Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) Rattus norvegicus
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Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
RGD ID: 2460
Description: Enables monooxygenase activity. Involved in several processes, including cellular response to cAMP; positive regulation of metabolic process; and response to glucocorticoid. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrion. Used to study myocardial infarction. Biomarker of breast adenocarcinoma; esophagus squamous cell carcinoma; hypertension; and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; steroid hormone biosynthetic pathway; tryptophan metabolic pathway; INTERACTS WITH (S)-nicotine; 1,2,3,4,6,7,8-Heptachlorodibenzodioxin; 1,2,3,4,6,7,8-Heptachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYPIB1; cytochrome P450 1b1; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450RAP; hydroperoxy icosatetraenoate dehydratase; P450RAP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,093,927 - 21,103,091 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl621,078,146 - 21,103,142 (+)EnsemblGRCr8
mRatBN7.2615,342,312 - 15,350,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,342,344 - 15,350,917 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx615,640,765 - 15,646,482 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0615,962,952 - 15,968,669 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0615,459,216 - 15,464,934 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.062,308,179 - 2,316,739 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl62,307,808 - 2,316,722 (-)Ensemblrn6Rnor6.0
Rnor_5.062,294,952 - 2,300,644 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.462,548,224 - 2,553,767 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera615,009,941 - 15,015,671 (+)NCBICelera
RGSC_v3.162,545,648 - 2,553,767 (-)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+-)-suloctidil  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-pantothenic acid  (ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,2,3,4,6,7,8-Heptachlorodibenzodioxin  (EXP)
1,2,3,4,6,7,8-Heptachlorodibenzofuran  (EXP)
1,2,3,4,7,8-Hexachlorodibenzofuran  (EXP)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (EXP)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,4-dihydroxy-2-naphthoic acid  (ISO)
1,4-naphthoquinone  (ISO)
1,8-Dinitropyrene  (ISO)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-Aminopyrene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methylnaphthalene  (ISO)
1-methylphenanthrene  (EXP)
1-methyltryptophan  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2',5'-Dideoxyadenosine  (ISO)
2'-deoxyguanosine  (ISO)
2'-hydroxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5,5'-Hexachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (EXP)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP,ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-D  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-methylnaphthalene  (ISO)
2-naphthol  (ISO)
3',4'-dimethoxyflavone  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[[oxo(pyridin-4-yl)methyl]hydrazo]-N-(phenylmethyl)propanamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Methylchrysene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4',5,7-Trimethoxyflavone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxychalcone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methoxy-17beta-estradiol  (ISO)
4-Methylchrysene  (ISO)
4-nonylphenol  (EXP)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-Hydroxyflavone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxyindole  (ISO)
5-Methylchrysene  (ISO)
6-chrysenamine  (ISO)
6-hydroxyluteolin  (ISO)
6-Methylchrysene  (ISO)
6-Nitrobenzo[a]pyrene  (ISO)
6-Nitrochrysene  (ISO)
6-prenylnaringenin  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7-hydroxyflavone  (ISO)
8-Br-cAMP  (EXP,ISO)
9-phenanthrol  (ISO)
abacavir  (ISO)
acenaphthene  (ISO)
acenaphthylene  (ISO)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
AH23848  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
alizarin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
amentoflavone  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
andrographolide  (ISO)
aniline  (ISO)
anthracene  (ISO)
anthraflavic acid  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apomorphine  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite ion  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
avobenzone  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benoxaprofen  (ISO)
benzarone  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benziodarone  (ISO)
Benzo[a]fluorene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (EXP,ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (EXP,ISO)
Benzo[b]fluorene  (ISO)
