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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tocopherol
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Accession:CHEBI:27013 term browser browse the term
Definition:A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.
Synonyms:related_synonym: Methyltocols;   Tocopherols;   tocoferol;   tocoferoles
 xref: CAS:1406-66-2
 xref_mesh: MESH:D024505
 xref: Wikipedia:Tocopherol



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tocopherol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C member 1 multiple interactions
decreases activity
ISO Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]
Tocopherols results in decreased activity of ABCC1 protein
CTD PMID:15617835 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases abundance
ISO resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols] CTD PMID:25654502 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Ar androgen receptor decreases activity
decreases expression
ISO Tocopherols results in decreased activity of AR protein
[Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of AR mRNA; Tocopherols results in decreased expression of AR protein
CTD PMID:12032296 PMID:16302272 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Arf3 ADP-ribosylation factor 3 increases expression EXP Tocopherols results in increased expression of ARF3 mRNA CTD PMID:17654050 NCBI chr15:98,635,505...98,660,999
Ensembl chr15:98,634,515...98,661,095
JBrowse link
G Aspm abnormal spindle microtubule assembly increases expression EXP Tocopherols results in increased expression of ASPM mRNA CTD PMID:17056531 NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide increases expression EXP Tocopherols results in increased expression of ATP1A2 mRNA CTD PMID:17654050 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
JBrowse link
G Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide increases expression EXP Tocopherols results in increased expression of ATP1B2 mRNA CTD PMID:17654050 NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768
JBrowse link
G Aurka aurora kinase A increases expression EXP Tocopherols results in increased expression of AURKA mRNA CTD PMID:17056531 NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455
JBrowse link
G Bax BCL2-associated X protein increases response to substance ISO BAX protein results in increased susceptibility to Tocopherols CTD PMID:16001965 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases response to substance
increases expression
ISO
EXP
BCL2 protein results in decreased susceptibility to Tocopherols
Tocopherols results in increased expression of BCL2 mRNA; Tocopherols results in increased expression of BCL2 protein
CTD PMID:8970189 PMID:16001965 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases response to substance ISO BCL2L1 protein results in decreased susceptibility to Tocopherols CTD PMID:16001965 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression EXP Tocopherols results in increased expression of BIRC5 mRNA CTD PMID:17056531 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma increases expression EXP Tocopherols results in increased expression of CAMK2G mRNA CTD PMID:17654050 NCBI chr14:20,784,943...20,844,225
Ensembl chr14:20,784,943...20,844,156
JBrowse link
G Ccnb2 cyclin B2 increases expression EXP Tocopherols results in increased expression of CCNB2 mRNA CTD PMID:17056531 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Tocopherols results in decreased expression of CCND1 protein CTD PMID:12504091 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Tocopherols results in decreased expression of CCND3 protein CTD PMID:12504091 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Tocopherols results in decreased expression of CCNE1 mRNA; Tocopherols results in decreased expression of CCNE1 protein CTD PMID:12504091 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Cdc6 cell division cycle 6 increases expression EXP Tocopherols results in increased expression of CDC6 mRNA CTD PMID:17056531 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
JBrowse link
G Cdk1 cyclin dependent kinase 1 increases expression EXP Tocopherols results in increased expression of CDK1 mRNA CTD PMID:17056531 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Tocopherols results in decreased expression of CDK2 protein CTD PMID:12504091 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk4 cyclin dependent kinase 4 multiple interactions ISO Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein CTD PMID:12504091 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Cdk5r1 cyclin dependent kinase 5, regulatory subunit 1 increases expression EXP Tocopherols results in increased expression of CDK5R1 mRNA CTD PMID:17654050 NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010
JBrowse link
G Clec4e C-type lectin domain family 4, member e increases expression EXP Tocopherols results in increased expression of CLEC4E mRNA CTD PMID:17056531 NCBI chr 6:123,258,748...123,266,830
Ensembl chr 6:123,258,748...123,266,829
JBrowse link
G Cplx1 complexin 1 increases expression EXP Tocopherols results in increased expression of CPLX1 mRNA CTD PMID:17654050 NCBI chr 5:108,666,420...108,697,893
Ensembl chr 5:108,666,420...108,697,890
JBrowse link
G Cplx2 complexin 2 increases expression EXP Tocopherols results in increased expression of CPLX2 mRNA CTD PMID:17654050 NCBI chr13:54,455,447...54,531,736
Ensembl chr13:54,519,162...54,531,730
Ensembl chr13:54,519,162...54,531,730
JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression EXP Tocopherols results in increased expression of CSF1R mRNA CTD PMID:17056531 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Tocopherols results in increased expression of CSRP2 mRNA CTD PMID:17056531 NCBI chr10:110,756,037...110,775,375
Ensembl chr10:110,755,650...110,775,483
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 increases expression EXP Tocopherols results in increased expression of DNAJC5 mRNA CTD PMID:17654050 NCBI chr 2:181,162,141...181,194,679
Ensembl chr 2:181,162,278...181,196,926
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Tocopherols results in increased expression of E2F1 protein CTD PMID:15883045 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G Egr1 early growth response 1 decreases activity ISO Tocopherols results in decreased activity of EGR1 protein CTD PMID:15878867 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide increases expression EXP Tocopherols results in increased expression of FCER1A mRNA CTD PMID:17056531 NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781
JBrowse link
G Fes feline sarcoma oncogene increases expression EXP Tocopherols results in increased expression of FES mRNA CTD PMID:17056531 NCBI chr 7:80,027,506...80,037,702
Ensembl chr 7:80,027,504...80,037,694
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Tocopherols results in decreased expression of FGF1 mRNA CTD PMID:15878867 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO Tocopherols results in decreased expression of FGF2 mRNA CTD PMID:15878867 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 decreases expression ISO Tocopherols results in decreased expression of FGFR1 mRNA CTD PMID:15144885 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
JBrowse link
G Fkbp9 FK506 binding protein 9 increases expression EXP Tocopherols results in increased expression of FKBP9 mRNA CTD PMID:17056531 NCBI chr 6:56,809,044...56,856,345
Ensembl chr 6:56,809,044...56,856,343
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression EXP Tocopherols results in increased expression of FOS mRNA; Tocopherols results in increased expression of FOS protein CTD PMID:8970189 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fpr-rs4 formyl peptide receptor, related sequence 4 increases expression EXP Tocopherols results in increased expression of FPR-RS4 mRNA CTD PMID:17056531 NCBI chr17:18,241,995...18,242,966
Ensembl chr17:18,241,995...18,242,966
JBrowse link
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) increases expression EXP Tocopherols results in increased expression of GRIA2 mRNA CTD PMID:17654050 NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) increases expression EXP Tocopherols results in increased expression of GRIN1 mRNA CTD PMID:17654050 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases activity ISO Tocopherols results in decreased activity of GSTO1 protein CTD PMID:16781109 NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229
JBrowse link
G Haspin histone H3 associated protein kinase increases expression EXP Tocopherols results in increased expression of HASPIN mRNA CTD PMID:17056531 NCBI chr11:73,026,310...73,029,120
Ensembl chr11:73,026,311...73,029,120
JBrowse link
G Jun jun proto-oncogene increases expression EXP Tocopherols results in increased expression of JUN mRNA; Tocopherols results in increased expression of JUN protein CTD PMID:8970189 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kif20a kinesin family member 20A increases expression EXP Tocopherols results in increased expression of KIF20A mRNA CTD PMID:17056531 NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330
JBrowse link
G Kif4 kinesin family member 4 increases expression EXP Tocopherols results in increased expression of KIF4 mRNA CTD PMID:17056531 NCBI chr  X:99,669,693...99,770,878
Ensembl chr  X:99,669,343...99,770,820
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases response to substance ISO MCL1 protein results in decreased susceptibility to Tocopherols CTD PMID:16001965 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Myc myelocytomatosis oncogene decreases activity
decreases expression
EXP Tocopherols results in decreased activity of MYC protein
Tocopherols results in decreased expression of MYC mRNA
CTD PMID:8970189 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Napb N-ethylmaleimide sensitive fusion protein attachment protein beta increases expression EXP Tocopherols results in increased expression of NAPB mRNA CTD PMID:17654050 NCBI chr 2:148,535,905...148,574,396
