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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1multiple interactionsEXP 6480464CTD[Glucocorticoids binds to NR3C1 protein] which results in decreased chemical synthesis of TestosteronePMID:16061069
Nr3c1decreases expressionISONr3c1 (Mus musculus)6480464CTDTestosterone results in decreased expression of NR3C1 mRNAPMID:20600201 PMID:21669218
Nr3c1decreases expressionISONR3C1 (Homo sapiens)6480464CTDTestosterone results in decreased expression of NR3C1 mRNAPMID:33359661
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