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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2741
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr3c1
Name: nuclear receptor subfamily 3, group C, member 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr3c1decreases expressionEXP 6480464CTDPhenobarbital results in decreased expression of NR3C1 mRNAPMID:19162173
Nr3c1affects expressionISONr3c1 (Mus musculus)6480464CTDPhenobarbital affects the expression of NR3C1 mRNAPMID:23091169
Nr3c1multiple interactionsISONR3C1 (Homo sapiens)6480464CTDDexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]]; NR3C1 protein promotes the reaction [NR1I3 protein affects the reaction [[Dexamethasone co-treated with Phenobarbital] results in increased expression of CYP2B6 mRNA]]; NR3C1 protein promotes the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA]PMID:10219967 PMID:12695351
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