Smad3 (SMAD family member 3) - Rat Genome Database

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Gene: Smad3 (SMAD family member 3) Rattus norvegicus
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Symbol: Smad3 (Ensembl: Smad2)
Name: SMAD family member 3 (Ensembl:SMAD family member 2)
RGD ID: 3032
Description: Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component biogenesis; and regulation of macromolecule metabolic process. Located in nucleus. Part of transcription regulator complex. Used to study cocaine dependence and pre-malignant neoplasm. Biomarker of alcoholic cardiomyopathy; alcoholic liver cirrhosis; and hypospadias. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (-)-ephedrine; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; MAD homolog 3 (Drosophila); mad3; Madh3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,022,204 - 73,132,324 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl873,024,760 - 73,132,324 (-)EnsemblGRCr8
mRatBN7.2864,126,829 - 64,236,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx869,641,910 - 69,752,073 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,914,370 - 68,024,539 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,784,499 - 65,894,665 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)Ensemblrn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera863,537,497 - 63,647,062 (-)NCBICelera
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
alcoholic cardiomyopathy  (IEP)
alcoholic liver cirrhosis  (IEP,ISO)
Aneurysm  (ISO)
aortic aneurysm  (ISO)
aortic disease  (ISO)
aortic dissection  (ISO)
ARTERIAL DISSECTION  (ISO)
Carotid Artery Injuries  (IEP)
cervical squamous cell carcinoma  (ISO)
cocaine dependence  (IMP)
Cocaine-Related Disorders  (ISO)
Colorectal Neoplasms  (ISO)
congenital contractural arachnodactyly  (ISO)
connective tissue disease  (ISO)
coronary artery disease  (ISO)
Craniofacial Abnormalities  (ISO)
Crohn's disease  (ISO)
Desbuquois dysplasia  (ISO)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (ISO)
endometrial cancer  (ISO)
Experimental Arthritis  (IEP)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (IEP)
Familial Thoracic Aortic Aneurysm 1  (ISO)
Familial Thoracic Aortic Aneurysm 6  (ISO)
Hypertrophic Cicatrix  (IEP)
Hypoglossal Nerve Injuries  (IEP)
hypospadias  (IEP)
juvenile rheumatoid arthritis  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
Loeys-Dietz syndrome  (ISO)
Loeys-Dietz syndrome 3  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
Lynch syndrome  (ISO)
Marfan syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA)
osteoarthritis  (ISO,ISS)
Osteoarthritis, Hip  (ISO)
pancreatic cancer  (ISO)
pre-malignant neoplasm  (IDA)
prostate cancer  (ISO)
Radiation Pneumonitis  (IEP)
Shprintzen-Goldberg Craniosynostosis  (ISO)
thoracic aortic aneurysm  (ISO)
Tubulointerstitial Fibrosis  (ISO)
ureteral obstruction  (ISO)
Uterine Neoplasms  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-O-oleoyl-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
20-HETE  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Methoxynobiletin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
aconitic acid  (ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
Ammothamnine  (ISO)
amphetamine  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
azithromycin  (ISO)
azoxystrobin  (ISO)
bellidifolin  (EXP,ISO)
benazepril  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
benzophenone  (ISO)
betulin  (EXP)
betulinic acid  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcipotriol  (EXP)
candesartan  (EXP)
Candesartan cilexetil  (EXP)
cantharidin  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
casticin  (ISO)
celastrol  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
CGS-21680  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
ebselen  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
Evodiamine  (EXP,ISO)
fenofibrate  (ISO)
fenthion  (ISO)
ferulic acid  (EXP)
fipronil  (EXP)
fluoranthene  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
gallic acid  (EXP)
Ganoderic acid A  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
glucose  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
Honokiol  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
