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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1affects methylationISOCYP1B1 (Homo sapiens)6480464CTDFulvestrant affects the methylation of CYP1B1 genePMID:31601247
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDfulvestrant results in increased expression of CYP1B1 mRNAPMID:28985473
Cyp1b1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTDfulvestrant inhibits the reaction [Estradiol results in increased expression of CYP1B1 mRNA]PMID:16280380
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD[bisphenol F co-treated with Fulvestrant] results in decreased methylation of CYP1B1 gene; Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1B1 mRNA]; Fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; Fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CYP1B1 mRNA]; Fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; Fulvestrant promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1B1 mRNA]; Fulvestrant promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]PMID:19460354 PMID:20093341 PMID:21513769 PMID:28985473 PMID:29362861 PMID:31601247
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