RGD Reference Report - Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system. - Rat Genome Database

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Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system.

Authors: Ogino, H  Yamada, K  Yuhara, M  Tsuchida, S  Maezawa, K  Kizu, J  Hori, S 
Citation: Ogino H, etal., J Infect Chemother. 2009 Apr;15(2):113-7. Epub 2009 Apr 25.
RGD ID: 4892316
Pubmed: PMID:19396522   (View Abstract at PubMed)
DOI: DOI:10.1007/s10156-009-0675-y   (Journal Full-text)

We studied the effect of fluoroquinolones (FQs) on carrageenan-induced edema in the rat footpad. Ciprofloxacin, gatifloxacin, sparfloxacin, norfloxacin, and enoxacin (s.c., 100 mg/kg), which have piperazinyl and/or cyclopropyl groups, inhibited carrageenan-induced edema, whereas levofloxacin, tosufloxacin, and pazufloxacin did not. The reduction of edema by ciprofloxacin, sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological responses through enhancing the glucocorticoid-glucocorticoid receptor system.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Edema  ISONr3c1 (Rattus norvegicus)4892316; 4892316 RGD 
Edema  IDA 4892316 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nr3c1  (nuclear receptor subfamily 3, group C, member 1)

Genes (Mus musculus)
Nr3c1  (nuclear receptor subfamily 3, group C, member 1)

Genes (Homo sapiens)
NR3C1  (nuclear receptor subfamily 3 group C member 1)


Additional Information