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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:39106
Term: pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.
Chemical ID: MESH:C030984
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1decreases expressionISOCYP1B1 (Homo sapiens)6480464CTDpyrene results in decreased expression of CYP1B1 mRNAPMID:32890658
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDpyrene results in increased expression of CYP1B1 proteinPMID:19365803
Cyp1b1increases hydroxylationISOCYP1B1 (Homo sapiens)6480464CTDCYP1B1 protein results in increased hydroxylation of pyrenePMID:15016593
Cyp1b1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTDpyrene inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein]PMID:35908932
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; pyrene binds to and results in decreased activity of CYP1B1 protein; pyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]PMID:15566942 PMID:19563207 PMID:30248327
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