RGD Reference Report - Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat. - Rat Genome Database

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Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat.

Authors: Papparella, I  Ceolotto, G  Berto, L  Cavalli, M  Bova, S  Cargnelli, G  Ruga, E  Milanesi, O  Franco, L  Mazzoni, M  Petrelli, L  Nussdorfer, GG  Semplicini, A 
Citation: Papparella I, etal., Cardiovasc Res. 2007 Jan 15;73(2):432-8. Epub 2006 Oct 20.
RGD ID: 1642525
Pubmed: PMID:17123493   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cardiores.2006.10.010   (Journal Full-text)

OBJECTIVE: Cardiovascular risk is increased among HIV-infected patients receiving antiretroviral therapy due to the development of hypertension and metabolic abnormalities. In this study, we investigated the effects of long-term treatment with zidovudine (AZT) and vitamin C, alone and in combination, on blood pressure and on the chain of events linking oxidative stress to cardiac damage in the rat. METHODS: Six adult Wistar Kyoto rats received AZT (1 mg/ml) in the drinking water for 8 months, six vitamin C (10 g/kg of food) and AZT, six vitamin C alone, and six served as controls. RESULTS: AZT increased systolic blood pressure, expression of gp91(phox) and p47(phox) subunits of NAD(P)H oxidase, and protein kinase C (PKC) delta activation and reduced antioxidant power of plasma and cardiac homogenates. AZT also caused morphological alterations in cardiac myocyte mitochondria, indicative of functional damage. All of these effects were prevented by vitamin C. CONCLUSION: Chronic AZT administration increases blood pressure and promotes cardiovascular damage through a NAD(P)H oxidase-dependent mechanism that involves PKC delta. Vitamin C antagonizes these adverse effects of AZT in the cardiovascular system.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to xenobiotic stimulus  IEP 1642525 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Prkcd  (protein kinase C, delta)


Additional Information