Ensembl chr 2:148,535,905...148,574,387
JBrowse link
G Nsf N-ethylmaleimide sensitive fusion protein increases expression EXP Tocopherols results in increased expression of NSF mRNA CTD PMID:17654050 NCBI chr11:103,712,608...103,844,882
Ensembl chr11:103,712,608...103,844,882
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Tocopherols results in decreased expression of PCNA CTD PMID:17927505 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform increases expression EXP Tocopherols results in increased expression of PPP3CA mRNA CTD PMID:17654050 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488
JBrowse link
G Prtn3 proteinase 3 increases expression EXP Tocopherols results in increased expression of PRTN3 mRNA CTD PMID:17056531 NCBI chr10:79,715,499...79,719,008
Ensembl chr10:79,710,310...79,719,008
JBrowse link
G Ptpro protein tyrosine phosphatase receptor type O increases expression EXP Tocopherols results in increased expression of PTPRO mRNA CTD PMID:17056531 NCBI chr 6:137,229,189...137,440,251
Ensembl chr 6:137,229,317...137,440,231
JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression EXP Tocopherols results in increased expression of RAB11B mRNA CTD PMID:17654050 NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504
JBrowse link
G Rab3a RAB3A, member RAS oncogene family increases expression EXP Tocopherols results in increased expression of RAB3A mRNA CTD PMID:17654050 NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323
JBrowse link
G Rab6b RAB6B, member RAS oncogene family increases expression EXP Tocopherols results in increased expression of RAB6B mRNA CTD PMID:17654050 NCBI chr 9:102,988,866...103,062,475
Ensembl chr 9:102,988,986...103,062,475
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Tocopherols results in decreased phosphorylation of RB1 protein CTD PMID:12504091 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Rrm1 ribonucleotide reductase M1 increases expression EXP Tocopherols results in increased expression of RRM1 mRNA CTD PMID:17056531 NCBI chr 7:102,090,902...102,118,978
Ensembl chr 7:102,090,902...102,118,978
JBrowse link
G Rrm2 ribonucleotide reductase M2 increases expression EXP Tocopherols results in increased expression of RRM2 mRNA CTD PMID:17056531 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
JBrowse link
G Snca synuclein, alpha increases expression EXP Tocopherols results in increased expression of SNCA mRNA CTD PMID:17654050 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sncb synuclein, beta increases expression EXP Tocopherols results in increased expression of SNCB mRNA CTD PMID:17654050 NCBI chr13:54,906,673...54,914,435
Ensembl chr13:54,906,673...54,914,408
JBrowse link
G Stx1a syntaxin 1A (brain) increases expression EXP Tocopherols results in increased expression of STX1A mRNA CTD PMID:17654050 NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954
JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression EXP Tocopherols results in increased expression of STXBP1 mRNA CTD PMID:17654050 NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a increases expression EXP Tocopherols results in increased expression of SV2A mRNA CTD PMID:17654050 NCBI chr 3:96,088,543...96,102,499
Ensembl chr 3:96,088,467...96,102,837
JBrowse link
G Syn1 synapsin I increases expression EXP Tocopherols results in increased expression of SYN1 mRNA CTD PMID:17654050 NCBI chr  X:20,726,750...20,787,157
Ensembl chr  X:20,726,750...20,787,243
JBrowse link
G Syn2 synapsin II increases expression EXP Tocopherols results in increased expression of SYN2 mRNA CTD PMID:17654050 NCBI chr 6:115,111,863...115,259,587
Ensembl chr 6:115,111,863...115,258,967
JBrowse link
G Syngr1 synaptogyrin 1 increases expression EXP Tocopherols results in increased expression of SYNGR1 mRNA CTD PMID:17654050 NCBI chr15:79,975,537...80,003,702
Ensembl chr15:79,975,535...80,003,702
JBrowse link
G Syp synaptophysin increases expression EXP Tocopherols results in increased expression of SYP mRNA CTD PMID:17654050 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495
JBrowse link
G Syt11 synaptotagmin XI increases expression EXP Tocopherols results in increased expression of SYT11 mRNA CTD PMID:17654050 NCBI chr 3:88,652,006...88,682,466
Ensembl chr 3:88,652,007...88,682,471
JBrowse link
G Syt13 synaptotagmin XIII increases expression EXP Tocopherols results in increased expression of SYT13 mRNA CTD PMID:17654050 NCBI chr 2:92,745,446...92,786,403
Ensembl chr 2:92,745,443...92,786,403
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Tocopherols inhibits the reaction [TNF protein results in decreased export of Potassium] CTD PMID:17337591 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfaip2 tumor necrosis factor, alpha-induced protein 2 increases expression EXP Tocopherols results in increased expression of TNFAIP2 mRNA CTD PMID:17056531 NCBI chr12:111,408,898...111,421,452
Ensembl chr12:111,408,903...111,421,452
JBrowse link
G Trp53 transformation related protein 53 increases activity ISO Tocopherols results in increased activity of TP53 protein CTD PMID:15883045 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 increases expression EXP Tocopherols results in increased expression of TTC3 mRNA CTD PMID:17654050 NCBI chr16:94,171,479...94,270,081
Ensembl chr16:94,171,477...94,270,202
JBrowse link
G Vamp1 vesicle-associated membrane protein 1 increases expression EXP Tocopherols results in increased expression of VAMP1 mRNA CTD PMID:17654050 NCBI chr 6:125,192,544...125,199,269
Ensembl chr 6:125,192,514...125,222,927
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 increases expression EXP Tocopherols results in increased expression of VAMP2 mRNA CTD PMID:17654050 NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor increases expression ISO Tocopherols results in increased expression of VDR mRNA CTD PMID:12032296 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link
(R,R,R)-alpha-tocopherol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A930009A15Rik RIKEN cDNA A930009A15 gene multiple interactions EXP alpha-Tocopherol inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein] CTD PMID:17532611 NCBI chr10:115,399,555...115,418,359
Ensembl chr10:115,405,891...115,418,353
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO alpha-Tocopherol inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein] CTD PMID:24448832 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcd1 ATP-binding cassette, sub-family D member 1 multiple interactions EXP alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD1 mRNA] CTD PMID:29065513 NCBI chr  X:72,760,203...72,782,140
Ensembl chr  X:72,760,203...72,782,140
JBrowse link
G Abcd3 ATP-binding cassette, sub-family D member 3 multiple interactions EXP alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD3 mRNA] CTD PMID:29065513 NCBI chr 3:121,552,553...121,609,851
Ensembl chr 3:121,552,423...121,608,951
JBrowse link
G Acat1 acetyl-Coenzyme A acetyltransferase 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [iron(II)-ascorbic acid complex results in decreased activity of ACAT1 protein] CTD PMID:10656290 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO alpha-Tocopherol inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
[alpha-Tocopherol co-treated with Paraoxon] results in decreased activity of ACHE protein; ALB protein inhibits the reaction [alpha-Tocopherol binds to and results in decreased activity of ACHE protein]; alpha-Tocopherol binds to and results in decreased activity of ACHE protein; alpha-Tocopherol promotes the reaction [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in decreased activity of ACHE protein]
CTD PMID:19464315 PMID:34506764 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Acvrl1 activin A receptor, type II-like 1 increases expression ISO alpha-Tocopherol results in increased expression of ACVRL1 mRNA CTD PMID:16908007 NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217
JBrowse link
G Agt angiotensinogen multiple interactions EXP alpha-Tocopherol inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; alpha-Tocopherol inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein] CTD PMID:17532611 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO alpha-Tocopherol results in increased expression of AKR1B1 mRNA CTD PMID:16908007 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased phosphorylation of and results in decreased activity of AKT1 protein]
alpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of AKT1 protein]
CTD PMID:19351882 PMID:22343715 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions EXP alpha-Tocopherol inhibits the reaction [[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein] CTD PMID:7728901 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155
JBrowse link
G Alas1 aminolevulinic acid synthase 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of ALAS1 protein] CTD PMID:12180188 NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853
JBrowse link
G Alb albumin multiple interactions ISO alpha-Tocopherol inhibits the reaction [beryllium nitrate results in decreased expression of ALB protein]; sodium-4,5-dihydroxy-1,3-benzene disulfonate promotes the reaction [alpha-Tocopherol inhibits the reaction [beryllium nitrate results in decreased expression of ALB protein]]
[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of ALB protein; ALB protein inhibits the reaction [alpha-Tocopherol binds to and results in decreased activity of ACHE protein]
CTD PMID:17429802 PMID:34506764 PMID:36372912 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Ano6 anoctamin 6 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Ozone results in increased expression of ANO6 mRNA] CTD PMID:27886375 NCBI chr15:95,688,724...95,873,353
Ensembl chr15:95,688,724...95,872,632
JBrowse link
G Apex2 apurinic/apyrimidinic endonuclease 2 multiple interactions
decreases expression
ISO alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]
