Nr3c1 (nuclear receptor subfamily 3, group C, member 1) - Rat Genome Database

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Gene: Nr3c1 (nuclear receptor subfamily 3, group C, member 1) Rattus norvegicus
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Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
RGD ID: 2741
Description: Enables several functions, including heat shock protein binding activity; receptor tyrosine kinase binding activity; and transcription coactivator activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; regulation of synaptic plasticity; and response to glucocorticoid. Located in chromatin; cytosol; and dendritic spine. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with nucleus. Used to study several diseases, including alcohol dependence; alcohol use disorder; alcoholic neuropathy; cocaine abuse; and morphine dependence. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; brain disease (multiple); cocaine dependence; and cognitive disorder (multiple). Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anorexia nervosa; heroin dependence; lung disease (multiple); and nicotine dependence. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1); PARTICIPATES IN cortisol signaling pathway; forkhead class A signaling pathway; prednisolone pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gcr; glucocorticoid receptor; GR; Grl; nuclear receptor subfamily 3 group C member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nr3c1em1Jhrmn
Genetic Models: LE-Nr3c1em1Jhrmn ; SD-Nr3c1em1Jhrmn
Is Marker For: QTLs:   Bp46   Bp47   Scl22   Sprol1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81831,522,783 - 31,644,508 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1831,522,783 - 31,643,843 (-)EnsemblGRCr8
mRatBN7.21831,271,681 - 31,393,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1831,271,681 - 31,393,375 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1831,375,854 - 31,463,901 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01832,142,851 - 32,230,932 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01831,471,103 - 31,559,156 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01831,728,373 - 32,704,022 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)Ensemblrn6Rnor6.0
Rnor_5.01832,347,227 - 32,348,480 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01831,408,742 - 31,442,725 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41832,371,496 - 32,459,145 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1830,905,394 - 30,993,522 (-)NCBICelera
RGSC_v3.11832,406,765 - 32,494,411 (-)NCBI
RH 3.4 Map18442.9RGD
Cytogenetic Map18p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
46, XX Disorders of Sex Development  (ISO)
alcohol dependence  (IMP,ISO)
alcohol use disorder  (IDA,IEP,IMP,ISO)
alcohol withdrawal syndrome  (IDA,IEP,ISO)
Alcohol-Related Disorders  (ISO)
Alcoholic Intoxication  (ISO)
alcoholic neuropathy  (IMP)
anorexia nervosa  (ISO)
asthma  (IDA,IEP,ISO)
atrial fibrillation  (ISO)
attention deficit hyperactivity disorder  (IEP)
Binge Drinking  (IMP)
bipolar disorder  (ISO)
brain ischemia  (IEP)
Burns  (IDA,IEP)
cataract  (IMP)
chronic obstructive pulmonary disease  (ISO)
cocaine abuse  (IMP,ISO)
cocaine dependence  (IEP)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (IEP)
congestive heart failure  (IMP)
coronary artery disease  (ISO)
Cushing Syndrome  (ISO)
depressive disorder  (IEP,IMP,ISO)
diabetic retinopathy  (IEP)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (IDA)
end stage renal disease  (IEP)
endometriosis  (ISO)
Endotoxemia  (IDA)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Seizures  (IEP)
Fetal Growth Retardation  (IDA,IEP)
galactokinase deficiency  (ISO)
genetic disease  (ISO)
Glucocorticoid Receptor Deficiency  (ISO)
glucose metabolism disease  (ISO)
graft-versus-host disease  (ISO)
Hearing Loss, Noise-Induced  (IEP)
Hereditary Neoplastic Syndromes  (ISO)
heroin dependence  (ISO)
hypertension  (IMP,ISO)
hypokalemia  (ISO)
interstitial lung disease  (ISO)
lipoid nephrosis  (ISO)
lung disease  (IEP,ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
major depressive disorder  (ISO)
Malocclusion  (IEP)
Memory Disorders  (IMP)
mood disorder  (ISO)
morphine dependence  (IDA)
muscular atrophy  (IEP)
nephrotic syndrome  (ISO)
nephrotic syndrome type 2  (ISO)
nicotine dependence  (ISO)
obesity  (IDA,ISO)
obstructive lung disease  (ISO)
obstructive sleep apnea  (ISO)
ocular hypertension  (ISO)
opioid abuse  (IMP)
Perennial Allergic Rhinitis  (ISO)
polycystic ovary syndrome  (IEP)
post-traumatic stress disorder  (IEP)
Postoperative Cognitive Dysfunction  (IDA,IEP)
Prenatal Exposure Delayed Effects  (IDA,IEP)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (ISS)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psychotic disorder  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (IEP)
schizophrenia  (ISO)
Sepsis  (IDA,ISO)
sinusitis  (ISO)
status epilepticus  (IEP)
stress-related disorder  (IDA,IEP,ISO)
stroke  (IDA)
Transplant Rejection  (ISO)
traumatic brain injury  (IEP)
type 2 diabetes mellitus  (IDA)
uveitis  (IEP)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP,ISO)
11-deoxycortisol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-Trimethylbenzaldehyde  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-aminophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-Dimethylbenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-phenoxybenzoic acid  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
agomelatine  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
amitriptyline  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP,ISO)
Aurin  (ISO)
avobenzone  (ISO)
aziridines  (ISO)
azoxystrobin  (ISO)
beclomethasone  (EXP,ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzoyl peroxide  (ISO)
betamethasone  (ISO)
betulin  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Bisphenol Z  (ISO)
bleomycin A2  (EXP)
budesonide  (EXP,ISO)
butachlor  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celecoxib  (EXP)
CGP 52608  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciclopirox  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt atom  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
compound 48/80  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
corticotropin  (ISO)
cortisol  (EXP,ISO)
cortisone  (ISO)
cortivazol  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (ISO)
