GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr3c1 | affects binding | EXP | | 6480464 | CTD | NR3C1 protein binds to Mifepristone | PMID:1597467 | Nr3c1 | decreases activity | EXP | | 6480464 | CTD | Mifepristone results in decreased activity of NR3C1 protein | PMID:32791177 | Nr3c1 | multiple interactions | EXP | | 6480464 | CTD | [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [Corticosterone results in increased expression of PTGS2 mRNA]; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [Corticosterone results in increased expression of PTGS2 protein]; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [HSD11B1 protein results in decreased activity of NFE2L2 protein]; [Mifepristone binds to and results in decreased activity of NR3C1 protein] which results in decreased susceptibility to Morphine; Mifepristone binds to and results in decreased activity of NR3C1 protein; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [NR3C1 protein binds to PTGS2 promoter]]; Mifepristone inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein]; Mifepristone promotes the reaction [CEBPB protein binds to NR3C1 protein] | PMID:11502894 PMID:15014116 PMID:18556366 PMID:18650268 PMID:22039522 PMID:22606287 PMID:26289146 | Nr3c1 | affects binding | ISO | NR3C1 (Homo sapiens) | 6480464 | CTD | Mifepristone binds to NR3C1 protein | PMID:15705660 | Nr3c1 | decreases expression | ISO | NR3C1 (Homo sapiens) | 6480464 | CTD | Mifepristone results in decreased expression of NR3C1 mRNA; Mifepristone results in decreased expression of NR3C1 protein | PMID:25110054 | Nr3c1 | increases activity | ISO | NR3C1 (Homo sapiens) | 6480464 | CTD | Mifepristone results in increased activity of NR3C1 protein | PMID:16608920 PMID:29777833 | Nr3c1 | increases expression | ISO | NR3C1 (Homo sapiens) | 6480464 | CTD | Mifepristone results in increased expression of NR3C1 mRNA | PMID:25056680 | Nr3c1 | multiple interactions | ISO | Nr3c1 (Mus musculus) | 6480464 | CTD | Mifepristone binds to and results in decreased activity of NR3C1 protein; Mifepristone binds to and results in increased activity of NR3C1 protein; Mifepristone inhibits the reaction [Corticosterone results in decreased expression of NR3C1 protein]; Mifepristone inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] | PMID:15249158 PMID:15829718 PMID:17509631 PMID:18272184 PMID:21647420 PMID:22140582 | Nr3c1 | multiple interactions | ISO | NR3C1 (Homo sapiens) | 6480464 | CTD | [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]]; [Mifepristone binds to and results in decreased activity of NR3C1 protein] which results in decreased susceptibility to Dexamethasone; Mifepristone analog binds to and results in decreased activity of NR3C1 protein; Mifepristone binds to and results in decreased activity of NR3C1 protein; Mifepristone inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein]; Mifepristone inhibits the reaction [Dexamethasone binds to and results in increased activity of NR3C1 protein]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of NR3C1 mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]; Mifepristone inhibits the reaction [Hydrocortisone affects the localization of NR3C1 protein]; Mifepristone inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]; Mifepristone inhibits the reaction [NR3C1 protein promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA]]; Mifepristone inhibits the reaction [teriflunomide results in increased activity of NR3C1 protein] | PMID:10219967 PMID:15946989 PMID:16019588 PMID:16608920 PMID:16806946 PMID:18722610 PMID:19022236 PMID:19672399 PMID:22606287 PMID:24091107 PMID:24418828 PMID:26647222 PMID:26778350 PMID:30364229 PMID:30528684 PMID:30582956 PMID:34273429 PMID:9371735 | | ||||||||||||||||||||||
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