Benzo[c]fluorene  (ISO)
benzo[c]phenanthrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[j]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bergomottin  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
biochanin A  (ISO)
biotin  (ISO)
biphenyl  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
brefeldin A  (ISO)
bromocriptine  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium telluride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calyculin A  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carvedilol  (ISO)
cefaloridine  (EXP)
ceric oxide  (EXP)
CGP 52608  (ISO)
chelerythrine  (ISO)
CHIR 99021  (ISO)
chloroacetaldehyde  (ISO)
chlorophyllin  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (ISO)
choline  (ISO)
Chorionic gonadotropin  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (EXP,ISO)
chrysin  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
chrysophanol  (ISO)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
cirsiliol  (ISO)
cisplatin  (ISO)
citral  (ISO)
clevidipine  (ISO)
clodronic acid  (ISO)
clomiphene  (ISO)
clomipramine  (ISO)
clopidogrel  (ISO)
clothianidin  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (EXP)
coumestrol  (ISO)
curcumin  (ISO)
Cyclofenil  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextromethorphan  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibenz[a,c]anthracene  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
Dibenzo[a,e]pyrene  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dibenzofurans  (ISO)
dibromoacetic acid  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
difluorine  (ISO)
dihydroergotamine  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
Droloxifene  (ISO)
dronedarone  (ISO)
ebrotidine  (ISO)
ellagic acid  (ISO)
ellipticine  (ISO)
emetine  (EXP)
emodin  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
Erucin  (EXP)
estrone  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP)
ethylbenzene  (ISO)
ethylisopropylamiloride  (ISO)
eugenol  (ISO)
eupatorin  (ISO)
Evodiamine  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
ferric oxide  (EXP)
filipin III  (ISO)
fingolimod hydrochloride  (ISO)
flavanone  (ISO)
flavone  (ISO)
flavonol  (ISO)
fluoranthene  (EXP,ISO)
fluorine atom  (ISO)
fluoxetine  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gardiquimod  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (EXP)
geranial  (ISO)
geraniol  (ISO)
glafenine  (ISO)
glucaric acid  (ISO)
glucoerucin  (EXP)
glucoerucin(1-)  (EXP)
glucoraphanin  (EXP)
glucose  (ISO)
glutathione  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (EXP)
homoeriodictyol  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
ICI 118551  (ISO)
ifosfamide  (ISO)
imperatorin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (EXP,ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (EXP,ISO)
indoles  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP,ISO)
iron dichloride  (ISO)
isoflavones  (ISO)
isoimperatorin  (ISO)
isoliquiritigenin  (ISO)
isopimpinellin  (ISO)
isoprenaline  (EXP,ISO)
isoproturon  (ISO)
isorhamnetin  (ISO)
Isradipine  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
kynurenine  (ISO)
L-methionine  (ISO)
L-tryptophan  (ISO)
lansoprazole  (ISO)
lapatinib  (ISO)
laquinimod  (EXP,ISO)
lead diacetate  (EXP,ISO)
leflunomide  (EXP,ISO)
Licochalcone A  (ISO)
linuron  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
menadione  (ISO)
mephenytoin  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methoxsalen  (ISO)
methoxychlor  (EXP,ISO)
methylmercury chloride  (ISO)
metoclopramide  (ISO)
midazolam  (ISO)
mifepristone  (EXP)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
montelukast  (ISO)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desmethylclozapine  (ISO)
N-Desmethyltamoxifen  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
naphthalenes  (EXP)
naringin  (ISO)
NCX-4040  (ISO)
nefazodone  (ISO)
nicardipine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP)
nifedipine  (ISO)
nilutamide  (ISO)
nimesulide  (ISO)
nobiletin  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
O-methyleugenol  (ISO)
o-xylene  (ISO)
okadaic acid  (ISO)
olsalazine  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
organophosphorus compound  (EXP)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
oxyphenisatine acetate  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
pazopanib  (ISO)
pentachlorobiphenyl  (ISO)
pentamidine  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
Pf-06840003  (ISO)
phenanthrene  (ISO)
phenanthrenes  (ISO)
Phenelzine  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pifithrin-alpha hydrobromide  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
primaquine  (ISO)
procarbazine  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propafenone  (ISO)
