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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:77319
Term: oltipraz
Definition: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
Chemical ID: MESH:C026209
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1affects activityISOCYP1B1 (Homo sapiens)6480464CTDoltipraz affects the activity of CYP1B1 proteinPMID:10775323
Cyp1b1decreases activityISOCYP1B1 (Homo sapiens)6480464CTDoltipraz metabolite results in decreased activity of CYP1B1 proteinPMID:10775323
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDoltipraz results in increased expression of CYP1B1 mRNAPMID:15890477
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