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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Paramyxoviridae Infections
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Accession:DOID:9007244 term browser browse the term
Definition:Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.
Synonyms:exact_synonym: Parainfluenza;   Parainfluenza Virus Infection;   Parainfluenza Virus Infections;   Paramyxoviridae Infection
 primary_id: MESH:D018184;   RDO:0006283
 xref: EFO:0007419


show annotations for term's descendants           Sort by:
Paramyxoviridae Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:nasal mucus (human) RGD PMID:20182399 RGD:4891406 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:20053825 RGD:4891886 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:nasal mucus RGD PMID:20182399 RGD:4891406 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
measles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin ISO protein:increased expression:plasma RGD PMID:1402029 RGD:6482707 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Cd46 CD46 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:8402913 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Muc1 mucin 1, cell surface associated severity ISO protein:increased expression:serum RGD PMID:11802251 RGD:5131281 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
Metapneumovirus infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule ISO protein:decreased expression:alveolar macrophage, monocyte (mouse) RGD PMID:32463330 RGD:127345107 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Mavs mitochondrial antiviral signaling protein severity ISO RGD PMID:25953917 RGD:40903044 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
Nasu-Hakola disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 ISO ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 ClinVar PMID:12080485 PMID:12754369 PMID:12883936 PMID:12925681 PMID:15883308 More... NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp ISO
ISS		 ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1
OMIM:221770
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
MouseDO
CTD		 PMID:10888890 PMID:11109371 PMID:12370476 PMID:15883308 PMID:17125796 More... NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
Pneumovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il21 interleukin 21 ISO mRNA:increased expression:lung (mouse) RGD PMID:22238461 RGD:6892925 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il21r interleukin 21 receptor ISO RGD PMID:22238461 RGD:6892925 NCBI chr 1:180,168,028...180,195,690
Ensembl chr 1:180,168,097...180,195,522 		JBrowse link
G Pdcd1 programmed cell death 1 treatment ISO associated with reinfection RGD PMID:25339663 RGD:40822811 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
respiratory syncytial virus infectious disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 severity
treatment		 ISO human protein in a mouse model RGD PMID:26813885 PMID:26813885 RGD:32716392, RGD:32716392 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Aicda activation-induced cytidine deaminase treatment ISO RGD PMID:27721128 RGD:127285642 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:lung RGD PMID:11134301 RGD:4891417 NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO RGD PMID:10955955 RGD:4145447 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO mRNA:increased expression:lung RGD PMID:17641031 RGD:4145495 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:altered expression:lung, T cell (mouse) RGD PMID:19124761 RGD:4891880 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO DNA:snps:5' utr:g.-2459A>G, g.-2554G>T (human)
protein:increased expression:blood, monocyte (human)		 RGD PMID:12964123 PMID:18439876 RGD:4892113, RGD:4892079 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd1d1 CD1d1 molecule ameliorates ISO RGD PMID:32463330 RGD:127345107 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Cd274 CD274 molecule severity ISO protein:increased expression: lung RGD PMID:25465101 PMID:25465101 RGD:11056952, RGD:11056952 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd28 Cd28 molecule ISO RGD PMID:18056387 RGD:5131621 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cftr CF transmembrane conductance regulator ISO DNA:mutation: : RGD PMID:20015999 RGD:4140389 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:12941892 PMID:16424189 RGD:4892018, RGD:4892016 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO mRNA:increased expression:blood RGD PMID:20843364 RGD:5134958 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:18624292 RGD:5135483 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:15916706 RGD:5135444 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:18624292 RGD:5135483 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G Dnase1 deoxyribonuclease 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28780505 NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased secretion:nasopharynx
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17425601 PMID:20209309 RGD:4140425 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma ISO associated with Otitis media;protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:21937650 PMID:19352211 RGD:8142352 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 severity ISO RGD PMID:20209309 RGD:4140425 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 ISO RGD PMID:18250447 RGD:4145641 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17a interleukin 17A severity ISO protein:increased expression:plasma RGD PMID:19738511 RGD:4889103 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 ISO DNA:polymorphism:intron:rs360721 (human) RGD PMID:20130064 PMID:18043444 RGD:4889550, RGD:4889584 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 ISO RGD PMID:11283151 RGD:5144238 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il27 interleukin 27 ameliorates ISO RGD PMID:22301139 RGD:126790525 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO RGD PMID:20639494 RGD:5147443 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il33 interleukin 33 ISO RGD PMID:28771101 PMID:26044350 RGD:39939029, RGD:11342984 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il5 interleukin 5 severity ISO RGD PMID:25410867 RGD:11354937 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il5ra interleukin 5 receptor subunit alpha ISO protein:decreased expression:blood, eosinophil RGD PMID:16734609 RGD:5128618 NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544 		JBrowse link