propiconazole  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pyrantel  (ISO)
pyrene  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
quinidine  (ISO)
rabeprazole  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
Riluzole  (ISO)
ritonavir  (ISO)
Rutecarpine  (ISO)
rutin  (ISO)
salicylamide  (ISO)
Salinomycin  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
scutellarein  (ISO)
senecionine  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sinensetin  (ISO)
sirolimus  (ISO)
skatole  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium propionate  (ISO)
sorafenib  (ISO)
StemRegenin 1  (ISO)
steviol  (ISO)
stevioside  (ISO)
stilbenoid  (ISO)
succimer  (ISO)
Sudan I  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sunitinib  (EXP,ISO)
suramin  (ISO)
tamoxifen  (ISO)
tangeretin  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetrahydrocurcumin  (ISO)
tetraphene  (EXP,ISO)
thapsigargin  (ISO)
thiram  (ISO)
ticlopidine  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
toluene  (ISO)
tolvaptan  (ISO)
topotecan  (EXP)
tranilast  (ISO)
trazodone  (ISO)
triadimefon  (ISO)
trichlorobiphenyl  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclocarban  (EXP,ISO)
triclosan  (EXP,ISO)
trimethylarsine oxide  (ISO)
triphenylene  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
undecane  (EXP)
urethane  (ISO)
Valacyclovir hydrochloride  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
varenicline  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
voriconazole  (ISO)
vorinostat  (EXP,ISO)
wortmannin  (EXP,ISO)
Yessotoxin  (ISO)
zafirlukast  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEP)
angiogenesis  (ISO)
arachidonate metabolic process  (IEA,ISO,ISS)
benzene-containing compound metabolic process  (IDA,IMP,ISO)
blood vessel morphogenesis  (IEA,ISO,ISS)
cell adhesion  (IEA,ISO,ISS)
cellular response to cAMP  (IEP)
cellular response to cortisol stimulus  (IEP)
cellular response to hydrogen peroxide  (IEA,ISO,ISS)
cellular response to luteinizing hormone stimulus  (IEP)
cellular response to progesterone stimulus  (IEP)
cellular response to toxic substance  (IMP)
cellular response to tumor necrosis factor  (IEP)
collagen fibril organization  (IEA,ISO,ISS)
DNA modification  (IMP)
endothelial cell migration  (ISO,ISS)
endothelial cell-cell adhesion  (ISO)
estrogen metabolic process  (IBA,IDA,IEA,IMP,ISO)
estrous cycle  (IEP)
fatty acid metabolic process  (IEA)
ganglion development  (IEP)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO,ISS)
lipid metabolic process  (IEA)
male gonad development  (IEP)
membrane lipid catabolic process  (IEA,ISO,ISS)
negative regulation of cell adhesion mediated by integrin  (IEA,ISO,ISS)
negative regulation of cell migration  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
nitric oxide biosynthetic process  (IEA,ISO,ISS)
obsolete negative regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of angiogenesis  (IEA,ISO,ISS)
positive regulation of apoptotic process  (IEA,IEP,ISO)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of reactive oxygen species metabolic process  (IMP)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO,ISS)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of translation  (IMP)
positive regulation of vascular endothelial growth factor production  (IEA,ISO,ISS)
regulation of reactive oxygen species metabolic process  (IEA,ISO,ISS)
response to 3-methylcholanthrene  (IEP)
response to arsenic-containing substance  (IEP)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to follicle-stimulating hormone  (IEP)
response to indole-3-methanol  (IEP)
response to nutrient  (IEP)
response to steroid hormone  (IEP)
response to toxic substance  (IEP,ISO)
retina vasculature development in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (IEA,ISO,ISS)
retinal metabolic process  (IEA,ISO,ISS)
retinol metabolic process  (IEA,ISO,ISS)
steroid catabolic process  (IBA)
steroid metabolic process  (IEA,ISO,ISS)
toxin metabolic process  (IBA,ISO)
trabecular meshwork development  (IEA,ISO,ISS)
xenobiotic catabolic process  (IBA)
xenobiotic metabolic process  (IEA,ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Molecular and clinical evaluation of primary congenital glaucoma in Kuwait. Alfadhli S, etal., Am J Ophthalmol. 2006 Mar;141(3):512-6.
3. Congenital glaucoma: CYP1B1 mutations in Israeli Bedouin kindreds. Bar-Yosef U, etal., J Glaucoma. 2010 Jan;19(1):35-8. doi: 10.1097/IJG.0b013e3181a98b6f.
4. Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma. Bhattacharjee A, etal., Mol Vis. 2008 May 8;14:841-50.
5. Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. Bhattacharyya KK, etal., J Biol Chem 1995 May 12;270(19):11595-602.
6. Developmental expression and regulation of adrenocortical cytochrome P4501B1 in the rat. Brake PB, etal., Endocrinology. 1999 Apr;140(4):1672-80.
7. Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: evidence for transcriptional repression by glucocorticoids. Brake PB, etal., Mol Pharmacol. 1998 Nov;54(5):825-33.
8. Glaucoma-associated CYP1B1 mutations share similar haplotype backgrounds in POAG and PACG phenotypes. Chakrabarti S, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5439-44.
9. Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Choudhary D, etal., Drug Metab Dispos. 2004 Aug;32(8):840-7.
10. Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland: cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones. Christou M, etal., Mol Cell Endocrinol. 1995 Nov 30;115(1):41-50.
11. Dehydroepiandrosterone inhibits the expression of carcinogen-activating enzymes in vivo. Ciolino H, etal., Int J Cancer. 2003 Jun 20;105(3):321-5.
12. Estrous cycle-regulated expression of CYP1B1 mRNA in the rat ovary. Dasmahapatra AK, etal., Comp Biochem Physiol B Biochem Mol Biol. 2002 Sep;133(1):127-34.
13. Association of CYP1B1 polymorphisms and breast cancer risk. De Vivo I, etal., Cancer Epidemiol Biomarkers Prev 2002 May;11(5):489-92.
14. Regulation of cytochrome P450 1B1 expression by luteinizing hormone in mouse MA-10 and rat R2C Leydig cells: role of protein kinase A. Deb S and Bandiera SM, Biol Reprod. 2011 Jul;85(1):89-96. doi: 10.1095/biolreprod.110.088971. Epub 2011 Mar 9.
15. Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux. Devlin AH, etal., Mol Carcinog. 2009 Feb;48(2):110-7. doi: 10.1002/mc.20459.
16. Molecular basis of Peters anomaly in Saudi Arabia. Edward D, etal., Ophthalmic Genet. 2004 Dec;25(4):257-70.
17. Molecular analysis of CYP1B1 in Omani patients with primary congenital glaucoma: a pilot study. El-Gayar S, etal., Mol Vis. 2009 Jul 8;15:1325-31.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner. Han Y, etal., Mol Cell Biochem. 2021 Mar;476(3):1387-1400. doi: 10.1007/s11010-020-03998-y. Epub 2021 Jan 3.
21. Screening of CYP1B1 and MYOC in Moroccan families with primary congenital glaucoma: three novel mutations in CYP1B1. Hilal L, etal., Mol Vis. 2010 Jul 2;16:1215-26.
22. Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology. Jennings BL, etal., Hypertension. 2010 Oct;56(4):667-74. doi: 10.1161/HYPERTENSIONAHA.110.154518. Epub 2010 Aug 30.
23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. Metabolism of benzopyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1. Kim JH, etal., Carcinogenesis. 1998 Oct;19(10):1847-53.
25. Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients. Kumar A, etal., Mol Vis. 2007 Apr 30;13:667-76.
26. Bifunctional modulating effects of an indigo dimer (bisindigotin) to CYP1A1 induction in H4IIE cells. Lai KP, etal., Toxicology. 2006 Sep 21;226(2-3):188-96. Epub 2006 Jul 4.
27. Transplacental exposure to indole-3-carbinol induces sex-specific expression of CYP1A1 and CYP1B1 in the liver of Fischer 344 neonatal rats. Larsen-Su SA and Williams DE, Toxicol Sci. 2001 Dec;64(2):162-8.
28. Developmental expression and endocrine regulation of CYP1B1 in rat testis. Leung GS, etal., Drug Metab Dispos. 2009 Mar;37(3):523-8. doi: 10.1124/dmd.108.025635. Epub 2008 Dec 15.
29. Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. Libby RT, etal., Science 2003 Mar 7;299(5612):1578-81.
30. Association of a common coding polymorphism (N453S) of the cytochrome P450 1B1 (CYP1B1) gene with optic disc cupping and visual field alteration in French patients with primary open-angle glaucoma. Melki R, etal., Mol Vis. 2005 Nov 23;11:1012-7.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Survey of familial glaucoma shows a high incidence of cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) mutations in non-consanguineous congenital forms in a Spanish population. Milla E, etal., Mol Vis. 2013 Aug 4;19:1707-22. Print 2013.
33. An immunohistochemical label to facilitate counting of ovarian follicles. Muskhelishvili L, etal., Toxicol Pathol. 2002 May-Jun;30(3):400-2.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Specificity determinants of CYP1B1 estradiol hydroxylation. Nishida CR, etal., Mol Pharmacol. 2013 Sep;84(3):451-8. doi: 10.1124/mol.113.087700. Epub 2013 Jul 2.
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. Cellular localization of hepatic cytochrome 1B1 expression and its regulation by aromatic hydrocarbons and inflammatory cytokines. Piscaglia F, etal., Biochem Pharmacol. 1999 Jul 1;58(1):157-65.
39. Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma. Plasilova M, etal., J Med Genet. 1999 Apr;36(4):290-4.
40. Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression. Putluri N, etal., Cancer Res. 2011 Dec 15;71(24):7376-86. doi: 10.1158/0008-5472.CAN-11-1154. Epub 2011 Oct 11.
41. Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1. Rahman M, etal., Toxicol Appl Pharmacol. 2006 Nov 1;216(3):469-78. Epub 2006 Jun 15.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats. Rowlands JC, etal., J Nutr. 2001 Dec;131(12):3281-7.
46. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
47. Inflammatory mediators accelerate metabolism of benzopyrene in rat alveolar type II cells: the role of enhanced cytochrome P450 1B1 expression. Smerdova L, etal., Toxicology. 2013 Dec 6;314(1):30-8. doi: 10.1016/j.tox.2013.09.001. Epub 2013 Sep 8.
48. Primary congenital glaucoma: a novel single-nucleotide deletion and varying phenotypic expression for the 1,546-1,555dup mutation in the GLC3A (CYP1B1) gene in 2 families of different ethnic origin. Soley GC, etal., J Glaucoma. 2003 Feb;12(1):27-30.
49. Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Stoilov I, etal., Hum Mol Genet. 1997 Apr;6(4):641-7.
50. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcripts in a rat model of mammary tumorigenesis. Trombino AF, etal., Breast Cancer Res Treat. 2000 Sep;63(2):117-31.
51. Tumor necrosis factor-alpha potentiates genotoxic effects of benzopyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression. Umannova L, etal., Mutat Res. 2008 Apr 2;640(1-2):162-9. doi: 10.1016/j.mrfmmm.2008.02.001. Epub 2008 Feb 9.
52. Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. Walker NJ, etal., Carcinogenesis 1995 Jun;16(6):1319-27.
53. Aryl hydrocarbon receptor activation and overexpression upregulated fibroblast growth factor-9 in human lung adenocarcinomas. Wang CK, etal., Int J Cancer. 2009 Aug 15;125(4):807-15. doi: 10.1002/ijc.24348.
54. Disease gene candidates revealed by expression profiling of retinal ganglion cell development. Wang JT, etal., J Neurosci. 2007 Aug 8;27(32):8593-603.
55. Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Watanabe J, etal., Pharmacogenetics. 2000 Feb;10(1):25-33.
56. Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. Wei M, etal., Toxicol Appl Pharmacol. 2013 Nov 15;273(1):1-9. doi: 10.1016/j.taap.2013.08.022. Epub 2013 Aug 30.
57. Angiotensin II-induced vascular smooth muscle cell migration and growth are mediated by cytochrome P450 1B1-dependent superoxide generation. Yaghini FA, etal., Hypertension. 2010 Jun;55(6):1461-7. doi: 10.1161/HYPERTENSIONAHA.110.150029. Epub 2010 May 3.
58. Investigation of CYP1B1 mutations in Chinese patients with primary congenital glaucoma. Yang M, etal., Mol Vis. 2009;15:432-7. Epub 2009 Feb 27.
59. Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by uremic toxin. Zhang Y, etal., Mol Med Rep. 2020 Jan;21(1):393-404. doi: 10.3892/mmr.2019.10810. Epub 2019 Nov 11.
Additional References at PubMed
PMID:1910294   PMID:9367523   PMID:9377560   PMID:10051580   PMID:10681376   PMID:10871058   PMID:11555828   PMID:12859982   PMID:12865317   PMID:16377763   PMID:16636061   PMID:17166882  
PMID:18059014   PMID:19005183   PMID:20032512   PMID:20852048   PMID:21147782   PMID:22888116   PMID:23275542   PMID:23568032   PMID:23692925   PMID:23979599   PMID:24477449   PMID:24557852  
PMID:25164943   PMID:29115507   PMID:31563143   PMID:33170892   PMID:33766215   PMID:35054909   PMID:37961023  


Genomics

Comparative Map Data
Cyp1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,093,927 - 21,103,091 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl621,078,146 - 21,103,142 (+)EnsemblGRCr8
mRatBN7.2615,342,312 - 15,350,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,342,344 - 15,350,917 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx615,640,765 - 15,646,482 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0615,962,952 - 15,968,669 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0615,459,216 - 15,464,934 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.062,308,179 - 2,316,739 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl62,307,808 - 2,316,722 (-)Ensemblrn6Rnor6.0
Rnor_5.062,294,952 - 2,300,644 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.462,548,224 - 2,553,767 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera615,009,941 - 15,015,671 (+)NCBICelera
RGSC_v3.162,545,648 - 2,553,767 (-)NCBI
Cytogenetic Map6q12NCBI
CYP1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38238,067,509 - 38,076,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl238,066,973 - 38,109,902 (-)Ensemblhg38GRCh38
GRCh37238,294,652 - 38,303,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36238,148,250 - 38,156,796 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34238,206,396 - 38,214,943NCBI
Celera238,135,623 - 38,144,201 (-)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef238,034,680 - 38,043,258 (-)NCBIHuRef
CHM1_1238,224,106 - 38,232,684 (-)NCBICHM1_1
T2T-CHM13v2.0238,074,395 - 38,083,037 (-)NCBIT2T-CHM13v2.0
Cyp1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,014,369 - 80,022,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,008,966 - 80,022,490 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381779,706,940 - 79,715,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,701,537 - 79,715,061 (-)Ensemblmm10GRCm38
MGSCv371780,106,293 - 80,114,381 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361779,615,279 - 79,623,367 (-)NCBIMGSCv36mm8
Celera1784,018,414 - 84,026,502 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1750.3NCBI
LOC102009223
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554415,803,032 - 5,812,131 (-)Ensembl
ChiLan1.0NW_0049554415,803,397 - 5,812,131 (-)NCBIChiLan1.0ChiLan1.0
CYP1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21288,409,864 - 88,419,099 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A88,413,479 - 88,423,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A38,087,863 - 38,096,529 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A38,851,000 - 38,859,883 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A38,851,000 - 38,859,824 (-)EnsemblpanPan2panpan1.1
CYP1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11730,273,281 - 30,278,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1730,272,749 - 30,278,554 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1730,086,594 - 30,091,868 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01730,923,029 - 30,928,301 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,922,243 - 30,928,321 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11730,148,312 - 30,153,581 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01730,216,274 - 30,221,549 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01730,431,572 - 30,436,860 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101970101
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629241,681,103 - 41,689,696 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936663348,368 - 355,191 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936663345,021 - 355,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3102,195,741 - 102,205,683 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13102,195,743 - 102,205,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11469,318,713 - 69,327,277 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1469,319,495 - 69,324,157 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604542,635,474 - 42,644,623 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701066
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473819,638,456 - 19,647,497 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473819,639,215 - 19,647,807 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116905862
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1713,352,650 - 13,358,426 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp1b1
82 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000066363
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat

Markers in Region
RH139891  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2615,350,234 - 15,350,432 (-)MAPPERmRatBN7.2
Rnor_6.062,308,633 - 2,308,830NCBIRnor6.0
Rnor_5.062,292,597 - 2,292,794UniSTSRnor5.0
RGSC_v3.462,545,869 - 2,546,066UniSTSRGSC3.4
Celera615,017,829 - 15,018,026UniSTS
RH 3.4 Map647.0UniSTS
Cytogenetic Map6q11UniSTS
Cyp1b1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2615,343,145 - 15,343,993 (-)MAPPERmRatBN7.2
Rnor_6.062,315,089 - 2,315,936NCBIRnor6.0
Rnor_5.062,299,011 - 2,299,858UniSTSRnor5.0
RGSC_v3.462,552,134 - 2,552,981UniSTSRGSC3.4
Celera615,010,727 - 15,011,574UniSTS
Cytogenetic Map6q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 87 86 55 42 55 6 291 142 11 137 70 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066363   ⟹   ENSRNOP00000061222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl621,078,146 - 21,103,142 (+)Ensembl
mRatBN7.2 Ensembl615,342,344 - 15,349,389 (+)Ensembl
Rnor_6.0 Ensembl62,314,928 - 2,316,722 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082017   ⟹   ENSRNOP00000071724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl62,310,988 - 2,316,717 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084171   ⟹   ENSRNOP00000075074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl621,094,552 - 21,103,088 (+)Ensembl
mRatBN7.2 Ensembl615,342,347 - 15,350,917 (+)Ensembl
Rnor_6.0 Ensembl62,307,808 - 2,311,781 (-)Ensembl
RefSeq Acc Id: NM_012940   ⟹   NP_037072
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,094,565 - 21,100,282 (+)NCBI
mRatBN7.2615,342,360 - 15,348,077 (+)NCBI
Rnor_6.062,310,988 - 2,316,722 (-)NCBI
Rnor_5.062,294,952 - 2,300,644 (-)NCBI
RGSC_v3.462,548,224 - 2,553,767 (-)RGD
Celera615,009,941 - 15,015,671 (+)RGD
Sequence:
RefSeq Acc Id: XM_017594046   ⟹   XP_017449535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,095,042 - 21,103,091 (+)NCBI
mRatBN7.2615,342,313 - 15,350,886 (+)NCBI
Rnor_6.062,308,179 - 2,316,279 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111803   ⟹   XP_038967731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,093,927 - 21,103,091 (+)NCBI
mRatBN7.2615,342,313 - 15,350,886 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037072 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449535 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967731 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA79864 (Get FASTA)   NCBI Sequence Viewer  
  CAA55320 (Get FASTA)   NCBI Sequence Viewer  
  CAA58748 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075074
  ENSRNOP00000075074.2
GenBank Protein Q64678 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037072   ⟸   NM_012940
- UniProtKB: Q64678 (UniProtKB/Swiss-Prot),   A6H9T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449535   ⟸   XM_017594046
- Peptide Label: isoform X1
- UniProtKB: Q64678 (UniProtKB/Swiss-Prot),   A6H9T3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071724   ⟸   ENSRNOT00000082017
Ensembl Acc Id: ENSRNOP00000061222   ⟸   ENSRNOT00000066363
Ensembl Acc Id: ENSRNOP00000075074   ⟸   ENSRNOT00000084171
RefSeq Acc Id: XP_038967731   ⟸   XM_039111803
- Peptide Label: isoform X1
- UniProtKB: Q64678 (UniProtKB/Swiss-Prot),   A6H9T3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64678-F1-model_v2 AlphaFold Q64678 1-543 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694374
Promoter ID:EPDNEW_R4886
Type:multiple initiation site
Name:Cyp1b1_1
Description:cytochrome P450, family 1, subfamily b, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.062,316,735 - 2,316,795EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2460 AgrOrtholog
BioCyc Gene G2FUF-38510 BioCyc
BioCyc Pathway PWY-6398 [melatonin degradation I] BioCyc
BioCyc Pathway Image PWY-6398 BioCyc
Ensembl Genes ENSRNOG00000040287 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000084171 ENTREZGENE
  ENSRNOT00000084171.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:25426 UniProtKB/Swiss-Prot
NCBI Gene 25426 ENTREZGENE
PANTHER CYTOCHROME P450 1B1 UniProtKB/Swiss-Prot
  STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP1B1 RGD
PhenoGen Cyp1b1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000040287 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A6H9T3 ENTREZGENE, UniProtKB/TrEMBL
  CP1B1_RAT UniProtKB/Swiss-Prot
  D4A6I4_RAT UniProtKB/TrEMBL
  M0RDN3_RAT UniProtKB/TrEMBL
  Q64678 ENTREZGENE
  Q9ESW3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp1b1  cytochrome P450, family 1, subfamily b, polypeptide 1    cytochrome P450, subfamily 1B, polypeptide 1  Name updated 1299863 APPROVED
2002-11-06 Cyp1b1  cytochrome P450, subfamily 1B, polypeptide 1    Cytochrome P450 1b1  Name updated 625702 APPROVED
2002-06-10 Cyp1b1  Cytochrome P450 1b1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation displays increased expression in response to adrenocorticotropic hormone and to aryl hydrocarbon receptor regulation 728267