alpha-Tocopherol results in decreased expression of APEX2 mRNA
CTD PMID:26332274 NCBI chr  X:149,286,625...149,371,175
Ensembl chr  X:149,302,515...149,372,864
JBrowse link
G Apoa1 apolipoprotein A-I decreases expression
decreases activity
ISO alpha-Tocopherol results in decreased expression of APOA1 mRNA; alpha-Tocopherol results in decreased expression of APOA1 protein
alpha-Tocopherol results in decreased activity of APOA1 promoter
CTD PMID:16423621 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
JBrowse link
G Apob apolipoprotein B multiple interactions ISO alpha-Tocopherol promotes the reaction [APOB protein results in increased reduction of Copper] CTD PMID:11368321 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein] CTD PMID:12684028 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein] CTD PMID:14645110 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA] CTD PMID:19196431 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO alpha-Tocopherol results in increased expression of BAD mRNA CTD PMID:26332274 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO alpha-Tocopherol affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
alpha-Tocopherol results in increased expression of BAX mRNA
CTD PMID:11805214 PMID:26332274 PMID:32134168 PMID:36058301 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP alpha-Tocopherol inhibits the reaction [Endosulfan results in decreased activity of BCHE protein] CTD PMID:24299906 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO alpha-Tocopherol affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; TNFRSF10B mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]
alpha-Tocopherol analog results in decreased expression of BCL2 mRNA; alpha-Tocopherol analog results in decreased expression of BCL2 protein
[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of BCL2 protein]
CTD PMID:11805214 PMID:16005924 PMID:16135673 PMID:20686688 PMID:29297235 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO alpha-Tocopherol results in decreased expression of BCL2L1 protein CTD PMID:18942769 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased expression of BDNF protein] CTD PMID:30776390 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Bpifb1 BPI fold containing family B, member 1 multiple interactions ISO [alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of BPIFB1 protein CTD PMID:36372912 NCBI chr 2:154,032,738...154,062,263
Ensembl chr 2:154,032,738...154,062,289
JBrowse link
G Canx calnexin affects localization
increases expression
ISO alpha-Tocopherol affects the localization of CANX protein
alpha-Tocopherol results in increased expression of CANX mRNA; alpha-Tocopherol results in increased expression of CANX protein
CTD PMID:16908007 NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
ISO
EXP
[alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein; [alpha-Tocopherol co-treated with Tretinoin] results in increased activity of CASP3 protein; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased cleavage of and results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Vitamin A results in increased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; alpha-Tocopherol results in increased cleavage of and results in increased activity of CASP3 protein
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased cleavage of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 protein]
alpha-Tocopherol results in decreased activity of CASP3 protein
CTD PMID:12450566 PMID:14599462 PMID:14722101 PMID:15095415 PMID:17618090 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 multiple interactions ISO alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP7 protein]; alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP7 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]] CTD PMID:23042730 PMID:29129777 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Casp8 caspase 8 increases cleavage ISO alpha-Tocopherol analog results in increased cleavage of CASP8 protein CTD PMID:20686688 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO
EXP
alpha-Tocopherol analog results in increased cleavage of CASP9 protein
alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 protein]; alpha-Tocopherol results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:20686688 PMID:21869839 PMID:31712109 PMID:36058301 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
ISO [Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; [Sodium Selenite co-treated with alpha-Tocopherol] inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [Copper Sulfate results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [flubendiamide results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]
alpha-Tocopherol results in increased activity of CAT protein
alpha-Tocopherol results in increased expression of CAT protein
alpha-Tocopherol results in increased expression of CAT mRNA; alpha-Tocopherol results in increased expression of CAT protein
CTD PMID:9306888 PMID:16979807 PMID:18547560 PMID:19083475 PMID:19464315 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions ISO alpha-Tocopherol inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA] CTD PMID:27257344 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO
alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of CCL2 protein]
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
CTD PMID:19735175 PMID:24333275 PMID:26332274 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA] CTD PMID:26332274 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA] CTD PMID:26332274 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
JBrowse link
G Cd36 CD36 molecule affects expression
multiple interactions
ISO alpha-Tocopherol affects the expression of CD36 mRNA
alpha-Tocopherol inhibits the reaction [[troglitazone co-treated with Ethanol] results in increased expression of CD36 protein]
CTD PMID:16407258 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
decreases expression
ISO alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]
alpha-Tocopherol results in decreased expression of CDKN1A mRNA
CTD PMID:26332274 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO alpha-Tocopherol inhibits the reaction [Cadmium results in decreased expression of CFTR protein] CTD PMID:20363832 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
JBrowse link
G Chat choline acetyltransferase multiple interactions ISO [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein; Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein] CTD PMID:25891525 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
JBrowse link
G Clcn3 chloride channel, voltage-sensitive 3 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Ozone results in increased expression of CLCN3 mRNA] CTD PMID:27886375 NCBI chr 8:61,363,423...61,436,351
Ensembl chr 8:61,363,423...61,436,334
JBrowse link
G Cldn2 claudin 2 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Potassium Dichromate affects the localization of CLDN2 protein] CTD PMID:19766176 NCBI chr  X:138,701,552...138,712,135
Ensembl chr  X:138,701,577...138,712,135
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions
increases expression
ISO alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CPT1A mRNA]; alpha-Tocopherol promotes the reaction [NR1I2 results in increased expression of CPT1A mRNA]
alpha-Tocopherol results in increased expression of CPT1A mRNA
CTD PMID:17936189 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
JBrowse link
G Crabp2 cellular retinoic acid binding protein II multiple interactions ISO [Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 mRNA; [Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 protein CTD PMID:15225641 NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein] CTD PMID:30776390 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO [alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein CTD PMID:18191645 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Cryaa crystallin, alpha A increases expression ISO alpha-Tocopherol results in increased expression of CRYAA mRNA CTD PMID:16908007 NCBI chr17:31,896,905...31,900,704
Ensembl chr17:31,896,781...31,900,707
JBrowse link
G Ctsd cathepsin D increases expression ISO alpha-Tocopherol results in increased expression of CTSD protein CTD PMID:18942769 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA] CTD PMID:24333275 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased expression of CXCL8 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; alpha-Tocopherol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA] CTD PMID:19135038 PMID:25551565 PMID:26270818 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] CTD PMID:24333275 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions EXP [alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CXCL1 mRNA]] CTD PMID:29284473 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO alpha-Tocopherol results in increased expression of CYP1A1 mRNA
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA]; alpha-Tocopherol results in increased expression of and results in increased activity of CYP1A1 protein
CTD PMID:15665910 PMID:22389237 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
multiple interactions
ISO
EXP
alpha-Tocopherol results in increased activity of CYP1A2 protein
alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]
CTD PMID:15665910 PMID:26102010 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases expression EXP alpha-Tocopherol results in decreased expression of CYP2B10 mRNA CTD PMID:26102010 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 decreases expression EXP alpha-Tocopherol results in decreased expression of CYP2B9 mRNA CTD PMID:26102010 NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 multiple interactions EXP alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] CTD PMID:26102010 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
multiple interactions
ISO alpha-Tocopherol results in increased expression of CYP2E1 mRNA
[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]
CTD PMID:26332274 PMID:27919644 PMID:28062356 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression
multiple interactions
EXP alpha-Tocopherol results in increased expression of CYP3A11; alpha-Tocopherol results in increased expression of CYP3A11 mRNA; alpha-Tocopherol results in increased expression of CYP3A11 protein
alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP3A11 mRNA]
CTD PMID:15649653 PMID:16008107 PMID:26102010 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases expression
multiple interactions
EXP
ISO
alpha-Tocopherol results in increased expression of CYP3A13 mRNA; alpha-Tocopherol results in increased expression of CYP3A13 protein
alpha-Tocopherol inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]
CTD PMID:26102010 PMID:31102695 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO alpha-Tocopherol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]
alpha-Tocopherol analog results in increased expression of DDIT3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]; DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]
CTD PMID:20459685 PMID:20686688 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization EXP alpha-Tocopherol affects the localization of DIABLO protein CTD PMID:15582575 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions
ISO alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]
CTD PMID:20686688 NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] CTD PMID:22389237 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] CTD PMID:22389237 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Fasl Fas ligand increases expression ISO alpha-Tocopherol results in increased expression of FASLG mRNA CTD PMID:26332274 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fbl fibrillarin decreases expression ISO alpha-Tocopherol deficiency results in decreased expression of FBL protein CTD PMID:15247049 NCBI chr 7:27,868,293...27,878,701
Ensembl chr 7:27,869,135...27,878,694
JBrowse link
G Fmo1 flavin containing monooxygenase 1 increases expression ISO alpha-Tocopherol results in increased expression of FMO1 mRNA CTD PMID:16908007 NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Glucose results in increased expression of and results in increased secretion of FN1 protein] CTD PMID:9225831 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Fyn Fyn proto-oncogene multiple interactions ISO alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein] CTD PMID:14572611 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO alpha-Tocopherol results in increased expression of GADD45A mRNA CTD PMID:26332274 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA CTD PMID:24530478 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]
[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLM mRNA
CTD PMID:22389237 PMID:24530478 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO alpha-Tocopherol results in increased expression of GFAP protein CTD PMID:18942769 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of GNAI2 protein] CTD PMID:18441196 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566
JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of GNAI3 protein] CTD PMID:18441196 NCBI chr 3:108,014,591...108,053,468
Ensembl chr 3:108,014,596...108,053,462
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO alpha-Tocopherol inhibits the reaction [beryllium nitrate results in increased activity of GPT protein] CTD PMID:17429802 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO
EXP
alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of GPX1 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 mRNA]
[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ovalbumin promotes the reaction [Ozone results in increased activity of GPX1 protein]]
CTD PMID:26365763 PMID:29284473 PMID:36058301 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA] CTD PMID:14642406 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Gsr glutathione reductase multiple interactions ISO alpha-Tocopherol inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GSR protein] CTD PMID:16979807 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA] CTD PMID:22389237 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 increases expression ISO alpha-Tocopherol results in increased expression of GSTT1 protein CTD PMID:9855024 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] CTD PMID:19135433 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890
JBrowse link
G Hal histidine ammonia lyase increases expression ISO alpha-Tocopherol results in increased expression of HAL mRNA CTD PMID:16908007 NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions ISO [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:19595682 PMID:21535577 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Hmox1 heme oxygenase 1 affects expression
multiple interactions
ISO alpha-Tocopherol affects the expression of HMOX1 mRNA
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]; alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]
alpha-Tocopherol inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]
CTD PMID:8743975 PMID:12180188 PMID:22053912 PMID:22389237 PMID:36058301 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hp haptoglobin affects activity
multiple interactions
ISO
EXP
alpha-Tocopherol affects the activity of HP protein polymorphism
Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism]
CTD PMID:19769483 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of HSD17B3 mRNA] CTD PMID:32134168 NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044
JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO alpha-Tocopherol results in increased expression of HSPA1B mRNA CTD PMID:16908007 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein] CTD PMID:22313677 PMID:25551565 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
[alpha-Tocopherol co-treated with Lipopolysaccharides] results in increased expression of IFNG mRNA; alpha-Tocopherol results in decreased susceptibility to [IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4]
alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IFNG protein]]
CTD PMID:16307444 PMID:24333275 PMID:29284473 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA CTD PMID:23859036 NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein] CTD PMID:34310962 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; alpha-Tocopherol promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]
[alpha-Tocopherol co-treated with Lipopolysaccharides] results in increased expression of IL10 mRNA
CTD PMID:24333275 PMID:25551565 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il13 interleukin 13 multiple interactions EXP [alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]] CTD PMID:29284473 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il17a interleukin 17A multiple interactions EXP alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL17A mRNA]] CTD PMID:29284473 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein] CTD PMID:15025948 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of IL1B mRNA]
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA]
CTD PMID:19135433 PMID:19735175 PMID:26332274 PMID:31712109 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il5 interleukin 5 multiple interactions EXP alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL5 mRNA]] CTD PMID:29284473 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
alpha-Tocopherol inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of and results in increased secretion of IL6 protein]
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of IL6 protein]
alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL6 protein]]
CTD PMID:15630180 PMID:24296301 PMID:29284473 PMID:32134168 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions ISO [Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 protein CTD PMID:12949374 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
ISO
EXP
alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of JUN protein]
alpha-Tocopherol results in increased expression of JUN mRNA; alpha-Tocopherol results in increased expression of JUN protein
CTD PMID:14645110 PMID:19000923 PMID:20025956 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Glucose results in decreased activity of KCNH2 protein] CTD PMID:12531891 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:36058301 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions ISO [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in decreased activity of LCAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] CTD PMID:19595682 PMID:21535577 NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014
JBrowse link
G Lck lymphocyte protein tyrosine kinase multiple interactions ISO alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein] CTD PMID:14572611 NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased secretion of LDHA protein]
CTD PMID:21322096 PMID:26270818 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions ISO [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHB protein] CTD PMID:21322096 NCBI chr 6:142,435,975...142,453,683
Ensembl chr 6:142,435,975...142,453,683
JBrowse link
G Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein multiple interactions ISO [alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of LGALS3BP protein CTD PMID:36372912 NCBI chr11:118,283,573...118,292,787
Ensembl chr11:118,283,577...118,292,918
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] CTD PMID:14572611 NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
affects activity
ISO
EXP
alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK1 protein]
[Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of MAPK1 protein]
[alpha-Tocopherol affects the activity of MAPK1 protein] which results in decreased susceptibility to Potassium Dichromate
CTD PMID:17011908 PMID:19766176 PMID:30776390 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO
EXP
alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK14 protein]
alpha-Tocopherol inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased phosphorylation of MAPK14 protein]
CTD PMID:12684028 PMID:14645110 PMID:29284473 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
affects activity
ISO
EXP
alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK3 protein]
[Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of MAPK3 protein]
[alpha-Tocopherol affects the activity of MAPK3 protein] which results in decreased susceptibility to Potassium Dichromate
CTD PMID:14645110 PMID:17011908 PMID:19766176 PMID:30776390 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK8 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein] CTD PMID:12684028 PMID:14645110 PMID:20686688 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein]
CTD PMID:20686688 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mb myoglobin multiple interactions ISO alpha-Tocopherol inhibits the reaction [MB modified form results in decreased secretion of very low density lipoprotein triglyceride] CTD PMID:17478120 NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870
JBrowse link
G Mbp myelin basic protein multiple interactions ISO alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased expression of MBP protein] CTD PMID:14645110 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
JBrowse link
G Mgat3 mannoside acetylglucosaminyltransferase 3 increases expression ISO alpha-Tocopherol results in increased expression of MGAT3 mRNA CTD PMID:16908007 NCBI chr15:80,057,852...80,099,720
Ensembl chr15:80,057,922...80,099,720
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA CTD PMID:23859036 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein] CTD PMID:31022331 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Muc4 mucin 4 multiple interactions ISO [alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of MUC4 protein CTD PMID:36372912 NCBI chr16:32,555,089...32,602,786
Ensembl chr16:32,555,015...32,602,754
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric multiple interactions ISO alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA] CTD PMID:24333275 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein] CTD PMID:16005924 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Nefh neurofilament, heavy polypeptide increases expression ISO alpha-Tocopherol results in increased expression of NEFH protein modified form CTD PMID:18942769 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]; [alpha-Tocopherol co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; alpha-Tocopherol inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 mRNA]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of NFE2L2 protein]
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] promotes the reaction [[Ozone co-treated with Oxygen] results in increased localization of NFE2L2 protein]; alpha-Tocopherol promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]
CTD PMID:22389237 PMID:26270818 PMID:29297235 PMID:31412289 PMID:32134168 More... NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
increases activity
ISO alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]
alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [RELA protein binds to NFKB1 protein]]
alpha-Tocopherol results in increased activity of NFKB1 protein
CTD PMID:15025948 PMID:16135673 PMID:17936189 PMID:19083475 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO
alpha-Tocopherol inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]; alpha-Tocopherol inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein]
[Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]
alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein]
CTD PMID:16135673 PMID:17532611 PMID:25551565 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein]
alpha-Tocopherol inhibits the reaction [Galactosamine results in increased expression of NOS2 mRNA]
CTD PMID:17936189 PMID:19135433 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO alpha-Tocopherol results in increased expression of NOS3 mRNA; alpha-Tocopherol results in increased expression of NOS3 protein CTD PMID:16949522 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein]
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]
CTD PMID:22389237 PMID:36058301 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO alpha-Tocopherol promotes the reaction [NR1I2 results in increased expression of CPT1A mRNA] CTD PMID:17936189 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) multiple interactions ISO alpha-Tocopherol inhibits the reaction [sodium arsenite results in decreased activity of OGDH protein] CTD PMID:12915223 NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP alpha-Tocopherol results in increased expression of ORM1 mRNA; alpha-Tocopherol results in increased expression of ORM1 protein CTD PMID:19000923 PMID:20025956 NCBI chr 4:63,262,793...63,266,400
Ensembl chr 4:63,262,797...63,266,400
JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Rotenone affects the localization of PARK7 protein] CTD PMID:16439141 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein]
alpha-Tocopherol inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]
CTD PMID:14645110 PMID:24448832 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator multiple interactions ISO alpha-Tocopherol inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR mRNA]; alpha-Tocopherol inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR protein] CTD PMID:10428045 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101
JBrowse link
G Pax3 paired box 3 multiple interactions
increases expression
EXP alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of PAX3 mRNA]
alpha-Tocopherol results in increased expression of PAX3 mRNA
CTD PMID:12739027 NCBI chr 1:78,077,904...78,173,773
Ensembl chr 1:78,077,904...78,173,771
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic decreases expression ISO alpha-Tocopherol results in decreased expression of PCK1 mRNA CTD PMID:11597575 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein] CTD PMID:22389237 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein CTD PMID:23859036 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] CTD PMID:18603805 NCBI chr  X:105,230,706...105,247,305
Ensembl chr  X:105,230,706...105,247,305
JBrowse link
G Plg plasminogen multiple interactions ISO alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]; alpha-Tocopherol inhibits the reaction [Humic Substances results in decreased activity of PLG protein] CTD PMID:11419606 NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272
JBrowse link
G Pltp phospholipid transfer protein decreases abundance EXP PLTP mutant form results in decreased abundance of alpha-Tocopherol CTD PMID:16675720 NCBI chr 2:164,681,441...164,699,564
Ensembl chr 2:164,681,438...164,699,631
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
ISO
EXP
alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of PPARA mRNA]
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of PPARA mRNA]
alpha-Tocopherol results in increased expression of PPARA mRNA
CTD PMID:17936189 PMID:29065513 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
multiple interactions
increases activity
ISO alpha-Tocopherol results in increased expression of PPARG mRNA; alpha-Tocopherol results in increased expression of PPARG protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein]
alpha-Tocopherol results in increased activity of PPARG protein
CTD PMID:11752099 PMID:14521714 PMID:19083475 PMID:22389237 PMID:28062356 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppia peptidylprolyl isomerase A increases expression ISO alpha-Tocopherol results in increased expression of PPIA mRNA CTD PMID:16908007 NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817
JBrowse link
G Prl2c3 prolactin family 2, subfamily c, member 3 increases expression EXP alpha-Tocopherol results in increased expression of PRL2C3 protein CTD PMID:20025956 NCBI chr13:12,805,705...12,814,982
Ensembl chr13:12,805,705...12,814,968
JBrowse link
G Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 multiple interactions EXP alpha-Tocopherol inhibits the reaction [AGT protein results in increased expression of PSMC6 protein] CTD PMID:17532611 NCBI chr14:45,567,285...45,587,150
Ensembl chr14:45,567,245...45,587,162
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity
multiple interactions
ISO alpha-Tocopherol metabolite results in decreased activity of PTGS2 protein; alpha-Tocopherol results in decreased activity of PTGS2 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein]
CTD PMID:15225597 PMID:22389237 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) affects localization
multiple interactions
ISO alpha-Tocopherol affects the localization of RELA protein
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased localization of RELA protein]; alpha-Tocopherol affects the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [RELA protein binds to NFKB1 protein]]
alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD PMID:15025948 PMID:16135673 PMID:16882165 PMID:17936189 PMID:26270818 More... NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO alpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of RPS6 protein] CTD PMID:22343715 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [Tretinoin co-treated with alpha-Tocopherol co-treated with Okadaic Acid] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with alpha-Tocopherol] results in decreased phosphorylation of RXRA protein CTD PMID:15225641 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of SELE protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:12566129 PMID:25551565 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 multiple interactions ISO alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein] CTD PMID:34310962 NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions ISO [alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 mRNA; [alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 protein CTD PMID:24530478 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions ISO [alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of SLPI protein CTD PMID:36372912 NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO SMAD4 results in decreased susceptibility to [Fluorouracil co-treated with alpha-Tocopherol] CTD PMID:20562578 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851
