• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp1b1 Name: cytochrome P450, family 1, subfamily b, polypeptide 1

Acc ID: CHEBI:16796 Term: melatonin Definition: A tryptamine that has formula C13H16N2O2. CasRN: 73-31-4 Chemical ID: MESH:D008550

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736765	6480464	CTD	2,4,3',5'-tetramethoxystilbene inhibits the reaction [CYP1B1 protein results in increased hydroxylation of Melatonin]	PMID:15616152
increases hydroxylation	ISO	RGD:736765	6480464	CTD	CYP1B1 protein results in increased hydroxylation of Melatonin	PMID:15616152
decreases activity	ISO	RGD:736765	6480464	CTD	Melatonin results in decreased activity of CYP1B1 protein	PMID:19919601