Cyclosporin H  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deflazacort  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Dicyclohexyl phthalate  (ISO)
diethyl hydrogen phosphate  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
diosgenin  (EXP,ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endrin  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
ethanol  (EXP,ISO)
ethiofencarb  (ISO)
ethyl myristate  (ISO)
farglitazar  (EXP)
fenchone  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
fludrocortisone  (ISO)
flumethasone  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (EXP,ISO)
fluticasone  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginsenoside Re  (ISO)
glafenine  (EXP)
glucose  (ISO)
hexadecanoic acid  (ISO)
homovanillic acid  (ISO)
hydralazine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
idazoxan  (EXP)
irinotecan  (ISO)
isoquinolines  (ISO)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lamotrigine  (ISO)
Laurolactam  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (EXP,ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP)
lithium hydride  (EXP,ISO)
LY 379268  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylprednisolone aceponate  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (EXP)
miconazole  (ISO)
mifepristone  (EXP,ISO)
mirex  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
molybdate  (EXP)
mometasone furoate  (EXP,ISO)
Monobutylphthalate  (ISO)
morphine  (EXP)
N,O-dimethyltyramine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
onapristone  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pararosaniline free base  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (ISO)
phenylbutazone  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (EXP)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
Polygodial  (EXP)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium cyanide  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
prednylidene  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
protoporphyrin  (ISO)
puromycin  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reserpine  (EXP)
resmethrin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
S-methyl methanethiosulfonate  (EXP)
Salmeterol xinafoate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
selenium atom  (ISO)
selenous acid  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
spiperone  (ISO)
spiroxamine  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tebufenpyrad  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethrin  (ISO)
tetraphene  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tolterodine tartrate  (ISO)
tolylfluanid  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
triamcinolone  (ISO)
triamcinolone acetonide  (EXP,ISO)
tributyl phosphate  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
trifluoperazine  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
Tris(2-ethylhexyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
undecan-2-one  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
associative learning  (IMP)
astrocyte differentiation  (IEA,ISO)
cellular response to dexamethasone stimulus  (IEA,IMP,ISO)
cellular response to glucocorticoid stimulus  (IEA,ISO,ISS)
cellular response to magnesium ion  (IEP)
cellular response to steroid hormone stimulus  (IEA,ISO,ISS)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
chromatin organization  (IEA)
chromatin remodeling  (IMP)
circadian rhythm  (IEP)
female pregnancy  (IEP)
gene expression  (ISO)
glucocorticoid metabolic process  (ISO)
Leydig cell differentiation  (IMP)
lung development  (IEP)
mammary gland duct morphogenesis  (ISO)
maternal behavior  (ISO)
microglia differentiation  (IEA,ISO)
motor behavior  (IEA,ISO)
muscle atrophy  (IEP)
negative regulation of apoptotic process  (IMP)
negative regulation of behavioral fear response  (IMP)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of long-term synaptic depression  (IMP)
negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway  (ISO)
negative regulation of synaptic plasticity  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular permeability  (IMP)
neuroinflammatory response  (IEA,ISO)
nuclear receptor-mediated corticosteroid signaling pathway  (IDA,IEA)
nuclear receptor-mediated glucocorticoid signaling pathway  (IEA,ISO)
nuclear receptor-mediated steroid hormone signaling pathway  (IBA)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cytokine production  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of glutamate secretion  (IMP)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IMP,ISO)
protein-containing complex assembly  (TAS)
regulation of cell population proliferation  (IDA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of glucocorticoid biosynthetic process  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of glucose metabolic process  (IEA,IMP)
regulation of hormone levels  (IEA)
regulation of nuclear receptor-mediated glucocorticoid signaling pathway  (IEA)
regulation of transcription by RNA polymerase II  (IBA,IEA)
response to activity  (IEP)
response to alcohol  (IEA)
response to arsenic-containing substance  (IDA)
response to calcium ion  (IEP)
response to corticosterone  (IDA,IEP)
response to cortisol  (ISO)
response to dexamethasone  (IEP)
response to electrical stimulus  (IEP)
response to glucocorticoid  (IEA)
response to inactivity  (IEP)
response to insulin  (IEP)
response to ketone  (IEA)
response to mercury ion  (IEP)
response to wounding  (ISO)
steroid metabolic process  (IEA)
synaptic transmission, glutamatergic  (IEA,ISO)
transcription initiation-coupled chromatin remodeling  (IMP)

Cellular Component
centrosome  (IEA)
chromatin  (IBA,IDA)
chromosome  (IEA)
cytoplasm  (IEA,ISO)
cytosol  (IDA,IEA,ISO)
dendritic spine  (IDA)
glutamatergic synapse  (IDA)
membrane  (IEA,ISO)
mitochondrion  (IEA,ISO)
nuclear speck  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA,ISO)
postsynaptic density, intracellular component  (IDA)
protein-containing complex  (IDA,IEA,ISO)
spindle  (IEA)
synapse  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

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129. Synthesized glucocorticoid, dexamethasone regulates the expressions of beta-adrenoceptor and glucocorticoid receptor mRNAs but not proteins in slow-twitch soleus muscle of rats. Sato S, etal., J Toxicol Sci. 2011;36(4):479-86.
130. Casted-immobilization downregulates glucocorticoid receptor expression in rat slow-twitch soleus muscle. Sato S, etal., Life Sci. 2011 Dec 19;89(25-26):962-7. Epub 2011 Oct 20.
131. Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors. Scheimann JR, etal., Elife. 2019 Jul 22;8:e44672. doi: 10.7554/eLife.44672.
132. Glucocorticoid receptor gene variants and lower expression of NR3C1 are associated with cocaine use. Schote AB, etal., Addict Biol. 2019 Jul;24(4):730-742. doi: 10.1111/adb.12632. Epub 2018 May 15.
133. [Effects of medicinal extract for tonifying kidney to relieve asthma on glucocorticoid receptor expression in lung tissues of rats with bronchial asthma]. Shi KH, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Aug;8(8):785-9.
134. Candidate placental biomarkers for intrauterine alcohol exposure. Shukla PK, etal., Alcohol Clin Exp Res. 2011 Mar;35(3):559-65. doi: 10.1111/j.1530-0277.2010.01373.x. Epub 2010 Dec 8.
135. Localization of the glucocorticoid receptor mRNA in cartilage and bone cells of the rat. An in situ hybridization study. Silvestrini G, etal., Eur J Histochem. 2003;47(3):245-52.
136. Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes. Sola S, etal., Hepatology. 2005 Oct;42(4):925-34.
137. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
138. Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages. Takano K, etal., J Pharmacol Exp Ther. 2011 Feb;336(2):381-90. Epub 2010 Nov 5.
139. Upregulation of hepatic 11beta-hydroxysteroid dehydrogenase-1 expression in calcium-deficient rats. Takaya J, etal., Ann Nutr Metab. 2011;59(2-4):73-8. Epub 2011 Dec 2.
140. Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells. Tao T, etal., Am J Respir Cell Mol Biol. 2006 Dec;35(6):668-80. Epub 2006 Jun 29.
141. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
142. A pilot study exploring the role of glucocorticoid receptor variants in primary biliary cirrhosis and primary sclerosing cholangitis. ter Borg PC, etal., Neth J Med. 2004 Oct;62(9):326-31.
143. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Tronche F, etal., Nat Genet. 1999 Sep;23(1):99-103.
144. Reduction in glucocorticoid receptors in renal biopsies of patients with lupus nephritis. Tziraki AA, etal., Clin Biochem. 2007 Nov;40(16-17):1188-93. Epub 2007 Aug 21.
145. Enhanced glucocorticoid receptor signaling in T cells impacts thymocyte apoptosis and adaptive immune responses. van den Brandt J, etal., Am J Pathol. 2007 Mar;170(3):1041-53.
146. Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats. Van Waes V, etal., Eur J Neurosci. 2006 Aug;24(4):1193-200. doi: 10.1111/j.1460-9568.2006.04973.x. Epub 2006 Aug 21.
147. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. Vendruscolo LF, etal., J Clin Invest. 2015 Aug 3;125(8):3193-7. doi: 10.1172/JCI79828. Epub 2015 Jun 29.
148. Modulation of presynaptic glucocorticoid receptors on glutamate release from rat hippocampal nerve terminals. Wang CC and Wang SJ, Synapse. 2009 Sep;63(9):745-51.
149. [Effects of neonatal recurrent seizures on glucocorticoid receptor expression in the rat brain]. Wang TM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Jan;12(1):47-50.
150. Changes of glucocorticoid receptor expression in the nasal polyps of patients with chronic sinusitis following treatment with glucocorticoid. Watanabe S and Suzaki H, In Vivo. 2008 Jan-Feb;22(1):37-42.
151. Icariin alters the expression of glucocorticoid receptor, FKBP5 and SGK1 in rat brains following exposure to chronic mild stress. Wei K, etal., Int J Mol Med. 2016 Jul;38(1):337-44. doi: 10.3892/ijmm.2016.2591. Epub 2016 May 17.
152. Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells. Widen C, etal., Biochem J. 2003 Jul 1;373(Pt 1):211-20.
153. Behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in FAE. Wilcoxon JS, etal., Mol Psychiatry. 2005 Oct;10(10):961-71. doi: 10.1038/sj.mp.4001694.
154. Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus. Wong EY and Herbert J, Eur J Neurosci. 2005 Aug;22(4):785-92.
155. Nr3C1-Bhlhb2 Axis Dysregulation Is Involved in the Development of Attention Deficit Hyperactivity. Wu LH, etal., Mol Neurobiol. 2017 Mar;54(2):1196-1212. doi: 10.1007/s12035-015-9679-z. Epub 2016 Jan 28.
156. Effect of artemisinin combined with glucocorticoid on the expressions of glucocorticoid receptor alpha mRNA, glucocorticoid receptor beta mRNA and P300/CBP protein in lupus nephritis mice. Wu XL, etal., Chin J Integr Med. 2011 Apr;17(4):277-82. Epub 2011 Apr 21.
157. [The effect of low-dose hydrocortisone on the expression of glucocorticoid receptor alpha of the septic kidney and its protective effect on kidney in rat]. Wu YX, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Jul;23(7):426-9.
158. Expression of the glucocorticoid receptor in renal cell neoplasms: an immunohistochemical and quantitative reverse transcriptase polymerase chain reaction study. Yakirevich E, etal., Hum Pathol. 2011 Nov;42(11):1684-92. Epub 2011 Apr 29.
159. Modeling circadian rhythms of glucocorticoid receptor and glutamine synthetase expression in rat skeletal muscle. Yao Z, etal., Pharm Res. 2006 Apr;23(4):670-9. Epub 2006 Feb 2.
160. Glucocorticoid receptor changes associate with age in the paraventricular nucleus of type II diabetic rat model. Yi SS, etal., Neurochem Res. 2009 May;34(5):851-8. Epub 2008 Aug 29.
161. Prenatal ethanol exposure increases susceptibility to depression- and anxiety-like behavior in adult female offspring and its underlying mechanism. Yu Y, etal., Reprod Toxicol. 2020 Sep;96:36-46. doi: 10.1016/j.reprotox.2020.05.015. Epub 2020 Jun 1.
162. Dexamethasone suppresses the differentiation of stem Leydig cells in rats in vitro. Zhang J, etal., BMC Pharmacol Toxicol. 2019 May 27;20(1):32. doi: 10.1186/s40360-019-0312-z.
163. Network Pharmacology Based Research on the Combination Mechanism Between Escin and Low Dose Glucocorticoids in Anti-rheumatoid Arthritis. Zhang L, etal., Front Pharmacol. 2019 Mar 22;10:280. doi: 10.3389/fphar.2019.00280. eCollection 2019.
164. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
165. The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice. Zhang Y, etal., Clin Exp Pharmacol Physiol. 2010 Nov;37(11):1044-8. doi: 10.1111/j.1440-1681.2010.05429.x.
166. PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation. Zhang Z, etal., J Biol Chem. 2013 Jan 4;288(1):42-58. doi: 10.1074/jbc.M112.427740. Epub 2012 Nov 17.
167. Differential Regulations of AQP4 and Kir4.1 by Triamcinolone Acetonide and Dexamethasone in the Healthy and Inflamed Retina. Zhao M, etal., Invest Ophthalmol Vis Sci. 2011 Aug 11;52(9):6340-7. Print 2011 Sep.
168. Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring. Zheng A, etal., J Nutr Biochem. 2015 Feb;26(2):190-9. doi: 10.1016/j.jnutbio.2014.10.006. Epub 2014 Nov 12.
169. Chronic stress and intestinal barrier dysfunction: Glucocorticoid receptor and transcription repressor HES1 regulate tight junction protein Claudin-1 promoter. Zheng G, etal., Sci Rep. 2017 Jul 3;7(1):4502. doi: 10.1038/s41598-017-04755-w.
170. [The regulative effects of Aspergillus fumigatus on expression of glucocorticoid receptor in asthmatic rats]. Zhou X, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2017 Mar 12;40(3):182-187. doi: 10.3760/cma.j.issn.1001-0939.2017.03.008.
171. Methylation of glucocorticoid receptor gene promoter modulates morphine dependence and accompanied hypothalamus-pituitary-adrenal axis dysfunction. Zhu J, etal., J Neurosci Res. 2017 Jul;95(7):1459-1473. doi: 10.1002/jnr.23913. Epub 2016 Sep 12.
172. GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model. Zhu T, etal., Glia. 2024 Mar;72(3):504-528. doi: 10.1002/glia.24486. Epub 2023 Oct 31.
173. Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period. Zhu Y, etal., J Neuroinflammation. 2017 Jan 7;14(1):6. doi: 10.1186/s12974-016-0782-5.
174. Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance. Zinker B, etal., Metabolism. 2007 Mar;56(3):380-7.
175. Prenatal Exposure to Methamphetamine: Up-Regulation of Brain Receptor Genes. Zoubková H, etal., Front Neurosci. 2019 Aug 1;13:771. doi: 10.3389/fnins.2019.00771. eCollection 2019.
176. Stress-induced glucocorticoid receptor activation determines functional recovery following ischemic stroke. Zucchi FC, etal., Exp Transl Stroke Med. 2010 Sep 22;2(1):18.
177. Hypothalamic NR3C1 DNA methylation in rats exposed to prenatal stress. Öztürk KH, etal., Mol Biol Rep. 2022 Aug;49(8):7921-7928. doi: 10.1007/s11033-022-07626-4. Epub 2022 Jun 3.
Additional References at PubMed
PMID:1751485   PMID:1865905   PMID:1894621   PMID:1936288   PMID:1939229   PMID:2115209   PMID:3191912   PMID:3216865   PMID:3684608   PMID:7628695   PMID:7883868   PMID:7914432  
PMID:8191545   PMID:8257681   PMID:8450530   PMID:8493115   PMID:9111344   PMID:9237103   PMID:9353307   PMID:9603939   PMID:10224232   PMID:10364267   PMID:10480874   PMID:10509797  
PMID:10744634   PMID:10770488   PMID:10866662   PMID:11278286   PMID:11435610   PMID:11555636   PMID:11739747   PMID:11809422   PMID:11812797   PMID:12118039   PMID:12198239   PMID:12489571  
PMID:12902338   PMID:14659477   PMID:14960289   PMID:14978266   PMID:15016838   PMID:15044366   PMID:15060156   PMID:15071092   PMID:15199138   PMID:15539428   PMID:15580339   PMID:15731366  
PMID:15769988   PMID:15870285   PMID:15932935   PMID:15940303   PMID:16150424   PMID:16297316   PMID:16580234   PMID:16644723   PMID:16728402   PMID:16897719   PMID:16899232   PMID:17081986  
PMID:17210632   PMID:17244200   PMID:17347454   PMID:17367809   PMID:17370312   PMID:17481888   PMID:17552876   PMID:17635946   PMID:17644267   PMID:17689506   PMID:17690167   PMID:17927667  
PMID:17982481   PMID:18427988   PMID:18434352   PMID:18524780   PMID:18534262   PMID:18583028   PMID:18615595   PMID:18625317   PMID:18643788   PMID:18650268   PMID:18725247   PMID:18829866  
PMID:19007760   PMID:19065825   PMID:19118409   PMID:19131573   PMID:19141540   PMID:19145310   PMID:19195790   PMID:19279295   PMID:19293335   PMID:19372434   PMID:19406955   PMID:19463811  
PMID:19521113   PMID:19562035   PMID:19563881   PMID:19596457   PMID:19628874   PMID:19638349   PMID:19665541   PMID:19684579   PMID:19782950   PMID:19816761   PMID:19833863   PMID:19875699  
PMID:19953342   PMID:20223255   PMID:20371704   PMID:20413910   PMID:20573576   PMID:20660300   PMID:20660302   PMID:20861076   PMID:21076867   PMID:21180159   PMID:21245955   PMID:21463019  
PMID:21835217   PMID:22022502   PMID:22253850   PMID:22350213   PMID:22371232   PMID:22456310   PMID:22579827   PMID:22622902   PMID:22641130   PMID:22715380   PMID:22717988   PMID:22750445  
PMID:22957049   PMID:23023726   PMID:23071095   PMID:23084728   PMID:23132854   PMID:23169346   PMID:23185000   PMID:23195113   PMID:23257260   PMID:23279724   PMID:23290935   PMID:23358504  
PMID:23460384   PMID:23508108   PMID:23525215   PMID:23683655   PMID:23686112   PMID:23728292   PMID:23823477   PMID:23846420   PMID:23878391   PMID:24097989   PMID:24334056   PMID:24420787  
PMID:24721039   PMID:25114262   PMID:25218493   PMID:25510864   PMID:25633096   PMID:25687413   PMID:25972460   PMID:26287126   PMID:26305887   PMID:26333123   PMID:26452320   PMID:26482332  
PMID:26504077   PMID:26593036   PMID:26598419   PMID:26779948   PMID:27334923   PMID:27686098   PMID:28200020   PMID:28212940   PMID:28324065   PMID:28414132   PMID:28696809   PMID:28916632  
PMID:29218729   PMID:29522858   PMID:29729371   PMID:29845273   PMID:30101500   PMID:30170158   PMID:30532228   PMID:31139184   PMID:31914623   PMID:34213722   PMID:36116554   PMID:36214984  
PMID:37040814   PMID:37863964   PMID:38557197  


Genomics

Comparative Map Data
Nr3c1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81831,522,783 - 31,644,508 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1831,522,783 - 31,643,843 (-)EnsemblGRCr8
mRatBN7.21831,271,681 - 31,393,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1831,271,681 - 31,393,375 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1831,375,854 - 31,463,901 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01832,142,851 - 32,230,932 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01831,471,103 - 31,559,156 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01831,728,373 - 32,704,022 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)Ensemblrn6Rnor6.0
Rnor_5.01832,347,227 - 32,348,480 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01831,408,742 - 31,442,725 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41832,371,496 - 32,459,145 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1830,905,394 - 30,993,522 (-)NCBICelera
RGSC_v3.11832,406,765 - 32,494,411 (-)NCBI
RH 3.4 Map18442.9RGD
Cytogenetic Map18p11NCBI
NR3C1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385143,277,931 - 143,435,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5143,277,931 - 143,435,512 (-)Ensemblhg38GRCh38
GRCh375142,657,496 - 142,815,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365142,637,689 - 142,795,270 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345142,639,324 - 142,763,087NCBI
Celera5138,738,770 - 138,896,297 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5137,804,733 - 137,962,312 (-)NCBIHuRef
