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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lansoprazole
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Accession:CHEBI:6375 term browser browse the term
Definition:A sulfoxide that has formula C16H14F3N3O2S.
Synonyms:exact_synonym: 2-({[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
 related_synonym: AG 1749;   Bamalite;   Formula=C16H14F3N3O2S;   InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22);   InChIKey=MJIHNNLFOKEZEW-UHFFFAOYSA-N;   Lanzol;   Lanzopral;   Lanzul;   Limpidex;   Monolitum;   Ogastro;   Opiren;   Prevacid;   SMILES=Cc1c(OCC(F)(F)F)ccnc1CS(=O)c1nc2ccccc2[nH]1;   lansoprazol;   lansoprazolum
 xref: Beilstein:4333393;   CAS:103577-45-3;   DrugBank:DB00448;   Drug_Central:1547;   KEGG:D00355;   LINCS:LSM-5064
 xref_mesh: MESH:D064747
 xref: Patent:EP174726;   Patent:US4628098;   Wikipedia:Lansoprazole


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lansoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression ISO
EXP		 Lansoprazole results in increased expression of ABCA1 protein
Lansoprazole results in increased expression of ABCA1 mRNA; Lansoprazole results in increased expression of ABCA1 protein		 CTD PMID:20060385 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance EXP ABCB1 affects the susceptibility to Lansoprazole CTD PMID:19238367 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G APOE apolipoprotein E increases expression EXP
ISO		 Lansoprazole results in increased expression of APOE mRNA; Lansoprazole results in increased expression of APOE protein CTD PMID:20060385 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G AQP4 aquaporin 4 increases expression ISO Lansoprazole results in increased expression of AQP4 mRNA; Lansoprazole results in increased expression of AQP4 protein CTD PMID:20437101 NCBI chr18:26,852,038...26,865,803
Ensembl chr18:26,852,043...26,865,771 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in decreased expression of BCL2 mRNA] CTD PMID:28412091 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G C1QA complement C1q A chain decreases expression ISO Lansoprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678 		JBrowse link
G C1QC complement C1q C chain decreases expression ISO Lansoprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 1:22,643,633...22,648,108
Ensembl chr 1:22,643,014...22,648,110 		JBrowse link
G C4BPA complement component 4 binding protein alpha decreases expression ISO Lansoprazole results in decreased expression of C4BPA mRNA CTD PMID:25626140 NCBI chr 1:207,104,233...207,144,972
Ensembl chr 1:207,104,233...207,144,972 		JBrowse link
G C4BPB complement component 4 binding protein beta decreases expression ISO Lansoprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr 1:207,088,860...207,099,993
Ensembl chr 1:207,088,860...207,099,993 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP
ISO		 Lansoprazole inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of CASP3 mRNA]; Lansoprazole inhibits the reaction [Ethanol results in increased expression of CASP3 protein]		 CTD PMID:12530016 PMID:28412091 PMID:29339218 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase multiple interactions ISO Lansoprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]; Lansoprazole inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:18726076 PMID:29339218 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CFI complement factor I decreases expression ISO Lansoprazole results in decreased expression of CFI mRNA CTD PMID:25626140 NCBI chr 4:109,730,982...109,801,999
Ensembl chr 4:109,731,008...109,802,150 		JBrowse link
G CGB3 chorionic gonadotropin subunit beta 3 multiple interactions EXP Lansoprazole inhibits the reaction [CGB3 protein results in increased abundance of Testosterone]; Lansoprazole metabolite inhibits the reaction [CGB3 protein results in increased abundance of Testosterone] CTD PMID:7589908 NCBI chr19:49,022,869...49,024,333
Ensembl chr19:49,022,869...49,024,333 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions		 ISO Lansoprazole results in decreased expression of CXCL1 mRNA; Lansoprazole results in decreased expression of CXCL1 protein
Lansoprazole inhibits the reaction [Indomethacin results in increased expression of CXCL1 mRNA]; Lansoprazole inhibits the reaction [Indomethacin results in increased expression of CXCL1 protein]		 CTD PMID:15334676 PMID:16328016 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression EXP Lansoprazole results in decreased expression of CXCL8 mRNA; Lansoprazole results in decreased expression of CXCL8 protein CTD PMID:15089887 PMID:15513378 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity
decreases activity
increases expression		 EXP
ISO		 Lansoprazole results in increased activity of CYP1A1 promoter
Lansoprazole results in decreased activity of CYP1A1 protein
Lansoprazole results in increased expression of CYP1A1 mRNA; Lansoprazole results in increased expression of CYP1A1 protein		 CTD PMID:8169844 PMID:8647108 PMID:8900397 PMID:9041675 PMID:9152597 More... NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP
ISO		 Lansoprazole results in increased expression of CYP1A2 mRNA; Lansoprazole results in increased expression of CYP1A2 protein CTD PMID:8169844 PMID:9152597 PMID:9744552 PMID:12623754 PMID:14550749 More... NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression
decreases activity		 EXP Lansoprazole results in increased expression of CYP1B1 mRNA
Lansoprazole results in decreased activity of CYP1B1 protein		 CTD PMID:12623754 PMID:33814510 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 increases hydroxylation EXP CYP2C18 protein results in increased hydroxylation of Lansoprazole CTD PMID:7870052 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions
increases expression
increases metabolic processing