JBrowse link
G Snca synuclein, alpha multiple interactions ISO alpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:16439141 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
increases expression
ISO [alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of SOD1 protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein]
alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of SOD1 protein]
alpha-Tocopherol results in increased expression of SOD1 mRNA; alpha-Tocopherol results in increased expression of SOD1 protein
CTD PMID:19083475 PMID:20194575 PMID:21344382 PMID:22732938 PMID:26365763 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases expression
increases expression
multiple interactions
ISO alpha-Tocopherol results in decreased expression of SOD2 protein
alpha-Tocopherol results in increased expression of SOD2 mRNA; alpha-Tocopherol results in increased expression of SOD2 protein
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein]
CTD PMID:16135673 PMID:18942769 PMID:20194575 PMID:22732938 PMID:23859036 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Srsf2 serine and arginine-rich splicing factor 2 decreases expression ISO alpha-Tocopherol deficiency results in decreased expression of SRSF2 protein CTD PMID:15247049 NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of STAR mRNA] CTD PMID:32134168 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO alpha-Tocopherol results in increased expression of STAT3 mRNA CTD PMID:16908007 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased activity of TERT protein] CTD PMID:20112180 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962
JBrowse link
G Tgfa transforming growth factor alpha decreases response to substance ISO alpha-Tocopherol results in decreased susceptibility to TGFA protein CTD PMID:7593635 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO alpha-Tocopherol inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]
alpha-Tocopherol results in decreased expression of TGFB1 mRNA
CTD PMID:9608545 PMID:14732287 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein; alpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:15790535 PMID:25891525 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
decreases response to substance
decreases expression
ISO
EXP
[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]]; alpha-Tocopherol promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased secretion of TNF protein]
alpha-Tocopherol affects the expression of TNF protein
alpha-Tocopherol results in decreased susceptibility to TNF protein
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of TNF mRNA]]; alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of TNF mRNA]
alpha-Tocopherol results in decreased expression of TNF protein
CTD PMID:10588948 PMID:11805214 PMID:12195823 PMID:15025948 PMID:15630180 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trf transferrin multiple interactions ISO [alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of TF protein CTD PMID:36372912 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 mRNA]; alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 protein] CTD PMID:12126965 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of TXN1 protein] CTD PMID:21344382 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA] CTD PMID:22389237 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of VCAM1 protein]; alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of VCAM1 protein] CTD PMID:12566129 PMID:22313677 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO alpha-Tocopherol analog results in increased expression of XBP1 mRNA CTD PMID:20686688 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link
G Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 multiple interactions ISO alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA] CTD PMID:26332274 NCBI chr15:81,868,805...81,924,286
Ensembl chr15:81,872,036...81,924,286
JBrowse link
G Yy1 YY1 transcription factor multiple interactions ISO alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein] CTD PMID:34310962 NCBI chr12:108,758,841...108,786,074
Ensembl chr12:108,758,899...108,786,074
JBrowse link
beta-tocopherol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]
beta-Tocopherol affects the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; beta-Tocopherol affects the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein]
CTD PMID:12450566 PMID:22389237 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA] CTD PMID:22389237 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] CTD PMID:22389237 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] CTD PMID:22389237 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA] CTD PMID:22389237 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA] CTD PMID:22389237 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein] CTD PMID:22389237 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein] CTD PMID:22389237 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein] CTD PMID:22389237 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein] CTD PMID:22389237 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein] CTD PMID:22389237 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein] CTD PMID:22389237 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA] CTD PMID:22389237 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
JBrowse link
delta-tocopherol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein] CTD PMID:22389237 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Crabp2 cellular retinoic acid binding protein II multiple interactions ISO [Tretinoin co-treated with delta-tocopherol] results in increased expression of CRABP2 mRNA CTD PMID:15225641 NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA] CTD PMID:22389237 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] CTD PMID:22389237 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] CTD PMID:22389237 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA] CTD PMID:22389237 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA] CTD PMID:22389237 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein] CTD PMID:22389237 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein] CTD PMID:22389237 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein] CTD PMID:22389237 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein] CTD PMID:22389237 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein] CTD PMID:22389237 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein] CTD PMID:22389237 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA] CTD PMID:22389237 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
JBrowse link
gamma-tocopherol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases activity
multiple interactions
ISO Tocopherols results in decreased activity of ABCC1 protein
Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]
CTD PMID:15617835 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Alb albumin multiple interactions ISO gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA] CTD PMID:19389874 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G App amyloid beta precursor protein decreases abundance
multiple interactions
ISO APP protein modified form results in decreased abundance of Tocopherols
resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols]
CTD PMID:25654502 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Ar androgen receptor decreases activity
decreases expression
ISO Tocopherols results in decreased activity of AR protein
[Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of AR mRNA; Tocopherols results in decreased expression of AR protein
CTD PMID:12032296 PMID:16302272 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Arf3 ADP-ribosylation factor 3 increases expression EXP Tocopherols results in increased expression of ARF3 mRNA CTD PMID:17654050 NCBI chr15:98,635,505...98,660,999
Ensembl chr15:98,634,515...98,661,095
JBrowse link
G Aspm abnormal spindle microtubule assembly increases expression EXP Tocopherols results in increased expression of ASPM mRNA CTD PMID:17056531 NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide increases expression EXP Tocopherols results in increased expression of ATP1A2 mRNA CTD PMID:17654050 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
JBrowse link
G Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide increases expression EXP Tocopherols results in increased expression of ATP1B2 mRNA CTD PMID:17654050 NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768
JBrowse link
G Aurka aurora kinase A increases expression EXP Tocopherols results in increased expression of AURKA mRNA CTD PMID:17056531 NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455
JBrowse link
G Bax BCL2-associated X protein increases response to substance
increases expression
multiple interactions
ISO BAX protein results in increased susceptibility to Tocopherols
gamma-Tocopherol results in increased expression of BAX mRNA
[Fluorouracil co-treated with gamma-Tocopherol] results in increased expression of BAX mRNA
CTD PMID:16001965 PMID:31587439 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression
multiple interactions
decreases expression
decreases response to substance
EXP
ISO
Tocopherols results in increased expression of BCL2 mRNA; Tocopherols results in increased expression of BCL2 protein
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of BCL2 mRNA
gamma-Tocopherol results in decreased expression of BCL2 mRNA
BCL2 protein results in decreased susceptibility to Tocopherols
