Smad3 Rat Gene (SMAD family member 3)

Help | FTP Download | Citing RGD | Contact Us

Keyword

Gene:
Smad3 ( Rattus norvegicus )
SMAD family member 3
Description: transcription factor; important component of the TGF-beta signaling pathway
Synonyms: MAD homolog 3 (Drosophila); MAD (mothers against decapentaplegic, Drosophila) homolog 3; Madh3; MAD (mothers against decapentaplegic Drosophila) homolog 3;  (details...)
ArrayIDs: 5892278; 1369528_at; 6141641; 6672587; 5933537; 5733832; 6515797; 5645953; 6359733; U66479_at; 6106795; 6148732; 6511307; GE1130191; A_43_P11709; 5993401; 6036693; 6746921; 6720065; A_44_P531593; 6133269; 6295939; 5924083; 6421015; 6266112; 5900495; 6190529; 6143418; 6652449; 5643881; 6669833; 5651645;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: SMAD3     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Smad3     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Smad3 genome assembly 3.1 8 67822964 - 67971110
Rat Celera Assembly 8 63520702 - 63647062
RGSC genome assembly v3.4 8 67803909 - 67952056
Cytogenetic 8 q24
Mus musculus Smad3 Mouse genome assembly build 36.1 9 63494574 - 63605801
Homo sapiens SMAD3 human genome assembly 15 65145248 - 65274586
Human genome assembly build 36.2 15 65145249 - 65274587
Cytogenetic 15 q22.33

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Gene Ontology

co-SMAD binding,  ubiquitin protein ligase binding,  protein kinase binding ... (details...)
Biological Process

Note Reference

plays an important role in osteoblastic bone formation 727387

involved in folliculogenesis 727374

an essential downstream intracellular target of the TGF-beta receptor signaling pathway 625421

Gene Ontology

heart looping,  cell cycle arrest,  somitogenesis ... (details...)
Cellular Component

Note Reference

translocated to the nucleus 727374

Gene Ontology

transcription factor complex,  protein complex,  nucleus ... (details...)
Disease

Note Reference

may be involved in pulmonary fibrosis 625421

Ontology

Prostatic Neoplasms,  Endometrial Neoplasms,  Colorectal Neoplasms, Hereditary Nonpolyposis ... (details...)
Phenotype

Ontology

liver fibrosis (details...)
Pathway

Ontology

transforming growth factor-beta Smad dependent signaling pathway,  altered transforming growth factor-beta Smad dependent signaling pathway,  SMAD dependent signaling pathways ... (details...)
Product

Note Reference

member of the family of Smad proteins 625421

Regulation

Note Reference

phosphorylated by activated TGF-beta type 1 receptor which induces the translocation of the protein from the cytoplasm to the nucleus 625421

Drugs

Note Reference

bleomycin at a dose of 9U/kg body weight causes down regulation of mRNA 625421

External Links
Databases
DATABASE ID SOURCE
SMART: DWB IPI
SMART: DWA IPI
PROSITE: MH1 IPI
PROSITE: MH2 IPI
UNIPARC: UPI0000023A91 IPI
KEGG Report: rno:25631 ENTREZGENE
HomoloGene Group ID: 55937 ENTREZGENE
Germonline: 3032
Pfam: MH2 IPI
Pfam: MH1 IPI
KEGG Pathway: 05212 ENTREZGENE
KEGG Pathway: 04520 ENTREZGENE
KEGG Pathway: 04110 ENTREZGENE
KEGG Pathway: 05220 ENTREZGENE
KEGG Pathway: 05210 ENTREZGENE
KEGG Pathway: 04310 ENTREZGENE
KEGG Pathway: 04350 ENTREZGENE
KEGG Pathway: 05200 ENTREZGENE
InterPro: Dwarfin. IPI
InterPro: MAD_homology1_Dwarfin-type. IPI
InterPro: SMAD_dom-like. IPI
InterPro: SMAD_dom_Dwarfin-type. IPI
InterPro: SMAD_FHA_domain. IPI
InterPro: MAD_homology_MH1. IPI
Ensembl Protein: ENSRNOP00000037346 IPI
IPI: IPI00209246 IPI
Gene3D-CATH: MH2_Dwarfin-type IPI
Gene3D-CATH: MAD_MH1 IPI
Entrez Gene: Smad3 ENTREZGENE
IMAGE_CLONE: IMAGE:5599910 IMAGE-MGC_LOAD
MGC_CLONE: MGC:72529 IMAGE-MGC_LOAD
Ensembl Genes: ENSRNOG00000008620 IPI
TIGR: TC221903
UniProt: SMAD3_RAT IPI
UniProt: Q206L0_RAT IPI
Superfamily-SCOP: SMAD_FHA IPI
Superfamily-SCOP: MAD_MH1 IPI
RatMap: 44368 ENTREZGENE
PANTHER: Dwarfin IPI
Sequences
Nucleotide: CH473975 Get FASTA Search GEO Profiles
Nucleotide: U66479 Get FASTA Search GEO Profiles
Nucleotide: NM_013095 Get FASTA Search GEO Profiles
Nucleotide: BC064437 Get FASTA Search GEO Profiles
Nucleotide: DQ409172 Get FASTA Search GEO Profiles
(View all 5 Nucleotide Accessions)
Protein: NP_037227 Get FASTA
Protein: EDL95777 Get FASTA
Protein: AAH64437 Get FASTA
Protein: ABD66605 Get FASTA
Protein: AAC52944 Get FASTA
Protein: P84025 Get FASTA
Protein: Q206L0 Get FASTA
(View all 7 Protein Accessions)
Clusters
UniGene: 10636

References
Curated References
28 references in RGD related to Smad3

Other References
44 other references at PubMed related to Smad3

Database Information
RGD ID 3032
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

23-OCT-08: Smad3 SMAD family member 3 Smad3 MAD homolog 3 (Drosophila) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

17-NOV-05: Smad3 MAD homolog 3 (Drosophila) Madh3 APPROVED Symbol updated 1299863

10-JUN-02: Madh3 MAD homolog 3 (Drosophila) APPROVED Name updated 70584