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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1increases expressionEXP 6480464CTDCaffeine results in increased expression of NR3C1 mRNA; Caffeine results in increased expression of NR3C1 proteinPMID:22583948 PMID:30423288 PMID:30528684 PMID:30776459 PMID:31306741 PMID:32663519
Nr3c1increases phosphorylationISONR3C1 (Homo sapiens)6480464CTDCaffeine results in increased phosphorylation of NR3C1 proteinPMID:35688186
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