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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1552386 | 6480464 | Ethinyl Estradiol results in increased expression of TLR6 mRNA | CTD | PMID:17942748 | 2,2',4,4',5,5'-hexachlorobiphenyl | decreases expression | ISO | RGD:1344850 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TLR6 mRNA | CTD | PMID:23146750 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TLR6 mRNA | CTD | PMID:22298810 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of TLR6 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of TLR6 mRNA | CTD | PMID:21346803 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | ISO | RGD:1344850 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TLR6 mRNA | CTD | PMID:23146750 | benzo[a]pyrene | increases expression | ISO | RGD:1552386 | 6480464 | Benzo(a)pyrene results in increased expression of TLR6 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:1552386 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of TLR6 mRNA] | CTD | PMID:22228805 | bisphenol A | decreases expression | ISO | RGD:1344850 | 6480464 | bisphenol A results in decreased expression of TLR6 mRNA | CTD | PMID:23146750 | butyric acid | increases expression | ISO | RGD:1344850 | 6480464 | Butyric Acid results in increased expression of TLR6 mRNA | CTD | PMID:15196572 | cadmium selenide | multiple interactions | ISO | RGD:1344850 | 6480464 | [cadmium selenide co-treated with zinc sulfide] results in increased expression of TLR6 mRNA | CTD | PMID:22342292 | choline | multiple interactions | ISO | RGD:1552386 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR6 mRNA | CTD | PMID:20938992 | cyclosporin A | increases expression | ISO | RGD:1344850 | 6480464 | Cyclosporine results in increased expression of TLR6 mRNA | CTD | PMID:20106945 | folic acid | multiple interactions | ISO | RGD:1552386 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR6 mRNA | CTD | PMID:20938992 | L-methionine | multiple interactions | ISO | RGD:1552386 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR6 mRNA | CTD | PMID:20938992 | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of TLR6 mRNA | CTD | PMID:22641619 | mangiferin | decreases expression | ISO | RGD:1552386 | 6480464 | mangiferin results in decreased expression of TLR6 mRNA | CTD | PMID:15135318 | perfluorooctanoic acid | decreases expression | ISO | RGD:1344850 | 6480464 | perfluorooctanoic acid results in decreased expression of TLR6 mRNA | CTD | PMID:23146750 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:1344850 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TLR6 mRNA | CTD | PMID:16979875 | rosiglitazone | decreases expression | EXP | | 6480464 | rosiglitazone results in decreased expression of TLR6 mRNA | CTD | PMID:21515302 | silver atom | increases expression | ISO | RGD:1344850 | 6480464 | Silver results in increased expression of TLR6 mRNA | CTD | PMID:22342292 | silver(0) | increases expression | ISO | RGD:1344850 | 6480464 | Silver results in increased expression of TLR6 mRNA | CTD | PMID:22342292 | titanium dioxide | increases expression | ISO | RGD:1344850 | 6480464 | titanium dioxide results in increased expression of TLR6 mRNA | CTD | PMID:22342292 | zinc atom | multiple interactions | ISO | RGD:1344850 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TLR6 mRNA | CTD | PMID:16979875 | zinc(0) | multiple interactions | ISO | RGD:1344850 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TLR6 mRNA | CTD | PMID:16979875 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chagas disease (American trypanosomiasis) |
| Phagosome | |
| Toll-like receptor signaling pathway | |
| Tuberculosis | |
| Pathway Interaction Database | Endogenous TLR signaling (PID:200208) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Chagas disease (American trypanosomiasis) |
| Phagosome | |
| Toll-like receptor signaling pathway | |
| Tuberculosis | |
| Pathway Interaction Database | Endogenous TLR signaling (PID:200208) |
References - curated| 1. |
Fong DJ, etal., Immunology. 2010 May;130(1):125-36. Epub 2010 Jan 11. |
| 2. |
Fuchs B, etal., Int Arch Allergy Immunol. 2010;152(2):131-9. Epub 2009 Dec 16. |
| 3. |
Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1. |
| 4. |
Hubschle T, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R180-7. Epub 2005 Sep 8. |
| 5. |
Kerber-Momot T, etal., Inflammation. 2010 Feb;33(1):58-64. |
| 6. |
Kesh S, etal., Ann N Y Acad Sci. 2005 Dec;1062:95-103. |
| 7. |
Knorr C, etal., Brain Res. 2008 Apr 18;1205:36-46. Epub 2008 Feb 21. |
| 8. |
Kormann MS, etal., J Allergy Clin Immunol. 2008 Jul;122(1):86-92, 92.e1-8. Epub 2008 Jun 10. |
| 9. |
Krishnegowda G, etal., J Biol Chem 2004 Dec 28;. |
| 10. |
Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34. |
| 11. |
Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16. |
| 12. |
MGD data from the GO Consortium |
| 13. |
Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19. |
| 14. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 15. |
Qian FH, etal., J Investig Allergol Clin Immunol. 2010;20(4):340-6. |
| 16. |
RGD automated data pipeline |
| 17. |
RGD automated import pipeline for gene-chemical interactions |
| 18. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 19. |
Tantisira K, etal., Genes Immun. 2004 Aug;5(5):343-6. |
RGD Disease Portals| Tlr6 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Tlr6 (Rattus norvegicus) |
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| TLR6 (Homo sapiens) |
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| Tlr6 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_207604 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06078790 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06078791 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06078792 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01079541 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC062390 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473981 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_207604 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_997487 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_997487 | (Get FASTA) |
| GenBank Protein | AAH62390 | (Get FASTA) |
| EDL90079 | (Get FASTA) | |
| EDL90080 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000002161 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000002933 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000002933 | UniProtKB/TrEMBL |
| Entrez Gene | 305353 | ENTREZGENE |
| HomoloGene Group ID | 21223 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:5621142 | IMAGE-MGC_LOAD |
| InterPro | Cys-rich_flank_reg_C | UniProtKB/TrEMBL |
| Leu-rich_rpt | UniProtKB/TrEMBL | |
| Leu-rich_rpt_2_copies | UniProtKB/TrEMBL | |
| Leu-rich_rpt_typical-subtyp | UniProtKB/TrEMBL | |
| TLR6 | UniProtKB/TrEMBL | |
| Toll-Interleukin_rcpt | UniProtKB/TrEMBL | |
| Toll-like_receptor | UniProtKB/TrEMBL | |
| KEGG Report | rno:305353 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:72634 | IMAGE-MGC_LOAD |
| PANTHER | PTHR24365:SF130 | UniProtKB/TrEMBL |
| Pfam | LRR_4 | UniProtKB/TrEMBL |
| TIR | UniProtKB/TrEMBL | |
| PIRSF | Toll-like_receptor | UniProtKB/TrEMBL |
| PROSITE | LRR | UniProtKB/TrEMBL |
| TIR | UniProtKB/TrEMBL | |
| SMART | LRR_TYP | UniProtKB/TrEMBL |
| LRRCT | UniProtKB/TrEMBL | |
| TIR | UniProtKB/TrEMBL | |
| Superfamily-SCOP | TIR | UniProtKB/TrEMBL |
| UniGene | Rn.163249 | ENTREZGENE |
| UniProt | G3V695_RAT | UniProtKB/TrEMBL |
| Q6P690_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Tlr6 | toll-like receptor 6 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2005-02-14 | Tlr6 | toll-like receptor 6 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Tlr6 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1303030 |
| Created: | 2004-12-03 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