decreases activity
increases hydroxylation
affects metabolic processing
decreases metabolic processing
affects response to substance		 EXP
ISO		 CYP2C19 affects the reaction [Lansoprazole affects the susceptibility to Tacrolimus]; CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP2C19 gene mutant form affects the susceptibility to [Lansoprazole co-treated with Tacrolimus]; Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole]; Lansoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]
Lansoprazole results in increased expression of CYP2C6 mRNA; Lansoprazole results in increased expression of CYP2C6 protein
CYP2C19 protein results in increased metabolism of Lansoprazole; Lansoprazole results in increased metabolism of CYP2C19 protein
Lansoprazole results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased hydroxylation of Lansoprazole
CYP2C19 protein affects the metabolism of Lansoprazole
CYP2C19 gene polymorphism results in decreased metabolism of Lansoprazole
CYP2C19 gene affects the susceptibility to Lansoprazole; CYP2C19 gene polymorphism affects the susceptibility to Lansoprazole		 CTD PMID:8627562 PMID:8930576 PMID:9152597 PMID:9272410 PMID:11829200 More... NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 affects metabolic processing
increases hydroxylation		 EXP CYP2C8 protein affects the metabolism of Lansoprazole
CYP2C8 protein results in increased hydroxylation of Lansoprazole		 CTD PMID:7870052 PMID:8627562 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases hydroxylation
multiple interactions		 EXP CYP2C9 protein results in increased hydroxylation of Lansoprazole
Lansoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]		 CTD PMID:8627562 PMID:12975331 PMID:15258107 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases degradation
multiple interactions		 ISO Lansoprazole results in decreased degradation of CYP2E1 protein
Lansoprazole results in increased expression of and results in increased activity of CYP2E1 protein		 CTD PMID:36243147 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases hydroxylation
increases expression
affects metabolic processing
increases metabolic processing		 EXP CYP3A4 protein results in increased hydroxylation of Lansoprazole
Lansoprazole results in increased expression of CYP3A4 mRNA; Lansoprazole results in increased expression of CYP3A4 protein
CYP3A4 protein affects the metabolism of Lansoprazole
CYP3A4 protein results in increased metabolism of Lansoprazole		 CTD PMID:7870052 PMID:8627562 PMID:8930576 PMID:9744552 PMID:10859152 More... NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions EXP CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole] CTD PMID:17377957 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 increases expression ISO Lansoprazole results in increased expression of CYP4A1 protein CTD PMID:9152597 NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727 		JBrowse link
G EGFR epidermal growth factor receptor increases expression EXP Lansoprazole results in increased expression of EGFR protein CTD PMID:9881512 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G FAS Fas cell surface death receptor multiple interactions ISO Lansoprazole inhibits the reaction [Ethanol results in increased expression of FAS protein] CTD PMID:29339218 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand multiple interactions ISO Lansoprazole inhibits the reaction [Ethanol results in increased expression of FASLG protein] CTD PMID:29339218 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FGF2 fibroblast growth factor 2 decreases expression EXP Lansoprazole results in decreased expression of FGF2 protein CTD PMID:9881512 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G FGF21 fibroblast growth factor 21 increases expression EXP Lansoprazole results in increased expression of FGF21 protein CTD PMID:8774986 NCBI chr19:48,755,524...48,758,330
Ensembl chr19:48,755,524...48,758,333 		JBrowse link
G GAST gastrin increases expression EXP
ISO		 Lansoprazole results in increased expression of GAST protein CTD PMID:7750667 PMID:8792694 PMID:11680587 PMID:11975934 PMID:12189558 More... NCBI chr17:41,712,331...41,715,969
Ensembl chr17:41,712,331...41,715,969 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Lansoprazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HAMP hepcidin antimicrobial peptide increases expression EXP Lansoprazole results in increased expression of HAMP mRNA CTD PMID:31669099 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
increases activity		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; Lansoprazole results in increased activity of and results in increased expression of HMOX1 protein
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [Lansoprazole results in increased expression of HMOX1 protein]
Lansoprazole results in increased expression of HMOX1 mRNA; Lansoprazole results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased activity of HMOX1 promoter]		 CTD PMID:16712795 PMID:19628634 PMID:19764090 PMID:28412091 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IFNG interferon gamma multiple interactions
decreases expression		 EXP
ISO		 Lansoprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
Lansoprazole results in decreased expression of IFNG mRNA		 CTD PMID:16932910 PMID:19232345 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO Lansoprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:29339218 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta decreases expression
multiple interactions		 ISO Lansoprazole results in decreased expression of IL1B mRNA
Lansoprazole inhibits the reaction [Ethanol results in increased expression of IL1B protein]		 CTD PMID:16932910 PMID:29339218 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions		 ISO Lansoprazole results in decreased expression of IL6 mRNA
