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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1affects bindingEXP 6480464CTDNR3C1 protein binds to ProgesteronePMID:1597467
Nr3c1affects expressionEXP 6480464CTDProgesterone affects the expression of NR3C1 mRNAPMID:19208548
Nr3c1affects bindingISONR3C1 (Homo sapiens)6480464CTDProgesterone binds to NR3C1 proteinPMID:16507850
Nr3c1increases expressionISONR3C1 (Homo sapiens)6480464CTDProgesterone results in increased expression of NR3C1 mRNAPMID:25056680
Nr3c1increases phosphorylationISONR3C1 (Homo sapiens)6480464CTDProgesterone results in increased phosphorylation of NR3C1 proteinPMID:18483179
Nr3c1multiple interactionsISONr3c1 (Mus musculus)6480464CTDProgesterone binds to and results in increased activity of NR3C1 protein; Progesterone inhibits the reaction [Ozone results in decreased expression of NR3C1 protein]PMID:17509631 PMID:28279894
Nr3c1multiple interactionsISONR3C1 (Homo sapiens)6480464CTD[Hydrocortisone co-treated with Progesterone] results in increased expression of NR3C1 mRNA; [Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of NR3C1 protein; [Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of NR3C1 mRNA; NR3C1 protein inhibits the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in decreased expression of GRIA1 mRNA]; NR3C1 protein inhibits the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of ZNF486 mRNA]; NR3C1 protein promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of WNT4 mRNA]; Progesterone binds to and results in increased activity of NR3C1 proteinPMID:18060946 PMID:23275455 PMID:25056680
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