View Ontology Report


The protein kinase C family (PKC) comprises ~2% of the human kinome and can be subdivided into three subclasses: conventional or classical (cPKC), novel (nPKC) and atypical (aPKC). All isoforms contain a C-terminal kinase domain and an N-terminal autoinhibitory pseudosubstrate but differ in their responsiveness to second messengers. A tandem DAG-sensitive C1 domain is present in cPKC and nPKC with the latter group displaying a higher sensitivity. The C2 domain is Ca2+ sensitive in cPKC only. The

Pathway Diagram:

Elsevier Inc. Ca2+ calcium transport pathway GPCRs upstream PKC G protein mediated signaling pathway via Galphaq family Phlpp1 ---| cPKC cPKC Phlpp1 ---| nPKC Phlpp2 ---| nPKC Phlpp2 ---| cPKC Pdpk1 --+> nPKC Pdpk1 --+> cPKC Pdpk1 --+> aPKC GPCRs upstream PKC --+> PLC-B members PLC-B members Phlpp1 Phlpp2 Pdpk1 Hsp90aa1 Cdc37 IP3 PKC interactors aPKC nPKC cPKC ---- PKC interactors nPKC ---- PKC interactors aPKC ---- PKC interactors Cdc37 ---- nPKC Cdc37 ---- cPKC Ca2+ ---- cPKC Hsp90aa1 ---- nPKC cPKC ---- Hsp90aa1 cPKC ---- DAG DAG ---- nPKC PIP2 ---> DAG PIP2 DAG PIP2 ---> IP3 cell polarity cell death cell proliferation cell differentiation cPKC ---> cell differentiation cPKC ---> cell proliferation nPKC ---> cell proliferation IP3 --+> Ca2+ calcium/calcium-mediated signaling pathway nPKC ---> cell death aPKC ---> cell polarity cPKC ---> cell death nPKC ---> cell differentiation

Genes in Pathway:

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protein kinase C (PKC) signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:5131492
G Cdc37 cell division cycle 37 JBrowse link 8 22,160,922 22,173,797 RGD:5131489
G Copb1 coatomer protein complex, subunit beta 1 JBrowse link 1 183,695,480 183,729,569 RGD:5131491
G Fscn1 fascin actin-bundling protein 1 JBrowse link 12 13,655,459 13,668,595 RGD:5131492
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:5131492
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:5131489
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:5131492
G Ldb3 LIM domain binding 3 JBrowse link 16 10,878,348 10,943,016 RGD:5131491
G Pard3 par-3 family cell polarity regulator JBrowse link 19 60,017,746 60,580,628 RGD:5132275
G Pard6a par-6 family cell polarity regulator alpha JBrowse link 19 37,668,133 37,670,450 RGD:5132275
G Pard6b par-6 family cell polarity regulator beta JBrowse link 3 164,822,111 164,843,395 RGD:5132275
G Pard6g par-6 family cell polarity regulator gamma JBrowse link 18 76,559,877 76,627,843 RGD:5132275
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:5131489
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:5131497
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 JBrowse link 19 41,731,845 41,798,451 RGD:5131497
G Pick1 protein interacting with PRKCA 1 JBrowse link 7 120,465,472 120,484,824 RGD:5131491
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:5131502
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,563 RGD:5131502
G Plcb3 phospholipase C beta 3 JBrowse link 1 222,207,887 222,224,993 RGD:5131502
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,163 128,971,720 RGD:5131502
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:5131489
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:5131489
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:5131489
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:5131489
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:5131489
G Prkch protein kinase C, eta JBrowse link 6 96,479,243 96,677,368 RGD:5131489
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:5131489
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:5131489
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:5131489
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:5131491
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:10002727

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassaPKCatypical protein kinase C members
Functional ClasscPKCclassical or conventional protein kinase C members
Small MoleculeDAGdiacylglycerol
Small MoleculeIP3inositol 1,4,5-triphosphate
Functional ClassnPKCnovel protein kinase C members
Small MoleculePIP2phosphoinositide-4,5-bisphosphate
Gene GroupPKC interactorsvarious proteins, binding partners and substrates

