GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1b1 | multiple interactions | EXP | | 6480464 | CTD | [Benzo(a)pyrene co-treated with Oxygen] affects the expression of CYP1B1 protein | PMID:24657529 | Cyp1b1 | decreases expression | ISO | CYP1B1 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in decreased expression of CYP1B1 mRNA | PMID:25596134 | Cyp1b1 | decreases response to substance | ISO | Cyp1b1 (Mus musculus) | 6480464 | CTD | CYP1B1 gene mutant form results in decreased susceptibility to Oxygen | PMID:29939353 | Cyp1b1 | increases expression | ISO | Cyp1b1 (Mus musculus) | 6480464 | CTD | Oxygen results in increased expression of CYP1B1 mRNA | PMID:29939353 | Cyp1b1 | multiple interactions | ISO | Cyp1b1 (Mus musculus) | 6480464 | CTD | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CYP1B1 mRNA; [Quercetin co-treated with Oxygen] results in increased expression of CYP1B1 mRNA; CYP1B1 gene mutant form promotes the reaction [Oxygen results in increased secretion of VEGFA protein] | PMID:29432836 PMID:29939353 PMID:30529165 | Cyp1b1 | multiple interactions | ISO | CYP1B1 (Homo sapiens) | 6480464 | CTD | [Oxygen co-treated with Glucose] inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of CYP1B1 protein]; [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of CYP1B1 protein; Oxygen deficiency inhibits the reaction [AHR protein binds to CYP1B1 promoter] | PMID:24355420 PMID:28400208 | |
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