Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1affects expressionEXP 6480464CTDbisphenol A affects the expression of NR3C1 mRNA; bisphenol A affects the expression of NR3C1 proteinPMID:24323913 PMID:24857958 PMID:25181051 PMID:32145629
Nr3c1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of NR3C1 mRNAPMID:25812946 PMID:26060449 PMID:27697584 PMID:34947998
Nr3c1increases expressionEXP 6480464CTDbisphenol A results in increased expression of NR3C1 mRNAPMID:33296240 PMID:36136478
Nr3c1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of NR3C1 genePMID:28505145
Nr3c1increases phosphorylationEXP 6480464CTDbisphenol A results in increased phosphorylation of NR3C1 proteinPMID:34165232
Nr3c1multiple interactionsEXP 6480464CTDlithospermate B inhibits the reaction [bisphenol A results in increased phosphorylation of NR3C1 protein]; LY 379268 inhibits the reaction [bisphenol A results in decreased expression of NR3C1 mRNA]PMID:25812946 PMID:34165232
Nr3c1affects bindingISONR3C1 (Homo sapiens)6480464CTDbisphenol A binds to NR3C1 proteinPMID:34706627
Nr3c1affects methylationISONr3c1 (Mus musculus)6480464CTDbisphenol A affects the methylation of NR3C1 promoterPMID:27334623
Nr3c1decreases activityISONR3C1 (Homo sapiens)6480464CTDbisphenol A results in decreased activity of NR3C1 proteinPMID:26196221
Nr3c1decreases expressionISONr3c1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of NR3C1 mRNAPMID:20739668
Nr3c1decreases expressionISONR3C1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of NR3C1 mRNAPMID:32030086
Nr3c1increases activityISONr3c1 (Mus musculus)6480464CTDbisphenol A results in increased activity of NR3C1 proteinPMID:19927138
Nr3c1multiple interactionsISONr3c1 (Mus musculus)6480464CTD[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of NR3C1 mRNA; bisphenol A promotes the reaction [[NR3C1 protein co-treated with CEBPB protein] results in increased expression of FABP4 mRNA]; bisphenol A promotes the reaction [[NR3C1 protein co-treated with CEBPD protein] results in increased expression of FABP4 mRNA]; bisphenol A promotes the reaction [NR3C1 protein results in increased expression of FABP4 mRNA]; bisphenol A results in increased activity of and results in increased phosphorylation of NR3C1 protein; MIR21A mRNA affects the reaction [bisphenol A results in increased activity of and results in increased phosphorylation of NR3C1 protein]PMID:25068083 PMID:26996129 PMID:32518293
Nr3c1multiple interactionsISONR3C1 (Homo sapiens)6480464CTDbisphenol A analog inhibits the reaction [Dexamethasone binds to NR3C1 protein]; bisphenol A analog inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]; bisphenol A inhibits the reaction [Dexamethasone binds to NR3C1 protein]; bisphenol A inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]; bisphenol A inhibits the reaction [Hydrocortisone binds to NR3C1 protein]; bisphenol A inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]; NR3C1 protein promotes the reaction [bisphenol A results in decreased expression of SCNN1G protein]PMID:25576683 PMID:26196221 PMID:27522653 PMID:28078411 PMID:30408883 PMID:30582956 PMID:31195007
Go Back to source page   Continue to Ontology report