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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67383 Species: Rattus norvegicus RGD Object: Gene Symbol: Prkcd Name: protein kinase C, delta

Acc ID: CHEBI:9288 Term: streptozocin Definition: An antibiotic that is produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. CasRN: 18883-66-4 Chemical ID: MESH:D013311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCD protein]	PMID:19682444
multiple interactions	EXP		6480464	CTD	Ethanol inhibits the reaction [Streptozocin results in increased expression of PRKCD protein]	PMID:12198386
increases expression	EXP		6480464	CTD	Streptozocin results in increased expression of PRKCD protein	PMID:12198386 PMID:19682444
increases expression	EXP		6480464	CTD	Streptozocin results in increased expression of PRKCD protein	PMID:19682444 PMID:12198386