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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67383
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkcd
Name: protein kinase C, delta
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcdincreases phosphorylationEXP 6480464CTDArsenic Trioxide results in increased phosphorylation of PRKCD proteinPMID:29986281
Prkcdmultiple interactionsISOPRKCD (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Bortezomib] results in increased cleavage of and results in increased activity of PRKCD protein; Arsenic Trioxide results in increased cleavage of and results in increased activity of PRKCD proteinPMID:17495969 PMID:19662097
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