RGD Reference Report - Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: an experimental murine model. - Rat Genome Database

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Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: an experimental murine model.

Authors: Chavez-Bueno, S  Mejias, A  Gomez, AM  Olsen, KD  Rios, AM  Fonseca-Aten, M  Ramilo, O  Jafri, HS 
Citation: Chavez-Bueno S, etal., Virol J. 2005 May 25;2:46.
RGD ID: 5135444
Pubmed: PMID:15916706   (View Abstract at PubMed)
PMCID: PMC1183251   (View Article at PubMed Central)
DOI: DOI:10.1186/1743-422X-2-46   (Journal Full-text)

BACKGROUND: Respiratory syncytial virus (RSV) is the leading respiratory viral pathogen in young children worldwide. RSV disease is associated with acute airway obstruction (AO), long-term airway hyperresponsiveness (AHR), and chronic lung inflammation. Using two different mouse strains, this study was designed to determine whether RSV disease patterns are host-dependent. C57BL/6 and BALB/c mice were inoculated with RSV and followed for 77 days. RSV loads were measured by plaque assay and polymerase chain reaction (PCR) in bronchoalveolar lavage (BAL) and whole lung samples; cytokines were measured in BAL samples. Lung inflammation was evaluated with a histopathologic score (HPS), and AO and AHR were determined by plethysmography. RESULTS: Viral load dynamics, histopathologic score (HPS), cytokine concentrations, AO and long-term AHR were similar in both strains of RSV-infected mice, although RSV-infected C57BL/6 mice developed significantly greater AO compared with RSV-infected BALB/c mice on day 5. PCR detected RSV RNA in BAL samples of RSV infected mice until day 42, and in whole lung samples through day 77. BAL concentrations of cytokines TNF-alpha, IFN-gamma, and chemokines MIG, RANTES and MIP-1alpha were significantly elevated in both strains of RSV-infected mice compared with their respective controls. Viral load measured by PCR significantly correlated with disease severity on days 14 and 21. CONCLUSION: RSV-induced acute and chronic airway disease is independent of genetic background.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
respiratory syncytial virus infectious disease  ISOCxcl9 (Mus musculus)5135444; 5135444protein:increased expression:respiratory system fluid/secretionRGD 
respiratory syncytial virus infectious disease  IEP 5135444protein:increased expression:respiratory system fluid/secretionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl9  (C-X-C motif chemokine ligand 9)

Genes (Mus musculus)
Cxcl9  (C-X-C motif chemokine ligand 9)

Genes (Homo sapiens)
CXCL9  (C-X-C motif chemokine ligand 9)


Additional Information