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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | decreases expression | ISO | RGD:2143 | 6480464 | Pilocarpine results in decreased expression of AQP4 protein | CTD | PMID:20886625 | (S)-nicotine | increases expression | ISO | RGD:10183 | 6480464 | Nicotine results in increased expression of AQP4 mRNA | CTD | PMID:21955143 | 1,3-dinitrobenzene | decreases expression | ISO | RGD:2143 | 6480464 | 3-dinitrobenzene results in decreased expression of AQP4 mRNA | CTD | PMID:16142770 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:10183 | 6480464 | 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of AQP4 mRNA] | CTD | PMID:19467301 | 3,3',4,4'-tetrachlorobiphenyl | affects expression | EXP | | 6480464 | 3,4,3',4'-tetrachlorobiphenyl affects the expression of AQP4 mRNA | CTD | PMID:20638727 | 5-(2-methylpiperazine-1-sulfonyl)isoquinoline | multiple interactions | ISO | RGD:2143 | 6480464 | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TNF protein results in increased expression of AQP4 mRNA] | CTD | PMID:22298391 | acetic acid | increases expression | ISO | RGD:2143 | 6480464 | Acetic Acid results in increased expression of AQP4 protein | CTD | PMID:18406487 | all-trans-retinoic acid | increases expression | ISO | RGD:10183 | 6480464 | Tretinoin results in increased expression of AQP4 mRNA; more ... | CTD | PMID:11311979 | ammonia | decreases expression | EXP | | 6480464 | Ammonia results in decreased expression of AQP4 mRNA | CTD | PMID:20217200 | ammonia | multiple interactions | EXP | | 6480464 | IL1B protein inhibits the reaction [Ammonia results in decreased expression of AQP4 mRNA] | CTD | PMID:20217200 | ammonium chloride | affects expression | ISO | RGD:2143 | 6480464 | Ammonium Chloride affects the expression of AQP4 mRNA | CTD | PMID:16483693 | ammonium chloride | increases expression | ISO | RGD:2143 | 6480464 | Ammonium Chloride results in increased expression of AQP4 protein | CTD | PMID:14663195 | benazepril | multiple interactions | ISO | RGD:2143 | 6480464 | benazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] | CTD | PMID:11510275 | benzo[a]pyrene | decreases expression | ISO | RGD:10183 | 6480464 | Benzo(a)pyrene results in decreased expression of AQP4 mRNA | CTD | PMID:22228805 | betamethasone | increases expression | ISO | RGD:2143 | 6480464 | Betamethasone results in increased expression of AQP4 mRNA | CTD | PMID:9409467 | choline | multiple interactions | ISO | RGD:10183 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP4 mRNA | CTD | PMID:20938992 | clofibrate | multiple interactions | ISO | RGD:10183 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of AQP4 mRNA; more ... | CTD | PMID:17585979 | cycloheximide | multiple interactions | ISO | RGD:2143 | 6480464 | [Lactic Acid co-treated with Cycloheximide] results in increased expression of AQP4 protein | CTD | PMID:18406487 | D-glucose | multiple interactions | ISO | RGD:2143 | 6480464 | benazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA]; more ... | CTD | PMID:11510275 | D-glucose | increases expression | ISO | RGD:2143 | 6480464 | Glucose results in increased expression of AQP4 mRNA | CTD | PMID:11510275 | Delta(9)-tetrahydrocannabinol | decreases expression | ISO | RGD:10183 | 6480464 | Tetrahydrocannabinol results in decreased expression of AQP4 mRNA | CTD | PMID:21955143 | desferrioxamine B | multiple interactions | ISO | RGD:2143 | 6480464 | Deferoxamine inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein] | CTD | PMID:20648640 | diarsenic trioxide | increases expression | EXP | | 6480464 | arsenic trioxide results in increased expression of AQP4 mRNA | CTD | PMID:22214486 | diprotium oxide | increases transport | ISO | RGD:2143 | 6480464 | AQP4 protein results in increased transport of Water | CTD | PMID:21251984 | doxorubicin | decreases expression | ISO | RGD:2143 | 6480464 | Doxorubicin results in decreased expression of AQP4 protein | CTD | PMID:9573539 | ethanol | increases expression | ISO | RGD:10183 | 6480464 | Ethanol results in increased expression of AQP4 mRNA | CTD | PMID:21955143 | ethanol | affects response to substance | ISO | RGD:10183 | 6480464 | AQP4 protein affects the susceptibility to Ethanol | CTD | PMID:20615459 | ethanol | multiple interactions | ISO | RGD:10183 | 6480464 | [AQP4 protein affects the susceptibility to Ethanol] which affects the abundance of Reactive Oxygen Species; more ... | CTD | PMID:20615459 | folic acid | multiple interactions | ISO | RGD:10183 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP4 mRNA | CTD | PMID:20938992 | glucose | multiple interactions | ISO | RGD:2143 | 6480464 | benazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA]; more ... | CTD | PMID:11510275 | glucose | increases expression | ISO | RGD:2143 | 6480464 | Glucose results in increased expression of AQP4 mRNA | CTD | PMID:11510275 | hydrogen chloride | increases expression | ISO | RGD:2143 | 6480464 | Hydrochloric Acid results in increased expression of AQP4 protein | CTD | PMID:18406487 | iron atom | increases expression | ISO | RGD:2143 | 6480464 | Iron deficiency results in increased expression of AQP4 mRNA | CTD | PMID:16629162 | L-methionine | multiple interactions | ISO | RGD:10183 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP4 mRNA | CTD | PMID:20938992 | lactic acid | affects localization | ISO | RGD:2143 | 6480464 | Lactic Acid affects the localization of AQP4 protein | CTD | PMID:18406487 | lactic acid | increases expression | ISO | RGD:2143 | 6480464 | Lactic Acid results in increased expression of AQP4 protein | CTD | PMID:18406487 | lactic acid | multiple interactions | ISO | RGD:2143 | 6480464 | [Lactic Acid co-treated with Cycloheximide] results in increased expression of AQP4 protein | CTD | PMID:18406487 | lansoprazole | increases expression | ISO | RGD:10183 | 6480464 | lansoprazole results in increased expression of AQP4 protein; more ... | CTD | PMID:20437101 | manganese atom | multiple interactions | ISO | RGD:2143 | 6480464 | Antioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein] | CTD | PMID:20648640 | manganese(0) | multiple interactions | ISO | RGD:2143 | 6480464 | Antioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein] | CTD | PMID:20648640 | morphine | decreases expression | ISO | RGD:10183 | 6480464 | Morphine results in decreased expression of AQP4 mRNA | CTD | PMID:21955143 | N-methyl-4-phenylpyridinium | multiple interactions | ISO | RGD:10183 | 6480464 | [AQP4 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium] which affects the expression of CYP2E1 mRNA; more ... | CTD | PMID:20615459 | N-methyl-4-phenylpyridinium | affects response to substance | ISO | RGD:10183 | 6480464 | AQP4 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium | CTD | PMID:20615459 | paracetamol | decreases expression | ISO | RGD:10183 | 6480464 | Acetaminophen results in decreased expression of AQP4 mRNA | CTD | PMID:17585979 | paracetamol | affects expression | ISO | RGD:10183 | 6480464 | Acetaminophen affects the expression of AQP4 mRNA | CTD | PMID:17562736 | paracetamol | multiple interactions | ISO | RGD:10183 | 6480464 | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AQP4 mRNA] | CTD | PMID:17585979 | phenobarbital | affects expression | ISO | RGD:10183 | 6480464 | Phenobarbital affects the expression of AQP4 mRNA | CTD | PMID:23091169 | terbutaline | increases expression | ISO | RGD:2143 | 6480464 | Terbutaline results in increased expression of AQP4 mRNA | CTD | PMID:9409467 | tert-butyl hydroperoxide | multiple interactions | ISO | RGD:2143 | 6480464 | tert-Butylhydroperoxide results in increased expression of and affects the localization of AQP4 protein | CTD | PMID:20648640 | tetrachloromethane | decreases expression | ISO | RGD:2143 | 6480464 | Carbon Tetrachloride results in decreased expression of AQP4 mRNA | CTD | PMID:17805973 | thiourea | decreases expression | ISO | RGD:2143 | 6480464 | Thiourea results in decreased expression of AQP4 mRNA | CTD | PMID:15248066 | valsartan | multiple interactions | ISO | RGD:2143 | 6480464 | valsartan inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] | CTD | PMID:11510275 | water | increases transport | ISO | RGD:2143 | 6480464 | AQP4 protein results in increased transport of Water | CTD | PMID:21251984 | zinc atom | decreases expression | ISO | RGD:2143 | 6480464 | Zinc deficiency results in decreased expression of AQP4 mRNA | CTD | PMID:19111725 | zinc(0) | decreases expression | ISO | RGD:2143 | 6480464 | Zinc deficiency results in decreased expression of AQP4 mRNA | CTD | PMID:19111725 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Bile secretion |
| Vasopressin-regulated water reabsorption | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Bile secretion |
| Vasopressin-regulated water reabsorption | |
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RGD Disease Portals| AQP4 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| AQP4 (Homo sapiens) |
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| Aqp4 (Rattus norvegicus) |
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Position Markers| WI-21214 |
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| A006W40 |
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| WI-13598 |
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| D18S1223 |
