RGD Reference Report - Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. - Rat Genome Database

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Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18.

Authors: Kovacs, P  Voigt, B  Kloting, I 
Citation: Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
RGD ID: 61055
Pubmed: PMID:9199194   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1997.6782   (Journal Full-text)

Hypertension and diabetes mellitus are known to be frequently associated. The genetic dissection of diseases such as hypertension or diabetes mellitus is possible by using experimental crosses, which allow identification of loci influencing phenotypic traits (quantitative trait loci - QTLs). In this study the spontaneously hypertensive rat (SHR) and spontaneously diabetic, but normotensive rat (BB/OK) were crossed and the F2 population was analysed in order to search for QTLs on selected chromosomes (1, 10, 18) for blood pressure and some metabolic traits related to diabetes, renal function and hypertension. There were 3 regions found on chromosome 1 which showed linkage to blood pressure. The strongest evidence for linkage was observed between loci Igf2 and D1Mgh12. On chromosome 10 there was a QTL for blood pressure found between Ppy and Abp and on chromosome 18 there were three regions (Ttr-Grl, Tilp-Gja1, Olf-D18Mit9) with linkage to blood pressure. Since the 24 hr albumin and phosphate excretion correlated with blood pressure in F2 hybrids, the same regions were linked to both parameters. Region with linkage to serum concentrations of cholesterol (probably located beyond the terminal marker Ttr of the linkage group) were also found. The results of this study with a new F2(BB x SHR) population confirm the existence of previously described blood pressure loci (Sa and Bp2) and showed novel QTLs on chromosomes 1, 10 and 18.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
disease of metabolism  IAGP 61055 RGD 
Hypercholesterolemia  IDA 61055 RGD 
hypertension  IDA 61055; 61055; 61055; 61055; 61055; 61055; 61055 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

QTLs
Bp42  (Blood pressure QTL 42)
Bp43  (Blood pressure QTL 43)
Bp44  (Blood pressure QTL 44)
Bp45  (Blood pressure QTL 45)
Bp46  (Blood pressure QTL 46)
Bp47  (Blood pressure QTL 47)
Bp48  (Blood pressure QTL 48)
Scl22  (Serum cholesterol level QTL 22)
Sprol1  (Serum protein level QTL 1)

Strains
BB/OK  (BioBreeding rat)
SHR/Mol  (NA)

Objects referenced in this article
Gene NR3C1 nuclear receptor subfamily 3 group C member 1 Homo sapiens
Gene Nr3c1 nuclear receptor subfamily 3, group C, member 1 Mus musculus
Marker D1Mgh12 D1Mgh12 Rattus norvegicus
Marker D18Mit9 D18Mit9 Rattus norvegicus
Marker D1Mit3 D1Mit3 Rattus norvegicus
Gene Acsm3 acyl-CoA synthetase medium-chain family member 3 Rattus norvegicus
Gene Aoc1 amine oxidase, copper containing 1 Rattus norvegicus
Strain BBDR/Rhw null Rattus norvegicus
QTL Bp2 Blood pressure QTL 2 Rattus norvegicus
QTL Bp32 Blood pressure QTL 32 Rattus norvegicus
Gene Gja1 gap junction protein, alpha 1 Rattus norvegicus
Gene Igf2 insulin-like growth factor 2 Rattus norvegicus
Gene Nr3c1 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus
Gene Ppy pancreatic polypeptide Rattus norvegicus
Gene Sct secretin Rattus norvegicus
Gene Sp1 Sp1 transcription factor Rattus norvegicus
Gene Spn sialophorin Rattus norvegicus
Gene Ttr transthyretin Rattus norvegicus
Strain Wild/K null Rattus norvegicus

Additional Information