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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:35861
Term: dibenzo[a,l]pyrene
Definition: An ortho- and peri-fused polycyclic arene that has formula C24H14.
Chemical ID: MESH:C041517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1affects expressionEXP 6480464CTDdibenzo(a,l)pyrene affects the expression of CYP1B1 mRNAPMID:27099206
Cyp1b1decreases activityEXP 6480464CTD[2,4,3',5'-tetramethoxystilbene results in decreased activity of CYP1B1 protein] which results in decreased activity of dibenzo(a,l)pyrene; [fluoranthene results in decreased activity of CYP1B1 protein] which results in decreased activity of dibenzo(a,l)pyrenePMID:17961608
Cyp1b1multiple interactionsEXP 6480464CTD[2,4,3',5'-tetramethoxystilbene results in decreased activity of CYP1B1 protein] which results in decreased susceptibility to dibenzo(a,l)pyrene; [fluoranthene results in decreased activity of CYP1B1 protein] which results in decreased susceptibility to dibenzo(a,l)pyrene; dibenzo(a,l)pyrene affects the reaction [Benzo(a)pyrene affects the expression of CYP1B1 mRNA]PMID:17961608 PMID:27099206
Cyp1b1decreases expressionISOCyp1b1 (Mus musculus)6480464CTDdibenzo(a,l)pyrene results in decreased expression of CYP1B1 mRNAPMID:23274566
Cyp1b1decreases expressionISOCYP1B1 (Homo sapiens)6480464CTDdibenzo(a,l)pyrene results in decreased expression of CYP1B1 mRNAPMID:31255691 PMID:32890658
Cyp1b1decreases response to substanceISOCyp1b1 (Mus musculus)6480464CTDCYP1B1 gene mutant form results in decreased susceptibility to dibenzo(a,l)pyrenePMID:26049101
Cyp1b1increases activityISOCyp1b1 (Mus musculus)6480464CTDCYP1B1 protein results in increased activity of dibenzo(a,l)pyrenePMID:15606143
Cyp1b1increases expressionISOCyp1b1 (Mus musculus)6480464CTDdibenzo(a,l)pyrene results in increased expression of CYP1B1 mRNA; dibenzo(a,l)pyrene results in increased expression of CYP1B1 proteinPMID:12117779 PMID:17060372 PMID:26496743
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDdibenzo(a,l)pyrene results in increased expression of CYP1B1 mRNAPMID:15566942
Cyp1b1increases metabolic processingISOCYP1B1 (Homo sapiens)6480464CTDCYP1B1 protein results in increased metabolism of dibenzo(a,l)pyrenePMID:21527924
Cyp1b1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTDdibenzo(a,l)pyrene promotes the reaction [Dust results in increased expression of CYP1B1 protein]; Dust promotes the reaction [dibenzo(a,l)pyrene results in increased expression of CYP1B1 protein]PMID:17060372
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD[Particulate Matter co-treated with dibenzo(a,l)pyrene] results in increased expression of CYP1B1 mRNA; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; [Vehicle Emissions co-treated with dibenzo(a,l)pyrene] results in increased expression of CYP1B1 mRNAPMID:15566942 PMID:17612574
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