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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with Oxygen] affects the expression of CYP1B1 proteinPMID:24657529
Cyp1b1decreases expressionISOCYP1B1 (Homo sapiens)6480464CTDOxygen deficiency results in decreased expression of CYP1B1 mRNAPMID:25596134
Cyp1b1decreases response to substanceISOCyp1b1 (Mus musculus)6480464CTDCYP1B1 gene mutant form results in decreased susceptibility to OxygenPMID:29939353
Cyp1b1increases expressionISOCyp1b1 (Mus musculus)6480464CTDOxygen results in increased expression of CYP1B1 mRNAPMID:29939353
Cyp1b1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTD[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CYP1B1 mRNA; [Quercetin co-treated with Oxygen] results in increased expression of CYP1B1 mRNA; CYP1B1 gene mutant form promotes the reaction [Oxygen results in increased secretion of VEGFA protein]PMID:29432836 PMID:29939353 PMID:30529165
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD[Oxygen co-treated with Glucose] inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of CYP1B1 protein]; [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of CYP1B1 protein; Oxygen deficiency inhibits the reaction [AHR protein binds to CYP1B1 promoter]PMID:24355420 PMID:28400208
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