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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:71418
Term: triamcinolone acetonide
Definition: A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.
Chemical ID: MESH:D014222
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1affects bindingEXP 6480464CTDTriamcinolone Acetonide binds to NR3C1 proteinPMID:15250541 PMID:16507850
Nr3c1multiple interactionsEXP 6480464CTDDithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]; Triamcinolone Acetonide binds to and affects the activity of NR3C1 proteinPMID:15250541 PMID:15976447
Nr3c1affects bindingISONr3c1 (Mus musculus)6480464CTDTriamcinolone Acetonide analog binds to NR3C1 protein; Triamcinolone Acetonide binds to NR3C1 proteinPMID:926113
Nr3c1affects bindingISONR3C1 (Homo sapiens)6480464CTDTriamcinolone Acetonide binds to NR3C1 proteinPMID:16507850 PMID:23765520
Nr3c1decreases expressionISONR3C1 (Homo sapiens)6480464CTDTriamcinolone Acetonide results in decreased expression of NR3C1 proteinPMID:16029572
Nr3c1multiple interactionsISONR3C1 (Homo sapiens)6480464CTD[Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide binds to and affects the localization of NR3C1 proteinPMID:15705660 PMID:16029572
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