Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
RGD ID: 2460
Description: Enables monooxygenase activity. Involved in several processes, including cellular response to cAMP; positive regulation of metabolic process; and response to glucocorticoid. Predicted to be located in mitochondrion. Predicted to be active in intracellular membrane-bounded organelle. Used to study myocardial infarction. Biomarker of breast adenocarcinoma; esophagus squamous cell carcinoma; hypertension; and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; steroid hormone biosynthetic pathway; tryptophan metabolic pathway; INTERACTS WITH (S)-nicotine; 1,2,3,4,6,7,8-Heptachlorodibenzodioxin; 1,2,3,4,6,7,8-Heptachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYPIB1; cytochrome P450 1b1; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450RAP; hydroperoxy icosatetraenoate dehydratase; P450RAP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,093,927 - 21,103,091 (+)NCBIGRCr8
mRatBN7.2615,342,312 - 15,350,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,342,344 - 15,350,917 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx615,640,765 - 15,646,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0615,962,952 - 15,968,669 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0615,459,216 - 15,464,934 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.062,308,179 - 2,316,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl62,307,808 - 2,316,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.062,294,952 - 2,300,644 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.462,548,224 - 2,553,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.162,545,648 - 2,553,767 (-)NCBI
Celera615,009,941 - 15,015,671 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 29 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratbreast adenocarcinoma  IEP 7829735mRNA:increased expression:mammary epithelium (rat)RGD 
Cyp1b1Ratbreast cancer susceptibilityISOCYP1B1 (Homo sapiens)7829734DNA:snp:cds:p.A119S (human)RGD 
Cyp1b1Ratbuphthalmos susceptibilityISOCYP1B1 (Homo sapiens)7800680DNA:deletion more ...RGD 
Cyp1b1Ratbuphthalmos  ISOCYP1B1 (Homo sapiens)7800719DNA:missense mutation:cds:p.A388T (human)RGD 
Cyp1b1Ratbuphthalmos  ISOCYP1B1 (Homo sapiens)7800711DNA:missense mutation more ...RGD 
Cyp1b1Ratbuphthalmos  ISOCYP1B1 (Homo sapiens)7800707DNA:duplication:exon:g.1546-1555dupTCATGCCACC (human)RGD 
Cyp1b1Ratbuphthalmos susceptibilityISOCYP1B1 (Homo sapiens)7800670DNA:snp:cds:p.E387K (human)RGD 
Cyp1b1Ratbuphthalmos  ISOCYP1B1 (Homo sapiens)7800688DNA:missense mutations:exons:p.G61E more ...RGD 
Cyp1b1Ratbuphthalmos susceptibilityISOCYP1B1 (Homo sapiens)7800689DNA:missense mutations:exons:p.G61E more ...RGD 
Cyp1b1Ratbuphthalmos  ISOCyp1b1 (Mus musculus)734869 RGD 
Cyp1b1Ratbuphthalmos susceptibilityISOCYP1B1 (Homo sapiens)7800657DNA:polymorphisms:multiple (human)RGD 
Cyp1b1RatCardiac Fibrosis treatmentIEP 401793732 RGD 
Cyp1b1RatCardiomegaly  ISOCyp1b1 (Mus musculus)7829714associated with HypertensionRGD 
Cyp1b1RatCardiomegaly treatmentIEP 401793732 RGD 
Cyp1b1RatCardiomegaly treatmentIDA 7829714associated with HypertensionRGD 
Cyp1b1Ratchronic kidney disease  ISOCyp1b1 (Mus musculus)401793746mRNA and protein:increased expression:heart (mouse)RGD 
Cyp1b1Ratesophagus squamous cell carcinoma  IEP 7829715protein:increased expression:esophagus (rat)RGD 
Cyp1b1Rathydrophthalmos  ISOCYP1B1 (Homo sapiens)1599716DNA:insertion more ...RGD 
Cyp1b1Rathypertension treatmentIEP 401793732 RGD 
Cyp1b1Rathypertrophic cardiomyopathy  IEP 401794453mRNA and protein:increased expression:heart (rat)RGD 
1 to 20 of 29 rows
1 to 14 of 14 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratanterior segment dysgenesis  ISOCYP1B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10655546 more ...
Cyp1b1Ratanterior segment dysgenesis 5  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: ANTERIOR SEGMENT DYSGENESIS 5ClinVarPMID:10655546 more ...
Cyp1b1Ratanterior segment dysgenesis 6  ISOCYP1B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10227395 more ...
Cyp1b1Ratbuphthalmos  ISOCYP1B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10227395 more ...
Cyp1b1Ratcentronuclear myopathy 5  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Myopathy more ...ClinVarPMID:10655546 more ...
Cyp1b1Ratcoloboma  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Coloboma of eyeClinVarPMID:10655546 more ...
Cyp1b1Ratgenetic disease  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:21306220 more ...
Cyp1b1RatGlaucoma 3, Primary Infantile, B  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary congenital glaucoma type 3BClinVarPMID:10426814 more ...
Cyp1b1Ratjuvenile glaucoma  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Glaucoma of childhoodClinVarPMID:10227395 more ...
Cyp1b1RatLynch syndrome  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasmsClinVarPMID:28492532
Cyp1b1RatPeters anomaly  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Irido-corneo-trabecular dysgenesisClinVarPMID:10655546 more ...
Cyp1b1Ratprimary congenital glaucoma  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary congenital glaucomaClinVarPMID:10227395 more ...
Cyp1b1Ratprimary open angle glaucoma  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary open angle glaucomaClinVarPMID:10655546 more ...
Cyp1b1RatRASopathy  ISOCYP1B1 (Homo sapiens)8554872ClinVar Annotator: match by term: RASopathyClinVarPMID:28492532
1 to 14 of 14 rows
1 to 20 of 20 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratacute lymphoblastic leukemia  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22674224
Cyp1b1Ratadenoma  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11376689
Cyp1b1Ratanterior segment dysgenesis  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Cyp1b1RatBreast Neoplasms  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16298037 and PMID:17297925
Cyp1b1Ratbuphthalmos  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Cyp1b1RatCardiomegaly  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18725507
Cyp1b1RatChemical and Drug Induced Liver Injury  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:33814510
Cyp1b1RatColorectal Neoplasms  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20878130
Cyp1b1Ratcontact dermatitis  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Cyp1b1RatGlaucoma 3, Primary Infantile, B  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Cyp1b1Ratglucose intolerance  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:27036855
Cyp1b1RatHepatomegaly  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:27036855
Cyp1b1RatLung Neoplasms  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11376689
Cyp1b1Ratmelanoma  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17145863
Cyp1b1RatMouth Neoplasms  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22114726
Cyp1b1Ratobesity  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:27036855
Cyp1b1RatOvarian Neoplasms  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17372243
Cyp1b1RatProstatic Neoplasms  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17704407
Cyp1b1Ratsquamous cell carcinoma  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22114726
Cyp1b1Ratsteatotic liver disease  ISOCYP1B1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:27036855
1 to 20 of 20 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratbuphthalmos  ISSCyp1b1 (Mus musculus)13592920OMIM:231300MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratanterior segment dysgenesis 6  ISOCYP1B1 (Homo sapiens)7240710 OMIM 
Cyp1b1Ratbuphthalmos  ISOCYP1B1 (Homo sapiens)7240710 OMIM 

1 to 20 of 1089 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Rat(+)-schisandrin B multiple interactionsISOCyp1b1 (Mus musculus)6480464schizandrin B inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP1B1 mRNA]CTDPMID:38227285
Cyp1b1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCYP1B1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CYP1B1 mRNACTDPMID:22079256
Cyp1b1Rat(-)-trans-epsilon-viniferin decreases activityISOCYP1B1 (Homo sapiens)6480464epsilon-viniferin results in decreased activity of CYP1B1 proteinCTDPMID:12818727
Cyp1b1Rat(R)-pantothenic acid increases expressionISOCYP1B1 (Homo sapiens)6480464Pantothenic Acid results in increased expression of CYP1B1 mRNACTDPMID:19397697
Cyp1b1Rat(S)-duloxetine hydrochloride decreases activityISOCYP1B1 (Homo sapiens)6480464Duloxetine Hydrochloride results in decreased activity of CYP1B1 proteinCTDPMID:33814510
Cyp1b1Rat(S)-naringenin multiple interactionsISOCYP1B1 (Homo sapiens)6480464naringenin binds to and results in decreased activity of CYP1B1 proteinCTDPMID:21053930
Cyp1b1Rat(S)-naringenin increases expressionISOCyp1b1 (Mus musculus)6480464naringenin results in increased expression of CYP1B1 mRNACTDPMID:31621310
Cyp1b1Rat(S)-nicotine multiple interactionsEXP 6480464bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP1B1 protein]CTDPMID:35577041
Cyp1b1Rat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of CYP1B1 proteinCTDPMID:35577041
Cyp1b1Rat1,2,3,4,6,7,8-Heptachlorodibenzodioxin increases expressionEXP 64804641 more ...CTDPMID:25654323 and PMID:29738842
Cyp1b1Rat1,2,3,4,6,7,8-Heptachlorodibenzofuran increases expressionEXP 64804641 more ...CTDPMID:25654323 and PMID:29738842
Cyp1b1Rat1,2,3,4,7,8-Hexachlorodibenzofuran increases expressionEXP 64804641 more ...CTDPMID:25654323 and PMID:29738842
Cyp1b1Rat1,2,3,6,7,8-Hexachlorodibenzodioxin increases expressionEXP 64804641 more ...CTDPMID:25654323 and PMID:29738842
Cyp1b1Rat1,2,3,7,8-Pentachlorodibenzodioxin increases expressionISOCYP1B1 (Homo sapiens)64804641 more ...CTDPMID:24472611 and PMID:29738842
Cyp1b1Rat1,2,3,7,8-Pentachlorodibenzodioxin increases expression ISOCYP1B1 (Homo sapiens)1521776881 more ...RGD 
Cyp1b1Rat1,2,3,7,8-Pentachlorodibenzodioxin increases expressionEXP 64804641 more ...CTDPMID:25654323 and PMID:29738842
Cyp1b1Rat1,2,3,7,8-Pentachlorodibenzodioxin increases expressionISOCyp1b1 (Mus musculus)64804641 more ...CTDPMID:23674508
Cyp1b1Rat1,3-Dinitropyrene multiple interactionsISOCYP1B1 (Homo sapiens)6480464[CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 1 and 3-dinitropyreneCTDPMID:11113705
Cyp1b1Rat1,4-dihydroxy-2-naphthoic acid multiple interactionsISOCyp1b1 (Mus musculus)6480464[1 and 4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNACTDPMID:27837168
Cyp1b1Rat1,4-dihydroxy-2-naphthoic acid multiple interactionsISOCYP1B1 (Homo sapiens)6480464[1 and 4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNACTDPMID:27837168

1 to 20 of 1089 rows

Biological Process
1 to 20 of 130 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratadrenal gland development  IEP 7829725 RGD 
Cyp1b1Ratangiogenesis acts_upstream_of_or_withinISOCyp1b1 (Mus musculus)1624291MGI:2154690 PMID:19005183RGDPMID:19005183
Cyp1b1Ratangiogenesis acts_upstream_of_or_withinIEAUniProtKB:Q64429 and ensembl:ENSMUSP000000248941600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratarachidonate metabolic process involved_inISOCYP1B1 (Homo sapiens)1624291 PMID:15258110RGDPMID:15258110
Cyp1b1Ratarachidonate metabolic process involved_inISOCyp1b1 (Mus musculus)1624291 PMID:15258110RGDPMID:15258110
Cyp1b1Ratarachidonate metabolic process involved_inIEAUniPathway:UPA003831600115GO_REF:0000041UniProtGO_REF:0000041
Cyp1b1Ratarachidonate metabolic process involved_inISSUniProtKB:Q644291600115GO_REF:0000024UniProtGO_REF:0000024
Cyp1b1Ratarachidonate metabolic process involved_inIEAUniProtKB:Q64429 and ensembl:ENSMUSP000000248941600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratarachidonate metabolic process involved_inIEAUniProtKB:Q16678 and ensembl:ENSP000004785611600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratbenzene-containing compound metabolic process  IMP 7829724benzo[a]pyreneRGD 
Cyp1b1Ratbenzene-containing compound metabolic process acts_upstream_of_or_withinIEAUniProtKB:Q64429 and ensembl:ENSMUSP000000248941600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratbenzene-containing compound metabolic process acts_upstream_of_or_withinISOCyp1b1 (Mus musculus)1624291MGI:2154690 PMID:10051580 more ...RGDPMID:10051580 more ...
Cyp1b1Ratbenzene-containing compound metabolic process  IDA 7800739benzo[a]pyreneRGD 
Cyp1b1Ratblood vessel endothelial cell migration acts_upstream_of_or_withinISOCyp1b1 (Mus musculus)1624291MGI:2154690 PMID:19005183RGDPMID:19005183
Cyp1b1Ratblood vessel endothelial cell migration acts_upstream_of_or_withinIEAUniProtKB:Q64429 and ensembl:ENSMUSP000000248941600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratblood vessel morphogenesis involved_inISSUniProtKB:Q644291600115GO_REF:0000024UniProtGO_REF:0000024
Cyp1b1Ratblood vessel morphogenesis involved_inIEAUniProtKB:Q64429 and ensembl:ENSMUSP000000248941600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratblood vessel morphogenesis involved_inISOCyp1b1 (Mus musculus)1624291 PMID:23568032RGDPMID:23568032
Cyp1b1Ratcell adhesion involved_inISSUniProtKB:Q644291600115GO_REF:0000024UniProtGO_REF:0000024
Cyp1b1Ratcell adhesion involved_inISOCyp1b1 (Mus musculus)1624291 PMID:23979599RGDPMID:23979599
1 to 20 of 130 rows

Cellular Component
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Cyp1b1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Cyp1b1Ratintracellular membrane-bounded organelle located_inIEAUniProtKB-KW:KW-04921600115GO_REF:0000043UniProtGO_REF:0000043
Cyp1b1Ratintracellular membrane-bounded organelle is_active_inIBAMGI:88590 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp1b1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Cyp1b1Ratmitochondrion located_inISOCyp1b1 (Mus musculus)1624291 PMID:23692925RGDPMID:23692925
Cyp1b1Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Cyp1b1Ratmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
Cyp1b1Ratmitochondrion located_inISSUniProtKB:Q644291600115GO_REF:0000024UniProtGO_REF:0000024
Cyp1b1Ratmitochondrion located_inIEAUniProtKB:Q64429 and ensembl:ENSMUSP000000248941600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 10 of 10 rows

Molecular Function
1 to 20 of 35 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratestrogen 16-alpha-hydroxylase activity enablesIEAUniProtKB:Q16678 and ensembl:ENSP000004785611600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratestrogen 16-alpha-hydroxylase activity enablesISOCYP1B1 (Homo sapiens)1624291 PMID:11555828RGDPMID:11555828
Cyp1b1Ratestrogen 16-alpha-hydroxylase activity enablesISSUniProtKB:Q166781600115GO_REF:0000024UniProtGO_REF:0000024
Cyp1b1Ratestrogen 2-hydroxylase activity enablesIEARHEA:47208 and RHEA:472121600115GO_REF:0000116RHEAGO_REF:0000116
Cyp1b1Ratheme binding enablesISOCYP1B1 (Homo sapiens)1624291 PMID:21147782RGDPMID:21147782
Cyp1b1Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp1b1Ratheme binding enablesIEAUniProtKB:Q16678 and ensembl:ENSP000004785611600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratheme binding enablesISSUniProtKB:Q166781600115GO_REF:0000024UniProtGO_REF:0000024
Cyp1b1Rathydroperoxy icosatetraenoate dehydratase activity enablesIEAEC:4.2.1.1521600115GO_REF:0000003UniProtGO_REF:0000003
Cyp1b1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp1b1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp1b1Ratlyase activity enablesIEAUniProtKB-KW:KW-04561600115GO_REF:0000043UniProtGO_REF:0000043
Cyp1b1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Cyp1b1Ratmonooxygenase activity  IDA 7829732estradiol 2-hydroxylationRGD 
Cyp1b1Ratmonooxygenase activity enablesIEAUniProtKB:Q16678 and ensembl:ENSP000004785611600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratmonooxygenase activity enablesIBAMGI:88588 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp1b1Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp1b1Ratmonooxygenase activity enablesIEAUniProtKB:Q64429 and ensembl:ENSMUSP000000248941600115GO_REF:0000107EnsemblGO_REF:0000107
Cyp1b1Ratmonooxygenase activity enablesIEAUniProtKB-KW:KW-05031600115GO_REF:0000043UniProtGO_REF:0000043
Cyp1b1Ratmonooxygenase activity enablesIEAARBA:ARBA000287881600115GO_REF:0000117UniProtGO_REF:0000117
1 to 20 of 35 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratphase I biotransformation pathway via cytochrome P450  IEP 728267 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp1b1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Cyp1b1Ratsteroid hormone biosynthetic pathway   IEA 6907045 KEGGrno:00140
Cyp1b1Rattryptophan metabolic pathway  IEA 6907045 KEGGrno:00380

1 to 20 of 59 rows
#
Reference Title
Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Molecular and clinical evaluation of primary congenital glaucoma in Kuwait. Alfadhli S, etal., Am J Ophthalmol. 2006 Mar;141(3):512-6.
3. Congenital glaucoma: CYP1B1 mutations in Israeli Bedouin kindreds. Bar-Yosef U, etal., J Glaucoma. 2010 Jan;19(1):35-8. doi: 10.1097/IJG.0b013e3181a98b6f.
4. Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma. Bhattacharjee A, etal., Mol Vis. 2008 May 8;14:841-50.
5. Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. Bhattacharyya KK, etal., J Biol Chem 1995 May 12;270(19):11595-602.
6. Developmental expression and regulation of adrenocortical cytochrome P4501B1 in the rat. Brake PB, etal., Endocrinology. 1999 Apr;140(4):1672-80.
7. Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: evidence for transcriptional repression by glucocorticoids. Brake PB, etal., Mol Pharmacol. 1998 Nov;54(5):825-33.
8. Glaucoma-associated CYP1B1 mutations share similar haplotype backgrounds in POAG and PACG phenotypes. Chakrabarti S, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5439-44.
9. Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Choudhary D, etal., Drug Metab Dispos. 2004 Aug;32(8):840-7.
10. Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland: cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones. Christou M, etal., Mol Cell Endocrinol. 1995 Nov 30;115(1):41-50.
11. Dehydroepiandrosterone inhibits the expression of carcinogen-activating enzymes in vivo. Ciolino H, etal., Int J Cancer. 2003 Jun 20;105(3):321-5.
12. Estrous cycle-regulated expression of CYP1B1 mRNA in the rat ovary. Dasmahapatra AK, etal., Comp Biochem Physiol B Biochem Mol Biol. 2002 Sep;133(1):127-34.
13. Association of CYP1B1 polymorphisms and breast cancer risk. De Vivo I, etal., Cancer Epidemiol Biomarkers Prev 2002 May;11(5):489-92.
14. Regulation of cytochrome P450 1B1 expression by luteinizing hormone in mouse MA-10 and rat R2C Leydig cells: role of protein kinase A. Deb S and Bandiera SM, Biol Reprod. 2011 Jul;85(1):89-96. doi: 10.1095/biolreprod.110.088971. Epub 2011 Mar 9.
15. Cytochrome P450 1B1 expression in rat esophageal tumorigenesis promoted by gastric and duodenal reflux. Devlin AH, etal., Mol Carcinog. 2009 Feb;48(2):110-7. doi: 10.1002/mc.20459.
16. Molecular basis of Peters anomaly in Saudi Arabia. Edward D, etal., Ophthalmic Genet. 2004 Dec;25(4):257-70.
17. Molecular analysis of CYP1B1 in Omani patients with primary congenital glaucoma: a pilot study. El-Gayar S, etal., Mol Vis. 2009 Jul 8;15:1325-31.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner. Han Y, etal., Mol Cell Biochem. 2021 Mar;476(3):1387-1400. doi: 10.1007/s11010-020-03998-y. Epub 2021 Jan 3.
1 to 20 of 59 rows
PMID:1910294   PMID:9367523   PMID:9377560   PMID:10051580   PMID:10681376   PMID:10871058   PMID:11555828   PMID:12859982   PMID:12865317   PMID:16377763   PMID:16636061   PMID:17166882  
PMID:18059014   PMID:19005183   PMID:20032512   PMID:20852048   PMID:21147782   PMID:22888116   PMID:23275542   PMID:23568032   PMID:23692925   PMID:23979599   PMID:24477449   PMID:24557852  
PMID:25164943   PMID:29115507   PMID:31563143   PMID:33170892   PMID:33766215   PMID:35054909   PMID:37961023  



Cyp1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,093,927 - 21,103,091 (+)NCBIGRCr8
mRatBN7.2615,342,312 - 15,350,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,342,344 - 15,350,917 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx615,640,765 - 15,646,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0615,962,952 - 15,968,669 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0615,459,216 - 15,464,934 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.062,308,179 - 2,316,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl62,307,808 - 2,316,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.062,294,952 - 2,300,644 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.462,548,224 - 2,553,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.162,545,648 - 2,553,767 (-)NCBI
Celera615,009,941 - 15,015,671 (+)NCBICelera
Cytogenetic Map6q12NCBI
CYP1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38238,067,509 - 38,076,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl238,066,973 - 38,109,902 (-)EnsemblGRCh38hg38GRCh38
GRCh37238,294,652 - 38,303,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36238,148,250 - 38,156,796 (-)NCBINCBI36Build 36hg18NCBI36
Build 34238,206,396 - 38,214,943NCBI
Celera238,135,623 - 38,144,201 (-)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef238,034,680 - 38,043,258 (-)NCBIHuRef
CHM1_1238,224,106 - 38,232,684 (-)NCBICHM1_1
T2T-CHM13v2.0238,074,395 - 38,083,037 (-)NCBIT2T-CHM13v2.0
Cyp1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,014,369 - 80,022,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,008,966 - 80,022,490 (-)EnsemblGRCm39 Ensembl
GRCm381779,706,940 - 79,715,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,701,537 - 79,715,061 (-)EnsemblGRCm38mm10GRCm38
MGSCv371780,106,293 - 80,114,381 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361779,615,279 - 79,623,367 (-)NCBIMGSCv36mm8
Celera1784,018,414 - 84,026,502 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1750.3NCBI
LOC102009223
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554415,803,032 - 5,812,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554415,803,397 - 5,812,131 (-)NCBIChiLan1.0ChiLan1.0
CYP1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21288,409,864 - 88,419,099 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A88,413,479 - 88,423,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A38,087,863 - 38,096,529 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A38,851,000 - 38,859,883 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A38,851,000 - 38,859,824 (-)Ensemblpanpan1.1panPan2
CYP1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11730,273,281 - 30,278,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1730,272,749 - 30,278,554 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1730,086,594 - 30,091,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01730,923,029 - 30,928,301 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,922,243 - 30,928,321 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11730,148,312 - 30,153,581 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01730,216,274 - 30,221,549 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01730,431,572 - 30,436,860 (-)NCBIUU_Cfam_GSD_1.0
LOC101970101
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629241,681,103 - 41,689,696 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936663348,368 - 355,191 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936663345,021 - 355,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3102,195,741 - 102,205,683 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13102,195,743 - 102,205,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11469,318,713 - 69,327,277 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1469,319,495 - 69,324,157 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604542,635,474 - 42,644,623 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701066
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473819,638,456 - 19,647,497 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473819,639,215 - 19,647,807 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Cyp1b1
42 total Variants

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000066363
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 32 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)6796416721301982Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat

1 to 10 of 32 rows
RH139891  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2615,350,234 - 15,350,432 (-)MAPPERmRatBN7.2
Rnor_6.062,308,633 - 2,308,830NCBIRnor6.0
Rnor_5.062,292,597 - 2,292,794UniSTSRnor5.0
RGSC_v3.462,545,869 - 2,546,066UniSTSRGSC3.4
Celera615,017,829 - 15,018,026UniSTS
RH 3.4 Map647.0UniSTS
Cytogenetic Map6q11UniSTS
Cyp1b1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2615,343,145 - 15,343,993 (-)MAPPERmRatBN7.2
Rnor_6.062,315,089 - 2,315,936NCBIRnor6.0
Rnor_5.062,299,011 - 2,299,858UniSTSRnor5.0
RGSC_v3.462,552,134 - 2,552,981UniSTSRGSC3.4
Celera615,010,727 - 15,011,574UniSTS
Cytogenetic Map6q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 87 86 55 25 55 6 214 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000066363   ⟹   ENSRNOP00000061222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl615,342,344 - 15,349,389 (+)Ensembl
Rnor_6.0 Ensembl62,314,928 - 2,316,722 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082017   ⟹   ENSRNOP00000071724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl62,310,988 - 2,316,717 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084171   ⟹   ENSRNOP00000075074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl615,342,347 - 15,350,917 (+)Ensembl
Rnor_6.0 Ensembl62,307,808 - 2,311,781 (-)Ensembl
RefSeq Acc Id: NM_012940   ⟹   NP_037072
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,094,565 - 21,100,282 (+)NCBI
mRatBN7.2615,342,360 - 15,348,077 (+)NCBI
Rnor_6.062,310,988 - 2,316,722 (-)NCBI
Rnor_5.062,294,952 - 2,300,644 (-)NCBI
RGSC_v3.462,548,224 - 2,553,767 (-)RGD
Celera615,009,941 - 15,015,671 (+)RGD
Sequence:
RefSeq Acc Id: XM_017594046   ⟹   XP_017449535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,095,042 - 21,103,091 (+)NCBI
mRatBN7.2615,342,313 - 15,350,886 (+)NCBI
Rnor_6.062,308,179 - 2,316,279 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111803   ⟹   XP_038967731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,093,927 - 21,103,091 (+)NCBI
mRatBN7.2615,342,313 - 15,350,886 (+)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_037072 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449535 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967731 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA79864 (Get FASTA)   NCBI Sequence Viewer  
  CAA55320 (Get FASTA)   NCBI Sequence Viewer  
  CAA58748 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075074
  ENSRNOP00000075074.2
GenBank Protein Q64678 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_037072   ⟸   NM_012940
- UniProtKB: Q64678 (UniProtKB/Swiss-Prot),   A6H9T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449535   ⟸   XM_017594046
- Peptide Label: isoform X1
- UniProtKB: Q64678 (UniProtKB/Swiss-Prot),   A6H9T3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071724   ⟸   ENSRNOT00000082017
Ensembl Acc Id: ENSRNOP00000061222   ⟸   ENSRNOT00000066363
Ensembl Acc Id: ENSRNOP00000075074   ⟸   ENSRNOT00000084171

Name Modeler Protein Id AA Range Protein Structure
AF-Q64678-F1-model_v2 AlphaFold Q64678 1-543 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694374
Promoter ID:EPDNEW_R4886
Type:multiple initiation site
Name:Cyp1b1_1
Description:cytochrome P450, family 1, subfamily b, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.062,316,735 - 2,316,795EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38510 BioCyc
BioCyc Pathway PWY-6398 [melatonin degradation I] BioCyc
BioCyc Pathway Image PWY-6398 BioCyc
Ensembl Genes ENSRNOG00000040287 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000084171 ENTREZGENE
  ENSRNOT00000084171.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:25426 UniProtKB/Swiss-Prot
NCBI Gene 25426 ENTREZGENE
PANTHER CYTOCHROME P450 1B1 UniProtKB/Swiss-Prot
  STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP1B1 RGD
PhenoGen Cyp1b1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000040287 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A6H9T3 ENTREZGENE, UniProtKB/TrEMBL
  CP1B1_RAT UniProtKB/Swiss-Prot
  D4A6I4_RAT UniProtKB/TrEMBL
  M0RDN3_RAT UniProtKB/TrEMBL
  Q64678 ENTREZGENE
  Q9ESW3_RAT UniProtKB/TrEMBL
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp1b1  cytochrome P450, family 1, subfamily b, polypeptide 1    cytochrome P450, subfamily 1B, polypeptide 1  Name updated 1299863 APPROVED
2002-11-06 Cyp1b1  cytochrome P450, subfamily 1B, polypeptide 1    Cytochrome P450 1b1  Name updated 625702 APPROVED
2002-06-10 Cyp1b1  Cytochrome P450 1b1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_regulation displays increased expression in response to adrenocorticotropic hormone and to aryl hydrocarbon receptor regulation 728267