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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:34795
Term: 3-isobutyl-1-methyl-7H-xanthine
Definition: A 3-isobutyl-1-methylxanthine that has formula C10H14N4O2.
Chemical ID: MESH:D015056
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTD[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CYP1B1 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CYP1B1 proteinPMID:15967407
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CYP1B1 mRNAPMID:28628672
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