Pathway Gene Annotations

Disease Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Disease TermsGene Symbols
Adenocarcinoma of LungRasa1
Alzheimer DiseaseFyn , Hsp90aa1
Amphetamine-Related DisordersPick1
Arteriovenous MalformationsRasa1
Arthritis, ExperimentalBtk
Arthritis, RheumatoidHsp90aa1 , Prkcq
Arthus ReactionBtk
Auriculo-condylar syndromePlcb4
Auriculocondylar Syndrome 2Plcb4
Autistic DisorderPrkcb
Autoimmune Lymphoproliferative Syndrome, Type IIIPrkcd
Bile Duct NeoplasmsFscn1
Brain IschemiaPrkca , Prkcd
Breast NeoplasmsHsp90aa1 , Pdpk1 , Prkca , Prkci
Bruton type agammaglobulinemiaBtk
BurnsFyn , Prkcd
Capillary Malformation-Arteriovenous MalformationRasa1
Carcinoma, Basal CellRasa1
Carcinoma, Intraductal, NoninfiltratingPrkca
Carcinoma, Large CellPrkca
Carcinoma, Pancreatic DuctalFscn1
Carcinoma, Squamous CellRack1 , Rasa1
CardiomegalyPrkca , Prkcb , Prkcd , Prkce
CardiomyopathiesLdb3 , Prkce
Cardiomyopathy, DilatedLck , Ldb3 , Prkca , Prkcb
Cardiomyopathy, Dilated, 1CLdb3
Cardiomyopathy, Dilated, with Left Ventricular NoncompactionLdb3
Cardiomyopathy, Familial Hypertrophic, 1Ldb3
Cardiomyopathy, HypertrophicLdb3
Cardiomyopathy, Hypertrophic, FamilialLdb3
Cardiomyopathy, RestrictivePrkcd
Cell Transformation, NeoplasticPhlpp1
Cerebral InfarctionPrkch
Colonic NeoplasmsPlcb1
Colorectal NeoplasmsPrkcb , Prkce
Common Bile Duct NeoplasmsFscn1
Conjunctivitis, AllergicLck
Coronary StenosisPrkce
Dermatitis, ContactHsp90aa1
Diabetes Insipidus, NephrogenicPrkca
Diabetes Mellitus, ExperimentalHsp90aa1 , Plcb3 , Prkca , Prkcb , Prkcd , Prkce , Prkci
Diabetes Mellitus, Type 1Prkcq
Diabetes Mellitus, Type 2Prkcb
Diabetic NephropathiesPrkcb , Prkce
Disease Models, AnimalPrkcg
Distal MyopathiesLdb3
Dwarfism, PituitaryBtk
Endometrial NeoplasmsPrkca
Epilepsy, Temporal LobeFyn
Epileptic Encephalopathy, Early Infantile, 12Plcb1
Fatty LiverPrkcd
Fetal DiseasesPrkcb
Frontotemporal Lobar DegenerationHsp90aa1
Gallbladder NeoplasmsFscn1
Heart FailurePdpk1 , Prkca , Prkcb
HIV InfectionsHsp90aa1 , Lck
HyperalgesiaPrkcb , Prkce , Prkcg
HyperglycemiaPrkcb , Prkcz
HyperinsulinismPrkcd , Prkcq
HypertensionPrkca , Prkcb , Prkcd , Prkce
Hypertension, PortalHsp90aa1 , Prkcd
Hypertrophy, Left VentricularPrkca , Prkcb , Prkcd , Prkcz , Rasa1
Hypertrophy, Right VentricularPrkca , Prkcd
Hypogammaglobulinemia and Isolated Growth Hormone Deficiency, X-LinkedBtk
Hypogammaglobulinemia, X-LinkedBtk
Immune System DiseasesPrkcb
Immunologic Deficiency SyndromesBtk
Insulin ResistancePrkcb , Prkcd , Prkcq , Prkcz
Intellectual DisabilityPrkcg
Intestinal NeoplasmsPrkca , Prkcd
Ischemic Attack, TransientRack1
Leukemia, Lymphocytic, Chronic, B-CellBtk
Leukemia, Myeloid, AcutePlcb1
Leukemia-Lymphoma, Adult T-CellFyn , Prkcb
Liver Cirrhosis, ExperimentalFyn , Prkcb , Prkcd
Liver NeoplasmsPrkce
Long QT SyndromePlcb4
Lymphoma, B-CellBtk
Lymphoma, Large B-Cell, DiffusePdpk1
Lymphoma, Large-Cell, AnaplasticHsp90aa1
Lymphoma, Mantle-CellBtk
Lymphoma, T-Cell, CutaneousPrkcq
Lymphoma, T-Cell, PeripheralFyn
Mammary Neoplasms, AnimalRasa1
Mammary Neoplasms, ExperimentalRasa1
Mild Cognitive ImpairmentHsp90aa1
Mobius SyndromePlcb2
Mouth NeoplasmsRack1
Muscular DiseasesPrkcd
Myelodysplastic SyndromesPlcb1
Myocardial InfarctionPlcb1 , Plcb3 , Prkce
Myocardial IschemiaPrkcd , Prkce
Myocardial Reperfusion InjuryPrkcb , Prkcd
Myofibrillar MyopathyLdb3
Myopathies, Structural, CongenitalLdb3
Myopathy, Myofibrillar, Zasp-RelatedLdb3
Myotonic DystrophyLdb3
Neoplasm MetastasisFscn1 , Hsp90aa1
Neurotoxicity SyndromesPrkcd
ObesityPrkcb , Prkcd , Prkch
Osteoarthritis, KneeHsp90aa1
Ovarian NeoplasmsPrkca , Prkci
Pancreatic NeoplasmsFscn1