CTD PMID:8970189 PMID:16001965 PMID:31587439 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases response to substance ISO BCL2L1 protein results in decreased susceptibility to Tocopherols CTD PMID:16001965 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression EXP Tocopherols results in increased expression of BIRC5 mRNA CTD PMID:17056531 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma increases expression EXP Tocopherols results in increased expression of CAMK2G mRNA CTD PMID:17654050 NCBI chr14:20,784,943...20,844,225
Ensembl chr14:20,784,943...20,844,156
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO gamma-Tocopherol results in increased activity of CASP3 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]
thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein]
CTD PMID:15596715 PMID:22389237 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 increases activity ISO gamma-Tocopherol results in increased activity of CASP9 protein CTD PMID:15596715 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase increases expression EXP gamma-Tocopherol results in increased expression of CAT protein CTD PMID:19115203 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccnb2 cyclin B2 increases expression EXP Tocopherols results in increased expression of CCNB2 mRNA CTD PMID:17056531 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO gamma-Tocopherol results in decreased expression of CCND1 mRNA; gamma-Tocopherol results in decreased expression of CCND1 protein; Tocopherols results in decreased expression of CCND1 protein
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCND1 mRNA
CTD PMID:12368234 PMID:12504091 PMID:31587439 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Tocopherols results in decreased expression of CCND3 protein CTD PMID:12504091 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions
ISO gamma-Tocopherol results in decreased expression of CCNE1 mRNA; gamma-Tocopherol results in decreased expression of CCNE1 protein; Tocopherols results in decreased expression of CCNE1 mRNA; Tocopherols results in decreased expression of CCNE1 protein
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCNE1 mRNA
CTD PMID:12368234 PMID:12504091 PMID:31587439 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Cdc6 cell division cycle 6 increases expression EXP Tocopherols results in increased expression of CDC6 mRNA CTD PMID:17056531 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
JBrowse link
G Cdk1 cyclin dependent kinase 1 increases expression EXP Tocopherols results in increased expression of CDK1 mRNA CTD PMID:17056531 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Tocopherols results in decreased expression of CDK2 protein CTD PMID:12504091 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk4 cyclin dependent kinase 4 multiple interactions ISO Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein CTD PMID:12504091 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Cdk5r1 cyclin dependent kinase 5, regulatory subunit 1 increases expression EXP Tocopherols results in increased expression of CDK5R1 mRNA CTD PMID:17654050 NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A decreases expression ISO gamma-Tocopherol results in decreased expression of CDKN1A protein CTD PMID:12368234 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B decreases expression ISO gamma-Tocopherol results in decreased expression of CDKN1B protein CTD PMID:12368234 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A decreases expression ISO gamma-Tocopherol results in decreased expression of CDKN2A protein CTD PMID:12368234 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Clec4e C-type lectin domain family 4, member e increases expression EXP Tocopherols results in increased expression of CLEC4E mRNA CTD PMID:17056531 NCBI chr 6:123,258,748...123,266,830
Ensembl chr 6:123,258,748...123,266,829
JBrowse link
G Cplx1 complexin 1 increases expression EXP Tocopherols results in increased expression of CPLX1 mRNA CTD PMID:17654050 NCBI chr 5:108,666,420...108,697,893
Ensembl chr 5:108,666,420...108,697,890
JBrowse link
G Cplx2 complexin 2 increases expression EXP Tocopherols results in increased expression of CPLX2 mRNA CTD PMID:17654050 NCBI chr13:54,455,447...54,531,736
Ensembl chr13:54,519,162...54,531,730
Ensembl chr13:54,519,162...54,531,730
JBrowse link
G Crabp2 cellular retinoic acid binding protein II multiple interactions ISO [Tretinoin co-treated with gamma-Tocopherol] results in increased expression of CRABP2 mRNA CTD PMID:15225641 NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683
JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO [alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein CTD PMID:18191645 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression EXP Tocopherols results in increased expression of CSF1R mRNA CTD PMID:17056531 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Tocopherols results in increased expression of CSRP2 mRNA CTD PMID:17056531 NCBI chr10:110,756,037...110,775,375
Ensembl chr10:110,755,650...110,775,483
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA] CTD PMID:22389237 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 increases expression EXP Tocopherols results in increased expression of DNAJC5 mRNA CTD PMID:17654050 NCBI chr 2:181,162,141...181,194,679
Ensembl chr 2:181,162,278...181,196,926
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Tocopherols results in increased expression of E2F1 protein CTD PMID:15883045 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G Egr1 early growth response 1 decreases activity ISO Tocopherols results in decreased activity of EGR1 protein CTD PMID:15878867 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein] CTD PMID:22389237 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA] CTD PMID:22389237 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide increases expression EXP Tocopherols results in increased expression of FCER1A mRNA CTD PMID:17056531 NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781
JBrowse link
G Fes feline sarcoma oncogene increases expression EXP Tocopherols results in increased expression of FES mRNA CTD PMID:17056531 NCBI chr 7:80,027,506...80,037,702
Ensembl chr 7:80,027,504...80,037,694
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Tocopherols results in decreased expression of FGF1 mRNA CTD PMID:15878867 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO Tocopherols results in decreased expression of FGF2 mRNA CTD PMID:15878867 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 decreases expression ISO Tocopherols results in decreased expression of FGFR1 mRNA CTD PMID:15144885 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
JBrowse link
G Fkbp9 FK506 binding protein 9 increases expression EXP Tocopherols results in increased expression of FKBP9 mRNA CTD PMID:17056531 NCBI chr 6:56,809,044...56,856,345
Ensembl chr 6:56,809,044...56,856,343
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression EXP Tocopherols results in increased expression of FOS mRNA; Tocopherols results in increased expression of FOS protein CTD PMID:8970189 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fpr-rs4 formyl peptide receptor, related sequence 4 increases expression EXP Tocopherols results in increased expression of FPR-RS4 mRNA CTD PMID:17056531 NCBI chr17:18,241,995...18,242,966
Ensembl chr17:18,241,995...18,242,966
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA] CTD PMID:22389237 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) increases expression EXP Tocopherols results in increased expression of GRIA2 mRNA CTD PMID:17654050 NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) increases expression EXP Tocopherols results in increased expression of GRIN1 mRNA CTD PMID:17654050 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 increases expression
multiple interactions
EXP
ISO
gamma-Tocopherol results in increased expression of GSTM1 mRNA; gamma-Tocopherol results in increased expression of GSTM1 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA]
CTD PMID:19115203 PMID:22389237 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases activity ISO Tocopherols results in decreased activity of GSTO1 protein CTD PMID:16781109 NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229
JBrowse link
G Haspin histone H3 associated protein kinase increases expression EXP Tocopherols results in increased expression of HASPIN mRNA CTD PMID:17056531 NCBI chr11:73,026,310...73,029,120
Ensembl chr11:73,026,311...73,029,120
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
gamma-Tocopherol results in increased expression of HMOX1 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]
CTD PMID:19115203 PMID:22389237 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Jun jun proto-oncogene increases expression EXP Tocopherols results in increased expression of JUN mRNA; Tocopherols results in increased expression of JUN protein CTD PMID:8970189 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kif20a kinesin family member 20A increases expression EXP Tocopherols results in increased expression of KIF20A mRNA CTD PMID:17056531 NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330
JBrowse link
G Kif4 kinesin family member 4 increases expression EXP Tocopherols results in increased expression of KIF4 mRNA CTD PMID:17056531 NCBI chr  X:99,669,693...99,770,878
Ensembl chr  X:99,669,343...99,770,820
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases response to substance ISO MCL1 protein results in decreased susceptibility to Tocopherols CTD PMID:16001965 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric multiple interactions ISO gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA] CTD PMID:19389874 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
JBrowse link
G Myc myelocytomatosis oncogene decreases activity
decreases expression
EXP Tocopherols results in decreased activity of MYC protein
Tocopherols results in decreased expression of MYC mRNA
