RGD Reference Report - Glucocorticoid receptor in active pulmonary sarcoidosis. - Rat Genome Database

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Glucocorticoid receptor in active pulmonary sarcoidosis.

Authors: De Carvalho, CR  Brentani, MM  Karialla, RA  Oshima, CT  Barbas Filho, JV  Saldiva, PH 
Citation: de Carvalho CR, etal., Sarcoidosis. 1990 Sep;7(2):93-5.
RGD ID: 4892566
Pubmed: PMID:2255800   (View Abstract at PubMed)

Glucorticoid receptor (GR) content of open-chest lung biopsies of 8 patients with active non treated pulmonary sarcoidosis was compared to 10 normal lungs. Results showed a higher GR level in sarcoid lungs (86.0 +/- 8.0 fMol/mg protein) than in control ones (8.2 +/- 3.1 fMol/mg protein). Our findings suggest that this increase is due to the accumulation of active cells in the sarcoid granuloma, possibly lymphocytes and or macrophages that may express cytosolic GR. The high level of this receptor in sarcoidosis may represent an indicator of the responsiveness of this disease to corticoids.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary sarcoidosis  IEP 4892566protein:increased expression:lungRGD 
pulmonary sarcoidosis  ISONR3C1 (Homo sapiens)4892566; 4892566protein:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nr3c1  (nuclear receptor subfamily 3, group C, member 1)

Genes (Mus musculus)
Nr3c1  (nuclear receptor subfamily 3, group C, member 1)

Genes (Homo sapiens)
NR3C1  (nuclear receptor subfamily 3 group C member 1)


Additional Information