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| D18S941E |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NG_029560 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001650 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_004028 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AB128929 | (Get FASTA) | Search GEO for Microarray Profiles |
| AB209156 | (Get FASTA) | Search GEO for Microarray Profiles | |
| ABBA01022569 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC018371 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK026728 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK222684 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK295069 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL119338 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL138136 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01008906 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AV725241 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC022286 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC030745 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC045780 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BI596912 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BI667387 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BI917845 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BQ638704 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CD105892 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471088 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CK001094 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D63412 | (Get FASTA) | Search GEO for Microarray Profiles | |
| HQ901095 | (Get FASTA) | Search GEO for Microarray Profiles | |
| N50070 | (Get FASTA) | Search GEO for Microarray Profiles | |
| R35726 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U34845 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U63613 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U63622 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U63623 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001650 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001641 | |||||||||||||||||||||||||
| Peptide Label: | isoform a | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_004028 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_004019 | |||||||||||||||||||||||||
| Peptide Label: | isoform b | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001641 | (Get FASTA) |
| NP_004019 | (Get FASTA) | |
| GenBank Protein | AAB26957 | (Get FASTA) |
| AAB26958 | (Get FASTA) | |
| AAC50284 | (Get FASTA) | |
| AAG17964 | (Get FASTA) | |
| AAH22286 | (Get FASTA) | |
| ADQ32133 | (Get FASTA) | |
| ADZ13511 | (Get FASTA) | |
| BAA09715 | (Get FASTA) | |
| BAD22823 | (Get FASTA) | |
| BAD92393 | (Get FASTA) | |
| BAD96404 | (Get FASTA) | |
| BAG58116 | (Get FASTA) | |
| EAX01228 | (Get FASTA) | |
| EAX01229 | (Get FASTA) | |
| P55087 | (Get FASTA) |
Promoters| RGD ID: | 6869520 | ||||||||||
| Promoter ID: | EPDNEW_H7925 | ||||||||||
| Type: | initiation region | ||||||||||
| Name: | EIF4EBP3_1 | ||||||||||
| Description: | eukaryotic translation initiation factor 4E binding protein 3 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| COSMIC | AQP4 | COSMIC |
| Ensembl Genes | ENSG00000171885 | ENTREZGENE |
| Ensembl Protein | ENSP00000372654 | ENTREZGENE |
| Ensembl Transcript | ENST00000383168 | ENTREZGENE |
| Entrez Gene | 361 | ENTREZGENE |
| Gene3D-CATH | MIP | UniProtKB/Swiss-Prot |
| Germonline | ENSG00000171885 | |
| HGNC ID | 637 | ENTREZGENE |
| HomoloGene Group ID | 37507 | ENTREZGENE |
| HPRD ID | 02631 | ENTREZGENE |
| InterPro | Aquaporin-like | UniProtKB/Swiss-Prot |
| MIP | UniProtKB/Swiss-Prot | |
| MIP_CS | UniProtKB/Swiss-Prot | |
| KEGG Report | hsa:361 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 600308 | OMIM |
| PANTHER | MIP | UniProtKB/Swiss-Prot |
| Pfam | MIP | UniProtKB/Swiss-Prot |
| PharmGKB | PA24922 | PharmGKB |
| PRINTS | MINTRINSICP | UniProtKB/Swiss-Prot |
| PROSITE | MIP | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | MIP | UniProtKB/Swiss-Prot |
| TIGRFAMs | MIP | UniProtKB/Swiss-Prot |
| UniGene | Hs.315369 | ENTREZGENE |
| UniProt | AQP4_HUMAN | UniProtKB/Swiss-Prot |
| F1DSG4_HUMAN | UniProtKB/TrEMBL | |
| H0Y3H5_HUMAN | UniProtKB/TrEMBL | |
| J3KRM4_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-16 | AQP4 | aquaporin 4 | AQP4 | aquaporin 4 | Symbol and/or name change | 39860 | APPROVED |
| More on AQP4 | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 735519 |
| Created: | 2004-02-06 |
| Species: | Homo sapiens |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