CTD PMID:8970189 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Napb N-ethylmaleimide sensitive fusion protein attachment protein beta increases expression EXP Tocopherols results in increased expression of NAPB mRNA CTD PMID:17654050 NCBI chr 2:148,535,905...148,574,396
Ensembl chr 2:148,535,905...148,574,387
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
EXP
ISO
gamma-Tocopherol results in increased expression of NFE2L2 mRNA; gamma-Tocopherol results in increased expression of NFE2L2 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]
CTD PMID:19115203 PMID:22389237 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein] CTD PMID:22389237 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nsf N-ethylmaleimide sensitive fusion protein increases expression EXP Tocopherols results in increased expression of NSF mRNA CTD PMID:17654050 NCBI chr11:103,712,608...103,844,882
Ensembl chr11:103,712,608...103,844,882
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
ISO [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein]
Tocopherols results in decreased expression of PCNA
CTD PMID:17927505 PMID:22389237 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
multiple interactions
ISO gamma-Tocopherol results in increased expression of PPARG mRNA; gamma-Tocopherol results in increased expression of PPARG protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein]
CTD PMID:14521714 PMID:22389237 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform increases expression EXP Tocopherols results in increased expression of PPP3CA mRNA CTD PMID:17654050 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488
JBrowse link
G Prtn3 proteinase 3 increases expression EXP Tocopherols results in increased expression of PRTN3 mRNA CTD PMID:17056531 NCBI chr10:79,715,499...79,719,008
Ensembl chr10:79,710,310...79,719,008
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity
multiple interactions
ISO gamma-Tocopherol results in decreased activity of PTGS2 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein]
CTD PMID:15225597 PMID:22389237 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptpro protein tyrosine phosphatase receptor type O increases expression EXP Tocopherols results in increased expression of PTPRO mRNA CTD PMID:17056531 NCBI chr 6:137,229,189...137,440,251
Ensembl chr 6:137,229,317...137,440,231
JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression EXP Tocopherols results in increased expression of RAB11B mRNA CTD PMID:17654050 NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504
JBrowse link
G Rab3a RAB3A, member RAS oncogene family increases expression EXP Tocopherols results in increased expression of RAB3A mRNA CTD PMID:17654050 NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323
JBrowse link
G Rab6b RAB6B, member RAS oncogene family increases expression EXP Tocopherols results in increased expression of RAB6B mRNA CTD PMID:17654050 NCBI chr 9:102,988,866...103,062,475
Ensembl chr 9:102,988,986...103,062,475
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Tocopherols results in decreased phosphorylation of RB1 protein CTD PMID:12504091 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Rrm1 ribonucleotide reductase M1 increases expression EXP Tocopherols results in increased expression of RRM1 mRNA CTD PMID:17056531 NCBI chr 7:102,090,902...102,118,978
Ensembl chr 7:102,090,902...102,118,978
JBrowse link
G Rrm2 ribonucleotide reductase M2 increases expression EXP Tocopherols results in increased expression of RRM2 mRNA CTD PMID:17056531 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
JBrowse link
G Snca synuclein, alpha increases expression EXP Tocopherols results in increased expression of SNCA mRNA CTD PMID:17654050 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sncb synuclein, beta increases expression EXP Tocopherols results in increased expression of SNCB mRNA CTD PMID:17654050 NCBI chr13:54,906,673...54,914,435
Ensembl chr13:54,906,673...54,914,408
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression EXP gamma-Tocopherol results in increased expression of SOD1 protein CTD PMID:19115203 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Stx1a syntaxin 1A (brain) increases expression EXP Tocopherols results in increased expression of STX1A mRNA CTD PMID:17654050 NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954
JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression EXP Tocopherols results in increased expression of STXBP1 mRNA CTD PMID:17654050 NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a increases expression EXP Tocopherols results in increased expression of SV2A mRNA CTD PMID:17654050 NCBI chr 3:96,088,543...96,102,499
Ensembl chr 3:96,088,467...96,102,837
JBrowse link
G Syn1 synapsin I increases expression EXP Tocopherols results in increased expression of SYN1 mRNA CTD PMID:17654050 NCBI chr  X:20,726,750...20,787,157
Ensembl chr  X:20,726,750...20,787,243
JBrowse link
G Syn2 synapsin II increases expression EXP Tocopherols results in increased expression of SYN2 mRNA CTD PMID:17654050 NCBI chr 6:115,111,863...115,259,587
Ensembl chr 6:115,111,863...115,258,967
JBrowse link
G Syngr1 synaptogyrin 1 increases expression EXP Tocopherols results in increased expression of SYNGR1 mRNA CTD PMID:17654050 NCBI chr15:79,975,537...80,003,702
Ensembl chr15:79,975,535...80,003,702
JBrowse link
G Syp synaptophysin increases expression EXP Tocopherols results in increased expression of SYP mRNA CTD PMID:17654050 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495
JBrowse link
G Syt11 synaptotagmin XI increases expression EXP Tocopherols results in increased expression of SYT11 mRNA CTD PMID:17654050 NCBI chr 3:88,652,006...88,682,466
Ensembl chr 3:88,652,007...88,682,471
JBrowse link
G Syt13 synaptotagmin XIII increases expression EXP Tocopherols results in increased expression of SYT13 mRNA CTD PMID:17654050 NCBI chr 2:92,745,446...92,786,403
Ensembl chr 2:92,745,443...92,786,403
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein
Tocopherols inhibits the reaction [TNF protein results in decreased export of Potassium]
CTD PMID:17337591 PMID:18191645 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfaip2 tumor necrosis factor, alpha-induced protein 2 increases expression EXP Tocopherols results in increased expression of TNFAIP2 mRNA CTD PMID:17056531 NCBI chr12:111,408,898...111,421,452
Ensembl chr12:111,408,903...111,421,452
JBrowse link
G Trp53 transformation related protein 53 increases activity ISO Tocopherols results in increased activity of TP53 protein CTD PMID:15883045 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 increases expression EXP Tocopherols results in increased expression of TTC3 mRNA CTD PMID:17654050 NCBI chr16:94,171,479...94,270,081
Ensembl chr16:94,171,477...94,270,202
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression
multiple interactions
EXP
ISO
gamma-Tocopherol results in increased expression of UGT1A1 mRNA
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]
CTD PMID:19115203 PMID:22389237 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
JBrowse link
G Vamp1 vesicle-associated membrane protein 1 increases expression EXP Tocopherols results in increased expression of VAMP1 mRNA CTD PMID:17654050 NCBI chr 6:125,192,544...125,199,269
Ensembl chr 6:125,192,514...125,222,927
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 increases expression EXP Tocopherols results in increased expression of VAMP2 mRNA CTD PMID:17654050 NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor increases expression ISO Tocopherols results in increased expression of VDR mRNA CTD PMID:12032296 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      chemical role 21425
        antioxidant 16416
          tocol 270
            tocopherol 245
              (2R)-2,5,8-Trimethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol 0
              13'-Carboxy-gamma-tocopherol 0
              13'-carboxy-alpha-tocopherol 0
              2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol 0
              2,5,8-Trimethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol 0
              alpha-tocopherol + 177
              beta-tocopherol 13
              dehydro-gamma-tocopherol 0
              delta-tocopherol 14
              gamma-tocopherol + 99
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21921
                        carbon atom 21847
                          organic molecular entity 21847
                            organic molecule 21664
                              organic cyclic compound 21273
                                organic heterocyclic compound 20345
                                  oxacycle 18875
                                    benzopyran 12213
                                      1-benzopyran 11970
                                        chromanes 4038
                                          chromanol 1875
                                            chroman-6-ol 1875
                                              tocol 270
                                                tocopherol 245
                                                  (2R)-2,5,8-Trimethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol 0
                                                  13'-Carboxy-gamma-tocopherol 0
                                                  13'-carboxy-alpha-tocopherol 0
                                                  2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol 0
                                                  2,5,8-Trimethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol 0
                                                  alpha-tocopherol + 177
                                                  beta-tocopherol 13
                                                  dehydro-gamma-tocopherol 0
                                                  delta-tocopherol 14
                                                  gamma-tocopherol + 99
paths to the root