CHM1_15142,091,205 - 142,248,804 (-)NCBICHM1_1
T2T-CHM13v2.05143,809,293 - 143,966,896 (-)NCBIT2T-CHM13v2.0
Nr3c1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391839,543,598 - 39,652,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1839,543,598 - 39,652,474 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381839,410,545 - 39,519,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1839,410,545 - 39,519,421 (-)Ensemblmm10GRCm38
MGSCv371839,570,199 - 39,646,899 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361839,537,961 - 39,615,820 (-)NCBIMGSCv36mm8
Celera1840,761,405 - 40,838,026 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1821.09NCBI
Nr3c1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541510,494,640 - 10,586,221 (+)Ensembl
ChiLan1.0NW_00495541510,494,704 - 10,585,778 (+)NCBIChiLan1.0ChiLan1.0
NR3C1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24138,522,276 - 138,977,269 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15136,661,826 - 137,116,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05138,634,278 - 139,089,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15144,741,452 - 144,865,341 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5144,741,452 - 144,865,269 (-)EnsemblpanPan2panpan1.1
NR3C1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,124,568 - 38,242,510 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,123,190 - 38,240,755 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha235,173,176 - 35,283,390 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0238,573,084 - 38,692,463 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,573,084 - 38,690,726 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1235,654,977 - 35,765,222 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0236,468,553 - 36,579,023 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0237,270,194 - 37,380,458 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nr3c1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213149,386,116 - 149,482,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650410,959,192 - 11,056,856 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650410,960,069 - 11,056,834 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR3C1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2144,822,939 - 144,956,451 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12144,822,937 - 144,956,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22151,051,816 - 151,185,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR3C1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12345,904,926 - 46,031,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2345,904,873 - 46,031,125 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603431,810,840 - 31,935,849 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr3c1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247742,495,304 - 2,602,632 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247742,496,276 - 2,603,894 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nr3c1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1155,431,948 - 5,522,978 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nr3c1
435 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1042
Count of miRNA genes:348
Interacting mature miRNAs:478
Transcripts:ENSRNOT00000019409, ENSRNOT00000044287
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
D18Mit5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81831,610,505 - 31,610,627 (+)Marker Load Pipeline
mRatBN7.21831,359,408 - 31,359,530 (+)MAPPERmRatBN7.2
Rnor_6.01832,670,352 - 32,670,473NCBIRnor6.0
Rnor_5.01832,348,154 - 32,348,275UniSTSRnor5.0
RGSC_v3.41832,458,819 - 32,458,940UniSTSRGSC3.4
Celera1830,993,196 - 30,993,317UniSTS
RGSC_v3.11832,494,084 - 32,494,206RGD
SHRSP x BN Map1817.1599UniSTS
SHRSP x BN Map1817.1599RGD
Cytogenetic Map18p12UniSTS
D18Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01832,348,153 - 32,348,275NCBIRnor5.0
RGSC_v3.41832,458,819 - 32,458,940UniSTSRGSC3.4
Celera1830,993,196 - 30,993,317UniSTS
RH 2.0 Map18490.0RGD
SHRSP x BN Map1817.1599UniSTS
AW529964  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,273,733 - 31,273,889 (+)MAPPERmRatBN7.2
Rnor_6.01831,730,426 - 31,730,581NCBIRnor6.0
Rnor_5.01831,410,795 - 31,410,950UniSTSRnor5.0
RGSC_v3.41832,373,549 - 32,373,704UniSTSRGSC3.4
Celera1830,907,447 - 30,907,602UniSTS
RH 3.4 Map18442.7UniSTS
Cytogenetic Map18p12UniSTS
RH94419  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81831,526,321 - 31,526,474 (+)Marker Load Pipeline
mRatBN7.21831,275,219 - 31,275,372 (+)MAPPERmRatBN7.2
Rnor_6.01831,731,912 - 31,732,064NCBIRnor6.0
Rnor_5.01831,412,281 - 31,412,433UniSTSRnor5.0
RGSC_v3.41832,375,035 - 32,375,187UniSTSRGSC3.4
Celera1830,908,933 - 30,909,085UniSTS
RH 3.4 Map18442.9UniSTS
Cytogenetic Map18p12UniSTS
NR3C1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,358,829 - 31,359,293 (+)MAPPERmRatBN7.2
Rnor_6.01832,669,773 - 32,670,236NCBIRnor6.0
Rnor_5.01832,347,575 - 32,348,038UniSTSRnor5.0
RGSC_v3.41832,458,240 - 32,458,703UniSTSRGSC3.4
Celera1830,992,617 - 30,993,080UniSTS
Cytogenetic Map18p12UniSTS
D18Mit17  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81831,610,441 - 31,610,661 (+)Marker Load Pipeline
mRatBN7.21831,359,344 - 31,359,564 (+)MAPPERmRatBN7.2
