RGD Reference Report - Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus. - Rat Genome Database

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Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus.

Authors: Herd, KA  Nelson, M  Mahalingam, S  Tindle, RW 
Citation: Herd KA, etal., J Gen Virol. 2010 May;91(Pt 5):1302-10. Epub 2010 Jan 6.
RGD ID: 4891886
Pubmed: PMID:20053825   (View Abstract at PubMed)
DOI: DOI:10.1099/vir.0.015396-0   (Journal Full-text)

Human metapneumovirus (hMPV) is a major cause of upper and lower respiratory-tract infection in infants, the elderly and immunocompromised individuals. Virus-directed cellular immunity elicited by hMPV infection is poorly understood, in contrast to the phylogenetically and clinically related pathogen human respiratory syncytial virus (hRSV). In a murine model of acute lower respiratory-tract infection with hMPV, we demonstrate the accumulation of gamma interferon (IFN-gamma)-producing CD8+ T cells in the airways and lungs at day 7 post-infection (p.i.), associated with cytotoxic T lymphocytes (CTLs) directed to an epitope of the M2-1 protein. This CTL immunity was accompanied by increased pulmonary expression of Th1 cytokines IFN-gamma and interleukin (IL)-12 and antiviral cytokines (IFN-beta), as well as chemokines Mip-1alpha, Mip-1beta, Mig, IP-10 and CX3CL1. There was also a moderate increase in Th2-type cytokines IL-4 and IL-10 compared with uninfected mice. At 21 days p.i., a strong CTL response could be recalled from the spleen. A similar pattern of CTL induction to the homologous M2-1 CTL epitope of hRSV, and of cytokine/chemokine induction, was observed following infection with hRSV, highlighting similarities in the cellular immune response to the two related pathogens.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Paramyxoviridae Infections  ISOCx3cl1 (Mus musculus)4891886; 4891886 RGD 
Paramyxoviridae Infections  IEP 4891886 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cx3cl1  (C-X3-C motif chemokine ligand 1)

Genes (Mus musculus)
Cx3cl1  (C-X3-C motif chemokine ligand 1)

Genes (Homo sapiens)
CX3CL1  (C-X3-C motif chemokine ligand 1)


Additional Information