irbesartan  (EXP)
irinotecan  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
ivermectin  (ISO)
KT 5720  (ISO)
L-methionine  (ISO)
lactucin  (EXP,ISO)
lead diacetate  (EXP)
leptomycin B  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
LY-2157299  (EXP,ISO)
LY294002  (ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mirtazapine  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
Muraglitazar  (EXP)
myriocin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nitric oxide  (EXP)
nitrofen  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
oridonin  (ISO)
osthole  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
patulin  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Phyllanthin  (ISO)
picoxystrobin  (ISO)
picrotoxin  (EXP)
pinostrobin  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
prednisone  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
roflumilast  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salvianolic acid B  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
SCH 23390  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (EXP)
streptozocin  (EXP,ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
tungsten  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vitamin D  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IBA,IEA,ISO)
adrenal gland development  (IDA)
anatomical structure morphogenesis  (IBA)
apoptotic process  (ISO)
apoptotic signaling pathway  (IEA,ISO)
cell differentiation  (IBA)
cell population proliferation  (ISO)
cell-cell junction organization  (IEA,ISO)
cellular response to glucose stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEA,IEP,ISO)
cellular response to virus  (IEA,ISO)
developmental growth  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic pattern specification  (ISO)
endoderm development  (ISO)
extrinsic apoptotic signaling pathway  (IEA,IMP,ISO)
gastrulation  (ISO)
heart looping  (ISO)
immune response  (IEA,ISO)
immune system development  (ISO)
in utero embryonic development  (ISO)
JNK cascade  (IEA,ISO)
lens fiber cell differentiation  (ISO)
liver development  (ISO)
MAPK cascade  (IEA,ISO)
mesoderm formation  (ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of cardiac muscle hypertrophy in response to stress  (IGI)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell population proliferation  (IDA,IEA,ISO)
negative regulation of cytosolic calcium ion concentration  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of lung blood pressure  (IGI)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of ossification  (IEA,ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of osteoblast proliferation  (IEA,ISO)
negative regulation of protein catabolic process  (IDA,IMP)
negative regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
negative regulation of wound healing  (IEA,ISO)
nodal signaling pathway  (IEA,ISO)
osteoblast development  (ISO)
osteoblast differentiation  (IEA,ISO)
paraxial mesoderm morphogenesis  (ISO)
pericardium development  (ISO)
positive regulation of alkaline phosphatase activity  (IDA)
positive regulation of bone mineralization  (IDA)
positive regulation of canonical Wnt signaling pathway  (IMP)
positive regulation of cell migration  (IMP)
positive regulation of chondrocyte differentiation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of extracellular matrix assembly  (IEA,ISO)
positive regulation of focal adhesion assembly  (IDA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IMP)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,IGI,ISO)
positive regulation of positive chemotaxis  (IDA)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of stress fiber assembly  (IDA)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,IMP,ISO)
positive regulation of transforming growth factor beta3 production  (IMP)
protein stabilization  (IMP)
regulation of dendritic spine morphogenesis  (IMP)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of immune response  (IEA,ISO)
regulation of mitochondrial membrane potential  (IMP)
regulation of striated muscle tissue development  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of transforming growth factor beta2 production  (IEA,ISO)
release of cytochrome c from mitochondria  (IMP)
response to alcohol  (IEP)