Parkinsonian DisordersPrkcd
Peripheral Nervous System DiseasesPrkce
Pituitary NeoplasmsPrkca
Port-Wine StainRasa1
Prostatic NeoplasmsPard3 , Phlpp1 , Plcb4 , Prkca , Prkcq , Prkcz
Psychoses, Substance-InducedPick1
Reperfusion InjuryPrkca
Retinitis PigmentosaPrkcg
SchizophreniaFyn , Plcb1
SepsisFyn , Prkcq
Skin UlcerPlcb3
Smith-Magenis SyndromePrkca
Spasms, InfantilePlcb1
Spinocerebellar Ataxia 14Prkcg
Spinocerebellar AtaxiasPrkcg
Status EpilepticusPrkcb
Stomach NeoplasmsFyn , Prkcb
Sturge-Weber SyndromeRasa1
Substance-Related DisordersPrkce , Prkch
Trigeminal NeuralgiaPrkcg
Urinary Bladder NeoplasmsPrkca
Uveal MelanomaPlcb4
Pathway Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPlcb1
adenosine signaling pathwayPard6a , Pdpk1 , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPlcb1
aldosterone signaling pathwayHsp90aa1 , Pdpk1 , Prkca , Prkcb , Prkcg
altered Reelin signaling pathwayFyn
Alzheimer disease pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
amiodarone pharmacodynamics pathwayPlcb1
amlodipine pharmacodynamics pathwayPlcb1
androgen signaling pathwayHsp90aa1
angiotensin II signaling pathwayPdpk1 , Prkcz
antigen processing and presentation pathwayHsp90aa1
atenolol pharmacodynamics pathwayPlcb1
B cell receptor signaling pathwayBtk , Prkcb
betaxolol pharmacodynamics pathwayPlcb1
bisoprolol pharmacodynamics pathwayPlcb1
bupranolol drug pathwayPlcb1
bupranolol pharmacodynamics pathwayPlcb1
calcium/calcium-mediated signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
carvedilol pharmacodynamics pathwayPlcb1
ceramide signaling pathwayPrkcd , Prkcz
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayPard3 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkcb , Prkcd , Prkcz
cortisol signaling pathwayHsp90aa1
diltiazem pharmacodynamics pathwayPlcb1
disopyramide pharmacodynamics pathwayPlcb1
dobutamine pharmacodynamics pathwayPlcb1
E-cadherin signaling pathwayFyn
eicosanoid signaling pathwayFyn , Lck , Plcb2 , Prkca , Prkcd , Prkce , Prkcg , Prkch , Prkcq , Prkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayPard3 , Pard6a , Pard6b , Pard6g , Prkci , Prkcz
endometrial cancer pathwayPdpk1
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1
endothelin signaling pathwayPlcb1 , Plcb2 , Plcb3 , Prkca , Prkcd , Prkce , Prkcg , Prkch , Prkcq
Entamoeba histolyca infection pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
ephrin - ephrin receptor bidirectional signaling axisFyn , Lck , Rasa1
epidermal growth factor/neuregulin signaling pathwayHsp90aa1 , Prkca , Prkcb , Prkcg , Prkcz , Rasa1
erythropoietin signaling pathwayBtk
esmolol pharmacodynamics pathwayPlcb1
estrogen signaling pathwayHsp90aa1
FasL mediated signaling pathwayBtk , Pdpk1
Fc epsilon receptor mediated signaling pathwayBtk , Fyn , Prkca , Prkcd , Prkce , Prkcg
Fc gamma receptor mediated signaling pathwayPrkca , Prkcb , Prkcd , Prkce , Prkcg
fibroblast growth factor signaling pathwayPdpk1
flecainde pharmacodynamics pathwayPlcb1
fosphenytoin pharmacodynamics pathwayPlcb1
G protein mediated signaling pathway via Galphaq familyPlcb1 , Plcb2 , Plcb3 , Plcb4
glioma pathwayPrkca , Prkcb , Prkcg
glutamate signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
glypican signaling pathwayFyn , Lck
gonadotropin-releasing hormone signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcd
Hedgehog signaling pathwayPrkcd
Huntington disease pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
hypoxia inducible factor pathwayRack1
ibutilide pharmacodynamics pathwayPlcb1
influenza A virus infection pathwayPrkca , Prkcb
inositol phosphate metabolic pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkci , Prkcz