Rnor_6.01832,670,288 - 32,670,507NCBIRnor6.0
Rnor_5.01832,348,090 - 32,348,309UniSTSRnor5.0
RGSC_v3.41832,458,755 - 32,458,974UniSTSRGSC3.4
Celera1830,993,132 - 30,993,351UniSTS
Cytogenetic Map18p12UniSTS


Genetic Models
This gene Nr3c1 is modified in the following models/strains:
LE-Nr3c1em1Jhrmn     SD-Nr3c1em1Jhrmn    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001408897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB115420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC096226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF455050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY066016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY293740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB699574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF495208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000044287   ⟹   ENSRNOP00000044335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1831,522,783 - 31,613,439 (-)Ensembl
mRatBN7.2 Ensembl1831,271,681 - 31,359,735 (-)Ensembl
Rnor_6.0 Ensembl1831,728,373 - 31,749,647 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094555   ⟹   ENSRNOP00000077321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1831,349,007 - 31,362,168 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103007   ⟹   ENSRNOP00000085495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1831,351,407 - 31,393,375 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130585   ⟹   ENSRNOP00000105496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1831,522,783 - 31,613,429 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146770   ⟹   ENSRNOP00000108341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1831,522,783 - 31,643,843 (-)Ensembl
RefSeq Acc Id: NM_001408897   ⟹   NP_001395826
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,783 - 31,614,219 (-)NCBI
mRatBN7.21831,271,681 - 31,363,122 (-)NCBI
RefSeq Acc Id: NM_012576   ⟹   NP_036708
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,783 - 31,613,439 (-)NCBI
mRatBN7.21831,271,681 - 31,362,342 (-)NCBI
Rnor_6.01831,728,373 - 32,670,678 (-)NCBI
Rnor_5.01831,408,742 - 31,442,725 (-)NCBI
Rnor_5.01832,347,227 - 32,348,480 (-)NCBI
RGSC_v3.41832,371,496 - 32,459,145 (-)RGD
Celera1830,905,394 - 30,993,522 (-)RGD
Sequence:
RefSeq Acc Id: XM_017600839   ⟹   XP_017456328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,613,458 (-)NCBI
mRatBN7.21831,271,681 - 31,362,278 (-)NCBI
Rnor_6.01831,728,373 - 32,672,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600840   ⟹   XP_017456329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,613,361 (-)NCBI
mRatBN7.21831,275,610 - 31,361,837 (-)NCBI
Rnor_6.01831,728,373 - 32,672,787 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600841   ⟹   XP_017456330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,614,244 (-)NCBI
mRatBN7.21831,275,610 - 31,363,144 (-)NCBI
Rnor_6.01831,728,373 - 32,673,965 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600843   ⟹   XP_017456332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,644,508 (-)NCBI
mRatBN7.21831,275,610 - 31,393,320 (-)NCBI
Rnor_6.01831,728,373 - 32,704,022 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600844   ⟹   XP_017456333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,614,690 (-)NCBI
mRatBN7.21831,275,610 - 31,363,460 (-)NCBI
Rnor_6.01831,728,373 - 32,674,418 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063277082   ⟹   XP_063133152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,614,424 (-)NCBI
RefSeq Acc Id: XM_063277083   ⟹   XP_063133153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,613,368 (-)NCBI
RefSeq Acc Id: XM_063277084   ⟹   XP_063133154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,612,449 (-)NCBI
RefSeq Acc Id: XM_063277085   ⟹   XP_063133155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,613,358 (-)NCBI
RefSeq Acc Id: XM_063277086   ⟹   XP_063133156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,614,774 (-)NCBI
RefSeq Acc Id: XM_063277087   ⟹   XP_063133157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,614,537 (-)NCBI
RefSeq Acc Id: XM_063277088   ⟹   XP_063133158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,644,508 (-)NCBI
RefSeq Acc Id: XM_063277089   ⟹   XP_063133159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,522,786 - 31,612,442 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001395826 (Get FASTA)   NCBI Sequence Viewer  
  NP_036708 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456328 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456329 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456330 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456332 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456333 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133152 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133153 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133154 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133155 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133156 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133157 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133158 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133159 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41203 (Get FASTA)   NCBI Sequence Viewer  