response to angiotensin  (ISO)
response to cocaine  (IEP)
response to gamma radiation  (IEP)
response to hypoxia  (IEA,ISO)
response to transforming growth factor beta  (ISO)
signal transduction involved in regulation of gene expression  (IMP)
skeletal system development  (ISO)
SMAD protein signal transduction  (IBA,IEA,IMP,ISO)
somitogenesis  (ISO)
T cell activation  (IEA,ISO)
thyroid gland development  (ISO)
transdifferentiation  (IDA)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,IMP,ISO)
trophoblast cell migration  (IEA,ISO)
ureteric bud development  (IEA,ISO)

Cellular Component

Molecular Function
beta-catenin binding  (IDA)
bHLH transcription factor binding  (IEA,ISO)
chromatin binding  (IEA,ISO)
chromatin DNA binding  (IEA,ISO)
cis-regulatory region sequence-specific DNA binding  (IEA,ISO,ISS)
co-SMAD binding  (IEA,ISO)
collagen binding  (IEA,ISO)
DEAD/H-box RNA helicase binding  (IEA,ISO)
DNA binding  (IEA,ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific  (IEA,ISO)
DNA-binding transcription factor activity  (IDA,IEA,ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (IBA,IEA,ISO)
DNA-binding transcription factor binding  (IEA,ISO)
DNA-binding transcription repressor activity  (IEA,ISO)
double-stranded DNA binding  (IEA,ISO)
enzyme binding  (IPI)
I-SMAD binding  (IBA)
identical protein binding  (IEA,ISO)
metal ion binding  (IEA)
nuclear glucocorticoid receptor binding  (IEA,ISO)
nuclear mineralocorticoid receptor binding  (IEA,ISO)
nuclear receptor binding  (IEA,ISO)
phosphatase binding  (IEA,ISO)
promoter-specific chromatin binding  (IEA,ISO)
protein binding  (IPI,ISO)
protein homodimerization activity  (IEA,ISO)
protein kinase binding  (IEA,ISO)
R-SMAD binding  (IEA,ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IBA,IEA,ISO)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (IDA,IEA,ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (IEA,ISO)
sequence-specific DNA binding  (IDA,IEA,ISO)
sterol response element binding  (IEA,ISO)
transcription cis-regulatory region binding  (IEA,ISO)
transcription coactivator binding  (IEA,ISO)
transcription corepressor binding  (IEA,ISO)
transcription factor binding  (IDA,IPI)
transforming growth factor beta receptor binding  (IEA,ISO)
ubiquitin binding  (IEA,ISO)
ubiquitin protein ligase binding  (IEA,ISO)
zinc ion binding  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. Aoki H, etal., Am J Physiol Cell Physiol. 2006 Apr;290(4):C1100-8. Epub 2005 Dec 21.
2. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
3. Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins. Chen Y, etal., Proc Natl Acad Sci U S A 1996 Nov 12;93(23):12992-7.
4. Gene expression profiling in the hippocampus of adolescent rats after chronic alcohol administration. Choi MR, etal., Basic Clin Pharmacol Toxicol. 2020 Apr;126(4):389-398. doi: 10.1111/bcpt.13342. Epub 2019 Nov 15.
5. Cited2 modulates TGF-beta-mediated upregulation of MMP9. Chou YT, etal., Oncogene. 2006 Sep 7;25(40):5547-60. Epub 2006 Apr 17.
6. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
7. Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats. Elkiki SM, etal., Toxicol Mech Methods. 2021 Sep;31(7):538-545. doi: 10.1080/15376516.2021.1934765. Epub 2021 Jun 21.
8. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
9. p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Furukawa F, etal., Hepatology. 2003 Oct;38(4):879-89.
10. Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity. Gancarz AM, etal., Nat Neurosci. 2015 Jul;18(7):959-61. doi: 10.1038/nn.4036. Epub 2015 Jun 1.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. Gressner OA, etal., J Hepatol. 2008 Nov;49(5):758-67. Epub 2008 Apr 30.
13. Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Hara S, etal., Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34. doi: 10.1016/j.etp.2014.02.002. Epub 2014 Mar 26.
14. Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Hu B, etal., Am J Respir Cell Mol Biol 2003 Sep;29(3 Pt 1):397-404. Epub 2003 Apr 17.
15. Gut-enriched Kruppel-like factor interaction with Smad3 inhibits myofibroblast differentiation. Hu B, etal., Am J Respir Cell Mol Biol. 2007 Jan;36(1):78-84. Epub 2006 Jul 20.
16. Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFbeta. Hu B, etal., Oncogene. 2006 Feb 16;25(7):1030-41.
17. Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-beta Induced Smad3 activation in vascular smooth muscle cell. Huang D, etal., PLoS One. 2011;6(10):e27123. doi: 10.1371/journal.pone.0027123. Epub 2011 Oct 31.
18. [Expression of tenascin-X in alcoholic cardiomyopathy and relation thereof to myocardial fibrosis: experiment with rats]. Jing L, etal., Zhonghua Yi Xue Za Zhi. 2008 Sep 23;88(36):2570-3.
19. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
20. S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model. Karaa A, etal., Shock. 2008 Aug;30(2):197-205. doi: 10.1097/shk.0b013e318160f417.
21. Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells. Kim BC, etal., Mol Cell Biol. 2002 Mar;22(5):1369-78.
22. Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways. Li CY, etal., J Cardiovasc Transl Res. 2021 Aug;14(4):636-646. doi: 10.1007/s12265-020-10089-2. Epub 2021 Jan 6.
23. Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. Li TF, etal., J Biol Chem. 2006 Jul 28;281(30):21296-304. doi: 10.1074/jbc.M600514200. Epub 2006 May 10.
24. Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. Liu G, etal., J Biol Chem. 2006 Oct 6;281(40):29479-90. Epub 2006 Aug 4.
25. Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells. Liu L, etal., Am J Physiol Gastrointest Liver Physiol 2003 Nov;285(5):G1056-67. Epub 2003 Jul 10.
26. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
27. MiRNA-199a-5p influences pulmonary artery hypertension via downregulating Smad3. Liu Y, etal., Biochem Biophys Res Commun. 2016 May 13;473(4):859-66. doi: 10.1016/j.bbrc.2016.03.140. Epub 2016 Mar 30.
28. Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice. Lu S, etal., Clin Cancer Res. 2007 Oct 1;13(19):5692-702.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. Expression and intracellular localization of Smad proteins in human endometrial cancer. Piestrzeniewicz-Ulanska D, etal., Oncol Rep. 2003 Sep-Oct;10(5):1539-44.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. Molecular Mechanism of MicroRNA-200c Regulating Transforming Growth Factor-β (TGF-β)/SMAD Family Member 3 (SMAD3) Pathway by Targeting Zinc Finger E-Box Binding Homeobox 1 (ZEB1) in Hypospadias in Rats. Qian C, etal., Med Sci Monit. 2016 Oct 29;22:4073-4081. doi: 10.12659/msm.896958.
37. Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum. Qin D, etal., Iran J Basic Med Sci. 2014 Nov;17(11):879-85.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal. Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300.
42. Reversible Smad-dependent signaling between tumor suppression and oncogenesis. Sekimoto G, etal., Cancer Res. 2007 Jun 1;67(11):5090-6.
43. Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-β/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study. Sferra R, etal., Eur J Histochem. 2018 Jul 31;62(3):2956. doi: 10.4081/ejh.2018.2956.
44. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
45. Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. Song K, etal., EMBO J. 2006 Jan 11;25(1):58-69. Epub 2005 Dec 15.
46. Formononetin protects against balloon injury‑induced neointima formation in rats by regulating proliferation and migration of vascular smooth muscle cells via the TGF‑β1/Smad3 signaling pathway. Song T, etal., Int J Mol Med. 2018 Oct;42(4):2155-2162. doi: 10.3892/ijmm.2018.3784. Epub 2018 Jul 18.
47. Parathyroid hormone-Smad3 axis exerts anti-apoptotic action and augments anabolic action of transforming growth factor beta in osteoblasts. Sowa H, etal., J Biol Chem. 2003 Dec 26;278(52):52240-52. Epub 2003 Sep 29.
48. Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells. Sowa H, etal., J Bone Miner Res 2002 Jul;17(7):1190-9.
49. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
50. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
51. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Uemura M, etal., Mol Biol Cell. 2005 Sep;16(9):4214-24. Epub 2005 Jun 29.
52. Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. Wang EY, etal., J Endocrinol 2003 Jul;178(1):137-48.
53. FOSL2 positively regulates TGF-beta1 signalling in non-small cell lung cancer. Wang J, etal., PLoS One. 2014 Nov 6;9(11):e112150. doi: 10.1371/journal.pone.0112150. eCollection 2014.
54. BRG1 in the Nucleus Accumbens Regulates Cocaine-Seeking Behavior. Wang ZJ, etal., Biol Psychiatry. 2016 Nov 1;80(9):652-660. doi: 10.1016/j.biopsych.2016.04.020. Epub 2016 May 6.
55. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Wei XH, etal., Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002.
56. Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund's Complete Adjuvant-Induced Arthritis in Rats. Wenjin C and Jianwei W, Inflammation. 2017 Aug;40(4):1401-1408. doi: 10.1007/s10753-017-0583-8.
57. Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-β pathways in macrophages. Xia Z, etal., Braz J Med Biol Res. 2021 Jul 23;54(8):e11184. doi: 10.1590/1414-431X2021e11184. eCollection 2021.
58. Stage-specific expression of Smad2 and Smad3 during folliculogenesis. Xu J, etal., Biol Reprod 2002 Jun;66(6):1571-8.
59. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
60. Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Zhang L, etal., J Mol Histol. 2020 Feb;51(1):77-87. doi: 10.1007/s10735-020-09859-8. Epub 2020 Feb 17.
61. Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. Zhang M, etal., J Biol Chem. 2010 Mar 19;285(12):8703-10. doi: 10.1074/jbc.M109.093526. Epub 2010 Jan 22.
62. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
63. Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling. Zhao X, etal., J Biol Chem. 2008 Feb 8;283(6):3272-80. doi: 10.1074/jbc.M708033200. Epub 2007 Nov 30.
64. Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling. Zhao Y and Geverd DA, Biochem Biophys Res Commun 2002 Jun 7;294(2):319-23.
Additional References at PubMed
PMID:8774881   PMID:9111321   PMID:9311995   PMID:9679056   PMID:9702197   PMID:9732876   PMID:9759503   PMID:10064594   PMID:10559937   PMID:10647776   PMID:10708948   PMID:10708949  
PMID:10823886   PMID:11160896   PMID:11278251   PMID:11585338   PMID:11711431   PMID:11937490   PMID:12411310   PMID:12446380   PMID:12543979   PMID:12686552   PMID:12845704   PMID:12874272  
PMID:12876289   PMID:12902338   PMID:12943993   PMID:14555988   PMID:14559231   PMID:14617288   PMID:14623893   PMID:14656760   PMID:14754879   PMID:15084457   PMID:15107418   PMID:15150273  
PMID:15150278   PMID:15183723   PMID:15239668   PMID:15282343   PMID:15326485   PMID:15334054   PMID:15464984   PMID:15489334   PMID:15647271   PMID:15761025   PMID:15799969   PMID:16007207  
PMID:16224064   PMID:16266486   PMID:16696323   PMID:16751101   PMID:16777850   PMID:16785237   PMID:16807527   PMID:16824956   PMID:16886151   PMID:16931807   PMID:16980030   PMID:17038494  
PMID:17159989   PMID:17215516   PMID:17251190   PMID:17392319   PMID:17541159   PMID:17723189   PMID:18022758   PMID:18057996   PMID:18395914   PMID:18466073   PMID:18505915   PMID:18548003  
PMID:18679024   PMID:18729074   PMID:18794808   PMID:18832382   PMID:19122240   PMID:19197123   PMID:19525370   PMID:19555739   PMID:19667256   PMID:19816956   PMID:19834880   PMID:19959709  
PMID:20129061   PMID:20182310   PMID:20226149   PMID:20375011   PMID:20404057   PMID:20423827   PMID:20739403   PMID:20874717   PMID:20943464   PMID:21035443   PMID:21158069   PMID:21307346  
PMID:21354414   PMID:21429339   PMID:21468608   PMID:21498085   PMID:21560355   PMID:21724602   PMID:21749980   PMID:21828274   PMID:21852586   PMID:21937600   PMID:21947082   PMID:22045334  
PMID:22338217   PMID:22384127   PMID:22447946   PMID:22674034   PMID:22926646   PMID:23056222   PMID:23064763   PMID:23176567   PMID:23291610   PMID:23390484   PMID:23403244   PMID:23690627  
