GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Prkcd | decreases activity | EXP | | 6480464 | CTD | rottlerin results in decreased activity of PRKCD protein | PMID:12720544 PMID:20488202 | Prkcd | multiple interactions | EXP | | 6480464 | CTD | [rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to 2-methylcyclopentadienyl manganese tricarbonyl; rottlerin inhibits the reaction [2-methylcyclopentadienyl manganese tricarbonyl results in increased cleavage of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [manganese chloride results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]]; rottlerin inhibits the reaction [sodium arsenite results in increased phosphorylation of PRKCD protein] | PMID:11880503 PMID:15681813 PMID:20488202 PMID:20830294 PMID:21310168 PMID:25773745 PMID:27658547 | Prkcd | decreases activity | ISO | PRKCD (Homo sapiens) | 6480464 | CTD | rottlerin results in decreased activity of PRKCD protein | PMID:15949478 PMID:15955695 PMID:18357586 | Prkcd | decreases activity | ISO | Prkcd (Mus musculus) | 6480464 | CTD | rottlerin results in decreased activity of PRKCD protein | PMID:21633170 | Prkcd | decreases phosphorylation | ISO | Prkcd (Mus musculus) | 6480464 | CTD | rottlerin results in decreased phosphorylation of PRKCD protein | PMID:19393235 | Prkcd | decreases response to substance | ISO | PRKCD (Homo sapiens) | 6480464 | CTD | PRKCD protein results in decreased susceptibility to rottlerin | PMID:22902833 | Prkcd | multiple interactions | ISO | PRKCD (Homo sapiens) | 6480464 | CTD | [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [IFNA2 protein results in increased phosphorylation of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [NSC606985 results in increased activity of and results in increased cleavage of PRKCD protein] | PMID:16260419 PMID:17171638 PMID:19662097 PMID:22643241 | Prkcd | multiple interactions | ISO | Prkcd (Mus musculus) | 6480464 | CTD | [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of DAT protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in increased metabolism of Dopamine]; [rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to Methamphetamine; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rottlerin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [p-Chloroamphetamine results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein] | PMID:15574884 PMID:22512859 PMID:25895139 PMID:30366073 PMID:32437895 PMID:34740715 | | ||||||||||||||||||||||
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