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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp1b1 Name: cytochrome P450, family 1, subfamily b, polypeptide 1

Acc ID: CHEBI:8405 Term: primaquine Definition: An 8-aminoquinoline-based drug used in the treatment of malaria and Pneumocystis pneumonia. CasRN: 90-34-6 Chemical ID: MESH:D011319

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:736765	6480464	CTD	Primaquine results in increased expression of CYP1B1 mRNA	PMID:12623754