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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741 Species: Rattus norvegicus RGD Object: Gene Symbol: Nr3c1 Name: nuclear receptor subfamily 3, group C, member 1

Acc ID: CHEBI:17347 Term: testosterone Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5. CasRN: 58-22-0 Chemical ID: MESH:D013739

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:10691	6480464	CTD	Testosterone results in decreased expression of NR3C1 mRNA	PMID:20600201 PMID:21669218
multiple interactions	EXP		6480464	CTD	[Glucocorticoids binds to NR3C1 protein] which results in decreased chemical synthesis of Testosterone	PMID:16061069