RGD Reference Report - CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections.

General

CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections.
Authors:	Heidema, J Lukens, MV Van Maren, WW Van Dijk, ME Otten, HG Van Vught, AJ Van der Werff, DB Van Gestel, SJ Semple, MG Smyth, RL Kimpen, JL Van Bleek, GM
Citation:	Heidema J, etal., J Immunol. 2007 Dec 15;179(12):8410-7.
RGD ID:	5131621
Pubmed:	PMID:18056387 (View Abstract at PubMed)
A protective role for CD8+ T cells during viral infections is generally accepted, but little is known about how CD8+ T cell responses develop during primary infections in infants, their efficacy, and how memory is established after viral clearance. We studied CD8+ T cell responses in bronchoalveolar lavage (BAL) samples and blood of infants with a severe primary respiratory syncytial virus (RSV) infection. RSV-specific CD8+ T cells with an activated effector cell phenotype: CD27+CD28+CD45RO+CCR7-CD38+HLA-DR+Granzyme B+CD127- could be identified in BAL and blood. A high proportion of these CD8+ T cells proliferated and functionally responded upon in vitro stimulation with RSV Ag. Thus, despite the very young age of the patients, a robust systemic virus-specific CD8+ T cell response was elicited against a localized respiratory infection. RSV-specific T cell numbers as well as the total number of activated effector type CD8+ T cells peaked in blood around day 9-12 after the onset of primary symptoms, i.e., at the time of recovery. The lack of a correlation between RSV-specific T cell numbers and parameters of disease severity make a prominent role in immune pathology unlikely, in contrast the T cells might be involved in the recovery process.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
respiratory syncytial virus infectious disease		IEP		5131621		RGD
respiratory syncytial virus infectious disease		ISO	CD28 (Homo sapiens)	5131621; 5131621		RGD

Objects Annotated

Genes (Rattus norvegicus)

Cd28 (Cd28 molecule)

Genes (Mus musculus)

Cd28 (CD28 antigen)

Genes (Homo sapiens)

CD28 (CD28 molecule)

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CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections.