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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of CYP1B1 mRNAPMID:33387578
Cyp1b1affects expressionISOCYP1B1 (Homo sapiens)6480464CTDAcetaminophen affects the expression of CYP1B1 mRNAPMID:25458485
Cyp1b1affects response to substanceISOCYP1B1 (Homo sapiens)6480464CTDCYP1B1 gene polymorphism affects the susceptibility to AcetaminophenPMID:26104854
Cyp1b1decreases expressionISOCYP1B1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of CYP1B1 mRNAPMID:26690555
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of CYP1B1 mRNAPMID:21420995 PMID:29067470
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