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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1increases expressionEXP 6480464CTDbeta-Naphthoflavone results in increased expression of CYP1B1 mRNA; beta-Naphthoflavone results in increased expression of CYP1B1 proteinPMID:19389873 PMID:19695238 PMID:19969063 PMID:20607812 PMID:22687991 PMID:25929820
Cyp1b1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP1B1 mRNAPMID:18164116 PMID:20045035
Cyp1b1increases expressionISOCyp1b1 (Mus musculus)6480464CTDbeta-Naphthoflavone results in increased expression of CYP1B1 mRNAPMID:19737545 PMID:20930378 PMID:28428138
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDbeta-Naphthoflavone results in increased expression of CYP1B1; beta-Naphthoflavone results in increased expression of CYP1B1 mRNAPMID:12623754 PMID:14990334 PMID:16985168 PMID:20823264 PMID:25218365 PMID:28601433 PMID:32151702 PMID:32858204 PMID:33263786
Cyp1b1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTDandrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]; Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]PMID:19737545 PMID:20930378 PMID:28428138
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTDbeta-Naphthoflavone binds to and results in decreased activity of CYP1B1 proteinPMID:19563207 PMID:21053930
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