PMID:24086569   PMID:24290497   PMID:24356887   PMID:24500776   PMID:24718260   PMID:24914373   PMID:24964035   PMID:25010983   PMID:25065622   PMID:25245272   PMID:25416030   PMID:25422985  
PMID:25538336   PMID:25867402   PMID:25893292   PMID:26138247   PMID:26153982   PMID:26253398   PMID:26276823   PMID:26311719   PMID:26483344   PMID:26738448   PMID:26945889   PMID:26946943  
PMID:26954391   PMID:27155082   PMID:27217701   PMID:27239849   PMID:27282665   PMID:27340942   PMID:27453280   PMID:27530924   PMID:27633729   PMID:28035691   PMID:28041981   PMID:28125630  
PMID:28193525   PMID:28230313   PMID:28539652   PMID:28552397   PMID:28586069   PMID:28623783   PMID:28647476   PMID:28943431   PMID:29102631   PMID:29104873   PMID:29215718   PMID:29309309  
PMID:29505748   PMID:29704604   PMID:30053527   PMID:30055965   PMID:30317638   PMID:30549198   PMID:31521890   PMID:31582430   PMID:31813251   PMID:31917288   PMID:31960436   PMID:32169420  
PMID:32274619   PMID:32949699   PMID:33448318   PMID:33577033   PMID:33769459   PMID:34175710   PMID:34834085   PMID:34898379   PMID:34938805   PMID:36030021   PMID:37187923   PMID:37921754  
PMID:38122948   PMID:38690917   PMID:39105875   PMID:39168432  


Genomics

Comparative Map Data
Smad3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,022,204 - 73,132,324 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl873,024,760 - 73,132,324 (-)EnsemblGRCr8
mRatBN7.2864,126,829 - 64,236,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx869,641,910 - 69,752,073 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,914,370 - 68,024,539 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,784,499 - 65,894,665 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)Ensemblrn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera863,537,497 - 63,647,062 (-)NCBICelera
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Cytogenetic Map8q24NCBI
SMAD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381567,065,602 - 67,195,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1567,063,763 - 67,195,173 (+)Ensemblhg38GRCh38
GRCh371567,357,940 - 67,487,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,145,249 - 65,274,587 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341565,145,248 - 65,274,586NCBI
Celera1544,246,635 - 44,375,039 (+)NCBICelera
Cytogenetic Map15q22.33NCBI
HuRef1544,193,465 - 44,321,904 (+)NCBIHuRef
CHM1_11567,476,260 - 67,605,488 (+)NCBICHM1_1
T2T-CHM13v2.01564,885,345 - 65,017,070 (+)NCBIT2T-CHM13v2.0
Smad3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)Ensemblmm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBIMGSCv36mm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.22NCBI
Smad3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)Ensembl
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBIChiLan1.0ChiLan1.0
SMAD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21656,319,096 - 56,448,455 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11560,491,695 - 60,621,061 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11564,284,949 - 64,414,185 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)EnsemblpanPan2panpan1.1
SMAD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,246,313 - 31,360,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,245,657 - 31,363,337 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3031,175,971 - 31,289,442 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03031,444,224 - 31,557,937 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3031,444,224 - 31,561,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13031,371,657 - 31,485,227 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03031,431,846 - 31,545,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,673,713 - 31,787,293 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Smad3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,232,767 - 109,341,735 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647127,080,575 - 27,189,793 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,998,103 - 165,124,449 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11164,998,457 - 165,124,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,902,348 - 182,926,370 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12616,319,959 - 16,446,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2616,320,933 - 16,446,527 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048125,021,354 - 125,151,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247815,795,652 - 5,890,371 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247815,795,652 - 5,890,047 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Smad3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1857,940,009 - 58,049,107 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Smad3
509 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:512
Count of miRNA genes:253
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000039730
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat

Markers in Region
Madh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,236,564 - 64,236,759 (+)MAPPERmRatBN7.2
Rnor_6.0868,677,954 - 68,678,148NCBIRnor6.0
Rnor_5.0868,397,332 - 68,397,526UniSTSRnor5.0
RGSC_v3.4867,951,661 - 67,951,855UniSTSRGSC3.4
Celera863,646,667 - 63,646,861UniSTS
Cytogenetic Map8q24UniSTS
RH130799  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,235,228 - 64,235,441 (+)MAPPERmRatBN7.2
Rnor_6.0868,676,610 - 68,676,822NCBIRnor6.0
Rnor_5.0868,396,418 - 68,396,630UniSTSRnor5.0
RGSC_v3.4867,950,063 - 67,950,275UniSTSRGSC3.4
Celera863,645,365 - 63,645,577UniSTS
RH 3.4 Map8810.0UniSTS
Cytogenetic Map8q24UniSTS
RH143351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,162,995 - 64,163,140 (+)MAPPERmRatBN7.2
Rnor_6.0868,605,604 - 68,605,748NCBIRnor6.0
Rnor_5.0868,327,124 - 68,327,268UniSTSRnor5.0
RGSC_v3.4867,856,537 - 67,856,681UniSTSRGSC3.4
Celera863,573,666 - 63,573,810UniSTS
RH 3.4 Map8805.0UniSTS
Cytogenetic Map8q24UniSTS
RH143448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,126,996 - 64,127,126 (+)MAPPERmRatBN7.2
Rnor_6.0868,569,698 - 68,569,827NCBIRnor6.0
Rnor_5.0868,291,095 - 68,291,224UniSTSRnor5.0
RGSC_v3.4867,820,872 - 67,821,001UniSTSRGSC3.4
Celera863,537,665 - 63,537,794UniSTS
RH 3.4 Map8809.9UniSTS
Cytogenetic Map8q24UniSTS
RH138729  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,126,876 - 64,127,014 (+)MAPPERmRatBN7.2
Rnor_6.0868,569,578 - 68,569,715NCBIRnor6.0
Rnor_5.0868,290,975 - 68,291,112UniSTSRnor5.0
RGSC_v3.4867,820,752 - 67,820,889UniSTSRGSC3.4
Celera863,537,545 - 63,537,682UniSTS
RH 3.4 Map8810.0UniSTS
Cytogenetic Map8q24UniSTS
PE5L-LSB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,216,656 - 64,217,035 (+)MAPPERmRatBN7.2
Rnor_6.0868,658,300 - 68,658,678NCBIRnor6.0
Rnor_5.0868,379,536 - 68,379,914UniSTSRnor5.0
RGSC_v3.4867,931,905 - 67,932,283UniSTSRGSC3.4
Celera863,626,945 - 63,627,323UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000039730   ⟹   ENSRNOP00000037346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl873,024,760 - 73,132,324 (-)Ensembl
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)Ensembl
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099327   ⟹   ENSRNOP00000081624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl873,024,760 - 73,076,660 (-)Ensembl
mRatBN7.2 Ensembl864,110,039 - 64,181,174 (-)Ensembl
RefSeq Acc Id: NM_013095   ⟹   NP_037227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,132,324 (-)NCBI
mRatBN7.2864,126,829 - 64,236,960 (-)NCBI
Rnor_6.0868,569,530 - 68,678,349 (-)NCBI
Rnor_5.0868,290,927 - 68,397,727 (-)NCBI
RGSC_v3.4867,803,909 - 67,952,056 (-)RGD
Celera863,537,497 - 63,647,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008766216   ⟹   XP_008764438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,042,099 (-)NCBI
