Prtn3 (proteinase 3) - Rat Genome Database

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Gene: Prtn3 (proteinase 3) Mus musculus
Analyze
Symbol: Prtn3
Name: proteinase 3
RGD ID: 1312602
MGI Page MGI
Description: Predicted to enable enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including mature conventional dendritic cell differentiation; membrane protein ectodomain proteolysis; and neutrophil extravasation. Predicted to act upstream of or within collagen catabolic process. Predicted to be located in azurophil granule lumen; cytosol; and plasma membrane raft. Predicted to be active in extracellular space. Predicted to colocalize with plasma membrane. Is expressed in early conceptus and liver. Orthologous to human PRTN3 (proteinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mP; mPR3; myeloblastin; P; PR-3; PR3
RGD Orthologs
Human
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,715,499 - 79,719,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,710,310 - 79,719,008 (+)EnsemblGRCm39 Ensembl
GRCm381079,879,667 - 79,883,174 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,874,476 - 79,883,174 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,342,412 - 79,345,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,282,796 - 79,286,303 (+)NCBIMGSCv36mm8
Celera1080,894,480 - 80,897,987 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9187364   PMID:9211743   PMID:9611252   PMID:9925946   PMID:10037495   PMID:10051312   PMID:11290610   PMID:12189154   PMID:14610273   PMID:15150076   PMID:15919778   PMID:16182289  
PMID:18023421   PMID:18166659   PMID:18568075   PMID:19494315   PMID:19833730   PMID:20015271   PMID:21160041   PMID:21464320   PMID:21677750   PMID:21873635   PMID:22213227   PMID:22270365  
PMID:22844112   PMID:25092677   PMID:25180606   PMID:25331958   PMID:25397578   PMID:26185250   PMID:26436651   PMID:27261776   PMID:30392974   PMID:32002713   PMID:32403136   PMID:36944270  
PMID:37463581  


Genomics

Comparative Map Data
Prtn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,715,499 - 79,719,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,710,310 - 79,719,008 (+)EnsemblGRCm39 Ensembl
GRCm381079,879,667 - 79,883,174 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,874,476 - 79,883,174 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,342,412 - 79,345,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,282,796 - 79,286,303 (+)NCBIMGSCv36mm8
Celera1080,894,480 - 80,897,987 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
PRTN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819840,999 - 848,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19840,999 - 848,175 (+)EnsemblGRCh38hg38GRCh38
GRCh3719840,999 - 848,175 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619791,985 - 799,175 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419791,964 - 799,051NCBI
Celera19766,135 - 773,326 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19610,181 - 617,038 (+)NCBIHuRef
CHM1_119840,583 - 847,665 (+)NCBICHM1_1
T2T-CHM13v2.019796,963 - 804,283 (+)NCBIT2T-CHM13v2.0
Prtn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,472,750 - 10,482,037 (-)NCBIGRCr8
mRatBN7.279,822,123 - 9,831,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,822,122 - 9,831,944 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,702,828 - 12,706,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,580,909 - 14,584,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,440,584 - 12,444,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,643,712 - 12,646,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,643,516 - 12,646,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,813,238 - 12,822,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,334,722 - 11,338,559 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,334,722 - 11,338,559 (-)NCBI
Celera77,997,078 - 8,000,317 (-)NCBICelera
Cytogenetic Map7q11NCBI
PRTN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,171,167 - 5,180,414 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,409,659 - 4,418,867 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019283,314 - 291,504 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119810,237 - 817,588 (+)NCBIpanpan1.1PanPan1.1panPan2
PRTN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,520,314 - 77,523,563 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,520,314 - 77,526,303 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,472,358 - 77,477,327 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRTN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16590,193 - 598,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660818,318,743 - 8,324,146 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prtn3
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1227
Count of miRNA genes:536
Interacting mature miRNAs:641
Transcripts:ENSMUST00000006679, ENSMUST00000163188, ENSMUST00000164134, ENSMUST00000165982, ENSMUST00000166201, ENSMUST00000171489
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse

Markers in Region
Prtn3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381079,881,097 - 79,881,175UniSTSGRCm38
MGSCv371079,343,842 - 79,343,920UniSTSGRCm37
Celera1080,895,910 - 80,895,988UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
U97073  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381079,883,019 - 79,883,128UniSTSGRCm38
MGSCv371079,345,764 - 79,345,873UniSTSGRCm37
Celera1080,897,832 - 80,897,941UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
Whitehead/MRC_RH10916.63UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000006679   ⟹   ENSMUSP00000006679
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,715,448 - 79,719,008 (+)Ensembl
GRCm38.p6 Ensembl1079,879,614 - 79,883,174 (+)Ensembl
RefSeq Acc Id: ENSMUST00000163188
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,710,310 - 79,718,875 (+)Ensembl
GRCm38.p6 Ensembl1079,874,476 - 79,883,041 (+)Ensembl
RefSeq Acc Id: ENSMUST00000164134
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,716,838 - 79,718,223 (+)Ensembl
GRCm38.p6 Ensembl1079,881,004 - 79,882,389 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165982
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,716,814 - 79,719,008 (+)Ensembl
GRCm38.p6 Ensembl1079,880,980 - 79,883,174 (+)Ensembl
RefSeq Acc Id: ENSMUST00000166201   ⟹   ENSMUSP00000129585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,716,876 - 79,718,678 (+)Ensembl
GRCm38.p6 Ensembl1079,881,042 - 79,882,844 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171489
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,717,617 - 79,718,714 (+)Ensembl
GRCm38.p6 Ensembl1079,881,783 - 79,882,880 (+)Ensembl
RefSeq Acc Id: NM_011178   ⟹   NP_035308
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,715,499 - 79,719,008 (+)NCBI
GRCm381079,879,667 - 79,883,174 (+)ENTREZGENE
MGSCv371079,342,412 - 79,345,919 (+)RGD
Celera1080,894,480 - 80,897,987 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035308   ⟸   NM_011178
- Peptide Label: precursor
- UniProtKB: O08809 (UniProtKB/Swiss-Prot),   Q61096 (UniProtKB/Swiss-Prot),   A0A0R4IZY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000006679   ⟸   ENSMUST00000006679
RefSeq Acc Id: ENSMUSP00000129585   ⟸   ENSMUST00000166201
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61096-F1-model_v2 AlphaFold Q61096 1-254 view protein structure

Promoters
RGD ID:8672566
Promoter ID:EPDNEW_M14314
Type:multiple initiation site
Name:Prtn3_1
Description:Mus musculus proteinase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14315  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381079,879,665 - 79,879,725EPDNEW
RGD ID:8672568
Promoter ID:EPDNEW_M14315
Type:initiation region
Name:Prtn3_2
Description:Mus musculus proteinase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14314  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381079,880,993 - 79,881,053EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:893580 AgrOrtholog
Ensembl Genes ENSMUSG00000057729 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006679 ENTREZGENE
  ENSMUST00000006679.15 UniProtKB/TrEMBL
  ENSMUST00000166201.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19152 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:893580 ENTREZGENE
NCBI Gene 19152 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYELOBLASTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prtn3 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4IZY6 ENTREZGENE, UniProtKB/TrEMBL
  B6ZCE5_MOUSE UniProtKB/TrEMBL
  F6ZK01_MOUSE UniProtKB/TrEMBL
  O08809 ENTREZGENE
  PRTN3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O08809 UniProtKB/Swiss-Prot