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 mRNA]		 CTD PMID:16932910 PMID:28412091 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 increases oxidation ISO Lansoprazole results in increased oxidation of KEAP1 protein CTD PMID:19628634 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions
increases expression		 ISO Lansoprazole inhibits the reaction [LHB protein results in increased abundance of Testosterone]
Lansoprazole results in increased expression of LHB protein		 CTD PMID:7589908 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO Lansoprazole results in increased phosphorylation of MAPK1 protein CTD PMID:19628634 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO Lansoprazole results in increased phosphorylation of MAPK3 protein CTD PMID:19628634 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPT microtubule associated protein tau affects binding EXP Lansoprazole binds to MAPT protein alternative form CTD PMID:20110603 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO Lansoprazole inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MPO protein]; Lansoprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:17151854 PMID:17895592 PMID:18726076 PMID:24337826 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
increases phosphorylation		 ISO Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of NFE2L2 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 protein]
Lansoprazole results in increased expression of NFE2L2 mRNA
Lansoprazole results in increased phosphorylation of NFE2L2 protein		 CTD PMID:19628634 PMID:28412091 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Lansoprazole inhibits the reaction [Ethanol results in decreased expression of and results in increased phosphorylation of NFKBIA protein] CTD PMID:29339218 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 increases activity EXP Lansoprazole results in increased activity of NR1H2 protein CTD PMID:20060385 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases activity EXP Lansoprazole results in increased activity of NR1H3 protein CTD PMID:20060385 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Lansoprazole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G PHOSPHO1 phosphoethanolamine/phosphocholine phosphatase 1 decreases activity EXP Lansoprazole results in decreased activity of PHOSPHO1 protein CTD PMID:17227223 NCBI chr17:49,223,366...49,230,787
Ensembl chr17:49,223,366...49,230,787 		JBrowse link
G POMC proopiomelanocortin increases expression EXP Lansoprazole results in increased expression of POMC protein CTD PMID:16524691 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO AG-041R inhibits the reaction [Lansoprazole results in increased expression of PTGS2 protein] CTD PMID:12438555 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Lansoprazole inhibits the reaction [Ethanol results in decreased expression of and results in increased phosphorylation of RELA protein] CTD PMID:29339218 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RETSAT retinol saturase decreases expression ISO Lansoprazole results in decreased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 2:85,341,955...85,354,528
Ensembl chr 2:85,341,955...85,354,531 		JBrowse link
G SERPING1 serpin family G member 1 decreases expression ISO Lansoprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr11:57,597,685...57,614,848
Ensembl chr11:57,597,387...57,619,171 		JBrowse link
G SHH sonic hedgehog signaling molecule decreases expression ISO Lansoprazole results in decreased expression of SHH mRNA CTD PMID:20437101 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Lansoprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 multiple interactions EXP [Lansoprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841 		JBrowse link
G TGFA transforming growth factor alpha increases expression EXP Lansoprazole results in increased expression of TGFA protein CTD PMID:9881512 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193 		JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression ISO Lansoprazole results in increased expression of TGFB1 protein CTD PMID:36243147 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 Lansoprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
Lansoprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
Lansoprazole results in decreased expression of TNF mRNA		 CTD PMID:16932910 PMID:19232345 PMID:29339218 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of TP53 mRNA] CTD PMID:28412091 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Lansoprazole results in increased expression of UGT1A1 mRNA CTD PMID:25626140 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases expression ISO Lansoprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
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          drug 24554
            anti-ulcer drug 1273
              lansoprazole 65
Path 2
Term Annotations click to browse term
  CHEBI ontology 26046
    subatomic particle 26021
      composite particle 26021
        hadron 26021
          baryon 26021
            nucleon 26021
              atomic nucleus 26021
                atom 26021
                  main group element atom 25846
                    p-block element atom 25846
                      carbon group element atom 25443
                        carbon atom 25401
                          organic molecular entity 25401
                            organic molecule 25229
                              organic cyclic compound 24284
                                organic heterocyclic compound 22333
                                  organic heteropolycyclic compound 21332
                                    organic heterobicyclic compound 18582
                                      benzimidazoles 1169
                                        lansoprazole 65
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