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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp1b1 Name: cytochrome P450, family 1, subfamily b, polypeptide 1

Acc ID: CHEBI:17026 Term: progesterone Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. CasRN: 57-83-0 Chemical ID: MESH:D011374

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:736765	6480464	CTD	Progesterone results in decreased expression of CYP1B1 mRNA	PMID:18037150
multiple interactions	EXP		6480464	CTD	[Estradiol co-treated with Progesterone co-treated with Hydrocortisone co-treated with PRL protein] inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 protein] Progesterone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 protein]	PMID:8674863
decreases expression	EXP		6480464	CTD	Progesterone results in decreased expression of CYP1B1 protein	PMID:8674863