RGD Reference Report - IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection. - Rat Genome Database

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IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection.

Authors: Dodd, JS  Lum, E  Goulding, J  Muir, R  Van Snick, J  Openshaw, PJ 
Citation: Dodd JS, etal., J Immunol. 2009 Dec 1;183(11):7006-13. Epub 2009 Nov 13.
RGD ID: 5128685
Pubmed: PMID:19915054   (View Abstract at PubMed)
DOI: DOI:10.4049/jimmunol.0900085   (Journal Full-text)

IL-9 is a cytokine of great current interest associated with allergic/Th2 responses. High levels of IL-9 are present in bronchial secretions from infants with respiratory syncytial virus (RSV) bronchiolitis. To test its effects in RSV disease with a Th2 profile, BALB/c mice were vaccinated with recombinant vaccinia virus expressing the RSV G protein. On RSV challenge, immunized mice developed augmented disease characterized by enhanced pulmonary Th2 and local IL-9 production peaking on days 7-10 of RSV infection. Depletion with anti-IL-9 Ab at vaccination or RSV challenge enhanced viral clearance. Depletion only at challenge had no effect on disease severity, whereas depletion at immunization and challenge enhanced Th1 responses, inhibited virus-specific IgG1 production, and enhanced disease severity. By contrast, depletion of IL-9 at immunization boosted IgG2a and inhibited the Th2 response and disease during subsequent infection without a concomitant increase in type 1 cytokines. Adoptive transfer of secondary memory CD4 T cells from the spleens of IL-9-depleted mice into naive recipients replicated many of the effects of depletion, indicating that IL-9 acts via CD4 T cells. Therefore, IL-9 is a previously unknown but key modulator of antiviral immunity, regulating T and B cell responses and having potent and specific effects on viral lung disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Il9  (interleukin 9)

Genes (Mus musculus)
Il9  (interleukin 9)

Genes (Homo sapiens)
IL9  (interleukin 9)


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