KEAP1 (kelch-like ECH-associated protein 1)

Help | FTP Download | Citing RGD | Contact Us

Keyword

Gene: KEAP1 (kelch-like ECH-associated protein 1) Homo sapiens

Symbol:

KEAP1

Name:

kelch-like ECH-associated protein 1

Description:

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

cytosolic inhibitor of Nrf2; INrf2; kelch-like ECH-associated protein 1; kelch-like family member 19; kelch-like protein 19; KIAA0132; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454

Orthologs:

Mus musculus : Keap1 (kelch-like ECH-associated protein 1) MGI
Rattus norvegicus : Keap1 (Kelch-like ECH-associated protein 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	19	10,533,682 - 10,550,933	-	NCBI
Human Genome Assembly HuRef	19	10,176,101 - 10,192,927	-	NCBI
Human Genome Assembly GRCh37	19	10,596,796 - 10,614,054	-	NCBI
Human Genome Assembly Build 36	19	10,457,796 - 10,475,054	-	NCBI
Human Cytogenetic Map	19	p13.2		NCBI