , Prkcb
HyperalgesiaPrkcb
HyperglycemiaPrkcb , Prkcz
Neoplasm MetastasisFscn1
Myocardial InfarctionPlcb1 , Plcb3
Pituitary NeoplasmsPrkca
SchizophreniaFyn
SepsisFyn , Prkcq
Status EpilepticusPrkcb
Reperfusion InjuryPrkca
Myocardial Reperfusion InjuryPrkcb , Prkcd
Endometrial NeoplasmsPrkca
Common Variable ImmunodeficiencyPrkcd
Hypertrophy, Left VentricularPrkca , Prkcb , Prkcz , Prkcd
Hypertrophy, Right VentricularPrkca , Prkcd
Carcinoma, Large CellPrkca
StrokePrkcd
Carcinoma, Pancreatic DuctalFscn1
MYOPATHY, MYOFIBRILLAR, 4Ldb3
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 12Plcb1
Cardiomyopathy, Dilated, 1CLdb3
AURICULOCONDYLAR SYNDROME 2Plcb4
Pathway Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Pathway TermsGene Symbols
mitogen activated protein kinase signaling pathwayPrkca , Prkcb , Prkcg
Wnt signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
Alzheimer disease pathwayPlcb1 , Plcb3 , Plcb2 , Plcb4
Huntington disease pathwayPlcb1 , Plcb3 , Plcb2 , Plcb4
prion diseases pathwayFyn
long term potentiationPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
long term depressionPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPrkcd
Hedgehog signaling pathwayPrkcd
insulin signaling pathwayPrkca , Prkcb , Prkcg , Prkcz , Pdpk1 , Prkci , Prkcq , Pard6a
inositol phosphate metabolic pathwayPlcb1 , Plcb3 , Plcb2 , Plcb4
epidermal growth factor/neuregulin signaling pathwayPrkca , Prkcb , Prkcg , Prkcz , Hsp90aa1
mTOR signaling pathwayPdpk1 , Prkca
type 2 diabetes mellitus pathwayPrkcz , Prkce , Prkcd
G protein mediated signaling pathway via Galphaq familyPlcb1 , Plcb3 , Plcb2 , Plcb4
phosphatidylinositol 3-kinase-Akt signaling pathwayPdpk1 , Hsp90aa1
tumor necrosis factor mediated signaling pathwayPrkcz , Gnb2l1 , Prkci
insulin-like growth factor signaling pathwayPrkcz , Prkcd , Gnb2l1 , Pdpk1
vascular endothelial growth factor signaling pathwayFyn , Prkca , Prkcb , Prkcg , Prkcz , Prkcd , Pdpk1 , Hsp90aa1
angiotensin II signaling pathwayPrkcz , Pdpk1
endocytosis pathwayPrkcz , Pard3 , Prkci , Pard6a , Pard6g , Pard6b
platelet-derived growth factor signaling pathwayFyn , Lck , Prkca , Prkcd , Prkce
ephrin - ephrin receptor bidirectional signaling axisFyn , Lck
fibroblast growth factor signaling pathwayPdpk1
hypoxia inducible factor pathwayGnb2l1
Reelin signaling pathwayFyn
altered Reelin signaling pathwayFyn
transforming growth factor-beta Smad dependent signaling pathwayPard6a , Pdpk1
nuclear factor kappa B signaling pathwayLck , Prkca
endothelin signaling pathwayPlcb1 , Prkca , Prkcg , Prkce , Plcb3 , Prkcd , Plcb2 , Prkch , Prkcq
estrogen signaling pathwayHsp90aa1
interleukin-6 signaling pathwayPrkcd
androgen signaling pathwayHsp90aa1
eicosanoid signaling pathwayFyn , Lck , Prkca , Prkcg , Prkcz , Prkce , Prkcd , Prkcq , Plcb2 , Prkch
aldosterone signaling pathwayPrkca , Prkcb , Pdpk1 , Hsp90aa1 , Prkcg
cortisol signaling pathwayHsp90aa1
neurotrophic factor signaling pathwayPrkcd
phosphatidylinositol 3-kinase signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
Wnt signaling, non-canonical pathwayPrkcz
prostate cancer pathwayHsp90aa1 , Pdpk1
endometrial cancer pathwayPdpk1
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkcz , Prkci
glypican signaling pathwayFyn , Lck
syndecan signaling pathwayFyn , Prkca , Prkcd , Gnb2l1
FasL mediated signaling pathwayBtk , Pdpk1
non-small cell lung cancer pathwayPrkca , Prkcb , Pdpk1 , Prkcg
glioma pathwayPrkca , Prkcb , Prkcg
p53 signaling pathwayPrkcd
NOD-like receptor signaling pathwayHsp90aa1
T cell receptor signaling pathwayFyn , Lck
B cell receptor signaling pathwayBtk , Prkcb
antigen processing and presentation pathwayHsp90aa1
chemokine mediated signaling pathwayPlcb1 , Plcb4 , Prkcb , Prkcz , Plcb3 , Prkcd , Pard3 , Plcb2
protein kinase C (PKC) signaling pathwayFyn , Lck , Plcb1 , Plcb4 , Prkca , Prkcb , Prkcg , Prkcz , Prkce , Plcb3 , Prkcd , Gnb2l1 , Pick1 , Cdc37 , Pdpk1 , Pard3 , Copb1 , Prkci , Prkcq , Plcb2 , Phlpp1 , Prkch , Hsp90aa1 , Pard6a , Pard6g , Pard6b , Btk , Phlpp2 , Ldb3 , Fscn1
glutamate signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
interleukin-1 signaling pathwayPrkcz , Prkci
type II interferon signaling pathwayPrkcd
interleukin-2 signaling pathwayFyn , Lck , Prkcb , Prkce
interleukin-12 signaling pathwayLck
sphingosine 1-phosphate signaling pathwayPlcb2
ceramide signaling pathwayPrkcz , Prkcd
phosphatidylinositol 3-kinase class I signaling pathwayFyn , Lck , Hsp90aa1 , Btk , Pdpk1
erythropoietin signaling pathwayBtk
E-cadherin signaling pathwayFyn
primary immunodeficiency disease pathwayBtk , Lck
myocarditis pathwayFyn
Leishmania infection pathwayPrkcb
Trypanosoma brucei infection pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
Trypanosoma cruzi infection pathwayPlcb1 , Plcb3 , Plcb2 , Plcb4
Entamoeba histolyca infection pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
influenza A virus infection pathwayPrkca , Prkcb
measles infection pathwayFyn , Gnb2l1 , Prkcq
gonadotropin-releasing hormone signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcd
calcium/calcium-mediated signaling pathwayPlcb1 , Plcb4 , Prkca , Prkcb , Plcb3 , Plcb2 , Prkcg
Fc gamma receptor mediated signaling pathwayPrkca , Prkcb , Prkce , Prkcd , Prkcg
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
Fc epsilon receptor mediated signaling pathwayFyn , Prkca , Prkce , Prkcd , Btk , Prkcg
Phenotype Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway

References Associated with the protein kinase C (PKC) signaling pathway:

Ontology Path Diagram:

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