G Il6 interleukin 6 severity ISO protein:increased expression:nasal mucus
associated with Otitis media;protein:increased expression:serum:		 RGD PMID:20622030 PMID:19352211 RGD:4143259, RGD:8142352 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il9 interleukin 9 susceptibility ISO DNA:SNPs: :rs2069885, rs1799962 (human) RGD PMID:20503287 PMID:19915054 RGD:5128684, RGD:5128685 NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895 		JBrowse link
G Irf1 interferon regulatory factor 1 IEP protein:increased expression:dorsal root ganglion RGD PMID:20045913 RGD:5128775 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Mir21 microRNA 21 ameliorates ISO associated with asthma; RGD PMID:27448447 RGD:41404696 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO associated with Respiratory Hypersensitivity; protein:increased expression:lung RGD PMID:15130904 RGD:5131205 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Ngf nerve growth factor IEP RGD PMID:19824047 RGD:4891065 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor IEP RGD PMID:19824047 RGD:4891065 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Pdcd1 programmed cell death 1 ISO protein:increased expression:CD4 Tcell, CD8 Tcell from lung:
protein:increased expression: CD8 Tcell from nasal wash:		 RGD PMID:25465101 PMID:25465101 RGD:11056952, RGD:11056952 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Pde12 phosphodiesterase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26055709 NCBI chr16:1,920,062...1,925,638
Ensembl chr16:1,915,386...1,925,887 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ameliorates ISO RGD PMID:33303545 RGD:127229923 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 treatment ISO RGD PMID:23018837 RGD:11554170 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 ISO RGD PMID:10706505 RGD:5144121 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Sarm1 sterile alpha and TIR motif containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chr10:63,369,456...63,393,016
Ensembl chr10:63,369,456...63,392,822 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO RGD PMID:12847279 RGD:5144208 NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610 		JBrowse link
G Sftpa1 surfactant protein A1 susceptibility ISO DNA:polymorphisms, haplotype: (human)
protein:decreased expression:lung		 RGD PMID:19287351 PMID:10194154 RGD:4143495, RGD:4143439 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685 		JBrowse link
G Sftpb surfactant protein B severity ISO DNA:SNPs:promoter, cds, intron:-32G>T (rs2077079), p.T131I (rs1130866), 5781A>C (rs2040349) (human)
protein:decreased expression:lung		 RGD PMID:17498296 PMID:10194154 RGD:4143382, RGD:4143439 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436 		JBrowse link
G Sftpc surfactant protein C ISO DNA:polymorphism: :138A>C, 186A>G (human) RGD PMID:19304906 PMID:17121584 RGD:4144065, RGD:4144116 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777 		JBrowse link
G Sftpd surfactant protein D susceptibility ISO DNA:polymorphisms: :p.M11T, p.A160T (human
protein:decreased expression:lung		 RGD PMID:19287351 PMID:10194154 RGD:4143495, RGD:4143439 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927 		JBrowse link
G Tac1 tachykinin, precursor 1 IEP mRNA,protein:increased expression:lung RGD PMID:10516226 RGD:5147822 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tacr1 tachykinin receptor 1 treatment IEP RGD PMID:10516226 RGD:5147822 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:19019963 RGD:4889534 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr3 toll-like receptor 3 ISO RGD PMID:16424225 RGD:5129224 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 no_association
susceptibility		 ISO DNA:SNP:cds:p.D299G (human)
DNA:polymorphisms:cds:p.D259G, T359I (human)
DNA:SNPs:cds:p.D299G, T399I (human)		 RGD PMID:19019963 PMID:17449325 PMID:17264400 PMID:17709532 RGD:4889534, RGD:4144164, RGD:4144167, RGD:4144161 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr6 toll-like receptor 6 ISO RGD PMID:19019963 RGD:4889534 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tlr7 toll-like receptor 7 ISO associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tlr8 toll-like receptor 8 ISO associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:Bronchoalveolar lavage fluid RGD PMID:15791294 RGD:4145715 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tslp thymic stromal lymphopoietin sexual_dimorphism ISO mRNA:increased expression:lung (mouse)
protein:increased expression:nasal mucus (human)		 RGD PMID:27156176 PMID:31076663 PMID:28471975 RGD:38549376, RGD:38596346, RGD:38596342 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
Respirovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl28 C-C motif chemokine ligand 28 ISO mRNA:increased expression:lung (mouse) RGD PMID:17954569 RGD:4892194 NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO RGD PMID:17641009 RGD:4892127 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP mRNA, protein:increased expression, increased activity:lung RGD PMID:16816895 RGD:5130923 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ppia peptidylprolyl isomerase A exacerbates ISO RGD PMID:28594325 RGD:150429629 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
subacute sclerosing panencephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO DNA:insertion/deletion: RGD PMID:16741935 RGD:40400901 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ifnl1 interferon, lambda 1 ISO protein:increased expression:blood serum (human) RGD PMID:30077763 RGD:126848745 NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    disease by infectious agent 2215
      viral infectious disease 1677
        RNA Virus Infections 1397
          Mononegavirales Infections 102
            Paramyxoviridae Infections 73
              Avulavirus Infections + 0
              Henipavirus Infections + 0
              Morbillivirus Infections + 7
              Pneumovirinae infections + 63
              Respirovirus Infections + 4
              Rubulavirus Infections + 0
paths to the root