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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:81508
Term: 2,3,4,7,8-Pentachlorodibenzofuran
Definition: A dibenzofuran that has formula C12H3Cl5O.
Chemical ID: MESH:C038890
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1increases expression ISOCYP1B1 (Homo sapiens)152177688RGD2,3,4,7,8-Pentachlorodibenzofuran increases expression of CYP1B1 mRNA in lung epithelial cell  
Cyp1b1increases expressionEXP 6480464CTD2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1B1 mRNAPMID:21724226 PMID:24046277 PMID:25654323 PMID:29738842
Cyp1b1increases expressionISOCyp1b1 (Mus musculus)6480464CTD2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1B1 mRNAPMID:23674508
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTD2,3,4,7,8-pentachlorodibenzofuran results in increased expression of CYP1B1 mRNAPMID:19358281 PMID:21703235 PMID:24472611 PMID:29738842
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [AHR protein binds to CYP1B1 promoter]; 2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1B1 promoter]; 2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [EP300 protein binds to CYP1B1 promoter]; 2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]PMID:21703235
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