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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp1b1 Name: cytochrome P450, family 1, subfamily b, polypeptide 1

Acc ID: CHEBI:33216 Term: bisphenol A Definition: A bisphenol that has formula C15H16O2. CasRN: 80-05-7 Chemical ID: MESH:C006780

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:736765	6480464	CTD	bisphenol A affects the expression of CYP1B1 mRNA	PMID:20170705
increases expression	ISO	RGD:736765	6480464	CTD	bisphenol A results in increased expression of CYP1B1 mRNA	PMID:16474171
decreases expression	ISO	RGD:736765	6480464	CTD	bisphenol A results in decreased expression of CYP1B1 mRNA	PMID:16474171
decreases expression	EXP		6480464	CTD	bisphenol A results in decreased expression of CYP1B1 mRNA	PMID:12075121
decreases expression	ISO	RGD:10439	6480464	CTD	bisphenol A results in decreased expression of CYP1B1 mRNA	PMID:22687993
increases expression	ISO	RGD:736765	6480464	CTD	bisphenol A results in increased expression of CYP1B1 mRNA	PMID:16474171 PMID:23524099
multiple interactions	ISO	RGD:736765	6480464	CTD	triclocarban promotes the reaction [bisphenol A results in increased expression of CYP1B1 mRNA] butylparaben promotes the reaction [bisphenol A results in increased expression of CYP1B1 mRNA] Estradiol promotes the reaction [bisphenol A results in increased expression of CYP1B1 mRNA]	PMID:23524099