mRatBN7.2864,126,829 - 64,146,730 (-)NCBI
Rnor_6.0868,569,530 - 68,589,751 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080896   ⟹   XP_038936824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,078,810 (-)NCBI
mRatBN7.2864,126,829 - 64,183,523 (-)NCBI
RefSeq Acc Id: XM_039080897   ⟹   XP_038936825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,099,691 (-)NCBI
mRatBN7.2864,126,829 - 64,191,240 (-)NCBI
RefSeq Acc Id: NP_037227   ⟸   NM_013095
- UniProtKB: P84025 (UniProtKB/Swiss-Prot),   A6J5A4 (UniProtKB/TrEMBL),   A0A8I5ZS20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764438   ⟸   XM_008766216
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000037346   ⟸   ENSRNOT00000039730
RefSeq Acc Id: XP_038936825   ⟸   XM_039080897
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZS20 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936824   ⟸   XM_039080896
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS20 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081624   ⟸   ENSRNOT00000099327
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84025-F1-model_v2 AlphaFold P84025 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696062
Promoter ID:EPDNEW_R6587
Type:multiple initiation site
Name:Smad3_1
Description:SMAD family member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0868,678,414 - 68,678,474EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3032 AgrOrtholog
BioCyc Gene G2FUF-30124 BioCyc
Ensembl Genes ENSRNOG00000008620 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039730 ENTREZGENE
  ENSRNOT00000039730.5 UniProtKB/Swiss-Prot
  ENSRNOT00000099327 ENTREZGENE
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot
  3.90.520.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599910 IMAGE-MGC_LOAD
InterPro Dwarfin UniProtKB/Swiss-Prot
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot
  MAD_homology_MH1 UniProtKB/Swiss-Prot
  SMAD-like_dom_sf UniProtKB/Swiss-Prot
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot
  SMAD_MH1_sf UniProtKB/Swiss-Prot
KEGG Report rno:25631 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72529 IMAGE-MGC_LOAD
NCBI Gene 25631 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3 UniProtKB/Swiss-Prot
  PTHR13703 UniProtKB/Swiss-Prot
Pfam MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
PhenoGen Smad3 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot
  MH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008620 RatGTEx
SMART DWA UniProtKB/Swiss-Prot
  DWB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot
  SSF56366 UniProtKB/Swiss-Prot
TIGR TC221903
UniProt A0A8I5ZS20 ENTREZGENE, UniProtKB/TrEMBL
  A6J5A4 ENTREZGENE, UniProtKB/TrEMBL
  P84025 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O09064 UniProtKB/Swiss-Prot
  O09144 UniProtKB/Swiss-Prot
  O14510 UniProtKB/Swiss-Prot
  O35273 UniProtKB/Swiss-Prot
  Q92940 UniProtKB/Swiss-Prot
  Q93002 UniProtKB/Swiss-Prot
  Q9GKR4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Smad3  SMAD family member 3  Smad3  MAD homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Smad3  MAD homolog 3 (Drosophila)  Madh3    Symbol updated 1299863 APPROVED
2002-06-10 Madh3  MAD homolog 3 (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization translocated to the nucleus 727374
gene_disease may be involved in pulmonary fibrosis 625421
gene_drugs bleomycin at a dose of 9U/kg body weight causes down regulation of mRNA 625421
gene_process an essential downstream intracellular target of the TGF-beta receptor signaling pathway 625421
gene_process plays an important role in osteoblastic bone formation 727387
gene_process involved in folliculogenesis 727374
gene_product member of the family of Smad proteins 625421
gene_regulation phosphorylated by activated TGF-beta type 1 receptor which induces the translocation of the protein from the cytoplasm to the nucleus 625421