insulin signaling pathwayPard6a , Pdpk1 , Prkca , Prkcb , Prkcg , Prkci , Prkcq , Prkcz , Rasa1
insulin-like growth factor signaling pathwayPdpk1 , Prkcd , Prkcz , Rack1
interleukin-1 signaling pathwayPrkci , Prkcz
interleukin-12 signaling pathwayLck
interleukin-2 signaling pathwayFyn , Lck , Prkcb , Prkce , Rasa1
interleukin-6 signaling pathwayPrkcd
isoprenaline pharmacodynamics pathwayPlcb1
isradipine pharmacodynamics pathwayPlcb1
Leishmania infection pathwayPrkcb
levobunolol pharmacodynamics pathwayPlcb1
lidocaine pharmacodynamics pathwayPlcb1
long term depressionPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
long term potentiationPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
measles infection pathwayFyn , Prkcq , Rack1
metoprolol pharmacodynamics pathwayPlcb1
mexiletine pharmacodynamics pathwayPlcb1
mitogen activated protein kinase signaling pathwayPrkca , Prkcb , Prkcg , Rasa1
mTOR signaling pathwayPdpk1 , Prkca
myocarditis pathwayFyn
nadolol pharmacodynamics pathwayPlcb1
nebivolol pharmacodynamics pathwayPlcb1
neurotrophic factor signaling pathwayPrkcd
nifedipine pharmacodynamics pathwayPlcb1
nimodipine pharmacodynamics pathwayPlcb1
nisoldipine pharmacodynamics pathwayPlcb1
nitrendipine pharmacodynamics pathwayPlcb1
NOD-like receptor signaling pathwayHsp90aa1
non-small cell lung cancer pathwayPdpk1 , Prkca , Prkcb , Prkcg
nuclear factor kappa B signaling pathwayLck , Prkca
p53 signaling pathwayPrkcd
penbutolol pharmacodynamics pathwayPlcb1
phenytoin pharmacodynamics pathwayPlcb1
phosphatidylinositol 3-kinase class I signaling pathwayBtk , Fyn , Hsp90aa1 , Lck , Pdpk1
phosphatidylinositol 3-kinase signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayHsp90aa1 , Pdpk1 , Phlpp1 , Phlpp2
phosphoinositide metabolic pathwayPlcb1
pindolol pharmacodynamics pathwayPlcb1
platelet-derived growth factor signaling pathwayFyn , Lck , Prkca , Prkcd , Prkce , Rasa1
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
primary immunodeficiency disease pathwayBtk , Lck
prion diseases pathwayFyn
procainamide pharmacodynamics pathwayPlcb1
propranolol pharmacodynamics pathwayPlcb1
prostate cancer pathwayHsp90aa1 , Pdpk1
protein kinase C (PKC) signaling pathwayBtk , Cdc37 , Copb1 , Fscn1 , Fyn , Hsp90aa1 , Lck , Ldb3 , Pard3 , Pard6a , Pard6b , Pard6g , Pdpk1 , Phlpp1 , Phlpp2 , Pick1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcd , Prkce , Prkcg , Prkch , Prkci , Prkcq , Prkcz , Rack1 , Rasa1
quinidine pharmacodynamics pathwayPlcb1
Reelin signaling pathwayFyn
ribosome biogenesis pathwayPrkcb , Rack1
sotalol pharmacodynamics pathwayPlcb1
sphingosine 1-phosphate signaling pathwayPlcb2
syndecan signaling pathwayFyn , Prkca , Prkcd , Rack1 , Rasa1
T cell receptor signaling pathwayFyn , Lck
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPrkcd
timolol pharmacodynamics pathwayPlcb1
transforming growth factor-beta Smad dependent signaling pathwayPard6a , Pdpk1
Trypanosoma brucei infection pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
tumor necrosis factor mediated signaling pathwayPrkci , Prkcz , Rack1
type 2 diabetes mellitus pathwayPrkcd , Prkce , Prkcz
type II interferon signaling pathwayPrkcd
vascular endothelial growth factor signaling pathwayFyn , Hsp90aa1 , Pdpk1 , Prkca , Prkcb , Prkcd , Prkcg , Prkcz
verapamil pharmacodynamics pathwayPlcb1
Wnt signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
Wnt signaling, non-canonical pathwayPrkcz
Phenotype Annotations Associated with Genes in the protein kinase C (PKC) signaling pathway

References Associated with the protein kinase C (PKC) signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: