RGD Reference Report - Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology. - Rat Genome Database

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Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology.

Authors: Jennings, BL  Sahan-Firat, S  Estes, AM  Das, K  Farjana, N  Fang, XR  Gonzalez, FJ  Malik, KU 
Citation: Jennings BL, etal., Hypertension. 2010 Oct;56(4):667-74. doi: 10.1161/HYPERTENSIONAHA.110.154518. Epub 2010 Aug 30.
RGD ID: 7829714
Pubmed: PMID:20805442   (View Abstract at PubMed)
PMCID: PMC2946077   (View Article at PubMed Central)
DOI: DOI:10.1161/HYPERTENSIONAHA.110.154518   (Journal Full-text)

Hypertension is the leading cause of cardiovascular diseases, and angiotensin II is one of the major components of the mechanisms that contribute to the development of hypertension. However, the precise mechanisms for the development of hypertension are unknown. Our recent study showing that angiotensin II-induced vascular smooth muscle cell growth depends on cytochrome P450 1B1 led us to investigate its contribution to hypertension caused by this peptide. Angiotensin II was infused via miniosmotic pump into rats (150 ng/kg per minute) or mice (1000 mug/kg per day) for 13 days resulting in increased blood pressure, increased cardiac and vascular hypertrophy, increased vascular reactivity to vasoconstrictor agents, increased vascular reactive oxygen species production, and endothelial dysfunction in both species. The increase in blood pressure and associated pathophysiological changes were minimized by the cytochrome P450 1B1 inhibitor 2,3',4,5'-tetramethoxystilbene in both species and was markedly reduced in Cyp1b1(-/-) mice. These data suggest that cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiological changes. Moreover, 2,3',4,5'-tetramethoxystilbene, which prevents both cytochrome P450 1B1-dependent and -independent components of angiotensin II-induced hypertension and inhibits associated pathophysiological changes could be clinically useful in the treatment of hypertension and associated cardiovascular and inflammatory diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cardiomegaly treatmentISOCyp1b1 (Rattus norvegicus)7829714; 7829714associated with HypertensionRGD 
Cardiomegaly  ISOCyp1b1 (Mus musculus)7829714; 7829714associated with HypertensionRGD 
Cardiomegaly treatmentIDA 7829714associated with HypertensionRGD 
Cardiomegaly  IMP 7829714associated with HypertensionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp1b1  (cytochrome P450, family 1, subfamily b, polypeptide 1)

Genes (Mus musculus)
Cyp1b1  (cytochrome P450, family 1, subfamily b, polypeptide 1)

Genes (Homo sapiens)
CYP1B1  (cytochrome P450 family 1 subfamily B member 1)


Additional Information