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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1affects expressionEXP 6480464CTDpirinixic acid affects the expression of NR3C1 mRNAPMID:19483382
Nr3c1decreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of NR3C1 mRNAPMID:19162173
Nr3c1increases expressionEXP 6480464CTDpirinixic acid results in increased expression of NR3C1 mRNAPMID:22112501
Nr3c1decreases expressionISONr3c1 (Mus musculus)6480464CTDpirinixic acid results in decreased expression of NR3C1 mRNAPMID:16221962 PMID:18445702
Nr3c1multiple interactionsISONr3c1 (Mus musculus)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NR3C1 mRNA; PPARA protein affects the reaction [pirinixic acid results in decreased expression of NR3C1 mRNA]PMID:16221962 PMID:19710929
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