  AAL66772 (Get FASTA)   NCBI Sequence Viewer  
  AAL78956 (Get FASTA)   NCBI Sequence Viewer  
  AAP37154 (Get FASTA)   NCBI Sequence Viewer  
  ABS19632 (Get FASTA)   NCBI Sequence Viewer  
  BAF82011 (Get FASTA)   NCBI Sequence Viewer  
  CAA68545 (Get FASTA)   NCBI Sequence Viewer  
  CAA72938 (Get FASTA)   NCBI Sequence Viewer  
  CAB72100 (Get FASTA)   NCBI Sequence Viewer  
  EDL76462 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044335
  ENSRNOP00000108341
GenBank Protein P06536 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036708   ⟸   NM_012576
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   A6J3I0 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456332   ⟸   XM_017600843
- Peptide Label: isoform X1
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   E9PT44 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456333   ⟸   XM_017600844
- Peptide Label: isoform X1
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   E9PT44 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456330   ⟸   XM_017600841
- Peptide Label: isoform X1
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   E9PT44 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456328   ⟸   XM_017600839
- Peptide Label: isoform X1
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   E9PT44 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456329   ⟸   XM_017600840
- Peptide Label: isoform X1
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   E9PT44 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044335   ⟸   ENSRNOT00000044287
Ensembl Acc Id: ENSRNOP00000077321   ⟸   ENSRNOT00000094555
Ensembl Acc Id: ENSRNOP00000085495   ⟸   ENSRNOT00000103007
RefSeq Acc Id: NP_001395826   ⟸   NM_001408897
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   A6J3I0 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133158   ⟸   XM_063277088
- Peptide Label: isoform X2
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   A6J3I0 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133156   ⟸   XM_063277086
- Peptide Label: isoform X2
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   A6J3I0 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133157   ⟸   XM_063277087
- Peptide Label: isoform X2
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   A6J3I0 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133152   ⟸   XM_063277082
- Peptide Label: isoform X1
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   E9PT44 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133153   ⟸   XM_063277083
- Peptide Label: isoform X1
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   E9PT44 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133155   ⟸   XM_063277085
- Peptide Label: isoform X2
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   A6J3I0 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133154   ⟸   XM_063277084
- Peptide Label: isoform X1
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   E9PT44 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133159   ⟸   XM_063277089
- Peptide Label: isoform X2
- UniProtKB: Q8R5J0 (UniProtKB/Swiss-Prot),   Q8R463 (UniProtKB/Swiss-Prot),   P06536 (UniProtKB/Swiss-Prot),   O08624 (UniProtKB/Swiss-Prot),   A6J3I0 (UniProtKB/TrEMBL),   A8IRI3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108341   ⟸   ENSRNOT00000146770
Ensembl Acc Id: ENSRNOP00000105496   ⟸   ENSRNOT00000130585
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06536-F1-model_v2 AlphaFold P06536 1-795 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2741 AgrOrtholog
BioCyc Gene G2FUF-7742 BioCyc
Ensembl Genes ENSRNOG00000014096 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000044287 ENTREZGENE
  ENSRNOT00000146770 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro Glcrtcd_rcpt UniProtKB/Swiss-Prot
  NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR3 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:24413 UniProtKB/Swiss-Prot
NCBI Gene 24413 ENTREZGENE
PANTHER KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam GCR UniProtKB/Swiss-Prot
  Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PharmGKB NR3C1 RGD
PhenoGen Nr3c1 PhenoGen
PRINTS GLCORTICOIDR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014096 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC216596
UniProt A0ABK0L6B3_RAT UniProtKB/TrEMBL
  A0ABK0M091_RAT UniProtKB/TrEMBL
  A6J3I0 ENTREZGENE, UniProtKB/TrEMBL
  A8IRI3 ENTREZGENE, UniProtKB/TrEMBL
  E9PT44 ENTREZGENE, UniProtKB/TrEMBL
  GCR_RAT UniProtKB/Swiss-Prot
  O08624 ENTREZGENE
  P06536 ENTREZGENE
  Q8R463 ENTREZGENE
  Q8R5J0 ENTREZGENE
UniProt Secondary O08624 UniProtKB/Swiss-Prot
  Q8R463 UniProtKB/Swiss-Prot
  Q8R5J0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Nr3c1  nuclear receptor subfamily 3, group C, member 1  Grl  glucocorticoid receptor  Symbol and Name updated 629477 APPROVED
2002-06-10 Grl  glucocorticoid receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to glucocorticoid, ligand-activated transcription factor 61055
gene_function binds to glucocorticoid, ligand-activated transcription factor 68694
gene_physical_interaction forms heterocomplexes with heat shock proteins Hsp90 and Hsp70 729398
gene_protein 795 amino acids residues 728978
gene_transcript contains 12 variable exons and eight constant exons 1302827